fSAA Test

Feline serum amyloid A protein Quantitative Test Kit

For pet disease diagnosis

Specs：25T / box
Testing Time：7-10 mins
Regulation： CN / EU / RU / US

Feline serum amyloid A protein (fSAA) is an acute phase reaction protein that can be used as a sensitive indicator of early inflammation and a marker of tissue damage in cat infectious diseases. In the cat, infection, inflammation, tissue damage and other stressors cause a series of early, highly complex reactions, resulting in a non-specific increase in fSAA in the blood, but combined with other clinical indicators can better achieve the diagnosis, treatment and surgery of the disease Observation of the situation afterwards.

Clinical：

1. Inflammation index and tissue damage judgment
2. Efficacy evaluation and medication guidance
3. Real-time observation of infection
4. Postoperative monitoring and prediction of complications

Performance：

Sensitivity：2mg/L

Linear range：2~200mg/L

Repeatability：CV≤10%

Specimen：Whole blood / Serum / Plasma

Detection time：5min

Storage：2-40℃

Shelf-life：24 months

Shipment ：＜50℃

Operation Guideline

If you want to know more, please contact us

Trivia questions : What is fSAA ?

serum amyloid a protein (SAA)

SAA is an acute phase protein and binds to plasma high density lipoprotein (HDL). Clinical studies now focus on SAA types during the acute response to inflammatory diseases. Compared with the well-proven acute phase protein-CRP, SAA has been used to test whether it has any advantages in the diagnosis of acute inflammatory diseases.

serum amyloid a protein function

A large number of studies have confirmed that SAA has the following biological functions:
(1) SAA has proinflammatory activity, and has the ability to induce chemokine and chemotaxis leukocyte migration when the mass concentration of SAA is as low as 10 μg / L;
(2) SAA has It is described as an angiogenic protein. When the mass concentration of SAA is greater than 10 to 60 mg / L, it can stimulate the capillary-like structure of endothelial cell proliferation, adhesion, invasion and formation, and stimulate new blood vessel formation in the body;
(3) SAA passes at physiological level Combined with outer membrane protein A as a conditioner for Gram-negative bacteria, thereby enhancing phagocytosis of bacteria, and being able to form ion channels during the synthesis and reconstruction of cell membranes, interfere with the ion homeostasis of cells and cause bacterial lysis;
(4) SAA has anti-virus Activity, but this antiviral activity may be limited to hepatitis C virus;
(5) SAA has the ability to induce matrix degrading enzymes;
(6) reports of the role of SAA in regulating cholesterol transport have conflicting descriptions: It is reported that SAA (10 mg / L) can inhibit cholesterol from flowing out of the cells and reduce the transport of cholesterol to the damaged cells, while other reports have shown that SAA (10 mg / L) promotes cholesterol outflow. Nonetheless, further features of SAA are for further study and discovery.

serum amyloid a protein test

Serum amyloid A ("SAA") is an early and sensitive biomarker of tissue injury and inflammation, which has been reported in many inflammatory diseases. SAA levels in the blood are known to increase significantly due to tissue damage or inflammation and are classified as acute phase proteins. After inflammation, infection, tissue damage and cell necrosis, the concentration of circulating ozone depleting substances may increase to '1000 times', and decrease rapidly after recovery. Use serum for routine analysis only.In several cases milk and synovial fluids can be used for SAA detection as well.

serum amyloid a protein normal range

Normal indicators:

<10mg / L, determined by the measurement method.

Anomaly indicators:

> 10mg / L, determined by the measurement method.

serum amyloid a protein levels

Studies have found that in cases of inflammatory arthritis, serum amyloid A is most closely related to disease activity. The concentration of serum amyloid A is a sensitive indicator of early inflammation in infectious diseases, which is helpful for diagnosing inflammation, assessing its activity, monitoring its activity, and treating it. So abnormal serum amyloid A may be caused by inflammation.

serum amyloid a protein uniprot

SAA is a multi-gene-encoded protein family, approximately 3.2 kb in length, with 4 exons and 3 introns. The SAA family has now found that four human SAA genes (SAA1-SAA4) are located on chromosome 11. According to its expression in vivo, SAA can be divided into two types: acute SAA (acute SAA, A-SAA) and constitutive SAA (constitutive SAA, C-SAA). A-SAA is encoded by SAA1 and SAA2, C-SAA is encoded by the SAA4 gene, and SAA3 encodes neither A-SAA nor C-SAA.

serum amyloid a protein sequence

Like serum amyloid A in other species, the recombinant protein matches isomer 1 ("SAA1") in different isomers. Cat SAA is composed of 111 amino acids. Unlike human SAA, there are 8 AA insertions in the middle of the sequence.

serum amyloid a protein in acute viral infections

Similar to CRP to assess the progress of the acute phase response. SAA is a sensitive parameter. It begins to increase after about 8 hours of inflammatory response, and exceeds the upper limit of the reference range earlier than CRP. However, the difference between the median value of CRP in normal people and the upper limit of the reference range is about 10 times. Only 5 times in SAA. For minor infections, for example, many viral infections, elevated SAA is more common than CRP. In infectious diseases, the absolute rise of SAA is higher than that of CRP, so the SAA measurement, especially for "normal" and minor acute phase reactions, can provide better identification. Usually about two-thirds of patients with a cold have elevated SAA, but less than one-half have the same CRP. In cases of viral infection, elevated SAA and CRP concentrations are seen in adenovirus-infected individuals.

Summary :

FSAA refers to Feline serum amyloid A protein is an acute phase reaction protein that can be used as a sensitive indicator of early inflammation and a marker of tissue damage in cat infectious diseases. Ballya fSAA-Test can detect the content of Feline serum amyloid A protein, and make timely countermeasures.