BALLYA Chlorpromazine Test is manufactured by BALLYA, it’s rapid test for detection chlorpromazine residues in feed, food and medicine, especially in feed and food. Lateral flow assay test base on the gold immunochromatography assay technology.
Chlorpromazine is a representative drug of phenothiazines, an antagonist of central dopamine receptors, and has a variety of pharmacological activities.
Pharmacological effects of Chlorpromazine
① Antipsychotic effect: mainly due to antagonizing dopamine receptors in the limbic system related to emotional thinking. The a-adrenergic receptor that antagonizes the up-activation system of the reticular structure is related to sedation and stability.
②Antiemetic effect: a small dose can inhibit the dopamine receptors in the chemically sensitive area of the emesis of the brain, and a large dose can directly inhibit the vomiting center and produce a strong antiemetic effect. But it has no effect on vomiting caused by stimulation of the vestibule.
③Cooling effect: inhibit the body temperature regulation center, lower body temperature, body temperature can change with changes in the external environment. When using a larger dose, placing the patient in a cold environment (such as an ice bag or ice-water bath) can cause "artificial hibernation".
④Enhance the effects of hypnosis, anesthesia and sedatives.
⑤ Effect on the cardiovascular system: It can antagonize peripheral α-adrenergic receptors, directly dilate blood vessels, and cause blood pressure drop. Large doses can cause orthostatic hypotension, so attention should be paid. It can also relieve spasm of small arteries and venules, improve microcirculation, and have anti-shock effects. At the same time, because the effect of dilating large veins is greater than that of the arterial system, it can reduce cardiac preload and improve cardiac function (especially left heart failure).
⑥ It has a certain impact on the endocrine system, such as reducing the release of prolactin inhibitors, causing breast enlargement and galactorrhea. Inhibit gonadotropin release, corticotropin and growth hormone secretion to delay ovulation.
What is Chlorpromazine used for?
Chlorpromazine indications
①Treatment of psychosis: It is used to control the symptoms of schizophrenia or other mental illnesses such as excitement, restlessness, hallucinations, delusions, etc. It has a poor effect on depression and stupor symptoms. It is not effective for patients with type II schizophrenia and can even aggravate the condition.
② Antiemetic: It is effective for almost all kinds of vomiting, such as uremia, gastroenteritis, cancer, pregnancy and drug-induced vomiting. It can also treat intractable hiccups. But it is not effective for motion sickness and vomiting.
③ Hypothermic anesthesia and artificial hibernation: It can prevent shock when used in hypothermic anesthesia. During artificial hibernation, it is formulated with pethidine and promethazine into a hibernation mixture for adjuvant treatment of traumatic shock, toxic shock, burns, high fever and thyroid crisis.
④ Combined with analgesics to treat severe pain in patients with advanced cancer.
⑤ Treat heart failure.
⑥ Try to treat gigantism.
What are the Chlorpromazine side effects?
Chlorpromazine adverse reactions
(1) The main adverse reactions include dry mouth, blurred vision, upper abdominal discomfort, fatigue, lethargy, constipation, and occasionally lactation, breast enlargement, obesity, amenorrhea, etc.
(2) High-dose injection or oral administration can cause orthostatic hypotension. After medication, you should lie still for 1 to 2 hours. When blood pressure is too low, intravenous infusion of norepinephrine or ephedrine can increase the blood pressure. But do not use adrenaline to prevent blood pressure from falling even lower.
(3) It can cause extrapyramidal reactions when used in large quantities for a long time, which is a common adverse reaction of antipsychotic drugs. Since blocking the dopaminergic striatal substantia nigra conduction pathway produces symptoms such as Parkin's syndrome, acute dystonia, akathisia, trihexyphenidyl can be used to combat it, but it can reduce the efficacy.
(4) Allergic reactions can occur, such as skin rash, contact dermatitis, exfoliative dermatitis, neutropenia (this reaction is rare, and the drug should be stopped immediately if it occurs), asthma, purpura, etc.
(5) It can cause ocular complications, mainly manifested as corneal and lens opacity, or increase intraocular pressure.
Precautions for use of Chlorpromazine
① Patients with hepatic insufficiency, uremia, hypertension, and coronary heart disease should be used with caution, and liver function should be checked regularly during long-term medication.
② This product is very irritating and can cause thrombophlebitis when injected intravenously. Intramuscular injection is more local pain. 1% procaine can be added for deep intramuscular injection.
③ This product can sometimes cause depression, so attention should be paid when taking medicine.
④ It is not recommended for infants under 6 months of age.
⑤ The tolerance of the elderly to this class of drugs is reduced, and they are prone to hypotension, excessive sedation and tardive dyskinesias that are difficult to eliminate.
Note: The above content is for reference only! Please strictly follow the instructions for use, don’t abuse, don’t misuse!
What specimen can be detected by BALLYA Chlorpromazine Test?
Specimen include: all kinds of feed, food and medicine. Widely used in feed industry and food processing industry. You can choose the right products according to your needs.
Significance of testing Chlorpromazine
To protect the animal have health feed, food and medicine, avoid contaminated food. The chlorpromazine is harmful for animal being, can’t take too much in the body.
1. Take some feed or food specimen 2. Add the supernatant to cassette 3. Wait for 15 minutes to result 4. The details of operation, refer to the kit instruction
Limitations of BALLYA Chlorpromazine Test?
BALLYA Chlorpromazine Test is a qualitative test kit. It’s only for screening purpose. If have positive cases or suspected case, maybe use other detection method to make a further detection, such as, ELISA, PCR, qPCR, etc.
Conclusion
Sedative drugs, as drugs that inhibit the central nervous system of animals, are widely used in veterinary clinics. The detection of sedative drug residues is a necessary way to accurately grasp the status of drug residues in animal-derived foods. For different detection sources and different detection drugs, choosing the correct detection method is crucial.
As the application of sedatives becomes more and more widespread, and there are more and more types, detection methods require not only high efficiency, sensitivity and accuracy, but also good reproducibility and stability.
BALLYA Chlorpromazine Test is suitable for the detection of hormone residues, toxic and harmful substances and antibiotic residues in feed, food and medicine. It can be widely used in food and drug administration, health departments, higher education institutions, scientific research institutes, agricultural departments, animal husbandry and veterinarians, breeding farms, slaughterhouses, food and meat products deep processing enterprises, inspection and quarantine departments and other units.
