Beta-lactam antibiotics are a wide range of antibiotics, including penicillin and its derivatives, cephalosporins, monoamide rings, carbapenems and penicillene enzyme inhibitors etc. β-lactam antibiotics (β-lactams) refer to a large class of antibiotics with β-lactam ring in the chemical structure. Basically all antibiotics that include β-lactam core in their molecular structure belong to β-lactams Antibiotics.
It is the most widely used class of existing antibiotics, including penicillins and cephalosporins that are most commonly used clinically, as well as newly developed cephalosporins, thiomycins, monocyclic β-lactams, etc.
Such antibiotics have the advantages of strong bactericidal activity, low toxicity, wide indications and good clinical efficacy. The chemical structure of this class of medicines, especially the change of the side chain, has formed many antibiotics with different antibacterial spectrum and antibacterial effects and various clinical pharmacological properties.
2. Mechanism of action
The mechanism of action of various β-lactam antibiotics is similar. They can inhibit cell wall mucopeptide synthase, namely penicillin binding proteins (PBPs), thereby hindering the synthesis of cell wall mucopeptides, causing bacterial cell wall defects and bacteria expansion.
In addition, the lethal effect on bacteria should also include triggering the autolysin activity of the bacteria, and mutant strains lacking autolysin show resistance. Animals have no cell wall and are not affected by β-lactam drugs. Therefore, this drug has a selective bactericidal effect on bacteria and has low toxicity to the host.
What is Cefalexin?
Cephalexin is the first-generation cephalosporin, also known as "Pioneer No. 4", which belongs to β-lactams. It can inhibit the synthesis of cell walls, swell the cell contents to rupture and dissolve, and kill bacteria. It is effective against a variety of gram-positive and gram-negative bacteria (such as Staphylococcus, Pasteurella and Escherichia coli).
Pseudomonas and Proteobacteria are usually resistant to it. Maintaining blood drug concentration higher than MIC is very important for the effect of the drug. Prolonging the dosing interval or missed dosing will reduce the therapeutic effect. The dosage and dosing interval are determined according to the site of infection, severity and pathogenic bacteria.
In severe or acute infections, the dose can be doubled or the frequency of administration can be increased. This product is toxic to rabbits and can only be used for special indications.
2. Mechanism of action
The antibacterial mechanism of cephalexin is to inhibit the synthesis of the bacterial cell wall, so that the cell swells to death, thereby achieving a bactericidal effect. Cephalexin is a broad-spectrum antibiotic.
It has antibacterial effect on both Gram-positive bacteria and Gram-negative bacteria. Its antibacterial ability is 20 times greater than penicillins, 10 times greater than sulfonamides, and 5 times greater than quinolones. Cephalexin is the first-generation cephalosporin, and its antibacterial spectrum is basically the same as cephalothin, but its antibacterial activity is weaker than the latter.
Except for Enterococcus and methicillin-resistant Staphylococcus aureus, most strains of Chemicalbook Streptococcus pneumoniae, Streptococcus hemolyticus, and Staphylococcus penicillinase producing or not producing are sensitive to this product. Cephalexin has obvious antibacterial effect on Neisseria, but it has no significant effect on Haemophilus influenzae.
The product has certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonellaand Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis showed resistance to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic gram-positive cocci are moderately sensitive to this product.
The Hazards of Betalactam and Cefalexin
Cephalexin is a β-lactam antibiotic shared by humans and animals, and is widely used in veterinary clinics. After veterinary drugs are used in animals, the drugs or their metabolites may accumulate or remain in meat and internal organs or enter milk, eggs and other livestock and poultry products.
These veterinary drugs that enter the food are veterinary drug residues. Veterinary drugs go through the processes of absorption, distribution, metabolism and excretion in animals. "Absorption" and "excretion" are the process by which the drug enters the animal body to exert its effect and remain.
"Metabolism" and "Excretion" are the process of removing drugs from animals. The hazards of antibiotics in food, especially meat and its products are also becoming increasingly apparent.
Regular consumption of foods containing low-dose antibacterial drug residues can cause allergic reactions in susceptible people. For example, penicillin, tetracycline, sulfa drugs and certain oxygenoside antibiotics, milder manifested as urticaria, fever, joint swelling and pain, etc., are antigenic, which can stimulate the body to produce antibodies and cause allergies when allergies are severe.
Long-term low-dose intake of certain antibiotics can also cause carcinogenesis, teratogenesis, and mutagenesis. For example, benzimidazole drugs can interfere with cell mitosis and have obvious teratogenic effects and potential carcinogenic and mutagenic effects; sulfonamides have a tendency to cause tumors; most of the quinolone drugs have photosensitizing effects.
Features of Betalactam Cefalexin Combo Test
1.8min reading results
2. Detection limits respond to EU and US FDA norms
3. Single test for every target sample
4. Neither professionals nor equipment required
5. Eyes interpretation or quantitative measurement, suitable for lab and field use
6. Room temperature storage
7. Non-toxic and harmless
Detection Method of Betalactam Cefalexin Combo Test
Betalactam Cefalexin Test Kit is a colloidal gold immunochromatography assay that detects Beta-lactams, Cefalexin in raw milk, milk powder, pasteurized milk and meets EU MRL. This kit can be applied for on-site rapid testing by various departments.
Samples for Betalactam Cefalexin Combo Test
Samples include: raw milk, milk powder, pasteurized milk.
Detection Limit of Betalactam Cefalexin Combo Test
The LOD may change according to requirement or specimen's difference, please refer to kit instruction for further details.
Importance of Betalactam Cefalexin Combo Test
Betalactam Cefalexin Combo Test can help manufacturers, regulatory agencies, and the public monitor product quality and help humans protect their health.
Components of Betalactam Cefalexin Combo Test
1. Micro-Well Reagent: 8 tests/tube, 12 tubes/box
2. Test Strip: 8pcs/tube, 96pcs/box
3. Manual Instruction: 1pc
Materials for Betalactam Cefalexin Combo Test
1. Sample Tube
2. Pipette & Pipette Tip
How to use Betalactam Cefalexin Combo Test?
1. Add 200ul milk into a well, then pipet up and down for 10 times to completely mix the sample with the reagent in the well.
2. Then incubate for 5min.
3. Insert the test strip into the micro-well with the sample pad fully dipped.
4. After 5 minutes, read the results.
When antibiotics were first used on humans, we regarded them as "magic drugs". As the problem of antibiotic abuse continues to worsen, their resistance has also brought huge harm to humans.
Therefore, in daily life, we should avoid food with antibiotic residues. The first step to self-help: we need to detect antibiotic residues.
How to order a Betalactam Cefalexin Combo Test?
Please check the online catalog and contact our sale representative via email: firstname.lastname@example.org or fill out contact form below: