Thiamphenicol is a white to off-white crystalline powder or crystal. Melting point (℃) 178-180 (mixed rotation), 164-166 (right-handed rotation). Its chemical formula is [R- (R *, R *)] N- [1- (hydroxymethyl) -2-hydroxy-2- [4- (methylsulfonyl) phenyl] ethyl] -2,2 -Dichloroacetamide, soluble in dimethylformamide, slightly soluble in absolute ethanol, slightly soluble in water.
Clinically, it is mainly used to treat respiratory, urinary, hepatobiliary, typhoid and other intestinal surgery, obstetrics and gynecology and facial features infections, especially for moderate to mild infections. It is easily soluble in dimethylformamide and slightly soluble in water.
2. Mechanism of action of Thiamphenicol
The methylsulfone derivative of chloramphenicol is a synthetic broad-spectrum antibacterial drug. Its antibacterial spectrum and antibacterial effect are basically similar to chloramphenicol. On the subunit, the growth of the peptide chain is blocked (probably the effect of transpeptidase is inhibited), the formation of the peptide chain is inhibited, and protein synthesis is prevented, thereby playing an antibacterial effect.
3. Thiamphenicol chemical class
Thiamphenicol belongs to the class of chloramphenicol antibiotics (also called chloramphenicol).
4. Thiamphenicol with food
Thiamphenicol is a kind of antibiotic with strong action and broad antibacterial spectrum. It is currently an important medicine for preventing and curing livestock and poultry diseases in China. The residue in animal food has attracted attention.
What is thiamphenicol used for?
1. Thiamphenicol Uses
It is mainly used to treat respiratory, urinary, hepatobiliary, typhoid and other intestinal surgery, obstetrics and gynecology and facial features infections, especially for moderate to mild infections.
2. Thiamphenicol uses in poultry
Poultry: Mainly prevent E. coli disease and chicken dysentery, typhoid fever, paratyphoid fever, salmonellosis, duck infectious serositis. Has a good effect on E.coli. It is suitable for sudden death of sick chickens without any symptoms, difficulty breathing, white or watery stool, decreased egg production rate of laying hens, perihepatitis, pericarditis, yolk peritonitis, abdominal cavity filled with yellowish smelly liquid and yolk intestinal adhesion; Symptoms such as decreased feed intake, central nervous system disorders, ataxia, cellulose pericarditis, pericardial effusion, perihepatitis, hepatomegaly, fragility, and thickened envelope.
3. Thiamphenicol typhoid fever
Thiamphenicol is the second-selected drug for typhoid fever. Its structure is similar to that of chloramphenicol. Its antibacterial efficacy in vitro is slightly weaker than that of chlorotoxin, and it is not toxic to bone marrow. It is usually 1.5-2 g / day, orally taken in 3-4 times. The course of treatment is the same as chloramphenicol.
4. Thiamphenicol dosage typhoid
For typhoid fever: 3g orally per day on days 1 to 3, 1.5g per day on days 4 to 6, and 1g per day thereafter.
The side effects of Thiamphenicol
1. Thiamphenicol indications
It is used for the infection of respiratory system, hepatobiliary system, urinary system and digestive system caused by influenza bacilli, Escherichia coli and Salmonella susceptible to this product. It also has a certain effect on typhoid fever, paratyphoid fever, and brucellosis; it is also used for gonorrhea and gonococcal urethritis.
2. Thiamphenicol contraindication
Bone marrow suppression: Reversible bone marrow suppression is the most serious adverse reaction of this drug. This reaction is related to the dosage and course of treatment. It is commonly seen in patients with a blood drug concentration exceeding 25 μg / ml. The clinical manifestations are anemia, and may be accompanied by leukocyte and thrombocytopenia.
Aplastic anemia: Aplastic anemia that occurs after medication is rare. Its clinical manifestations include bleeding tendency caused by thrombocytopenia, complicated with petechiae, ecchymosis and epistaxis, and signs of infection caused by granulocyte reduction, such as high fever, sore throat, jaundice, etc.
Gray infant syndrome: There have been no reports of "grey infant syndrome" caused by the use of this drug in premature infants and newborns. Only cases of transient skin and pale skin have been reported.
Hepatotoxicity: The original liver disease may cause jaundice, liver fat infiltration, and even acute severe hepatitis after medication.
Allergic reactions: Allergic reactions such as rash, solar dermatitis, angioedema, drug fever, etc. are rare after taking the drug, and the general symptoms are mild, which can be improved quickly after the drug is stopped.
Nervous system: Peripheral neuritis and optic neuritis can appear after long-term medication, manifested as hearing loss, insomnia, illusion, delirium and other neurological symptoms, mostly reversible. There are also reports of optic atrophy and blindness after long-term medication.
Gastrointestinal reactions: Gastrointestinal symptoms such as loss of appetite, nausea, vomiting, upper abdominal discomfort, and diarrhea after medication are more common, and their incidence is about 10% or less.
Double infection: After long-term medication, the normal flora in the body can be reduced, causing double infection.
Others: Some patients with congenital glucose-6-phosphate dehydrogenase deficiency may develop hemolytic anemia after medication; Long-term oral administration may inhibit intestinal flora and block vitamin K synthesis, causing bleeding tendency.
Features of Thiamphenicol Test
1. 7min reading results
2. Detection limits respond to EU and US FDA norms
3. Neither professionals nor equipment required
4. Easy to operate and read
Detection method of Thiamphenicol Test
Thiamphenicol Test, based on colloidal gold competition method, is used for testing Thiamphenicol residues in egg sample and meets EU MRL. This kit can be applied for on-site rapid testing by various departments.
Samples for Thiamphenicol test
Samples include: egg, egg products.
Detection limit of Thiamphenicol Test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of Thiamphenicol Test
Thiamphenicol Test can help manufacturers, regulatory agencies, and the general public monitor product quality and help humans protect their health.