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BALLYA Dexamethasone Test

Ballya-antibiotic-testBALLYA Dexamethasone Test

What is BALLYA Dexamethasone Test?

BALLYA Dexamethasone Test is manufactured by BALLYA, it’s rapid test for detection dexamethasone residues in pork liver, or pork, especially in pork. Lateral flow assay test base on the gold immunochromatography assay technology.
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What is Dexamethasone?

Dexamethasone structure

1. Molar refractive index: 100.23
2. Molar volume (cm3/mol): 296.2
3. Isotonic specific volume (90.2K): 812.3
4. Surface tension (dyne/cm): 56.5
5. Polarizability (10-24cm3): 39.73

Dexamethasone mechanism of action

Its pharmacological effects are mainly anti-inflammatory, anti-toxic, anti-allergic and anti-rheumatic, and it is widely used in clinical practice. Easily absorbed from the digestive tract, the plasma T1/2 is 190 minutes, and the tissue T1/2 is 3 days. After intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate, the peak plasma concentration is reached at 1 hour and 8 hours, respectively. . The plasma protein binding rate of this product is lower than other corticosteroids. The anti-inflammatory activity of this product 0.75 mg is equivalent to 5 mg prednisolone. Adrenal corticosteroids have stronger anti-inflammatory, anti-allergic and anti-toxic effects than prednisone, and have a very light effect on water and sodium retention and promoting potassium excretion. They can be injected intramuscularly or intravenously to inhibit the pituitary and adrenal glands.
1. Anti-inflammatory effect: It can reduce and prevent the tissue's response to inflammation, thereby reducing the performance of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and white blood cells, at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators.
2. Immunosuppressive effects: including preventing or suppressing cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, and reducing the ability of immunoglobulin to bind to cell surface receptors, And inhibit the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes into lymphoblasts, and reducing the expansion of the primary immune response. It can reduce the passage of immune complexes through the basement membrane, and can reduce the concentration of complement components and immunoglobulins.

Dexamethasone synthesis

A new process for the production of dexamethasone 21-hydroxy compound. The intermediate 21-acetate is used as the substrate, and an appropriate amount of methanol containing 0-10% chloroform is used as a solvent to semi-dissolve the substrate, and a base is used as a catalyst. The hydrolysis reaction is carried out, and after the reaction is complete, the reaction solution is neutralized with acetic acid, the reaction solution is concentrated under reduced pressure to an appropriate volume, the temperature is lowered, the filter cake is washed, and dried to obtain 21-hydroxyl compound. The process can shorten the production cycle, improve the quality and yield of 21-hydroxyl compounds, and reduce the content of impurities in 21-hydroxyl compounds.

Dexamethasone half life

The biological half-life of dexamethasone is about 190 minutes, and the tissue half-life is about 3 days. More than 65% of the drug is excreted in urine within 24 hours, mainly inactive metabolites.

How Dexamethasone uses for?

It acts as the main therapeutic drug in the treatment of different diseases. In some diseases, it also acts as an auxiliary treatment. For example, it is the main therapeutic drug in allergic and autoimmune diseases. Some chemotherapy processes are also the main chemotherapy drugs. For example, the malignant lymphoma program contains hormonal drugs such as dexamethasone or prednisone as the main chemotherapy drugs. Secondly, in the treatment of nausea and vomiting caused by chemotherapy, dexamethasone is an adjuvant chemotherapy drug, which can stop vomiting. Its pharmacological effects are very powerful, and its usage and dosage are also very wide. When treating some basic allergic and autoimmune diseases, the method of administration can be oral or intravenous drip. For oral administration, the recommended starting dose for adults starts with a low dose, 0.75 to 3 mg, which is 1 to 4 tablets, two to four times a day. Maintain a certain dose, such as once a day, one piece at a time for maintenance, and the response of individual patients is different.

What's Dexamethasone side effect?

Clinically, the side effects of dexamethasone will first affect water and sodium. Because hormones can cause water and sodium storage, patients will experience increased blood pressure and promote potassium excretion, which will lead to hypokalemia and high sodium in patients. Blood pressure can cause high blood pressure, especially hormones in patients with severe hypertension should be used with caution. At the same time, it can affect the metabolism of sugar and fat, leading to fat redistribution. Therefore, if the hormone is used for too long, it will cause the patient to have a full moon face and buffalo back, similar to the clinical symptoms of Cushing syndrome. In addition, dexamethasone can also cause wounds to not heal because it affects tissue repair. For some severely infected patients, it can also cause infections that are not easy to control, especially for tuberculosis patients, which may cause some tuberculosis in the incubation period to be reactivated Status, aggravating infection. Dexamethasone can also promote the dissipation of calcium, and long-term clinical use of hormones is known to cause femoral head necrosis, which is caused by the loss of calcium by hormones. It can also lead to peptic ulcers, etc. These are common side effects of hormone application.

