Ceftiofur yog dawb rau lub teeb daj hmoov. Nws yog insoluble hauv dej, me ntsis soluble hauv acetone, thiab yuav luag tsis yaj hauv ethanol. Ceftiofur yog ib nrab hluavtaws thib peb tiam tsiaj tshwj xeeb cephalosporin.
Cephalosporin tshuaj tua kab mob yog cov tshuaj muaj txiaj ntsig zoo rau kev kho tsiaj, thiab tam sim no lawv tau siv ntau thiab dav dua hauv kev lag luam tsiaj txhu thiab nqaij qaib. Los ntawm qhov pom ntawm cov qauv tshuaj yeeb tshuaj, txhua yam tshuaj cephalosporin muaj cov qauv ntawm cephem, yog li lawv koom nrog beta lawm tshuaj tua kab mob, uas yog 7-aminocephalosporan acid (7-ACA) hauv beta lawm tshuaj tua kab mob, yog li lawv muaj cov txheej txheem kom tsis muaj menyuam zoo ib yam.
Los ntawm kev xav ntawm cov txheej txheem tua kab mob tua kab mob, hom tshuaj tua kab mob no tuaj yeem rhuav tshem cov phab ntsa ntawm cov kab mob thiab qhia pom cov kab mob muaj zog tshaj plaws nyob rau lub sijhawm rov tsim dua. Nws muaj zog xaiv cov nyhuv ntawm cov kab mob, tab sis yuav luag tsis muaj tshuaj lom rau tsiaj lub cev; thiab muaj qhov zoo ntawm cov tshuaj tua kab mob dav, muaj zog tiv thaiv kab mob, tiv taus penicillinase, thiab tsis tshua muaj kev fab tshuaj ntau dua li penicillins. Yog li ntawd, lawv yog hom tshuaj tua kab mob tseem ceeb nrog kev ua haujlwm siab, tsis muaj tshuaj lom thiab siv dav hauv chaw kho mob.
Nws yog tiam thib peb cephalosporins rau cov tsiaj uas muaj zog tiv thaiv kab mob, nthuav dav cov kab mob tua kab mob. Nws muaj zog tiv thaiv kab mob Gram-negative xws li Escherichia coli, Salmonella, Pasteurella multocida, thiab Actinobacillus pleuropneumoniae, thiab lwm yam; cov nyhuv tiv thaiv kab mob gram-positive tsis muaj zog dua li ntawm thawj tiam.
Cov khoom no tsis nqus los ntawm kev tswj qhov ncauj. Nws tau nqus sai los ntawm kev txhaj tshuaj intramuscular thiab subcutaneous, thiab tau nthuav dav dav. Cov ntshav muaj txiaj ntsig zoo tau khaws cia ntev. Nws thawj zaug metabolized rau hauv deoxyfuroyl ceftiofur, thiab tom qab ntawd hloov mus ua cov khoom lag luam mis tsis muaj sia. Feem ntau ntawm lawv raug tshem tawm los ntawm cov zis thiab quav hauv 24 teev tom qab txhaj tshuaj intramuscular.
Piv nrog ob tiam dhau los, tiam thib peb cephalosporins tau txo qis kev tawm tsam G+ cocci, txhim kho kev ruaj ntseg rau G-bacillus lactamase, thiab muaj txiaj ntsig zoo tiv thaiv G-bacillus, uas yog qhov zoo dua li thawj thiab tiam thib ob; cov kab mob tua kab mob tau nthuav dav, thiab cov tshuaj tua kab mob ntawm cov kab mob anaerobic thiab Pseudomonas aeruginosa tau nce ntxiv. Cephalosporins-tiam thib peb tuaj yeem ncav cuag cov ntaub so ntswg sib txawv, kab noj hniav synovial thiab lub cev ua kua, thiab tuaj yeem ncaj qha mus rau cov kua dej hauv lub paj hlwb ntawm cov neeg mob meningeal o; tsis muaj nephrotoxicity. Cov sawv cev tshuaj feem ntau suav nrog ceftiofur.
Cephalosporins tiam thib peb yog cephalosporins siv dav tshaj plaws hauv tsev kho mob. Lawv tau muab faib ua ob pawg raws li lawv tus yam ntxwv ntawm kev tua gram-negative bacilli. Ib hom feem ntau tua cov kab mob Enterobacteriaceae xws li Escherichia coli, Proteus, Klebsiella, thiab tseem muaj cov nyhuv tua cov kab mob Gram-positive. Feem ntau siv yog ceftriaxone thiab ceftiofur, thiab lwm yam; lwm qhov feem ntau yog tua Pseudomonas aeruginosa, thiab tseem suav nrog lwm yam gram-negative bacilli.
Cov khoom no tau nqus sai tom qab txhaj tshuaj thiab txhaj tshuaj subcutaneous, nrog cov tshuaj siab hauv cov ntshav thiab cov ntaub so ntswg, thiab cov tshuaj ntshav muaj txiaj ntsig zoo tau khaws cia ntev, tshem tawm qeeb, thiab ib nrab ntawm lub neej yog ntev. Tom qab txhaj tshuaj intramuscular rau nyuj thiab npua, nws tau nqus sai sai hauv 15 feeb thiab tsim thawj qib metabolite Desfuroyl ceftiofur (DFC) hauv cov ntshav. Txij li lub nplhaib lactam tsis puas, nws cov tshuaj tua kab mob ua tau zoo ib yam ntawm Ceftiofur. DFC tuaj yeem txuas ntxiv ua cov tsis ua haujlwm DFC cysteine difluid hauv cov nqaij. Pom tseeb ntim ntawm kev faib khoom ntawm cov khoom no: 1L/KG. Npua, yaj, thiab nyuj muaj qhov siab tshaj plaws hauv lub raum tom qab txhaj tshuaj ntau ntxiv, ua raws li lub ntsws, daim siab, rog thiab nqaij, uas feem ntau tuaj yeem tswj tau qhov siab tshaj MIC.
