The Erythromycin Test is based on the Colloidal Gold Immunochromatography to detect the erythromycin residues in honey products. This kit can be applied for on-site rapid or lab testing by various departments.
Erythromycin is a class of antibacterial drugs with antibacterial effects. It is an antibiotic belonging to the class of macrolides. It is mainly used for a variety of infections, including respiratory infections, skin infections, as well as early syphilis, urogenital infections, oral Infection, etc. Its antibacterial spectrum is actually similar to penicillin. It has a strong inhibitory effect on Gram-positive bacteria like Staphylococcus, Streptococcus pyogenes, and Streptococcus pneumoniae. Bacillus also has a considerable inhibitory effect.
Erythromycin is an alkaline antibiotic produced by Streptomyces erythreus and belongs to macrolides.
2. Mechanism of action
Its mechanism of action is to penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site ("P" position), blocking the transfer of ribonucleic acid (tRNA) binding to the "P" position. Blocking the displacement of the polypeptide chain from the accepting position ("A" position) to the "P" position inhibits bacterial protein synthesis, thereby playing an antibacterial effect.
3. Erythromycin ophthalmic ointment
As an antibiotic ointment, erythromycin eye ointment was first used to treat trachoma, conjunctivitis, blepharitis, and external eye infections. There are other uses for erythromycin eye ointment.
A. Slight trauma: erythromycin ointment can be used for minor bruises, scratches, or other traumas. The general usage is to clean and disinfect the affected area, and then apply the appropriate amount of ointment to the affected area twice a day.
B. Mild burns: For small burns and scalds, first rinse the wound with cold water, then apply a thin layer of erythromycin ointment to the surface.
C. Mosquito bites: When the mosquito bites are serious, the bitten parts should be cleaned and disinfected in time, and the appropriate amount of this ointment should be applied and applied twice a day for 5-7 days.
D. Nosebleed: Apply erythromycin ointment to the nasal septum in an appropriate amount, 4-5 times a day. It can disinfect and soften the nasal cavity, moisturize the nasal mucosa, improve the internal environment of the nasal cavity, and prevent bleeding again. Do not apply too much to prevent the ointment from flowing back into the inlet.
E. Angular cheilitis: angular cheilitis is mostly caused by infection, more common in preschool children. For bacterial angular cheilitis, apply a small amount of erythromycin ointment while taking vitamin B2.
A. Common oral dosage: 1 ～ 2g per day, taken in 3 ～ 4 times. Legionnaires' disease: The daily dose can be increased to 2 ~ 4g, taken in 4 times.
B. Local administration: Treat trachoma, conjunctivitis, keratitis, apply an appropriate amount of ointment to the eyelid, several times a day.
C. Dose for renal insufficiency: patients with renal impairment generally do not need to reduce the dosage.
D. Children: Oral administration: 30 to 50 mg / kg daily, taken in 3 to 4 times.
E. Local administration: trachoma, conjunctivitis, keratitis, apply an appropriate amount of ointment to the eyelid several times a day.
F. Intravenous infusion: Adult: General dosage: 1 ～ 2g per day, divided into 2 ～ 4 times. Legionnaires' disease: 3 to 4g per day, divided into 4 doses. The high dose cannot exceed 4g. Children: 20 to 40 mg / kg per day, divided into 2 to 4 times.
The hazards of Erythromycin
Erythromycin can penetrate the placental barrier and enter breast milk, pregnant women and nursing women should be used with caution. Those who are allergic to macrolides. Common adverse reactions are gastrointestinal reactions, nausea, vomiting, stomach pain, diarrhea, mouth and tongue pain, loss of appetite, etc. The incidence is related to the dose. Can induce pseudomembranous enteritis.
Allergic reactions: various rashes, drug fever, eosinophilia, etc. There have been reports of 1 case of allergic purpura and renal failure. Esterified erythromycin can cause bile accumulating liver damage.
The application of high-dose erythromycin can occasionally cause tinnitus and temporary hearing impairment. Intravenous infusion medication can easily cause phlebitis.
Features of Erythromycin Test
1. 15min reading results
2. Detection limits respond to EU and US FDA norms
3. Neither professionals nor equipment required
4. Easy to operate and read
Detection Method of Erythromycin Test
The Erythromycin Test, based on colloidal gold competition method, is used for testing Erythromycin residues in honey sample and meets EU MRL. This kit can be applied for on-site testing by various departments.
Samples of Erythromycin Test
Samples include: honey
Detection Limit of Erythromycin Test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of Erythromycin Test
Erythromycin Test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.