Ko te Cephalexin (Cefalexin) he rongoā paturopi cephalosporin ā-waha o te whakatupuranga tuatahi, he mea hanga-ā-hanga , ka taea te aukati i te hanganga o ngā pakitara pūtau, te pupuhi i ngā ihirangi o te pūtau kia pakaru rā anō, kia memeha rā anō te pūtau. He kawa te reka o te tioata mā, he paku kakara hoki. He paku wairewa te Cephalexin i roto i te wai, engari kāore e wairewa i roto i te etanoru, te chloroform, te ether rānei.
He kaha te kukume o te Cephalexin ki te mimi me te pana. He pai rawa atu mo nga mate urogenital. He pai mo te mate toto, te endocarditis kitakita, te meningitis, te tonsillitis palatine nui, te pharyngitis, te niumonia, te niumonia kakaho me te mate ngoikore o te mate na te streptococcus.
He rerekē ngā rongoā e rua a Cefadroxil me te cephalexin, nō te momo paturopi kotahi. Ā, he rite tonu ngā tohu me ngā pānga rongoā. Ka taea te whakamahi tauwhitiwhiti i te Cefadroxil me te cephalexin i te nuinga o ngā wā. He nui ake te kaha patu huakita o te cephalexin i tō te cephalexin. He iti ake, he māmā ake hoki ngā pānga kino o te cefadroxil, me te tapeke o te 4%. He nui ake ngā pānga kino o te cephalexin, me te tapeke o te 8%.
Ko te Cephalexin he cephalosporin ā-waha o te whakatupuranga tuatahi, he mea hanga-haurua. Ko tana tikanga mahi he aukati i te hanganga o te pakitara pūtau huakita mā te whakakotahi me te kotahi, neke atu rānei o ngā pūmua here penicillin (PBP) o ngā huakita (ko te cephalexin te nuinga e herea ana ki te PBP-3), ā, ka whai pānga patu huakita. He rite te whānuitanga patu huakita o te cephalexin ki te cephalothin , engari he kino ake tana mahi patu huakita i te mea whakamutunga.
Haunga ngā enterococci me ngā staphylococci ātete-methicillin, he tairongo ngā cocci gram-positive ki te cephalexin. He pai te pānga patu huakita a te Cephalexin ki a Neisseria spp. ā, he iti ake te tairongo ki ngā bacilli rewharewha. He pānga patu huakita ōna ki ētahi Escherichia coli , Proteus mirabilis, Klebsiella pneumoniae, Salmonella, me ētahi atu Enterobacter spp. He ātete ki te cephalexin ngā Acinetobacter, Pseudomonas aeruginosa me Bacteroides fragilis.
He pai te ngongo o te Cefalexina, ana ko te tihi toto (Cmax) ka tae ki te 1 haora i muri i te tango i te 0.5 go te hua i runga i te puku kau, me te toharite 18 mg / L. Ko te tango i te raau taero i muri o te kai ka roa te mimiti, ka whakaiti i te kaha o te puranga plasma, engari kaore e heke te nui o te ngongo. Ko te mimiti o te hua ka taea te whakanui ake i nga kohungahunga me te mate celiac me te iti o te neke o te puku, a ka taea te whakaroa me te whakaheke i nga tuuroro e pa ana ki te mate o Crohn me te fibrosis cystic pulmonary.
Ahakoa kaore he whakaheke o te mimiti gastrointestinal i roto i nga kaumatua, he roa ake te kaha o te tarukino toto i tera ki nga taiohi. Ko te haurua whakaheke toto (t1 / 2b) o tenei hua ko te 0.6-1.0 haora. Ma te taapiri i te probenecid ka taea te whakanui ake i te toto, ka taea te toro atu ki te 1 haora ki te 2 haora; Ka taea te toro atu ki te t1.8 / 1b ki te 2-5 haora i te ngoikoretanga o te whatukuhu; Ko te whanau hou30 / 1b ko 2 haora.
Whai muri i te ngongo, ka tohaina te cefalexina ki roto i nga momo kiko me nga wai o te tinana. Ko te toharite toharite o te pungawerewere i muri i te whakahaere-a-waha o te 0.5g ia 6 haora ko te 0.32mg / L, a he teitei ake te kukume o te pungarehu purulent. Ko te kukume o te tarukino kei te nuku he rite ki te kukume o te tarukino toto, a ko te tarukino i roto i te kohanga whanui he 50% o te kukume tarukino toto.
Ka taea e te Cefalexina te tomo ki te rere toto o te pēpi mā te whenua whānau; ko te kukū waiū o te whaea e whāngai ana i muri i te horopeta 0.5g he 5mg/L. Tata ki te 5% o te horopeta ā-waha ka puta mai i te au, ā, ko te kukū o te rongoā i roto i te au he 1 ki te 4 ngā wā o te kukū o te rongoā toto. Ko te tere here pūmua toto he 10% ki te 15%. Kāore te hua e whakapūngaohia i roto i te tinana, ā, ko te putanga kua kohia i roto i te mimi i roto i ngā hāora 24 he 80% ki te 90% o te horopeta. Ko te kukū tihi o te mimi i muri i te horopeta ā-waha o te 0.5g ka eke ki te 2.2g/L. Ka taea te tango i te Cephalexin mā te hemodialysis me te peritoneal dialysis.
He rite tonu te whānuitanga o ōna patu huakita ki tō te cefalotin me te ceftazidime , ā, he ngoikore ake tōna pānga patu huakita i ngā mea e rua. Heoi, ko te āhuatanga o te hua he ātete ki te waikawa me te mimiti pai ki te waha. He pānga patu huakita pai tōna ki te Staphylococcus aureus ātete.
