BALLYA Aristolochic Acids Test
is manufactured by BALLYA, it’s rapid test for detection the content of Aristolochic Acids in all kinds of tobaccos. Lateral flow assay test base on the gold immunochromatography
is a kind of nitrophenanthrene carboxylic acid with strong carcinogenicity and nephrotoxicity. Such organic compounds naturally occur in Aristolochia plants such as Aristolochia and Asarum, and these plants have been widely used as Chinese herbal medicines.
In different plants containing aristolochic acid, the types of aristolochic acid are very different, but aristolochic acid I is the most important component in aristolochic acid and has the strongest toxicity.
The biological activities and pharmacological effects of Aristolochia plants are relatively extensive.Modern pharmacological research mainly includes anti-tumor, antibacterial, anti-inflammatory, analgesic, anti-fertility, and cardiovascular pharmacological effects.
Aristolochic acid I and aristolochic acid Ia have cytotoxic effects on specific lymphocytic leukemia and lung cancer cells, and also have a certain antibacterial effect. Aristolochic acid Ⅱ shows significant effects on three special cancer cells in the human body. With its cytotoxic activity, Aristolochia heterophylla has a certain effect in improving immune function, enhancing phagocyte function and anti-tumor therapy.
In vitro experiments show that aristolochic acid has inhibitory effects on a variety of bacteria, fungi
and yeasts in vitro. For chronic cases that are difficult to cure with antibacterial drugs alone, aristolochic acid can achieve better curative effect.
Aristolochic acid has a significant inhibitory effect on the inflammation of experimental animal tissues. The total alkaloids extracted from Aristolochia chinensis have obvious analgesic effects.
With the in-depth study of aristolochic acid and its wide clinical application, it has been found that it has strong nephrotoxic, mutagenic, carcinogenic and other adverse reactions.
Aristolochic acid has a large accumulation effect in the body, and is prone to acute and chronic poisoning, especially for rodents.It has a strong carcinogenic effect.
Pharmacokinetic studies suggest that when aristolochic acid accumulates in the human body, it can reduce the glomerular filtration rate, increase hematuria and creatinine, impair the kidney concentration function, and cause renal failure.
In addition to renal toxicity, aristolochic acid also has toxic effects on the gastrointestinal tract and liver, as well as strong mutagenicity and carcinogenicity.
Types of aristolochic acid nephropathy: clinically based on the clinical manifestations and pathological changes of aristolochic acid nephropathy, aristolochic acid nephropathy is divided into acute aristolochic acid nephropathy, chronic aristolochic acid nephropathy and renal tubular dysfunction type aristolochic acid nephropathy.
On October 27, 2017, the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization was preliminarily compiled for reference. Aristolochic acid and plants containing aristolochic acid were included in the list of carcinogens.
Note: The above content is for reference only, please use this substance under the guidance of experts!
Specimen include: all kinds of grain. Widely used in grain and Chinese herbal medicine
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BALLYA Aristolochic Acids Test
is suitable for the detection of Aristolochic Acids residues in all kinds of tobaccos. Simple operation, high accuracy and short detection time are the characteristics of this product.
It can be widely used in food and drug administration, health departments, higher education institutions, scientific research institutes, agricultural departments, animal husbandry and veterinarians, breeding farms, slaughterhouses, food and meat products deep processing enterprises, inspection and quarantine departments and other units.