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Sulfonamides Test Kit

Sulfonamides-Test-Kit

For Milk, Milk Powder, Pasteurized Milk

Specs:96T / box
Testing Time:7-10 mins
Regulation: CN / EU / RU / US

Operation video

Instrution For Sulfonamides Test

Introduction
Single Test Kit, rapid to detect an antibiotic residues in milk and dairy product by using colloidal gold immunochromatography technology. As soon as 7-10 minutes to results.

Application
For raw milk, whole milk powder, Pasteurized milk.

Spicifications
1. Specificity
Not cross-react with macrolides, spectinomycin, chloramphenicol drugs, etc.

2. Limit of Detection
Refer to instruction.

Storage & Shelf-Life
At 2~8℃ out of sunlight, 12 months

Compolents (96T / box)
Instruction                          1
Tube                                     12

Equipments (Option)
Timer
Incubator
Mini Pipette(200μL)
Tips for mini pipette
Reader

Operations
1. Take 200 μL milk specimen, add into micro well, mix with the pink agent 10 times.
Remark: avoid specimen residues too much in the well.
2. Incubate 3 minutes
3. Insert strips into the wells
4. Incubate 5 minutes
5. Take out strips and read results by eye or reader.

Interpretation
Visual inspection
1. If C line visible, interpret according to the instruction. T line compare with C line to interpret positive or negative.
2. If C & T are invisible, it’s invalid detection, repeat testing again.

Reader Interpretation
Refer to the instruction

Results Illustration

If you want to know more, please contact us

Trivia questions: What is sulfonamides?

Sulfonamides definition

Sulfonamides antibiotics

Sulfonamide, also known as diaminosulfonyl, sulfamide. Chemical formula SO2 (NH2) 2. The molecular weight is 96.11. Orthogonal flaky crystals can absorb dry ammonia at normal temperature to form a colorless ammonia complex, which is stable in acid, neutral and alkaline aqueous solutions.

Sulfonamide structure

The sulfonamides commonly used in clinical practice are derivatives with para-aminobenzenesulfonamide (sulfonamide for short) as the basic structure.
The hydrogen on the sulfonamide group can be substituted by different heterocycles to form different kinds of sulfa drugs. Compared with the parent sulfa, they have the advantages of high potency, low toxicity, broad antibacterial spectrum, and easy absorption by oral administration. The free amino group in the para position is an antibacterially active part, and if substituted, the antibacterial effect is lost. The amino group must be released again after decomposition in the body in order to restore activity.

How do sulfonamides work

Sulfonamides mechanism of action

The chemical structure of sulfa drugs is similar to that of PABA, and it can compete with PABA for dihydrofolate synthase, which affects the synthesis of dihydrofolate, thereby inhibiting the growth and reproduction of bacteria. Because sulfa drugs can only inhibit bacteria without bactericidal effect, the elimination of pathogenic bacteria in the body ultimately depends on the defense ability of the body.

Sulfonamides uses

Sulfonamides drugs

Sulfonamides drugs are synthetic antibacterials that have been used in the clinic for nearly 50 years. They have the advantages of a broad antibacterial spectrum, stable properties, easy use, and no food consumption during production.

Sulfonamides list

According to clinical use, it can be divided into three categories:
1. Intestinal sulfa drugs are easily absorbed. Mainly used for systemic infections;
2. Intestinal sulfonamides are difficult to absorb. Mainly used for intestinal infections;
3. Topical sulfa drugs. Mainly used for burn infections, purulent wound infections, ophthalmic diseases, etc.

Sulfonamides side effects

1. Allergic reactions. The most common are rashes and fevers. It usually occurs 5 to 9 days after medication, and is more common in children.
2. Kidney damage. Due to the low solubility of acetylated sulfonamide, especially when the urine is acidic, crystals are easily precipitated in the renal tubules, causing symptoms such as hematuria, dysuria, and urination.
3. Influence of hematopoietic system. Sulfa drugs can inhibit bone marrow leukocyte formation and cause leukopenia.
4. Central nervous system and gastrointestinal reactions. Mostly due to the sufficient amount of sulfa.

Sulfonamides allergy

Allergies to sulfa drugs are common. The overall incidence of adverse drug reactions to sulfa antibiotics is about 3%, which is close to penicillin.
The most common are rashes and fevers. It usually occurs 5 to 9 days after medication, and is more common in children. There is cross-allergy between sulfa drugs, so it is not safe to switch to another sulfa drug when the patient is allergic to one sulfa drug. Once an allergic reaction occurs, the drug should be discontinued immediately. Long-acting sulfa drugs are very dangerous because they have a high binding rate to plasma proteins and there are drugs in the blood for several days after the drug is stopped.

Sulfonamide drug hypersensitivity syndrome

Sulfonamide hypersensitivity syndrome is similar to anticonvulsant hypersensitivity syndrome, but usually develops earlier during treatment (usually 7 to 14 days after treatment).

Summary

After the discovery of trimethoprim (TMP), the combined application with sulfa drugs can enhance its antibacterial effect and expand the scope of treatment. Therefore, although there are numerous antibiotics, sulfa drugs are still important chemotherapy drugs. Not only that, sulfa antibiotics are also used as veterinary antibiotics and widely used in various industries, especially in dairy farming. The timely detection of residual sulfa antibiotics in milk is the first step to ensuring milk safety. Ballya  will provide a rapid test kit for sulfa antibiotics to ensure that residual sulfa antibiotics in milk can be detected in a timely manner. The test results comply with EU standards. Ballya will continue to do more in-depth research in this area.

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