Tylosin yog ib hom tshuaj tua kab mob macrolide uas tau los ntawm cov kua zaub ntawm Streptomyces fradiae hauv Tebchaws Meskas xyoo 1959. Tylosin yog ib lub phaj dawb zoo li siv lead ua, me ntsis soluble hauv dej thiab alkaline. Nws cov khoom muaj xws li tartrate , phosphate, hydrochloride, sulfate thiab lactate, uas yooj yim soluble hauv dej. Nws cov kua dej tuaj yeem khaws cia rau 3 lub hlis ntawm 25 ° C thiab pH 5.5-7.5, tab sis yog tias cov kua dej muaj cov hlau ions xws li hlau thiab tooj liab, cov khoom yuav tsis raug.
Cov mis mos molecular ntawm tylosin tartrate yog 2 (C46H77NO17) · C4H6O6, thiab qhov hnyav hnyav yog 1982.31. Nws yog xim dawb lossis lub teeb daj, yooj yim soluble hauv dej (600mg/ml). Vim tias nws txoj hnyuv nqus tau zoo, nthuav tawm sai hauv lub cev, thiab ntshav siab, nws feem ntau yog siv hauv tshuaj kho mob rau kev kho mob.
Muaj ntau txoj kev siv tshuaj kho mob, xws li cov ntsiav tshuaj noj, haus hmoov, txhaj tshuaj rau hauv cov leeg, txhaj tshuaj rau hauv qab daim tawv nqaij, kev pub mis sib xyaw, da dej tshuaj tsuag thiab lwm yam. Tylosin tartrate feem ntau yog siv rau kev kho mob thiab tiv thaiv Mycoplasma , Staphylococcus aureus, Pseudomonas, Pneumococcus, Erysipelas, Haemophilus, Neisseria meningitidis, Pasteurella, spirochetes, kev ua pa, plab hnyuv, kev yug me nyuam thiab kev kis kab mob los ntawm cov kab mob xws li kab.
Xws li: nqaij qaib mob ua pa kab mob, mob khaub thuas rhinitis, nqaij qaib lub hnab cua ua paug, kis mob sinusitis, salpingitis, swine hawb pob, atrophic rhinitis, swine liab dysentery, gastroenteritis, swine erysipelas, mycoplasma mob caj dab, tawv nqaij tawv thiab nqaij qaib raws plab, necrotizing enteritis, endometritis , purulent tus kab mob kis ntawm sab nraud ntawm cov tsiaj txhu, tshis pleuropneumonia, rho menyuam tawm ntawm ewe, daim siab mob plab ntawm nyuj, nyuj hoof rot hauv nyuj thiab yaj.
Nws kuj tseem siv hauv kev ua liaj ua teb qaib rau kev ua kom huv ntawm mycoplasma xws li kev txhaj tshuaj qe thiab soaking. Thiab nws muaj txiaj ntsig zoo rau kev tiv thaiv thiab kho mob mycoplasma theem ob kis mob kis mob hnyav hauv tsiaj txhu thiab nqaij qaib. Nws tau lees paub thoob ntiaj teb tias yog cov tshuaj nyiam rau kev kho thiab tiv thaiv kev kis mob mycoplasma hauv tsiaj txhu thiab nqaij qaib.
A. Cov kab mob tua kab mob mycoplasma
Mycoplasma hyopneumoniae, M. gallisepticum, M. bovis, M. capricolum, M. bovigenitalium, thiab M. gallisepticum agalactiae), Mycoplasma mob caj dab (M.arthritidis), Mycoplasma hyorhinis (M.hyorhinis), Mycoplasma npua (M.hyosynoviae) thiab Mycoplasma (M.synoviae).
B. Cov kab mob tiv thaiv kab mob Gram-positive
Cov kab mob gram-positive xws li Staphylococcus, Streptococcus, Corynebacterium, Erysipelothrix rhuriopathiae thiab Clostridium.
C. Cov kab mob tiv thaiv kab mob Gram-negative
Tshuaj tua kab mob Pasteurella, Salmonella , Escherichia coli , Shigella, Klebsiella, Meningococcus, Niu Mo Gram-negative bacteria xws li Moraxella bovis, Bordetella bronchiseptica, Mycobacterium, Brucella, Haemophilus paragallinarum, thiab lwm yam.
