BALLYA Ivermectin Test is manufactured by BALLYA, it’s rapid test for detection ivermectin residues in milk & beef product, especially in milk. Lateral flow assay test base on the gold immunochromatography assay technology.
Ivermectin is a sixteen-membered macrolide antibiotic with a basic structure of a large ester ring at the carbon 16 position and three main substituent groups, namely hexahydrophenylpropane at the C2 to C8 Furans, diglycosyl groups at position C13, ketone groups at positions C17 to C18.
Ivermectin mechanism of action
Since the flukes and tapeworms do not use GABA as the transmitter, and lack the Cl channel controlled by glutamic acid, this class of drugs is ineffective. The peripheral neurotransmitter in mammals is acetylcholine. Although GABA is distributed in the central nervous system, it is relatively safe because it is not easy to pass through the blood-brain barrier and has little effect on it.
How Ivermectin uses for?
This drug is mainly used for clinical treatment of onchocerciasis and angiostrongyloidosis, as well as some infections of parasites such as hookworm, roundworm, whipworm, and worm. Its usage and dosage are different according to different dosage forms, and its usage and dosage are also different. The general administration route is oral dosage form and injection dosage form. Its usage and dosage are also based on the treatment of different parasitic diseases, and the dosage is also different. The general principle is to administer the drug according to the patient's kilogram body weight, and the dosage of different parasitic diseases is not the same.
Ivermectin cream can be used for chronic inflammatory skin diseases that occur in the erythema and telangiectasia in the center of the face.
What's Ivermectin side effect?
Systemic reactions: including weakness, weakness, abdominal pain, fever; gastrointestinal reactions: including anorexia, constipation, diarrhea, nausea, vomiting; nervous system reactions: including dizziness, drowsiness, dizziness, tremor; skin: including itching, rash, papules , Rubella, small pustule; ophthalmology: the following ophthalmic adverse reactions are caused by the disease itself, but it has also been reported that it appears after treatment with ivermectin. These adverse reactions include visual abnormalities, eyelid edema, anterior uveitis, conjunctivitis, Limbitis, keratitis, choroidal retinitis or choroiditis. The above symptoms are generally mild and do not cause blindness. They are generally relieved without corticosteroid treatment. Others: Including arthralgia, synovitis, axillary lymphadenopathy and tenderness, cervical lymphadenopathy and tenderness, inguinal lymphadenopathy and tenderness, lymphadenopathy and tenderness in other parts, facial edema, peripheral edema, standing Hypotension, tachycardia, medical headache, and muscle pain laboratory abnormalities: including elevated ALT and / or AST, leukopenia, eosinophilia, and hemoglobin.
The different adjuvants contained in the commercial preparation of ivermectin can affect the effect of the drug. For example, the preparation of sheep containing Tween-80 as an adjuvant. It is still safe when the dosage of ivermectin reaches 4000 μg / kg, but if Propylene glycol as an adjuvant caused sheep to have ataxia and hemoglobinuria for 3 days. The ivermectin injection containing Tween-80 as an adjuvant in the United States is a special commercial preparation for equine animals, but it cannot be used in dogs, otherwise it is extremely unsafe.
Ivermectin use as a veterinary medicine
Ivermectin for dogs
There are special dosage forms abroad (according to the amount of 6 ~ 12μg / kg) for the prevention and treatment of heartworm microfilariae infection in dogs. China can try 50μg / kg oral treatment for heartworm microfilariae infection (invalid for adults). Clinical trials have confirmed that high-dose ivermectina is highly effective against various parasites in dogs, such as a single subcutaneous injection of 50μg / kg against H. elegans, H. brasiliensis, H. elegans in Europe, and 100, 200μg / kg has an excellent effect of repelling adult Toxocara canis and fourth stage larvae. For lion bowworms, according to the amount of 200μg / kg, the effect of subcutaneous injection is only 69%, while the oral administration is 95%.
Ivermectin dosage for dogs
This product is injected subcutaneously once, to the dogs parasitic capillary nematodes (200μg / kg) and Oslerosis ostracis (400μg / kg).
Ivermectin for cattle
Ivermectina is administered orally or subcutaneously to cattle at 0.2 mg / kg, which is effective against blood worms, Oster nematodes, Cooper worms, Trichostrongylus worms (including Trichostrongylus elegans), round nematodes, and nematodes, Nematode, Trichoderma elegans, Esophageal nematode, Net tail nematode, Chabert elegans adult and fourth stage larvae, the anthelmintic rate is 97% -100%. The above doses are also very effective for arthropods: such as fly maggots (bovine fly, dermatoglyphus, sheep mad fly), mites (bovine mange mites, sheep itch mites) and lice (bovine palatal lice, bovine blood lice and sheep palatal lice) Wait. Ivermectina is slightly less effective against chewing lice (Licetus) and sheep and sheep ticks.
Ivermectin for horses
Oral administration of 0.2 mg / kg ivermectin is highly effective (95% ～ 100%) on the following adults and the fourth stage larvae of large and small round nematodes; such as large round nematodes (common round nematodes, horse round Nematode, round tooth nematode), roundworm (paracoccus elegans), pinworm (horse-tailed nematode), stomach worm (Dalaxis elegans, nematode), intestinal nematode (Trichostrongylus elegans Angiostrongylus websterii), Pneumocystis elegans (Anura elegans), etc. 2 mg / kg is also very limited, but the best solution for the three types of bots in the transition or gastric residence period, onchocerciasis microfilariae and the third stage larvae of gastritis caused by skin damage It is to take the medicine again according to the above amount after one month.
Ivermectin for chickens
For poultry nematodes such as Ascaris lumbricoides and closed capillaria and arthropods parasitic for poultry, such as knee mites (mutant knee mites), etc., oral or subcutaneous injections at 200 to 300 μg / kg are highly effective. However, this product is not effective against Heterorhabditis elegans.
What specimen can be detected by BALLYA Ivermectin Test?
Specimen include: milk, beef, etc. Widely used in milk and beef industry.
Significance of testing Ivermectin
To protect human have health food and avoid contaminated food. The ivermectin is harmful for human being, can not take too much in body.
1. Take milk or beef specimen 2. Add the supernatant to cassette 3. Wait for 15 minutes to result 4. The details of operation, refer to the kit instruction
Limitations of BALLYA Ivermectin Test?
BALLYA Ivermectin Test is a qualitative test kit. It’s only for screening purpose. If have positive cases or suspected case, maybe use other detection method to make a further detection, such as, ELISA, PCR, qPCR, etc.
Ivermectin has been widely used as an insect repellent in various industries. The dairy farming industry deserves special attention. Milk provides people with rich nutrients and makes them indispensable in daily life. The problem of Ivermectin residues in milk has always troubled people, and it is quite necessary to conduct timely detection of milk. BALLYA Ivermectin Test provided by BALLYA can effectively and quickly detect whether milk contain Ivermectin residues. Not only is the operation simple and the detection time is short, it allows the tester to obtain the test results in the first time.