BALLYA Nitrofurantoin Test is manufactured by BALLYA, it’s rapid test for detection nitrofurantoin residues in chicken meat and bee product, especially in chicken meat. Lateral flow assay test base on the gold immunochromatography assay technology.
Nitrofurantoin is an antibiotic. It has antibacterial effect, especially sensitive to Escherichia coli, and then more sensitive to Aerobacter and Proteus. In addition, P. aeruginosa is usually resistant to this drug and has no effect. Nitrofurantoin is mainly used clinically to treat infections caused by sensitive bacteria. For example, Escherichia coli, Enterococcus, Staphylococcus, this kind of infection caused by bacteria, especially for acute, simple lower urinary tract infection can also be used for the prevention of urinary tract infection.
Nitrofurantoin mechanism of action
Escherichia coli is most sensitive to this product, and some strains of Enterobacteriaceae bacteria such as Enterobacter aerogenes, Enterobacter cloacae, Proteus, Klebsiella are sensitive to this product, and Pseudomonas aeruginosa is usually Product resistance. This product has antibacterial effect on Gram-positive bacteria such as Enterococcus. The antibacterial activity of the product is not affected by pus and tissue decomposition products, and has strong activity in acid urine. The antibacterial action mechanism is to interfere with the oxidoreductase system in the bacteria, thereby blocking its metabolic process. The product is an enteric sugar-coated tablet, which is yellow after removal of the coating.
Nitrofurantoin synthesis
It can be made from hydrazine hydrate, urea, etc., and then condensed with nitrofuran diethyl ester.
How Nitrofurantoin uses for?
Organic synthesis and biochemical research medicine. This product is an excellent antibacterial drug with a broad antibacterial spectrum. It is quickly and completely absorbed after oral administration and excreted quickly. It can be excreted in the urine up to 40-50%. It is often used to treat urinary tract caused by various sensitive bacteria infection. It has effects on Gram-negative and positive bacteria, and is mainly used for urinary tract infections caused by sensitive bacteria, especially for acute urinary tract infections caused by Escherichia coli and Proteus. Clinically used for urinary system infections caused by sensitive bacteria, such as pyelonephritis, urinary tract infections, cystitis and prostatitis.
Nitrofurantoin drug class
Nitrofurantoin oral capsules are used to prevent and treat urinary tract infections caused by certain bacteria. Nitrofurantoin can also be used as an oral suspension.
Nitrofurantoin tablets
It is used for acute simple lower urinary tract infection caused by Escherichia coli, Enterococcus, Staphylococcus, Klebsiella, Enterobacter and other bacteria, and can also be used for the prevention of urinary tract infection. Nitrofurantoin dosage: Oral adults 50 to 100 mg once, 3 to 4 times a day. Low dose for simple lower urinary tract infections; children over 1 month take 5 to 7 mg / kg of body weight daily in 4 divided doses. The course of treatment is at least 1 week, or at least 3 days after the urine culture turns negative. For the prevention of recurrent episodes of urinary tract infections, 50-100 mg a day for adults, 1 mg / kg a day for children.
What's Nitrofurantoin side effect?
The most common side effects of nitrofurantoin are nausea, headaches and flatulence. Less common adverse events (less than 1% of those taking the drug) include: Gastrointestinal tract: diarrhea, indigestion, abdominal pain, constipation, vomiting Nervous system: dizziness, drowsiness, amblyopia Respiratory tract: acute lung hypersensitivity Allergies: itching, hives Skin disease: hair loss Miscellaneous: fever, chills, discomfort Patients should be advised that nitrofurantoin will make the urine brown; this is completely harmless. Some of the more serious but rare side effects of nitrofurantoin have caused concern. These include lung reactions, liver toxicity and neuropathy.
Nitrofurantoin interactions
1. Drugs that can cause hemolysis combined with furantoin have a tendency to increase the hemolytic response. 2. Both probenecid and benzofurone can inhibit the renal tubular secretion of furantoin, resulting in an increase in the plasma concentration and / or half-life of the latter, while a decrease in urine concentration and a decrease in efficacy. The probenecid dose should be adjusted. 3. This product is used in combination with antacids to reduce the absorption of this medicine. This product can reduce the antibacterial effect of nalidixic acid, because they have antagonistic effects, so the two cannot be used together.
What's Nitrofurantoin macrocrystal?
Nitrofurantoin macrocrystal are synthetic chemicals with controlled crystal size. The macrocrystalline nitrofurantoin is a larger crystalline form of nitrofurantoin. Compared with nitrofurantoin, nitrofurantoin absorbs large crystals more slowly and excretes less. Blood concentrations at therapeutic doses are usually low. It is highly soluble in urine and may turn brown. Nitrofurantoin macrocrystal are an antibacterial agent for specific urinary tract infections.
What specimen can be detected by BALLYA Nitrofurantoin Test?
Specimen include: chicken meat, bee product etc. Widely used in chicken meat and bee product industry.
Significance of testing Nitrofurantoin
To protect human have health food and avoid contaminated food. The nitrofurantoin is harmful for human being, can not take too much in body.
1. Take chicken meat specimen and extrat supernatant or bee product specimen 2. Add the supernatant to cassette 3. Wait for 15 minutes to result 4. The details of operation, refer to the kit instruction
Limitations of BALLYA Nitrofurantoin Test?
BALLYA Nitrofurantoin Test is a qualitative test kit. It’s only for screening purpose. If have positive cases or suspected case, maybe use other detection method to make a further detection, such as, ELISA, PCR, qPCR, etc.
Conclusion
As a veterinary drug, this product is absorbed orally quickly but not completely. It is widely distributed in animals and can enter tissues and body fluids well. Mainly excreted from urine in the form of original drugs. But it is inevitable that there will be residual drugs left in the body. This is likely to cause nitrofurantoin residues in chicken. It is necessary to detect nitrofurantoin in chicken. BALLYA Nitrofurantoin Test provided by BALLYA can effectively and quickly detect whether chicken contain nitrofurantoin residues. Not only is the operation simple and the detection time is short, it allows the tester to obtain the test results in the first time.
