Quinolones Test is based on the Colloidal Gold Immunochromatography to detect the Quinolones residues in agricultural products. This kit can be applied for on-site rapid or lab testing by various departments.
The basic skeleton of quinolone antibiotics has a nitrogen (hetero) biparacyclic structure. The quinolone and other antibacterials have different points of action.
They target bacterial DNA (DNA). The double-stranded DNA of bacteria is twisted into a maggot or spiral (called supercoil).
The enzyme that makes DNA into a supercoil is called DNA gyrase. Quinolones hinder this enzyme and further cause irreversible damage to bacterial DNA. The cells no longer divide.
They show selective toxicity to bacteria. Currently, the resistance of some bacteria to many antibiotics can be widely spread due to plasmid transmission.
This class of drugs is not affected by plasmid-transmitted resistance, so there is no cross-resistance between this class of drugs and many antibacterials.
2. Quinolones Drugs
A. Broad antibacterial spectrum Especially for aerobic gram-negative bacilli, including Pseudomonas aeruginosa, it has a strong bactericidal effect, and it also has a good antibacterial effect on Staphylococcus aureus and enzyme-producing Staphylococcus aureus. Some species also have an effect on Mycobacterium tuberculosis, Mycoplasma, Chlamydia and anaerobic bacteria.
B. Good oral absorption and wide distribution in the body. The plasma protein binding rate is low and the plasma half-life is relatively long. Partially excreted in the kidneys, high urine concentration, and partly metabolized by the liver.
C. Less adverse reactions and well tolerated. Nausea, vomiting, loss of appetite, rash, headache, and dizziness are common. Occasionally convulsions and other mental symptoms, withdrawal can be subsided. All fluoroquinolones should not be used in pre-pubertal children or pregnant women because they can cause arthropathy in juvenile animals and cause joint pain and swelling in children.
D. Suitable for sensitive pathogens (such as Staphylococcus aureus, Pseudomonas aeruginosa, intestinal gram-negative bacilli, Campylobacter and Neisseria gonorrhoeae, etc.) known urinary infections, prostate infections, gonorrhea, respiratory infections, stomach Intestinal infections and infections of bones, joints, and soft tissues.
1. Quinolone ear drops
Ofloxacin ear drops, the indication is for the treatment of otitis media, external auditory canalitis, and tympanitis caused by sensitive bacteria.
Ofloxacin is a bactericide, which acts on the A subunit of bacterial DNA helicase, inhibits DNA synthesis and replication and causes bacterial death.
2. Quinolones antibiotics
Quinolone antibiotics are members of numerous broad-spectrum fungicides that share a bicyclic core structure associated with 4-quinolone substances. They are used in human and veterinary medicine to treat bacterial infections as well as animal husbandry.
Almost all quinolone antibiotics used are fluoroquinolones. The chemical structure of fluoroquinolones contains fluorine atoms, which is effective for both Gram-negative and Gram-positive bacteria.
3. Which antibiotics are quinolones?
Norfloxacin, ofloxacin, levofloxacin, pefloxacin, enoxacin, pipic acid, cinofloxacin, and mexoquinic acid, norfloxacin, ofloxacin, levofloxacin, culture Fluoxacin, enoxafloxacin, ciprofloxacin, lomefloxacin, travafloxacin mesylate, and clinfloxacin hydrochloride are all quinolone antibiotics.
The hazards of Quinolones
1. Adverse Effects
The main adverse reactions of this class of drugs are:
① gastrointestinal reactions: nausea, vomiting, discomfort, pain, etc.;
② central reactions: headache, dizziness, poor sleep, etc., and can cause mental symptoms;
③ because this class of drugs can inhibit γ -The effect of aminobutyric acid (GABA), so it can induce epilepsy, with caution in those with a history of epilepsy;
④ This class of drugs can affect cartilage development, pregnant women and minor children should be used with caution;
⑤ can produce crystalline urine, still in alkali Sexual urine is more likely to occur;
⑥ Large doses or long-term application of this class of drugs are likely to cause liver damage.
2. Quinolones contraindications
It is generally believed that quinolone drugs cannot be used by pregnant women and children, because the drug affects cartilage development; patients with epilepsy cannot use quinolone drugs because quinolone drugs can inhibit the aminobutyric acid.
Patients with epilepsy can cause seizures; quinolone drugs can have side effects on the liver, so patients with poor liver function should not use them; patients with poor renal function should not use quinolone drugs, because this drug will cause urine crystallization, can cause alkaline uremia in patients.
3. Allergic to quinolones
The main allergic reactions of quinolone drugs are: local redness, swelling, rash, urticaria, and photosensitivity.
Among allergic reactions, anaphylactic shock is most harmful to patients, and even causes death. The incidence of anaphylactic shock is low.
Why quinolones are not recommended in paediatrics?
In most countries, fluoroquinolones are approved for use in children only with stenosis, in part because of the high rates of skeletal and muscle adverse events observed in young animals treated with fluoroquinolones.
Features of Quinolones Test
1. 15min reading results.
2. Detection limits respond to EU and US FDA norms.
3. Neither professionals nor equipment required.
4. Easy to operate and read.
Detection Method of Quinolones Test
Quinolones Test for Agricultural Products is based on the Colloidal Gold Immuno-chromatography to detect the Quinolones residues in agricultural products.
This kit can be applied for on-site or lab testing by various departments.
Samples of Quinolones Test
Samples include: agricultural products.
Detection Limit of Quinolones Test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of Quinolones Test
Quinolones Test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.
1. Read the instruction and let the sample at room temperature （20-25℃）.
2. Take out the test strip, use within 1h.
3. Drop 100µL of sample into the micro well, pipetting up and down for 6 times to dissolve the reagent. Then, incubate for 5mins at room temperature.
4. Drop 100µL sample into the sample well, stand for 5mins at room temperature.
5. Read the result within 5-8mins. The result after 5-8mins is invalid.
Quinolone, a broad class of broad-spectrum antibacterial drugs, is mainly used for the treatment of human diseases. In order to avoid human beings from consuming quinolone drug residues and causing harm to the human body, it is necessary to develop quinolone drugs for animals.
The Quinolones Test (0.5PPB) kit provided by BALLYA can effectively detect the presence of Quinolones residues in agricultural products.
This kit is not only simple to operate, but also has a short test time and high accuracy, and the test results comply with EU standards. Can effectively ensure the safety of agricultural products.
How to order Quinolones Test?
Please check the online catalog and contact our sale representative via email: firstname.lastname@example.org or fill out contact form below: