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Macrolides Test

Macrolides-Test-Kit

For Milk, Milk Powder, Pasteurized Milk

Specs:96T / box
Testing Time:7-10 mins
Regulation: CN / EU / RU / US

Operation video

Instrution For Macrolides Test

Introduction
Single Test Kit, rapid to detect an antibiotic residues in milk and dairy product by using colloidal gold immunochromatography technology. As soon as 7-10 minutes to results.

Application
For raw milk, whole milk powder, Pasteurized milk.

Spicifications
1. Specificity
Not cross-react with lincomycin, aflatoxin-m1, sulfonamides drugs, etc.

2. Limit of Detection
Refer to instruction.

Storage & Shelf-Life
At 2~8℃ out of sunlight, 12 months

Compolents (96T / box)
Instruction                          1
Tube                                     12

Equipments (Option)
Timer
Incubator
Mini Pipette(200μL)
Tips for mini pipette
Reader

Operations
1. Take 200 μL milk specimen, add into micro well, mix with the pink agent 10 times.
Remark: avoid specimen residues too much in the well.
2. Incubate 3 minutes
3. Insert strips into the wells
4. Incubate 5 minutes
5. Take out strips and read results by eye or reader.

Interpretation
Visual inspection
1. If C line visible, interpret according to the instruction. T line compare with C line to interpret positive or negative.
2. If C & T are invisible, it’s invalid detection, repeat testing again.

Reader Interpretation
Refer to the instruction

Results Illustration

If you want to know more, please contact us

    Trivia questions: What is macrolide?

    Macrolide definition

    Macrolide is a kind of natural product consisting of a large macrolide ring, wherein one or more deoxidized sugars, usually cladosaccharide and dextrosamine, can be attached. Lactone ring is usually 14-, 15-, or 16-membered. Macrolides belong to polyketides of natural products. Some macrolides have antibiotic or antifungal activities and are used as drugs.

    Macrolide antibiotics

    Macrolide antibiotics are mainly erythromycin, roxithromycin, azithromycin, clarithromycin, erythromycin, fluorocranine, and telithromycin. These drugs are macrolide antibiotics. It has anti-infective effects, mainly treating gram-positive and gram-negative bacilli and anaerobic, legionella, mycoplasma, chlamydia and other infections, and especially treating chlamydia and mycoplasma infections very well.

    Macrolide antibiotics list

    Erythromycin: Erythromycin is a basic antibiotic produced by Streptomyces erythreus and belongs to the class of macrolides.

    Roxithromycin: Western medicine is a new generation of macrolide antibiotics, mainly acting on Gram-positive bacteria, anaerobic bacteria, chlamydia and mycoplasma, etc.

    Azithromycin: Semi-synthetic fifteen-membered macrolide antibiotics.

    Clarithromycin: Clarithromycin is a derivative of erythromycin, a macrolide antibiotic, used to treat upper and lower respiratory tract infections, subcutaneous soft tissue infections, etc.

    Flurberry: Fluoroerythromycin is a fluorinated macrolide antibiotic with strong in vitro antibacterial activity and still maintains high stability in a low pH environment.

    Telithromycin: Telithromycin is the first antibacterial drug in the semisynthetic macrolide-lincophthalamide-streptomycin B (MLSB) family.

    How does macrolides work

    Macrolide mechanism of action

    Macrolide antibiotics stop bacteria from multiplying by preventing bacteria from producing proteins that are essential for their growth. The bacteria eventually die or are killed by the immune system.

    Macrolide uses

    Macrolide drugs

    There are three generations of macrolide antibiotics:
    1. The first generation of macrolide antibiotics: erythromycin and its ester derivatives: erythromycin, erythromycin succinate, erythromycin stearate, erythromycin ethyl carbonate, and stearyl red Erythromycin, erythromycin lactobionate, etoromycin, etc.;

    2. Second-generation macrolide antibiotics: azithromycin, roxithromycin, clarithromycin, dirithromycin, and fluoroerythromycin;

    3. The third generation has telithromycin.
    In short, each generation of macrolide antibiotics has its own characteristics. As the number of generations increases, bioavailability is higher, side effects are smaller, and compliance is better.

    Macrolide side effects

    1 Digestive system: Erythromycin and a new generation of macrolide antibiotics are mainly manifested as gastrointestinal symptoms and liver toxicity.

    2 Allergic reactions: cause drug rash and drug fever, occasionally cause allergies and temporary deafness, as well as dermatitis, perineal erosion, etc., and even shock.

    3 Cardiotoxicity: Cardiotoxicity of macrolide antibiotics such as erythromycin, spiramycin and clarithromycin is mainly manifested by prolonged QT interval and apical torsional ventricular tachycardia, which is dangerous and can be seen in clinical patients. Coma and sudden death are mostly induced by erythromycin, which is a special type of adverse effect of macrolide antibiotics.

    4 Blood system: In recent years, there have been reports of rapid decrease of blood cells in patients after application of erythromycin. There have also been reports of leukopenia.

    Summary

    Generally speaking, macrolide antibiotics are broad-spectrum antibiotics produced by Streptomyces. They have a basic lactone ring structure and are effective against both Gram-positive and Gram-negative bacteria, especially Mycoplasma, Chlamydia, Legionella, Spirochetes and Rickettsia have strong effects. Therefore, it is often used as a veterinary antibiotic in dairy farming. Residual antibiotics in milk have become a very serious problem. Ballya independently developed a rapid detection kit for macrolide antibiotics, not only macrolide antibiotics, but also a variety of antibiotics rapid detection kits. These kits are not only easy to use but also short in time and high in accuracy. The test results comply with EU standards. Ballya will continue to do more in-depth research in this area in the future.

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