Tylosin is a macrolide antibiotic obtained from the culture of Streptomyces fradiae in the United States in 1959. Tylosin is a white plate-like crystal, slightly soluble in water and alkaline.
2. Mechanism of action
The mechanism of action is mainly combined with the 50S subunit of the ribonucleosome, inhibiting the peptide acyltransferase, affecting the translocation process of the ribonucleosome, hindering the growth of the peptide chain, inhibiting the synthesis of bacterial proteins, and being a bacteriostatic agent.
3. Tylosin products
A. Tylosin injection
Properties: This product is yellow clear liquid.
Tylosin injection is used to treat pneumonia and bronchitis caused by Mycoplasma canis and Pasteurella and other infections in dogs and cats. The following allergic reactions may occur: redness, itchiness, rapid breathing, mild perianal edema, and prolapse of the anus. These symptoms will soon disappear. Adverse reactions:
Intravenous injection can cause tremor, dyspnea, and depression; equine animals can be lethal by injection. Tylosin can cause contact dermatitis by veterinarians.
B. Tylosin powder
Pharmacodynamics The antibacterial spectrum of this product is similar to erythromycin. It has a weak effect on bacteria and a strong effect on Mycoplasma. It is one of the drugs with the strongest effect on Mycoplasma among macrolides. Sensitive bacteria can develop resistance to this product, and Staphylococcus aureus has some cross-resistance to this product and erythromycin. This product is mainly used for the prevention and treatment of swine and poultry mycoplasma diseases, such as chronic respiratory disease of chicken and infectious sinusitis. It can also be used as a growth promoter for pigs.
It has special effect on mycoplasma and is used as the drug of first choice against mycoplasmal diseases, especially it has very high activity against Actinobacillus pleuropneumoniae.
4. Tylosin tartrate
This product belongs to special antibiotics for macrolide animals. Its mechanism of action mainly plays a sterilizing role by hindering the synthesis of bacterial proteins. This product is easily absorbed in the body, excreted quickly, and has no residue in the tissue. The positive bacteria and mycoplasma have special effects. In particular, it has very high activity against Actinobacillus pleuropneumoniae and is the first choice for the treatment of chronic respiratory diseases of livestock and poultry caused by Mycoplasma.
Mainly used for various respiratory tract, intestinal, reproductive and motor system infections caused by sensitive bacteria. Such as: Chronic respiratory disease of poultry, infectious rhinitis, avian balloonitis, infectious sinusitis, salpingitis, swine asthma, atrophic rhinitis, swine dysentery, gastroenteritis, swine erysipelas, mycoplasma arthritis, stubborn livestock Diarrhea, necrotizing enteritis embolism. It has a good effect on the secondary infection of mycoplasma in the outbreak of toxic diseases in livestock and poultry.
Tylosin veterinary medicine
1. Tylosin in dogs
Tylosin is antibacterial, anti-inflammatory, antipyretic and analgesic, and it is a good medicine for dogs and colds.
2. Tylosin honey
American beekeepers are deeply troubled by the larvae of American larvae (AFB). At present, they cannot solve the resistance of AFB bacteria to oxytetracycline. The researchers have not developed new and effective substitutes, and honey pollution will occur. The USDA Bee Research Laboratory has done a lot of work to find the best tylosin in the control of beauty and young diseases.
The US Food and Drug Administration approved it for the treatment of AFB, but it cannot be prevented in healthy bee colonies use. Although tylosin is better than oxytetracycline, if beekeepers use tylosin as a preventive drug and formulate tylosin in proportion to syrup to feed bees, the risk of honey contamination will increase.
A. Significant anti-mycoplasma (mycoplasma) effect It has a strong inhibitory effect on mycoplasma pleuropneumoniae and many other mycoplasmas, and is the drug of choice for infectious diseases of livestock mycoplasma.
B. Broad antibacterial spectrum Mainly has a strong inhibitory effect on a variety of Gram-positive (G +) bacteria, and also has some Gram-negative (G-) bacteria, Campylobacter (formerly belonged to Vibrio), spirochetes, and anticoccidial effect.
C. Absorb and excrete quickly Whether it is taken orally or injected, it can reach the effective bacteriostatic concentration in a short time (several to 10 minutes) and keep it for a certain period of time. After stopping the drug, it is quickly excreted from the body and has almost no residue in the tissue.
D. good diffusion ability It can penetrate into all organs, tissues and body fluids, especially through the serous membrane, blood brain, blood eye and blood testis barrier, which makes the tylosin clinical application range very wide.
E. Significant growth promoting effect The continuous low-dose tylosin feeding of livestock and poultry in the growing period can not only prevent diseases, but also significantly promote animal growth, shorten the growth cycle, and increase feed rewards.
F. Specificity of use Tylosin is a special antibiotic for livestock and poultry, which avoids the problem of cross-resistance that is common to human and animal antibiotics.
Features of Tylosin Test
1. 15min reading results
2. Detection limits respond to EU and US FDA norms
3. Neither professionals nor equipment required
4. Easy to operate and read
Detection Method of Tylosin Test
The Tylosin Test, based on colloidal gold competition method, is used for testing Tylosin residues in honey sample and meets EU MRL. This kit can be applied for on-site testing by various departments.
Samples of Tylosin Test
Samples include: honey
Detection Limit of Tylosin Test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of Tylosin Test
Tylosin Test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.