The main adverse reaction is the inhibition of bone marrow
One is the reversible reduction of various types of blood cells, in which granulocytes first decrease, and this response is related to dose and treatment course. Once found, the drug should be stopped in time and can be resumed;
The second is irreversible aplastic anemia. Although rare, it has a high mortality rate. This reaction is allergic and has no direct relationship with the dose course. May be related to the inhibition of chloramphenicol in bone marrow hematopoietic cells by the same 70S ribosomes as bacteria.
In order to prevent toxic reactions of the hematopoietic system, abuse should be avoided, and blood images should be checked frequently when applied. Chloramphenicol can also produce gastrointestinal reactions and secondary infections.
A few patients may develop allergic reactions such as rash and angioedema, but they are relatively mild.