BALLYA Sildenafil Test is manufactured by BALLYA, it’s rapid test for detection the content of sildenafil in grains, food and seafood, especially in grains and food.
Lateral flow assay test base on the gold immunochromatography assay technology.
Sildenafil is a white crystalline powder. It is a drug for the treatment of male erectile dysfunction accidentally invented during the development of drugs for the treatment of cardiovascular diseases. It is generally known by its commercial name Viagra.
Sildenafil is a selective inhibitor of cyclic guanosine phosphate (cGMP) specific type 5 phosphodiesterase (PDE5), and is an oral drug for the treatment of ED.
Sildenafil has no direct relaxation effect on the isolated human sponge, but it can enhance the effect of nitric oxide by inhibiting the decomposition of cGMP by PDE5 in the sponge. When sexual stimulation causes local nitric oxide release, sildenafil inhibits PDE5, increases cGMP levels in the cavernous body, relaxes the smooth muscle of the cavernous body, and blood flows into the cavernous body.
Common adverse reactions include headache, dizziness, facial flushing, indigestion, nasal congestion, and visual abnormalities. This abnormality may manifest as abnormal blue/green color discrimination, increased light perception, or blurred vision.
More serious adverse reactions also include: decreased supine blood pressure and decreased cardiac output. In addition, clinical studies have shown that having sex after taking sildenafil increases the risk of heart abnormalities, including symptoms such as angina, dizziness, and nausea, and it may cause sudden cardiac death.
(1) When combined with CYP450 3A4 enzyme inhibitors (such as ketoconazole, itraconazole,
erythromycin) and CYP450 non-specific inhibitors (such as cimetidine), the AUC of sildenafil increases and The clearance rate is reduced.
(2) When combined with HIV protease inhibitors [such as saquinavir, ritonavir (Ritonavir)], the cmax and AUC of sildenafil are increased, while saquinavir and ritonavir are drugs at steady state Kinetics is not affected.
(3) Combined use with loop diuretics, potassium-sparing diuretics and non-selective beta blockers can increase the AUC of the active metabolite of sildenafil (N-desmethylsildenafil) by 62 % And 102%, but this effect has no clinical significance.
(4) Co-administration with CYP4503A4 inducers (such as
rifampicin) may reduce sildenafil plasma levels.
(5) When combined with CYP450 2C9 inhibitors (such as tolbutamide, warfarin), no obvious interaction was seen.
(6) With CYP450 2D6 enzyme inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazides and thiazide diuretics, angiotensin converting enzyme inhibitors, calcium channels Combination of blockers, etc. has no effect on the pharmacokinetics of sildenafil.
BALLYA Sildenafil Test, 25 cassettes
Sample Buffer, 1 vial
Mini
Pipette (optional)
Disposable micropipette tips (optional)
Kit Instruction, 1pcs
BALLYA Sildenafil Test is suitable for the detection of sildenafil residues in grain, food and seafood. Simple operation, high accuracy and short detection time are the characteristics of this product.
It can be widely used in food and drug administration, health departments, higher education institutions, scientific research institutes, agricultural departments, animal husbandry and veterinarians, breeding farms, slaughterhouses, food and meat products deep processing enterprises, inspection and quarantine departments and other units.