Ko te Cefalexina te nuinga e whakamahia ana mo nga mate manawa manawa, nga mate mimi, mate pukupuku me nga mate pukupuku a te mate wahine, te mate kiri me te kiri ngohengohe, gonorrhea na te huakita tairongo.
Ko te Cephalexin he paturopi whanui-whanui, ka whakamahia mo nga mate kitakita-pai me te kino, penei i te rewharewha, te mate hemorrhagic, te mate streptococcal, te erysipelas, te anthrax, te gangesene empysema, te edema kino, me te hypertermia o te Septic septic (41 ～ 43 ℃) ranei te pāmahana iti tonu (kei raro iho i te 37 ℃) na te mycosis, nekrotosis, leptospirosis, me era atu.
I te wa ano, ka whakamahia te keflex ki te hamani i nga momo mate mumura, penei: -7 ra i muri mai o te whanautanga, te pupuhi o te u, te miraka o te miraka, te whakaheke i te hanga miraka, te whewhe o te waewae me te waha, te whakahekeheke, nga mamae me te pupuhi.
E tohuhia ana a Keflex mō te mate tonsillitis whakapeka, te angina, te otitis media, te sinusitis, te bronchitis, te niumōnia me ētahi atu mate urutā o te ara manawa, ngā mate urutā o te ara mimi me ngā mate kiri me ngā kiko ngohengohe i puta mai i ngā huakita tairongo. He rongoā ā-waha a Keflex , ā, kaua e whakamahia mō ngā mate urutā kino.
He paturopi te Cephalexin e whakamahia ana i roto i ngā kurī me ngā ngeru. Nō roto i ngā rongoā cephalosporin, ā, e pā ana ki ngā rongoā penicillin i roto i te patu huakita. He whānui ake te kaha patu huakita o ngā Cephalosporin i te penicillin. Ko Keflex tētahi o ngā paturopi e whakamahia whānuitia ana mō ngā ngeru me ngā kurī.
He rite te tikanga patu huakita o ngā cephalosporins ki ērā atu rongoā beta lactam , arā, he pānga patu huakita tōna mā te whakataetae mō te pae here pokapū o te hanganga hohe o te pakitara pūtau, me te aukati i te hanganga o te hanganga peptidoglycan o te pakitara pūtau huakita. I tēnei wā, e whakamahia whānuitia ana ngā cephalosporins i roto i te ao rongoā tangata, engari he iti noa te whakamahinga i roto i te rongoā kararehe.
He maha ngā whenua kua āta wehea ngā cephalosporin tangata me ngā cephalosporin kararehe hei whakaiti i te ātete i puta mai i te whakamahinga noa o ngā cephalosporin e te tangata me ngā kararehe, me te putanga mai o te ātete whakawhiti i waenga i ngā mea e rua. Ka whakarōpūtia ngā mema o te whānau cephalosporin i runga i te wā whanaketanga, te pumau o te beta lactamase , me te rerekētanga o te mahi paturopi ki ngā bacilli gram-negative. I tēnei wā, e rau ngā hua cephalosporin, engari ko te nuinga he hua tangata, he iti noa iho ngā hua kararehe.
Ka aukati te Cephalexin i nga huakita mai i te hanga i nga pakitara o te pūtau tiaki. Ma tenei ka ngoikore me te mate o te kitakita. Ko te Cephalexin he rongoa rongoa a ka taea noa e te kaitohutohu kararehe te tiki. Kaore te US Food and Drug Administration (FDA) i whakaae ki te rongoa mo nga kararehe, engari na nga kaitautoko kararehe i whakarite hei rongoa rongoa hou na te ture.
Ka taea te whakamahi i te Cephalexin hei rongoā i ngā mate kitakita maha i roto i ngā ngeru me ngā kuri, tae atu ki: ngā mate kiri, ngā mate patunga, ngā mate wheua, te niumōnia me ngā mate pūkahukahu. He rite te Cephalexin ki te rongoā kararehe cefadroxil , ā, he maha ngā wā ka whakamahia ngātahitia e ngā tākuta kararehe ngā rongoā e rua nā te mea he rite tonu te pānga. Kāore he pānga rongoā o te Cephalexin ki ngā mate i puta mai i ngā pirinoa (pērā i ngā kutukutu whekau), ngā mite, ngā huaketo, ngā harore rānei.
He paturopi beta lactam te Cephalexin , he paturopi penicillin haurua-hanga, he paturopi whānui-ahurea hoki. He whānui te whānuitanga o ōna patu huakita, kāore he ātete whakawhiti, he iti ngā toenga, he iti ngā pānga taha me ētahi atu āhuatanga pai.
Kua whakamahia whānuitia i roto i te rongoa me te porowhita kararehe. Te nuinga o te aukati i te whakahiatotanga o te pakitara o te ruma, kia pupuhi ai te kiko o te pūtau ki te pakaru me te memeha, kia tutuki ai te painga kitakita. He paanga paturopi tona ki nga kitakita pai-karamu me te karamu huakita-kino, a he tere, he oti hoki te mimiti i muri o te weronga me te koiora nui.
Ka whakarato a BALLYA i tētahi whakamātautau-whakakotahi betalactam-cefalexin hei whakaatu ki a koe mēnā kei roto i ngā hua miraka e kainga ana e koe i ia rā ngā toenga beta lactam me ngā toenga cephalexin.
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