Beta lactam have the advantages of strong bactericidal activity, low toxicity, wide indications and good clinical efficacy. The chemical structure of this class of drugs, especially the side chain changes, has formed many antibiotics with different antibacterial spectrum and antibacterial effect, as well as various clinical pharmacological properties.
Betalactam inhibitors (β-Lactamase inhibitors) are a new class of β-lactam drugs. They can inhibit β-lactamase type n, in, w, v, and are not effective for type I enzymes. This results in a significant decrease in the minimum inhibitory concentration (MIC) of penicillins and cephalosporins, and the drug can be multiplied by several to dozens of times, and enzyme-producing strains can be made sensitive to drug recovery. This class of drugs alone has almost no antibacterial effect.
A. Penicillins: such as penicillin G, amoxicillin, ampicillin, and piperacillin. Before using penicillin antibacterial drugs, you must ask in detail whether you have a history of penicillin allergies, other drug allergies, and allergic diseases. Skin test, the concentration of skin test solution is generally 500U/ml. Once anaphylactic shock occurs, 0.1% epinephrine 0.5-1ml should be injected subcutaneously immediately, and there is no improvement in clinical performance. Repeat it 3-5 minutes later, and cooperate with other symptomatic rescue measures.
B. Cephalosporins: According to the antibacterial spectrum, antibacterial activity, stability to β-lactamase and renal toxicity, it is divided into four generations. The first generation: cefalexin, cefazolin, cefradine, cefadroxil; the second generation: cefaclor, cefuroxime, cefprozil, cefotiam, etc. According to the drug package, decide whether to conduct a drug allergy test. Those who are allergic to cephalosporins and those with penicillin anaphylactic shock or immediate reaction history are prohibited from this class of drugs.
C. New β-lactams
Is penicillin a beta lactam?
Penicillin G is the earliest antibiotic used in the clinic. Because of its advantages of strong bactericidal power, low toxicity, low price and convenient use, it is still the first choice for the treatment of various infections caused by sensitive bacteria.
However, penicillin has shortcomings such as acid intolerance, intolerance to penicillinase, narrow antibacterial spectrum, and easy to cause allergic reactions, which has been limited in clinical application.
Since 1959, people have used 6-aminopenicillanic acid (6-APA), the parent nucleus of penicillin, to carry out chemical transformations, connected to different side chains, and synthesized hundreds of "semi-synthetic penicillins". The chemical structure and pharmacological properties of commonly used penicillin
Beta lactam cephalosporin
Cephalosporins are a class of semi-synthetic monolactam antibiotics obtained by structural modification of natural cephalosporin C.
It has strong selection effect on bacteria, almost no toxicity to human body, broad antibacterial spectrum, strong antibacterial effect, allergic reactions are rarer than penicillin, and stable to β-lactamase.
What are tetracyclines?
Tetracycline antibiotics mainly include chlortetracycline, oxytetracycline, and tetracycline. Tetracycline antibiotics have a common chemical structure. Both chlortetracycline and oxytetracycline are derivatives of tetracycline, the former is chloretracyelin, the latter is oxyeracyein, and the tetracycline family are both acid-base amphoteric compounds.
Tetracycline antibiotics include chlortetracycline, oxytetracycline, tetracycline, and demeclocycline, and semi-synthetic tetracyclines such as doxycycline, minocycline, and guantetracycline.
2. Tetracycline drugs
A. Tetracycline capsule This product is used as an optional drug in the following diseases. Rickettsia, including epidemic typhus, endemic typhus, Rocky Mountain fever, tsutsugamushi disease and Q fever. Mycoplasma is an infection. Chlamydia is an infection, including parrot fever, sexually transmitted diseases, lymphogranuloma, non-specific urine.
B. Tetracycline powder As a veterinary medicine, it is used as a feed additive and has a good effect on Escherichia coli and Proteus. The oral absorption effect is better than oxytetracycline.
C. Tetracycline pills This product is used as the first choice or selected medicine for the following diseases: Rickettsial disease, including epidemic typhus, endemic typhus, Rocky Mountain fever, tsutsugamushi disease and Q fever. Mycoplasma is an infection. Chlamydia infections, including psittacosis, sexually transmitted diseases, lymphogranuloma, nonspecific urethritis, salpingitis, cervicitis and trachoma. Return to fever. Brucellosis. Cholera. Rabbit fever. Plague. Soft chancre.
The harm of beta lactam and tetracycline
Tetracycline antibiotics include chlortetracycline, oxytetracycline and tetracycline, etc., which can be used as veterinary drugs to prevent and treat livestock diseases or as feed additives to promote the growth of livestock and poultry, and are widely used in edible animals.
However, excessive use inevitably forms the metabolites and other related antibiotics remains in the animal's muscles, eggs, milk, and organ tissues affecting human health through the food chain. The abuse of antibiotics causes bacteria to develop resistance, bringing difficulties to the treatment of human diseases.
Features of betalactam tetracyclines test
1. 7min reading results
2. Detection limits respond to EU and US FDA norms
3. Neither professionals nor equipment required
4. Easy to operate
Detection Method of Beta lactam tetracycline combo test
The Betalactam Tetracyclines Test is a colloidal gold immunochromatography assay that detects Penicillin G, Penicillin V, Ampicillin, Amoxicillin, Oxacillin, Cloxacillin, Dicloxacillin, Nafcillin, Cefquinome, Cefacetrile, Cefalonium, Cefazolin, Cefoperazone, Cephapirin, Ceftiofur and Tetracycline in egg and egg products and meets EU MRL.
Samples for betalactam tetracyclines test
Samples include: raw milk, milk powder, pasteurized milk, egg and egg products, etc.
Limit of Detection for betalactam tetracyclines test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of betalactam tetracyclines test
Betalactam tetracyclines test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.
Components of Betalactam tetracyclines test
1. Micro-Well Reagent: 8 tests/tube, 12 tubes/box
2. Test Strip: 8pcs/tube, 96pcs/box
3. Manual Instruction: 1pc
Materials of Betalactam tetracyclines test
1. Sample Tube
2. Pipette & Pipette Tip
How to use betalactam tetracyclines test?
1. Add 200ul test solution into a well, then pipet up and down for 10 times to completely mix the sample with the reagent in the well.
2. Then incubate for 3min.
3. Insert the test strip into the micro-well with the sample pad fully dipped.
4. After 5 minutes, read the results.
When antibiotics were first used on humans, we regarded them as "panacea". As the problem of antibiotic abuse continues to worsen, their resistance has also brought huge harm to humans.
Therefore, in daily life, we should avoid food with antibiotic residues. The first step to self-help: we need to detect antibiotic residues.
How to order betalactam tetracyclines test?
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