Dexamethasone interactions

Dexamethasone and calcium chloride, sulfadiazine sodium, tetracycline hydrochloride, oxytetracycline hydrochloride, diphenhydramine, chlorpromazine, promethazine, sulfacetamide, procaine hydrochloride, scopolamine hydrobromide, etc. Compatibility is prone to turbidity or precipitation, making the drug ineffective; combined with furosemide and sodium salicylate can increase its toxicity.

Dexamethasone contraindications

1. Those who are allergic to adrenaline corticosteroids.
2. A history of severe mental illness.
3. Active gastric and duodenal ulcers.
4. After the recent gastrointestinal anastomosis.
5. Heavier osteoporosis.
6. Obvious diabetes.
7. Severe high blood pressure.
8. Virus, bacteria, and fungal infections that cannot be controlled with antibacterial drugs.
9. Systemic fungal infection.
10. Ophthalmic preparations should not be used for corneal ulcers, herpes simplex keratitis, varicella and other viral diseases of the cornea and conjunctiva, fungal infections of the eye tissue, mycobacterial infections, glaucoma or family history of glaucoma, eardrum puncture.
11. Thrombophlebitis.
12. Active tuberculosis

What products does Dexamethasone have?

Dexamethasone injection

Dexamethasone injection belongs to the adrenal cortex hormone drug, which has anti-inflammatory, anti-allergic and anti-shock effects. It is mainly used clinically for allergic and autoimmune diseases. Such as rheumatoid arthritis, bronchial asthma, dermatitis and other allergic diseases. Mainly used for allergic and autoimmune inflammatory diseases, such as connective tissue disease, rheumatoid arthritis, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma, etc.

Dexamethasone tablet

Function and indication: Mainly suitable for allergic and autoimmune inflammatory diseases, such as connective tissue disease, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma, etc. This medicine is also used for the diagnosis of certain adrenal cortex diseases-dexamethasone suppression test.
Usage and dosage: Orally. The starting dose for adults is 0.75-3.00 mg (1-4 tablets) once, 2-4 times a day. The maintenance amount depends on the condition, about 0.75 mg per day (1 tablet).
Adverse reactions: A larger dose of this product can easily cause diabetes, osteoporosis, digestive ulcers and Cushing's syndrome-like symptoms, and has a strong inhibitory effect on the hypothalamic-pituitary-adrenal axis. Concurrent infection is the main adverse reaction.
Contraindications: patients with a history of allergy to this product and adrenal corticosteroids are contraindicated

Dexamethasone cream

Indications: Used for neurodermatitis, contact dermatitis, seborrheic dermatitis and chronic eczema.
Usage and dosage: external use. Once a day, apply a small amount to the affected area and knead gently for a while.
Adverse reactions: long-term use can cause skin atrophy, telangiectasia, pigmentation and secondary infections. Occasionally allergic reactions.
Taboo: People who are allergic to this product are prohibited. It is contraindicated if the affected area has been ruptured, suppurated or has obvious exudation. People with virus infection (such as herpes, blisters) are forbidden.

What specimen can be detected by BALLYA Dexamethasone Test?

Specimen include: pork liver, or pork, etc. Widely used in pork liver and pork industry.

Significance of testing Dexamethasone

To protect human have health food and avoid contaminated food. The dexamethasone is harmful for human being, can not take too much in body.

Component of BALLYA Dexamethasone Test?

BALLYA Dexamethasone Test, 25 cassettes
Sample Buffer, 1 vial
Mini Pipette (optional)
Disposable micropipette tips (optional)
Kit Instruction, 1pcs
Dexamethasone Test

How to use BALLYA Dexamethasone Test?

1. Take pork specimen and extrat supernatant
2. Add the supernatant to cassette
3. Wait for 15 minutes to result
4. The details of operation, refer to the kit instruction

Limitations of BALLYA Dexamethasone Test?

BALLYA Dexamethasone Test is a qualitative test kit. It’s only for screening purpose. If have positive cases or suspected case, maybe use other detection method to make a further detection, such as, ELISA, PCR, qPCR, etc.

Conclusion

Dexamethasone has been widely used as an anabolic hormone in various industries. The pig breeding industry deserves special attention. Pork provides people with rich nutrition, making it indispensable in daily life. The problem of dexamethasone hormone residues in pork has been bothering people, so it is necessary to detect pork in time.
BALLYA Dexamethasone Test provided by BALLYA can effectively and quickly detect the presence of dexamethasone residues in pork. Not only the operation is simple, the test time is short, but the tester can get the test result in the first time.

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