β-lactam antibiotics (β-lactams) refer to a large class of antibiotics with a β-lactam ring in the chemical structure. Basically, all antibiotics including β-lactam nucleus in their molecular structure belong to β-lactams Antibiotics, which are the most widely used types of existing antibiotics.
Beta lactam family includes penicillin and its derivatives, cephalosporins, monoamide rings, carbapenems and penicillin enzyme inhibitors, as well as newly developed cephamycins, thiomycins, monocyclics β-lactams and other atypical β-lactam antibiotics.
2. Beta lactamase
Beta-lactamase is a class of enzymes secreted by resistant bacteria against lactam antibiotics. It can be combined with beta-lactam ring to cleave beta-lactam ring and be destroyed, and lose antibacterial activity. It is the main reason for the resistance of these bacteria.
What are Tetracyclines?
Tetracyclines are a class of broad-spectrum antibiotics produced by actinomycetes, including chlortetracycline, oxytetracycline, tetracycline, and the semi-synthetic derivatives metoxycycline The structure of cyclamycin, dimethylaminotetracycline, etc. contains naphthylphenyl skeleton.
2. Mechanism of action
The mechanism of action is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, preventing the connection of the aminoacyl-tRNA at this position, thereby inhibiting the growth of the peptide chain and affecting bacterial protein synthesis.
Tetracyclic antibiotics are a class of broad-spectrum antibiotics produced by actinomycetes. Because their structures contain a tetraphenyl skeleton, they are called tetracyclic antibiotics.
Common tetracyclic antibiotics are oxytetracycline, chlortetracycline, tetracycline and semi-synthetic derivatives, such as doxycycline. Tetracycline antibiotics are widely used for Chlamydia, Mycoplasma and Rickettsia infections.
It can be used to treat malignant tumors, refractory liquid pneumothorax, axillary odor, various cysts, acne, pemphigus, etc. Its adverse drug reactions mainly include gastrointestinal reactions, liver and kidney function damage, allergic reactions, especially affecting the development of teeth and bones.
Therefore, the use of tetracycline antibiotics is prohibited for children under eight years of age.
What is cefalexin?
Cefalexin, antibiotics β-lactams cephalosporins. It can inhibit the synthesis of the cell wall, swell the cell contents to rupture and dissolve, and kill bacteria.
2. Mechanism of action
Its mechanism of action is to inhibit the cell wall synthesis of bacterial dividing cells by binding to one or more penicillin-binding proteins (PBPs) (cephalexin mainly binds to PBP-3), thereby playing an antibacterial effect.
Broad-spectrum antibiotics. Mainly used for Gram positive and negative bacterial infections, such as: influenza, hemorrhagic septicemia, streptococcosis, swine erysipelas, anthrax, emphysema, malignant edema, actinomycosis, necrotizing bacillus disease, hook end Septicemic fever (41-43 °C) or persistent low temperature (below 37 °C) caused by spirochete disease, indigestion, drinking cold water, sleeplessness, cripple walking, blue ears, tearing, etc.
At the same time, it is used to treat various inflammatory diseases, such as: infectious pleura pneumonia, pneumonia, atrophic rhinitis, blue ear disease, mastitis, hysteritis, stomatitis, urethritis and other cough and wheezing, difficulty breathing, low pregnancy, more stillbirths or death of piglets 7-10 days after birth, breast swelling, milk deterioration, decreased milk production, foot and mouth ulceration, salivation, sores and purulence.
4. Cefalexin for dogs
Cephalosporins are the most widely used anti-inflammatory drugs in the clinic. They are mainly aimed at Gram-negative and Gram-positive bacteria, and can treat bacterial infections in the respiratory tract, digestive tract, and urinary tract.
5. Cefalexin side effects
A. Gastrointestinal reactions: nausea, vomiting, diarrhea and abdominal discomfort are more common gastrointestinal symptoms, occasionally pseudomembranous enteritis.
B. Nervous system reaction: A few patients may experience dizziness, diplopia, tinnitus, convulsions and other nervous system reactions.
C. Hepatotoxicity: A few patients may have transient liver dysfunction (temporal elevation of serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase) after medication.
D. Nephrotoxicity: A few patients may experience temporary increases in urea nitrogen, creatine, and creatinine, and occasional proteinuria and oliguria may occur.
E. Blood system: Occasional drop in hemoglobin, thrombocytopenia, neutropenia, eosinophilia, etc. after medication.
F. Others: Long-term medication may cause bacterial flora imbalance and double infection; vitamin K and vitamin B deficiency may also occur.
G. Allergic reactions such as rash, urticaria, erythema, and drug fever are more common, and occasionally anaphylactic shock.
The hazards of Betalactam, Tetracycline and Cefalexin
Some drugs with stable properties can still exist stably for a long time after being excreted into the environment, resulting in drug residues in the environment.
Streptomycin and oxytetracycline are not easily degraded in the environment; spiramycin is degraded quickly at low concentrations, but it takes 6 months to degrade at high concentrations; bacitracin zinc needs 3 to 4 months for complete degradation under aerobic conditions. It takes longer to degrade in an oxygen-free environment.
According to reports, the concentration of erythromycin and sulfamethoxazole in the sewage pond of animal farms can reach 69g/L. The discharge of these drugs pollutes the environment and destroys the ecological balance.
In recent years, researchers have suspected that the increasing incidence of tumors in the population is related to environmental pollution and animal food drug residues. Estrogen, nitrofurans, arsenic preparations, etc. have all been proven to have carcinogenic, teratogenic, and mutagenic effects.
Features of Betalactams Tetracyclines Cefalexin Test
1. 8min reading results
2. Detection limits respond to EU and US FDA norms
3. Single test for every target sample
4. Neither professionals nor equipment required
5. Eyes interpretation or quantitative measurement, suitable for lab and field use
6. Room temperature storage
7. Non-toxic and harmless
Detection Method of Betalactams Tetracyclines Cefalexin Cobo Test
The Betalactams Tetracyclines Cefalexin Test is a colloidal gold immunochromatography assay that detects Beta-lactams, Tetracycline and Cefalexin in egg and egg products and meets EU MRL. This kit can be applied for on-site rapid testing by various departments.
Samples for Betalactams Tetracyclines Cefalexin Test
Samples include: egg and egg products.
Detection Limit of Betalactams Tetracyclines Cefalexin Test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of Betalactams Tetracyclines Cefalexin Test
Betalactams Tetracyclines Cefalexin Test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.
Components of Betalactams Tetracyclines Cefalexin Test
1. Micro-Well Reagent: 8 tests/tube, 12 tubes/box
2. Test Strip: 8pcs/tube, 96pcs/box
3. Manual Instruction: 1pc
Materials for Betalactams Tetracyclines Cefalexin Test
1. Sample Tube
2. Pipette & Pipette Tip
How to use Betalactams Tetracyclines Cefalexin Test?
1. Add 200ul test solution into a well, then pipet up and down for 10 times to completely mix the sample with the reagent in the well.
2. Then incubate for 3min.
3. Insert the test strip into the micro-well with the sample pad fully dipped.
4. After 5 minutes, read the results.
When antibiotics were first used on humans, we regarded them as "panacea". As the problem of antibiotic abuse continues to worsen, their resistance has also brought huge harm to humans.
Therefore, in daily life, we should avoid food with antibiotic residues. The first step to self-help: we need to detect antibiotic residues.
How to order a Betalactams Tetracyclines Cefalexin Test?
Please check the online catalog and contact our sale representative via email: email@example.com or fill out contact form below: