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Quinolones Rapid Test For Agricultural Products

cat-fsaa-test-kit

For Agricultural Products

Specs:10 T / box
Testing Time:15 mins
Worldwide shipping, free sample
Introduction
The Quinolones Rapid Test For Agricultural Products is based on the Colloidal Gold Immunochromatography to detect the Quinolones residues in aquaculture products. This kit can be applied for on-site or lab rapid testing by various departments.

Components
Test Kit
10pcs
Hexane(12ml)
1bottle
Product Instruction
1
Micro well
10pcs
Re-Hydration Fluid(2ml)
1bottle
Centrifuge Tube (15ml)
20pcs
Storage & shelf-life
At 4~30℃, out of sun light & moisture, 12 months

Performance Information
Fluoroquinolones
MRL (ug/kg)
Enrofloxacin
0.5
Ciprofloxacin
1
Norfloxacin
1
Ofloxacin
0.5
Flumequine
1
Danofloxacin
0.5
Norfloxacin
0.5
Oxilinic acid
1
Lomefloxacin
5
Gatifloxacin
9
Enoxacin
7
Levofloxacin
7.5
Danofloxacin
5
Pefloxacin
5
Sarafloxacin
2
Product reference
Ethyl Acetate
Mixer
Oscillator
Electronic Balance
Centrifuge
Organomation
Pipette

Preprocessing procedure
Refer to the instruction
Test procedure 
1. Read the instruction and let the sample at room temperature (20-25℃).
2. Take out the test strip, use within 1h.
3. Drop 100µL of sample into the micro well, pipetting up and down for 6 times to dissolve the reagent. Then, incubate for 5mins at room temperature.
4. Drop 100µL sample into the sample well, stand for 5mins at room temperature.
5. Read the result within 5-8mins. The result after 5-8mins is invalid
Interpretation of results
Negative: line T is same or stronger than line C
Positive: only line C appear or line T is hardly appearing
Invalid: line C does not appear 

Results illustration
Negative:
Positive:
Invalid:
Precautions
Refer to the instruction

If you want to know more, please contact us

Trivia questions : What is quinolones?

About quinolones

Quinolones definition

Quinolones (4-quinolones), also known as pyridonic acid or pyridonic acid, are a class of synthetic antibacterials. Quinolones are antibacterial drugs that mainly act on Gram-negative bacteria, and have weaker effects on Gram-positive bacteria (some varieties have better antibacterial effects on Staphylococcus aureus).

Quinolone structure

The basic skeleton of quinolone antibiotics has a nitrogen (hetero) biparacyclic structure. The quinolone and other antibacterials have different points of action. They target bacterial DNA.

Quinolones mechanism of action

The basic skeleton of quinolone antibiotics has a nitrogen (hetero) biparacyclic structure. The quinolone and other antibacterials have different points of action. They target bacterial DNA (DNA). The double-stranded DNA of bacteria is twisted into a maggot or spiral (called supercoil). The enzyme that makes DNA into a supercoil is called DNA gyrase. Quinolones hinder this enzyme and further cause irreversible damage to bacterial DNA. The cells no longer divide. They show selective toxicity to bacteria. Currently, the resistance of some bacteria to many antibiotics can be widely spread due to plasmid transmission. This class of drugs is not affected by plasmid-transmitted resistance, so there is no cross-resistance between this class of drugs and many antibacterials.

Quinolones resistance

In the treatment of various infectious diseases, doctors should strictly grasp the indications and contraindications of the drug, and use it reasonably, reduce the occurrence of side effects and drug resistance, and extend its use cycle.

Quinolones drugs

Quinolones are synthetic antibacterial drugs. The earliest applications such as nalidixic acid and pipemidic acid are only used for urinary and intestinal infections. Due to poor efficacy and drug resistance Development is rapid and applications are decreasing.

Quinolones classification

Quinolone is divided into first, second, third, and fourth generations according to the invention and its antibacterial properties.
The first-generation quinolones have antibacterial effects only on E. coli, Shigella, Klebsiella, and a few Proteus. Specific varieties include Nalidixic acid and Piromidic acid, etc., which have been rarely used due to poor efficacy.

The second-generation quinolones have been expanded in antibacterial spectrum and have certain antibacterial effects on Enterobacter, Citrobacter, Pseudomonas aeruginosa, and Serratia. Pyridenic acid is the main domestic application. In addition, there are also Cinoxacin and Miloxacin, which are produced abroad.

The antibacterial spectrum of the third-generation quinolones has been further expanded. It also has antibacterial effects on Gram-positive bacteria such as staphylococci, and further strengthens antibacterial effects on some Gram-negative bacteria. Of this class of drugs, norfloxacin has been produced in China. There are still Ofloxacin, Perfloxacin, Enoxacin, Ciprofloxacin and so on. This generation of drugs has a fluorine atom in the molecule. It is therefore called fluoroquinolone.

The fourth-generation quinolones are structurally modified compared to the previous three generations of drugs. The introduction of 8-methoxy in the structure helps to strengthen the anti-anaerobic activity, while the nitrogen-dioxy ring structure at the C-7 position strengthens the anti-gram positive Bacteria activity and maintain the original activity against Gram-negative bacteria, adverse reactions are smaller, but the price is more expensive. It has enhanced antibacterial activity against Gram-positive bacteria, enhanced effects on anaerobic bacteria including Bacteroides fragile, and enhanced effects on typical pathogens such as Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella and Mycobacterium tuberculosis. Most products have extended half-life, such as Gatifloxacin and Moxifloxacin.

What are quinolones antibiotics

Quinolones antibiotics

Quinolone antibiotics are members of numerous broad-spectrum fungicides that share a bicyclic core structure associated with 4-quinolone substances. They are used in human and veterinary medicine to treat bacterial infections as well as animal husbandry.
Almost all quinolone antibiotics used are fluoroquinolones, which contain fluorine atoms in their chemical structure and are effective against both Gram-negative and Gram-positive bacteria. An example is ciprofloxacin, which is one of the most widely used antibiotics in the world.

Quinolones antibiotics list

1.Nalidixic acid and pyrrolic acid
2.Cinoxacin and Pyrupic acid
3.Norfloxacin, enoxacin, ciprofloxacin, ofloxacin, lomefloxacin, pefloxacin, fleroxacin, toxafloxacin, and spafloxacin
4.Moxifloxacin, clinfloxacin, Jimifloxacin

Quinolones side effects

Quinolones interactions

(1) Alkaline drugs, anticholinergics, and H2 receptor blockers can all reduce the acidity of gastric juice and reduce the absorption of this class of drugs. Avoid taking them together.
(2) Rifampicin (RNA synthesis inhibitor) and chloramphenicol (protein synthesis inhibitor) can reduce the effects of this class of drugs, completely eliminate the effects of nalidixic acid and norfloxacin, and make oxazine and The effect of ciprofloxacin was partially offset.
(3) Fluoroquinolone inhibits theophylline metabolism. When it is used in combination with theophylline, the blood concentration of theophylline is increased, and the theophylline toxic reaction may occur, which should be paid attention to.

Quinolones allergy

The main allergic reactions of quinolone drugs are: local redness, swelling, rash, urticaria, and photosensitivity. Among allergic reactions, anaphylactic shock is most harmful to patients, and even causes death.

Summary

Quinolone, a broad class of broad-spectrum antibacterial drugs, is mainly used for the treatment of human diseases. In order to avoid human beings from consuming quinolone drug residues and causing harm to the human body, it is necessary to develop quinolone drugs for animals.
The Quinolones Rapid Test For Agricultural Products kit provided by BALLYA can effectively detect the presence of Quinolones residues in agricultural products. This kit is not only simple to operate, but also has a short test time and high accuracy, and the test results comply with EU standards. Can effectively ensure the safety of agricultural products.
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