Serum immunoglobulin E (IgE) belongs to one of the five main types of human immunoglobulin. The other four are immunoglobulin A (IgA), immunoglobulin D (IgD), immunoglobulin G (IgG), and immunoglobulin. M (lgM). lgE can trigger and promote type I allergies. Therefore, the detection of total IgE and specific IgE in serum is very valuable for the diagnosis of type I allergy and the determination of allergens.

The IgE value in normal human serum is about 0.1-0.9mg / L, which is usually slightly higher in men than in women. In patients with allergies or hypersensitivity, serum IgE is significantly higher than in normal people, while patients with exogenous asthma are several times higher than normal people. Therefore, IgE levels in the serum are too high, which usually indicates the presence of a genetic or type I allergy.

Detecting the content of human immunoglobulin can understand the body's humoral immune function status and help diagnose many diseases, such as immune proliferation, immune deficiency, infection and autoimmunity, which has important clinical significance.

Increased IgE, IgE multiple myeloma, atopic asthma, atopic dermatitis, allergic rhinitis, parasitic infection, SLE, rheumatoid arthritis, tropical eosinophilia, certain fungal infections, high IgE syndrome and certain cellular immunodeficiency syndromes (Nezelof syndrome and Wiskott-aldrich syndrome are more common, etc.), as well as some pediatric nephrotic syndromes.

IgE reduction is seen in primary aglobulinemia, ataxia-telangiectasia, malignancy and cytotoxic drugs.

IgE is associated with type I allergies. In patients with allergies or hypersensitivity, serum IgE is significantly higher than in normal people. Therefore, the level of IgE in the serum is too high, which usually indicates the presence of a genetic or type I allergy.

Atopic dermatitis in dogs (CAD) is a common skin disease that is defined as a genetically susceptible disease that develops into itchy inflammatory skin diseases associated with IgE antibodies and is usually directed against environmental allergens. This disease usually affects dogs from 6 months to 3 years of age and is characterized by itching and secondary skin lesions distributed on the face (mouth, eyes), auricle depressions, abdomen, elbow flexors, wrists and fingers Other areas and areas between the perineum joints and the skin.

Allergy tests, including serological assessment of allergen-specific IgE and intradermal skin tests, should not be used to diagnose CAD. Many healthy dogs are sensitive to environmental allergens and are therefore positive. In addition, many dogs with clinical symptoms of CAD showed negative results in these tests. The term "atopic dermatitis" describes this group of dogs. Allergy tests can only be performed to identify allergens for allergen-specific immunotherapy and desensitization.

If the reaction is due to a genetic allergy, genetic allergens can be used for the allergic reaction, such as desensitization treatment. Your veterinarian will inject your pet with a sensitive allergen. This can reduce the dog's itching by 60-80%, but it takes about 6 months to a year to take effect.
Your veterinarian may recommend immunomodulatory drugs. These are available as daily pills (Apoquel) or as injections every 4-10 weeks (Cytopoint). In addition, antibiotics or antifungals are often required to treat skin infections caused by allergies.
In addition, regular baths or shampoos can greatly improve pet comfort and help resolve skin infections faster. Shampoos and other topical treatments can also be used as maintenance treatments to reduce the risk or severity of future skin infections.

The most common cause of CAD is environmental allergens in dust mites and pollen. House dust mite glycoprotein is probably the most common allergen in atopic dogs. Therefore, reducing the number of mites and their allergens in the home may help alleviate CAD symptoms. There are several products on the market that reduce dust mite allergens. However, only one uncontrolled study has shown that the use of acaricide benzyl benzoate spray to control house dust mites to combat the clinical symptoms of CAD in dogs with atopic allergies. Other controlled studies related to reducing and improving atopic dog dust mite allergens are also needed; these studies should continue for months due to the long-term presence of mite allergens in the environment. Theoretically, another measure to reduce mite allergens includes regular thorough cleaning of pet mattresses, as well as cleaning and vacuuming the environment.

IgE acts as an antibody to allergens, especially proteins in allergens. IgE encapsulates mast cells in the skin. When the allergen enters the skin again, it degranulates mast cells and causes inflammation. At this point, we can start to see changes in the skin of cats and dogs.
The Canine Total IgE Test (Ab) kit provided by BALLYA can effectively detect whether the IgE content in the dog is normal. The kit is not only simple to operate, but also has short detection time and high accuracy, so that the veterinarian can understand the dog's physical condition and take appropriate treatment measures in time.

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