Chloramphenicol Test Fluorescence

Chloramphenicol antibiotics can act on the 50S subunit of bacterial ribonucleoproteins and hinder the synthesis of proteins.

Chloramphenicol antibiotics include chloramphenicol, sulfomycin, and odorless chloramphenicol.

Sulfomycin: This product is a methylsulfone derivative of chloramphenicol. It is a synthetic broad-spectrum antibacterial drug. Its antibacterial spectrum and antibacterial effect are basically similar to chloramphenicol. It mainly diffuses into bacterial cells and reversibly binds to the 50S of bacterial ribosomes On the subunit, the growth of the peptide chain is blocked (possibly inhibiting the effect of transpeptidase), the formation of the peptide chain is inhibited, and the synthesis of the protein is prevented, thereby playing an antibacterial effect.

Odorless chloramphenicol: Chloramphenicol palmitate has no bitter taste and is suitable for children to take orally. Chloramphenicol is gradually decomposed in the intestine after taking it, so it has a long-lasting effect. It has the same use as chloramphenicol and is only for oral use.

A variety of bacteria can develop resistance to chloramphenicol. Among them, E. coli, Shigella, and Proteus are more common, and typhoid and Staphylococcus are rare. Bacterial resistance to chloramphenicol is relatively slow. It may be caused by gradual mutation of chloramphenicol resistance gene, but it can disappear automatically.

Chloramphenicol reversibly binds to the 50S subunit, blocking the effect of transpeptidylase, and interfering with the binding of the aminoacyl-tRNA terminal with the 50S subunit, thereby blocking the formation of new peptide chains and inhibiting protein synthesis . Because chloramphenicol can also be combined with human mitochondria 70S, it can also inhibit human mitochondrial protein synthesis and cause toxicity to the human body. Because the binding of chloramphenicol to 70S ribosomes is reversible, it is considered a bacteriostatic antibiotic, but it can also have a bactericidal effect on some bacteria at high drug concentrations, even at lower concentrations of influenza bacilli. Produce bactericidal effect.

Chloramphenicol eye drops are indicated for the treatment of eye infections such as trachoma, trachoma, Escherichia coli, Haemophilus influenzae, Klebsiella, Staphylococcus aureus, Streptococcus hemolyticus and other sensitive bacteria. Conjunctivitis, keratitis, blepharitis, etc.

Chloramphenicol ear drops are used for the treatment of external otitis, acute and chronic otitis media caused by sensitive bacterial infections.

1. Typhoid and other Salmonella infections: the drug of choice for typhoid and paratyphoid caused by sensitive strains, gastroenteritis infected by Salmonella is generally not suitable for this product. If the disease is severe, it may still be used when combined septicemia is possible; In adults with typhoid and paratyphoid infections, fluoroquinolones are the first choice (not suitable for pregnant women and children).
2. Ampicillin-resistant Haemophilus influenzae type B meningitis or Streptococcus pneumoniae, Neisseria meningitidis meningitis, and sensitive gram-negative meningitis in patients allergic to penicillin. This product can be used as one of the drugs of choice.
3. Brain abscesses, especially otogenic, are often a mixed infection of aerobic and anaerobic bacteria.
4. Severe anaerobic infections, such as those caused by Bacteroides fragilis, are particularly suitable for those with lesions involving the central nervous system. They can be used in combination with aminoglycoside antibiotics to treat abdominal infections and pelvic infections to control coexisting aerobic and anaerobic bacteria infection.
5. No other low-toxic antibacterial drugs can be used to treat various serious infections caused by sensitive bacteria, such as sepsis and lung infections caused by Haemophilus influenzae, Salmonella and other Gram-negative bacilli, often with aminoglycosides. Combined.
6. Rickettsia infection can be used for the treatment of Q fever, Rocky Mountain spotted fever, and endemic typhus.

It is used to treat conjunctivitis, keratitis, blepharitis, trachoma, etc. caused by E. coli, Haemophilus influenzae, Klebsiella, Staphylococcus aureus, hemolytic streptococcus and other sensitive bacteria.

1. Ocu-Chlor

1. Ak-Chlor
2. Chloromycetin
3. Chloroptic
4. Fenicol
5. Isopto Fenicol
6. Minims Chloramphenicol 05
7. Ophtho-Chloram
8. Pentamycetin Ophthalmic Solution 025
9. Pentamycetin Ophthalmic Solution 05
10. Pms-Chloramphenicol
11. Sopamycetin

Although the use of chloramphenicol in veterinary medicine is severely restricted, chloramphenicol has some important veterinary uses. Dairy farming is one of the important uses. The problem of chloramphenicol residues in milk is becoming increasingly serious. The chloramphenicol rapid test kit independently developed by Ballya can effectively solve such problems. The test results comply with EU standards, not only simple operation, but also short time and high accuracy. Ballya will conduct more in-depth research in this area in the future.