Neomycin Test

For Milk, Milk Powder, Pasteurized Milk

Specs：96T / box
Testing Time：7-10 mins
Regulation： CN / EU / RU / US

What is Neomycin Test?

Single Test Kit, rapid to detect Neomycin residues in milk and dairy product by using colloidal gold immunochromatography technology. As soon as 7-10 minutes to results.

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What is neomycin?

1. Definition

Neomycin is an aminoglycoside broad-spectrum antibiotic, which has a good effect on gram-negative bacteria, positive bacteria and tubercle bacilli.

Escherichia coli is the most sensitive, and it is more sensitive to Staphylococcus aureus, Bacillus anthracis, Diphtheria, Aerogenes, Proteus and Shigella, and less sensitive to Pseudomonas aeruginosa. Cross-resistance of bacteria to this product and streptomycin, kanamycin and gentamicin may occur.

Due to the clinical toxicity of this product, it is generally not administered by injection, and is only used for oral and topical applications. It has little oral absorption and can be used to treat diarrhea. It has a good effect on children's diarrhea caused by E. coli. It can also be used for medication before abdominal and intestinal surgery.

The effect of topical application is also good, and the effect is good for skin and mucosal infections such as abscesses, boils, ulcers and burns caused by sensitive bacteria. It is an antibiotic with less intestinal absorption. It can be used to inhibit the growth of intestinal flora, reduce the production of ammonia, and achieve the effect of reducing blood ammonia. It can be used for the treatment of ammonia poisoning.

2. Pharmacological effects

It is rarely absorbed by oral administration. The intact intestinal mucosa can only absorb about 3%, but a considerable amount can be absorbed by mucosa with ulcers or exfoliation or inflammation.

Most of it is excreted with feces unchanged. Neomycin has a strong antibacterial effect on Mycobacterium tuberculosis, and its minimum inhibitory concentration is generally 0.5 mg/ml. Most nontuberculous mycobacteria are resistant to this product. Neomycin is also effective against many gram-negative bacilli such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Salmonella, Shigella, Brucella, Pasteurella, etc.

Neisseria meningitidis and Neisseria gonorrhoeae are also sensitive to this product. Neomycin has a poor effect on Staphylococcus and other gram-positive cocci. Each group of streptococci, Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product.

Neomycin mainly binds to the 30S subunit of bacterial ribosomes and inhibits bacterial protein synthesis. Bacteria can easily develop resistance after contact with neomycin. The combined application of neomycin and other antibacterial drugs or antituberculosis drugs can reduce or delay the development of drug resistance. The product is white or almost white powder.

3. Motivation

Oral absorption is poor, and intravenous administration is required. After intravenous injection, it is quickly distributed to the body tissues. Among them, the liver and kidney have the highest concentration, which is concentrated in nucleated cells and high in white blood cells.

This product does not easily penetrate the brain barrier, so it does not enter the cerebrospinal fluid: the product is metabolized very little, 12% to 25 within 24 hours % is excreted by the kidneys, and 50%～90% is excreted in the bile. Due to the slow release of the product from the storage tissues, the plasma elimination half-life is long, about 36h.

The hazards of Neomycin

With the improvement of people's quality of life, food safety issues have become more and more concerned by consumers. In particular, the problem of pesticide and antibiotic residues is the focus of consumers.

On food safety, a hot issue of global concern, how to detect food safety quickly and accurately has become the top priority. After people eat meat, eggs, milk and other foods with antibiotic residues, antibiotics tend to accumulate in the body, making people resistant to antibiotics, causing various tissues and organs, and even cancer.

People and fishermen’s shared antibiotics, mainly include streptomycin and neomycin. Residues of such drugs have nephrotoxicity, ototoxicity, and allergic reactions, and can cause the production of drug-resistant strains in humans.

The human intestinal flora is a balanced ecosystem, which plays a very important role in maintaining human health. If people eat foods containing antibiotics for a long time, sensitive bacteria will be killed or inhibited, while drug-resistant bacteria will multiply, which will break the original balance and cause flora imbalance, which may cause long-term diarrhea, malnutrition and drug-resistant bacterial infections in severe cases, bring difficulties to clinical treatment.

Features of Neomycin Test

1. 7min reading results

2. Detection limits respond to EU and US FDA norms

3. Neither professionals nor equipment required

4. Easy to operate and read

Detection Method of Neomycin Test

Neomycin Test, based on colloidal gold competition method, is used for testing Neomycin residues in milk sample and meets EU MRL. This kit can be applied for on-site rapid testing by various departments.

Samples of Neomycin Test

Samples include: raw milk, milk powder, pasteurized milk.

Detection Limit of Neomycin Test

The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.

Importance of Neomycin Test

Neomycin Test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.

Components of Neomycin Test

1.Micro-Well Reagent: 8 tests/tube, 12 tubes/box

2. Test Strip: 8pcs/tube, 96pcs/box

3.Manual Instruction: 1pc

Materials for Neomycin Test

1. Sample Tube

2. Pipette & Pipette Tip

3. Well-Tray-Plate

How to use Neomycin Test?

1. Add 200ul milk into a well, then pipet up and down for 10 times to completely mix the sample with the reagent in the well.

2. Then incubate for 5min.

3. Insert the test strip into the micro-well with the sample pad fully dipped.

4. After 5 minutes, read the results.

Summary

When antibiotics were first used on humans, we regarded them as "magic drugs". As the problem of antibiotic abuse continues to worsen, their resistance has also brought huge harm to humans.

Therefore, in daily life, we should avoid food with antibiotic residues. The first step to self-help: we need to detect antibiotic residues.