is an antibiotic, which belongs to aminoglycoside antibiotics together with streptomycin, kanamycin and gentamicin. It is produced by Streptomyces flexneri; it is effective against both Gram-positive and negative bacteria, and the product is mainly a mixture of neomycin B and C.
Neomycin mechanism of action
Neomycin has a strong antibacterial effect on Mycobacterium tuberculosis, against many Gram-negative bacilli such as Escherichia coli, Klebsiella, Proteus, Enterobacter, Salmonella, Shigella, Brucella Bacteria, Pasteurella, etc. also have antibacterial effects. Neomycin mainly binds to the bacterial ribosomal 30S subunit and inhibits bacterial protein synthesis.
Neomycin sulfate is an aminoglycoside antibiotic. Oral can be used for: intestinal infection; can also be used as an adjuvant treatment for bowel preparation before colon surgery or liver coma. Neomycin is not suitable for the treatment of systemic infections.
In clinical practice, it is mainly used for some ointments or plasters for skin anti-infection treatment. The topical application of this drug can kill bacteria to some extent in infected skin areas, such as some bacterial infections secondary to chronic eczema. You can use compound neomycin ointment, or trimexin ointment, which can play an anti-infective role to a certain extent. However, due to the extensive bactericidal effect of this drug, it cannot be used in a large area for a long time.
Prepared for colon surgery and used as an adjuvant treatment during liver coma. Neomycin is not suitable for the treatment of systemic infections. Neomycin is not effective against Pseudomonas aeruginosa.
1. Oral dosage for adults, 0.25-0.5g at a time (calculated as neomycin, the same below), 1-2g a day. Adjuvant treatment of hepatic encephalopathy, 0.5 to 1.0g once, once every 6 hours, course of treatment 5-6 days. Preparation before colon surgery, 0.5g per hour, medication for 4 hours, followed by 0.5g every 4 hours for a total of 24 hours.
2. The usual dosage for children is 25 to 50 mg / kg per day, divided into 4 doses.
Precautions for neomycin
Follow-up examination: Patients with audiogram, renal function measurement, original renal function damage or the eighth pair of cerebral nerve damage or long-term treatment need to be checked before and during medication. Those who have not progressed for several days after taking the medicine should be examined.
① Neomycin can be taken on an empty stomach or after a meal;
② Patients with impaired renal function or the eighth pair of cerebral nerve dysfunction need to be reduced;
③ If patients with liver coma cannot take neomycin, sterile neomycin powder can be used Formulated as a 1% solution for retention enema;
④ Neomycin sulfate is too toxic and is no longer used for injection. It is not advisable to place numerous indwelling drugs in the body cavity, which can cause ear, kidney toxicity and respiratory inhibition due to absorption.
Neomycin side effects
Occurred more frequently were mouth or perianal irritation or pain, nausea or vomiting; rarely occurred were diarrhea or malodorous fatty feces, or a large amount of gas deflation (absorption syndrome), rash.
Can cause kidney and hearing impairment, gastrointestinal reactions, loss of appetite, nausea, vomiting, etc.
Delayed allergic reactions can occur. Large doses can have symptoms of neurotoxicity, respiratory depression, etc.
1. Cross-allergy, those who are intolerant to one aminoglycoside antibiotic may not tolerate other aminoglycosides.
2. The following conditions should be used with caution: Section 8 on cerebral nerve damage, intestinal obstruction, myasthenia gravis, patients with Parkinson's disease, renal impairment, and colon ulcerative lesions.
1. Systemic application with other aminoglycosides or curlycin at the same time may increase ototoxicity, nephrotoxicity and neuromuscular blockade; hearing loss may occur, and even after stopping the drug, it may continue to progress to permanent deafness.
2. Simultaneous application with neuromuscular blocking drugs may increase the neuromuscular blocking effect, resulting in skeletal muscle weakness and respiratory depression or paralysis (apnea).
3. Systemic application with cisplatin, etanilic acid injection, furosemide injection or vancomycin may cause hearing loss and may continue to progress to deafness after drug withdrawal, often permanently.
4. The long-term combination of oral contraceptives (including estrogen) and oral neomycin may cause contraceptive failure and increase the incidence of bleeding.
5. Oral neomycin can affect the absorption of digitalis glycosides, vitamin A or vitamin B12, and reduce the efficacy; therefore, it should be closely observed whether the efficacy of digitalis drugs has changed. Patients taking oral neomycin, especially when combined with colchicine and vitamin A, their vitamin B12 requirements may increase.
6. Systemic application with polymyxins at the same time may increase nephrotoxicity and neuromuscular blockade.
The most obvious is the reaction of the skin, similar to long particles, or fever, redness, fever, etc., and even shock, affecting life safety.
Neomycin is a veterinary drug that people often use in bee breeding, but excessive or frequent use will cause the bees themselves and the honey produced by bees to contain residual neomycin.
Neomycin Rapid Test Dipsticks can quickly detect whether the honey contains residual neomycin. It is not only simple to operate, but also has short detection time and high accuracy, and the test results comply with EU standards.