BALLYA Carbamazepine Test is manufactured by BALLYA, it’s rapid test for detection carbamazepine residues in feed, food and medicine, especially in feed and food. Lateral flow assay test base on the gold immunochromatography assay technology.
Carbamazepine is a white or almost white crystalline powder. It is a dibenzazepine anti-epileptic drug and has anti-epileptic effects similar to phenytoin sodium.
It is most effective for psychomotor seizures. It is also effective for major seizures, localized seizures and mixed seizures.
Carbamazepine has better anti-peripheral neuralgia effect than phenytoin, and can be used for trigeminal neuralgia and glossopharyngeal neuralgia. It can also be used for the treatment of arrhythmia and diabetes insipidus.
Pharmacological effects of carbamazepine
Membrane stabilization can reduce the permeability of nerve cell membranes to Na+ and Ca2+, thereby reducing cell excitability and prolonging the refractory period; it may also enhance the synaptic transmission function of GABA.
The anticonvulsant mechanism is similar to phenytoin, which inhibits the late strengthening of the rigidity of the synapse and limits the spread of abnormal discharge of the epileptic foci. It can also inhibit the electrical activity in the anterior abdominal nucleus of the thalamus.
The mechanism of pain relief is unknown, which may reduce the synaptic transmission of the central nervous system.
What is Carbamazepine used for?
Carbamazepine indications
1. The treatment of epilepsy is the drug of choice for simple and complex partial seizures, and has better efficacy than other antiepileptic drugs for complex partial seizures. It is not effective for typical or atypical absence seizures and muscle spasm seizures.
2. Anti-peripheral neuralgia includes trigeminal neuralgia, glossopharyngeal neuralgia, multiple sclerosis, diabetic peripheral neuralgia and postherpetic neuralgia. It can also be used as a long-term preventive medication after trigeminal neuralgia is relieved. The curative effect of trigeminal neuralgia and glossopharyngeal neuralgia is better than phenytoin sodium, and it can be effective within 24 hours after administration.
3. The treatment of neurogenic diabetes insipidus may be due to the promotion of antidiuretic hormone secretion.
4. Prevention or treatment of manic depression, clinical use proves that this drug has obvious therapeutic effects on mania and depression, and can also reduce or eliminate the symptoms of mania and delusion in patients with schizophrenia.
5. Anti-arrhythmic effect, can fight arrhythmia caused by digoxin poisoning. Can make it completely or basically return to normal heart rhythm. Clinical trials have proved that it is effective for ventricular or supraventricular premature beats, and can eliminate symptoms, especially those with chronic cardiac insufficiency.
What are the Carbamazepine side effects?
Common adverse reactions are central nervous system reactions such as blurred vision, diplopia, and nystagmus, as well as dizziness, fatigue, nausea, and vomiting; most of them occur 1 to 2 weeks after medication.
Rarely, skin rash, urticaria, itching, behavioral disorders in children, abnormal liver function, cholestasis, hepatocellular jaundice and hypothyroidism, etc.; rare neutropenia and bone marrow suppression, arrhythmia, allergic hepatitis, liver failure, acute kidney Failure and hypersensitivity reactions in multiple organs throughout the body.
Precautions for carbamazepine
1. Use with caution in glaucoma, serious cardiovascular diseases, diabetes, patients who cannot tolerate tricyclic antidepressants, and patients with alcoholism, urinary retention, kidney disease and the elderly.
2. Interference with diagnosis: it can increase the test values of aminotransferase, serum bilirubin, alkaline phosphatase, urea nitrogen, urine sugar, etc.; decrease the blood calcium concentration and decrease the thyroid function test value.
3. Pay attention to follow-up inspections during medication (especially within the first month): blood picture, urine routine, blood urea nitrogen, liver function, thyroid function and monitor the blood concentration of carbamazepine.
4. Due to the self-induced effect of this product, after the first stage of treatment, it may be necessary to increase the dose to maintain the original blood concentration and seizure control level.
Carbamazepine drug interactions
1. Combined use with acetaminophen can cause liver poisoning.
2. Combined with phenobarbital, phenytoin, and primidone, the blood concentration of carbamazepine will decrease.
3. Erythromycin, aceto-eandomycin, cimetidine, isoniazid and dextropropoxyphene can inhibit the metabolism of carbamazepine, causing the latter to increase the plasma concentration.
4. Combined with carbonic anhydrase inhibitors, the risk of osteoporosis increases.
Note: The above content is for reference only! Please strictly follow the instructions for use, don’t abuse, don’t misuse!
What specimen can be detected by BALLYA Carbamazepine Test?
Specimen include: all kinds of feed, food and medicine. Widely used in feed industry and food processing industry. You can choose the right products according to your needs.
Significance of testing Carbamazepine
To protect the animal have health feed, food and medicine, avoid contaminated food. The carbamazepine is harmful for animal being, can’t take too much in the body.
1. Take some feed or food specimen 2. Add the supernatant to cassette 3. Wait for 15 minutes to result 4. The details of operation, refer to the kit instruction
Limitations of BALLYA Carbamazepine Test?
BALLYA Carbamazepine Test is a qualitative test kit. It’s only for screening purpose. If have positive cases or suspected case, maybe use other detection method to make a further detection, such as, ELISA, PCR, qPCR, etc.
Conclusion
Sedative drugs, as drugs that inhibit the central nervous system of animals, are widely used in veterinary clinics. The detection of sedative drug residues is a necessary way to accurately grasp the status of drug residues in animal-derived foods. For different detection sources and different detection drugs, choosing the correct detection method is crucial.
As the application of sedatives becomes more and more widespread, and there are more and more types, detection methods require not only high efficiency, sensitivity and accuracy, but also good reproducibility and stability.
BALLYA Carbamazepine Test is suitable for the detection of hormone residues, toxic and harmful substances and antibiotic residues in feed, food and medicine. It can be widely used in food and drug administration, health departments, higher education institutions, scientific research institutes, agricultural departments, animal husbandry and veterinarians, breeding farms, slaughterhouses, food and meat products deep processing enterprises, inspection and quarantine departments and other units.