D. Cov kab mob tiv thaiv kab mob curvebacteria
Tiv thaiv kab mob Campylobacter hauv plab (Campylobacter fetus, yav tas los hu ua Vibrio fetus), C. coli (yav tas los hu ua Vibrio coli, uas yog Vibrio coli thiab lwm yam Campylobacter.)
E. Antispira
Serpulina hyodysenteriae (Serpulina hyodysenteriae, yav tas los hu ua Treponemal hyodysenteriae, Treponemal hyodysenteriae, Borrelia anserina, thiab lwm yam).
F. Tiv thaiv kab mob fungal
Tiv taus Candida, Trichophytom thiab lwm yam fungi.
G. Tshuaj tua kab mob coccidial
Eimeria coccidia thiab lwm yam.
Tylosin muaj cov teebmeem tshwj xeeb rau mycoplasma, uas yog ib qho tshwj xeeb ntawm tylosin . Tylosin tau dhau los ua cov tshuaj nyiam rau kev tiv thaiv thiab kho cov kab mob mycoplasma hauv cov tsiaj txhu thiab nqaij qaib.
Nws feem ntau yog siv rau kev tiv thaiv thiab kev kho mob ntawm mycoplasma mob ntsws (tseem hu ua mob ntsws ntev hauv npua, hu ua mob hawb pob), Mycoplasma gallisepticum kis (tseem hu ua mob ua pa ntev hauv nqaij qaib), yaj kis mob pleuropneumonia (tseem hu ua mycoplasma mob ntsws), Bovine mycoplasma mastitis thiab mob caj dab, yaj mycoplasma agalactia thiab mob caj dab, npua mycoplasma serositis, mob caj dab, avian mycoplasma synovitis, thiab lwm yam.
Swine dysentery tshwm sim los ntawm Swine dysentery, thiab avian spirochetes tshwm sim los ntawm Borrelia.
Tylosin ntxiv rau pub kom tiv thaiv Eimeria coccidiosis hauv qaib.
Tylosin muaj txiaj ntsig zoo rau kev txhawb nqa kev loj hlob. Qhov tsim nyog siv tylosin ua cov khoom noj ntxiv tuaj yeem tsis tsuas yog tiv thaiv tsiaj txhu thiab kab mob qaib thiab tiv thaiv lawv txoj kev noj qab haus huv, tab sis kuj tseem txhawb nqa kev loj hlob ntawm tsiaj txhu thiab nqaij qaib, tshwj xeeb tshaj yog rau cov tsiaj nyeg thiab nqaij qaib. Nws muaj cov txiaj ntsig tseem ceeb ntawm cov tsiaj nyeg thiab nqaij qaib, uas tuaj yeem txhim kho kev siv pub mis, ua kom luv lub voj voog pub mis, thiab nce nyiaj txiag txiaj ntsig ntawm kev yug me nyuam.
Ntxiv 50mg/kg tylosin tartrate rau hauv cov zaub mov muaj qhov cuam tshuam pom tseeb tshaj plaws rau cov npua. Qhov nruab nrab txhua hnub nce (ADG) yog 0.69kg, uas yog siab dua (P <0.05) dua li 30mg/kg tylosin pawg (0.63kg), 40mg/kg olaquindox pawg (0.61kg). Lub teb chaws txhua xyoo kev tsim khoom noj npua yog li 40.15 lab tons. Yog tias siv cov koob tshuaj saum toj no, ntau dua 20,000 tons ntawm 10% tylosin premix yuav raug noj rau npua txhua xyoo.
Ib qho ntxiv, Mycoplasma pneumonia yog kab mob sib kis ntawm npua los ntawm Mycoplasma pneumoniae. Nws kuj tseem hu ua mob ntsws ntev hauv npua, thiab nws ib txwm hu ua mob hawb pob. Tus kab mob no tau kis thoob plaws lub ntiaj teb, thiab nws tau tshwm sim hauv cov tebchaws loj hauv npua thiab thaj chaw xws li Europe, Asia, America, Africa thiab Oceania, ua rau muaj kev phom sij loj rau kev lag luam npua.
Mycoplasma muaj nyob hauv qhov zais pa ntawm cov pa ua pa thiab tuaj yeem muaj sia nyob ntev hauv npua. Txawm rau rau lub hlis txog ib xyoos tom qab cov tsos mob ploj mus, mycoplasma tseem nyob hauv lub cev thiab tseem raug tso tawm.
Yog li ntawd, thaum tus kab mob tau nkag mus rau hauv pab tsiaj npua, nws tuaj yeem tshwm sim tsis tu ncua thiab nyuaj rau tshem tawm. Cov xwm txheej ntuj ntawm mycoplasma mob ntsws tsuas yog pom hauv npua, thiab lwm yam tsiaj txhu, tsiaj thiab tib neeg tsis tau kis tus kabmob no. Npua ntawm cov hnub nyoog sib txawv, poj niam txiv neej thiab tsiaj yug tsiaj yog txhua tus muaj kev phom sij. Kev pub niam mis rau menyuam mos thiab nyuam qhuav yug menyuam tshiab yog qhov ua rau muaj kev phom sij tshaj plaws, ua raws li sows thaum cev xeeb tub thiab pub niam mis, thaum cov rog rog thiab cov neeg laus npua muaj mob tsawg dua thiab mob me dua. Cov npua ib txwm muaj cov xwm txheej tshwm sim ntau dua li cov npua sib xyaw thiab cov npua tuaj txawv teb chaws.
Tylosin yog thawj qhov kev xaiv rau kev kho mob. Tylan hmoov rau txhaj Zhongchuankang (Tailing No. 1), 10 mg/kg lub cev hnyav, txhaj tshuaj intramuscular, ob zaug ib hnub rau 5-7 hnub.
Cov txiaj ntsig tau qhia pom tias qhov hnyav nce ntawm qaib hauv 20 mg/kg, 10 mg/kg tylosin tartrate pawg thiab 8.5 mg/kg tylosin phosphate pawg tau siab dua li ntawm 40 mg/kg chlortetracycline pab pawg thaum muaj hnub nyoog 1 txog 3 lub lis piam. Thiab 50mg/kg roxoxan pab pawg, hauv 1-3 lub lis piam ntawm hnub nyoog, qhov hnyav nce ntawm 10mg/kg tylosin tartrate pawg tau nce siab dua li ntawm pawg chlortetracycline thiab pab pawg roxoxan (P <0.05). Thaum muaj hnub nyoog 1 ~ 7 lub lim tiam, kev noj zaub mov qis tshaj plaws hauv pawg 10mg/kg tylosin tartrate (2.03: 1), ua raws li 20mg/kg tylosin tartrate group (2.04: 1) thiab 8.5mg/kg tylosin phosphate group (2.07) : 1), peb pawg tylan tau qis dua li 40mg/kg chlortetracycline pawg (2.13: 1) thiab 50mg/kg roxoxasan pawg (2.09: 1).
Los ntawm qhov kev xav ntawm cov txiaj ntsig kev lag luam, kev tiv thaiv ib puag ncig thiab kev tu cev, qhov ntau npaum li cas ntawm tylosin tartrate hauv cov zaub mov noj yog 10 mg / kg. Cov khoom noj qaib txhua xyoo yog 51 lab tons, thiab 10% tylenol premix ua cov khoom ntxiv yog ntau dua 25 txhiab tons rau tag nrho lub tebchaws.
Ib qho ntxiv, tom qab cov qaib tau kis tus kab mob Mycoplasma gallisepticum, lawv feem ntau tsuas yog pom cov tsos mob ua pa me ntsis, thiab qee zaum muaj cov kab mob paug nyob ib puag ncig lub qhov ntswg, tab sis kua txiv qhov ntswg tsis tshua pom, thiab feem ntau ntawm lawv yog cov txheej txheem tsis pom kev. Vim yog kev noj zaub mov tsis zoo thiab ib puag ncig ib puag ncig, tshwj xeeb tshaj yog thaum sib xyaw nrog lwm cov kab mob hauv lub cev, pom cov tsos mob ua pa nyuaj, nce kua txiv qhov ntswg, muaj kua los yog mucopurulent kua txiv qhov ntswg, txhaws qhov ntswg, ua pa nyuaj, lub taub hau tshee lossis lub suab txawv txawv yuav tshwm sim. Yog tias lub tshuab ntxhua khaub ncaws los yog lub qhov ncauj ua rau lub qhov paug, cov hnoos qeev yuav nce ntxiv, ua pa nyuaj, txham, hnoos, ua pa ntawm lub qhov ncauj, thiab tuaj yeem ua rau cov leeg hauv plab.
Tom qab ntawd, rhinitis, sinusitis thiab kab mob sib kis tau tshwm sim, exudate sau rau hauv lub qhov ntswg thiab qhov infraorbital sinus, lub qhov muag tau ntub dej, dej, qhov muag o, thiab lub qhov muag nthuav tawm zoo li qog. Ib lossis ob qho ntawm ob lub qhov muag tau nrawm, atrophy tshwm sim thiab dig muag tshwm sim. Cov tsos mob tshwm sim ua rau lub cev kub zuj zus, tsis qab los noj mov, ncua kev loj hlob, thiab poob phaus maj mam.
Tylosin yog cov tshuaj tshwj xeeb rau tus kab mob no, tshwj xeeb tshaj yog rau cov qaib nrog cov tsos mob me me.
Siv tylan 500 mg/liter nrog dej rau 5 txog 7 hnub yuav muaj txiaj ntsig zoo. Cov qaib broiler siv tau ntawm 500-1000 mg/kg pub thawj zaug thaum muaj 1 txog 5 hnub, 1 txog 2 zaug hauv ib hnub, thiab tom qab ntawd siv thaum muaj 3 txog 5 lub lis piam rau 24 txog 48 teev, uas tuaj yeem tiv thaiv thiab kho tus kab mob tau zoo.
Ua rau raws plab yog nyuab dua. Clinically, nws tau tshwm sim raws li lub plab nquag nquag, cov dej muaj cov dej ntau hauv cov quav, thiab qee zaum sib xyaw ntshav. Muaj ob qhov laj thawj tseem ceeb ntawm kev mob plab zom zaub mov hauv plab, mob hnyav rau lub cev thiab kab mob hauv plab hnyuv.
Kab mob raws plab hauv dev feem ntau yog los ntawm kab mob parvovirus hauv dev, cov kab mob bacteria, kev ua xua rau zaub mov, cov kab mob parasitic, thiab lwm yam. Kab mob Enterocolitis thiab colitis yog ib qho uas tshwm sim ntau.
Cov tsos mob raws plab los ntawm ntau yam ua rau:
Thaum mob raws plab ntev ntev yog tshuaj tiv thaiv kev o, sulfasalazine (40-60MG/KGBW. ib hnub, 4-6 zaug noj), tylosin thiab metronidazole (20-50MG/KGBW. ib hnub, noj) siv tau. Metronidazole muaj cov nyhuv tua kab mob trichomoniasis thiab yog thawj qhov kev xaiv rau kev kho mob ntawm qhov chaw mos trichomoniasis. Nws tuaj yeem siv los kho amoebic dysentery thiab amoebic daim siab abscess, thiab nws cov txiaj ntsig zoo ib yam li emetine.
Tylosin, zoo li spiramycine , yog ib feem ntawm cov tshuaj tua kab mob macrolides. Tylosin tau siv dav hauv kev kho mob tom qab nws tau tsim tiav hauv Tebchaws Meskas. Tylosin yog tshuaj tua kab mob tshwj xeeb uas tsim los rau kev siv tsiaj, uas muaj txiaj ntsig zoo rau mycoplasma thiab cov kab mob bacterial. Ntxiv mus, tylosin feem ntau ntxiv rau hauv pub, uas tuaj yeem ua kom cov qaib thiab npua loj hlob sai dua thiab txhim kho kev ua haujlwm ntawm cov liaj teb.
BALLYA muab kev kuaj ballya-tylosin los qhia rau koj seb puas muaj cov seem tylosin hauv nqaij, tshwj xeeb tshaj yog nqaij qaib.
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