Amoxicilina is one of the most commonly used semi-synthetic penicillin broad-spectrum beta lactam antibiotics. It is a white powder with a half-life of approximately 61.3 minutes. It is stable under acidic conditions, and the gastrointestinal absorption rate reaches 90%. Amoxicilina has a strong bactericidal effect and a strong ability to penetrate cell membranes.
Amoxicilina is currently one of the most widely used oral semi-synthetic penicillins. Its preparations include capsules, tablets, granules, dispersible tablets, etc., and are often combined with clavulanic acid to make dispersible tablets. Amoxicilina and clavulanate potassium is suitable for lower respiratory tract infections, otitis media, and sinusitis caused by beta lactamase producing Haemophilus influenzae and Moraxella catarrhalis.
The product is white or almost white crystalline powder; the taste is slightly bitter. Amoxicilina is slightly soluble in water and almost insoluble in ethanol.
Amoxicilina has a strong bactericidal effect and a strong ability to penetrate cell walls. It is one of the most widely used oral penicillins, and its preparations include capsules, tablets, granules, dispersible tablets and so on. Patients with penicillin allergy and penicillin skin test positive should be kept from this medicine.
Amoxicilina is a semi-synthetic broad-spectrum penicillin. Its antibacterial spectrum and antibacterial activity are basically the same as ampicillin, but its acid resistance is stronger than ampicillin, and its bactericidal effect is stronger and faster than the latter, but it cannot be used for the treatment of meningitis. The half-life is approximately 61.3 minutes. Amoxicilina is stable under acidic conditions, with a gastrointestinal absorption rate of 90%. It is absorbed more quickly and completely than ampicillin. It has similar effects except for Shigella that is less effective than ampicillin.
Amoxicilina has a strong bactericidal effect and a strong ability to penetrate cell walls. After oral administration, the lactam group in the drug molecule is immediately hydrolyzed to form a peptide bond, which is quickly combined with the transpeptidase in the bacteria to inactivate it, cutting off the only way that the bacteria rely on the transpeptidase to synthesize glycopeptides to build the cell wall, making the bacteria cells quickly become spherical bodies and rupture and dissolve, and the bacteria eventually swell and die due to the loss of the cell wall and the continuous penetration of water.
It has strong antibacterial and bactericidal effects on most pathogenic G+ bacteria and G-bacteria (including cocci and bacilli). Among them, amoxicilina has good antibacterial activity towards Streptococcus pneumoniae, Streptococcus hemolyticus, aerobic gram-positive cocci such as Staphylococcus faecalis and Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic gram-negative bacteria that do not produce beta lactamase and Helicobacter pylori. Hemodialysis can remove some drugs, but peritoneal dialysis has no effect on removing this product.
Amoxicilina can be used to treat typhoid fever, other Salmonella infections and typhoid carriers. The treatment of urinary tract infections caused by sensitive bacteria that do not produce beta lactamase has also achieved good results. For patients with lower urinary tract infections and non-enzyme-producing Neisseria gonorrhoeae urethritis and cervicitis, a single oral dose of 3 g is sufficient to obtain satisfactory results.
Ear, nose, throat infections, respiratory tract infections and skin and soft tissue infections caused by Streptococcus pneumoniae, Staphylococcus aureus which does not produce penicillinase, Streptococcus hemolyticus and Haemophilus influenzae which does not produce β-lactamase are all indications. Leptospirosis can also use amoxicillin. This product can also be used for urogenital infections caused by sensitive Escherichia coli, Proteus mirabilis and Enterococcus faecalis. This product, combined with clarithromycin and lansoprazole, has a good effect on the treatment of Helicobacter pylori infection.
Adults and children weighing more than 40 kg take 1 to 2 capsules (0.25 ~ 0.5 g) each time, once every 6 to 8 hours, and the daily dose does not exceed 4 g (16 capsules); children weighing less than 40 kg should weigh 20 ~ 40mg/kg/day, taken in 2 to 3 times; 30mg/kg/day for infants under three months of age, taken in divided doses, once every 12 hours; patients with severe renal impairment need to adjust the dosage. People with 10~30ml/kg endogenous creatinine clearance rate take 0.25-0.5g every 12 hours. This product can be taken on an empty stomach or after meals, and can be taken with milk and other foods. Patients with Neisserial gonococcal urethritis can take orally 3g once.
Animal reproduction experiments showed that amoxicillin at 10 times the human dose did not harm the fertility and fetus of rats and mice. However, there is still a lack of adequate controlled studies in humans. Since animal reproduction tests cannot fully predict human response, pregnant women should only use this product when it is really necessary. Since a small amount of amoxicillin can be secreted in breast milk, and it may cause allergies to the baby.
Amoxicilina is not an anti-inflammatory drug, but a semi-synthetic penicillin antibiotic commonly used clinically. It has a strong antibacterial effect and is widely used in clinical practice. It is compatible with omeprazole, ranitidine and erythromycin. The combined use of drugs such as Helicobacter pylori, peptic ulcer, gastric ulcer, endocarditis, chronic bronchitis and other diseases has high application value and good curative effect, and can significantly improve the clinical symptoms of patients and relieve their pain.
However, as an antibiotic, after use, it will cause patients to have convulsions, dizziness, blurred vision, anemia and other adverse reactions, which will have a certain impact on the treatment effect. Therefore, you must consult a doctor when you need to take the medicine, never prescribe the medicine yourself, and be sure to follow the doctor's advice when using it.
The national health department stipulates that a penicillin skin test must be performed before using amoxicillin, and those with a positive reaction are not allowed to use it. In addition, penicillin sodium and penicillin potassium are also penicillin antibiotics, and skin tests must be done before use. If it is inconvenient to do a skin test, you can take one-third of a capsule first. If there is no adverse reaction, you can take it normally. If you feel unwell, go to the hospital as soon as possible.
Amoxicillin has a variety of dosage forms, including injections, capsules, tablets, granules, etc. However, no matter which dosage form, it has high requirements for the storage environment. It should be shaded, sealed, and stored in a cool, dark and dry place. Even if the storage conditions are appropriate, chemical changes such as decomposition and polymerization of amoxicillin may still occur during storage, forming new allergic substances. In the hot and humid season, the rate of deterioration and failure will accelerate.
In addition, amoxicillin and aminoglycoside drugs (such as gentamicin, kanamycin), ciprofloxacin, pefloxacin and other drugs are contraindicated and cannot be placed in the same container. The use of amoxicillin capsules must be in accordance with the doctor's advice. Taking it as a family medicine by yourself is blind and dangerous. In the process of taking amoxicillin, if allergic reactions such as rashes occur, or serious adverse reactions of the digestive system, such as diarrhea, vomiting, etc., the drug must be stopped immediately.
Amoxicilina is a semi-synthetic penicillin antibiotic and is widely used. But because amoxicillin is also a kind of penicillin, the adverse reactions and precautions of penicillin are also applicable to amoxicillin.
BALLYA provides a betalactam test (amoxicillin belongs to beta lactam antibiotics) to tell you if there are beta lactams residues in dairy products you eat every day.