Piv txwv li, npua raug txhaj intramuscularly ntawm 3 mg/kg ib hnub ib zaug rau 3 hnub. Cov ntaub so ntswg muaj: plasma 3.25, ua pa 0.60, tawv nqaij 0.57, ntsws 0.49, tonsil 0.30, thiab sib koom ua kua 0.29. Nyuj tau txhaj tshuaj intramuscularly ntawm 1 mg/kg, ib hnub ib zaug rau 5 hnub, thiab lawv cov ntaub so ntswg tau ntshav 1.0 (7.5H tom qab txhaj tshuaj), sib koom ua ke 0.65 (2.5H tom qab txhaj tshuaj), ntsws 0.36, thiab jejunum 0.34. Nws feem ntau tshwm sim hauv kev tsim cov tsis ua haujlwm dawb metabolite-DFC cysteine disulfide hauv mis. Cefoxifur tau tso tawm qeeb, thiab nws ib nrab-lub neej ntawm cov tsiaj yog qhov sib txawv (T1/2 rau nees, nyuj, yaj, npua, dev, qaib, thiab qaib ntxhw) yog 3.15, 7.12, 2.83, 14.5, 4.12, 6.77 thiab 7.45H . Tab sis feem ntau ntawm lawv tuaj yeem tso tawm hauv cov zis thiab quav hauv 24 teev tom qab txhaj tshuaj. DFC tau hloov pauv sai sai rau cov tshuaj tsis ua haujlwm hauv cov quav nyuj, npua thiab qaib.
Nws yog siv rau tsiaj ua pa thiab cov kab mob tso zis los ntawm cov kab mob rhiab, xws li mob npaws tsheb thauj mus los thiab mob ntsws, mob raws plab, ua rau daj daj, actinobacillus haemophilus ua rau porcine pleuropneumonia, kab mob ua pa kab mob ua rau los ntawm streptococcus, Escherichia coli thiab Proteus mirabilis cov kab mob tso zis tso zis los ntawm kab mob E. coli hauv qaib.
Nws muaj cov peev xwm ua kom tsis muaj menyuam ntau. Nws muaj txiaj ntsig zoo tiv thaiv kab mob gram-positive thiab blue-negative. Cov tshuaj tua kab mob muaj zog dua li tshuaj ampicillin, thiab kev tawm tsam tiv thaiv streptococcus zoo dua li ntawm quinolones. Cov khoom no tau nqus sai tom qab txhaj tshuaj, thiab feem ntau yog siv rau cov kab mob ua pa (ua npaws, mob ntsws) los ntawm Pasteurella hemolyticus, Pasteurella multocida thiab Haemophilus saccharum. Nws kuj tseem muaj txiaj ntsig zoo rau kev kis kab mob ua pa xws li Corynebacterium pyogenes. Nws kuj tseem tuaj yeem kho tus kab mob ko taw los ntawm Fusobacterium necrosis thiab Bacteroides niger.
Kev txhaj tshuaj intramuscular: Ib koob tshuaj rau 1kg lub cev hnyav, nyuj 1.1 ~ 2.2mg, nees 2.2 ~ 4.4mg, ib hnub ib zaug rau 3 hnub.
Kev txhaj tshuaj subcutaneous: ib zaug rau 1 kg lub cev hnyav Dog 2.2 mg ib hnub ib hnub, siv tas li rau 5 txog 14 hnub
Ib hnub qub qaib 0.08 ~ 0.20mg ib noog (hauv qab daim tawv nqaij)
Kev npaj thiab kev qhia tshwj xeeb: Ceftiofur Hydrochloride Suspension Txhaj 100ml: 5g
Cephalosporins tau siv dav rau tib neeg thiab tsiaj siv tsiaj, thiab muaj ntau yam sib txawv, tab sis thaum peb siv lawv, peb yuav tsum xyuam xim rau lawv qhov sib xws. Nws yog qhov zoo tshaj los ua raws tus kws kho mob cov lus qhia rau kev siv tshuaj, thiab tsis txhob siv lawv ib leeg, txwv tsis pub qhov poob yog qhov loj! Ntawm lawv, ceftiofur tsis tuaj yeem sib xyaw nrog dexamethasone, hydrocortisone thiab lwm yam tshuaj.
Ceftiofur yog cephalosporin thib peb tiam uas muaj cov kab mob tua kab mob dav.
Dexamethasone yog cov tshuaj ua kom ntev ntev, tiv thaiv cov tshuaj lom, thiab tiv thaiv kev ua xua adrenal glucocorticoid tshuaj. Ceftiofur yog oxidizing (muaj ntau pawg imino thiab amide pawg), thiab dexamethasone yog txo qis (muaj ob daim ntawv cog lus ethylenic). Yog tias ob qho sib xyaw ua ke, cov tshuaj tiv thaiv redox lossis cov tshuaj tiv thaiv polymerization yuav tshwm sim.
Ob yam tshuaj no tau siv dav hauv chaw kho tsiaj. Tshwj xeeb tshaj yog thaum kis mob nrog kub cev, yuav tsum tau saib xyuas ntau dua.
Ceftiofur yog thawj tsiaj tshwj xeeb thib peb tiam cephalosporin tshuaj tua kab mob. Nws muaj cov yam ntxwv ntawm cov tshuaj tua kab mob dav thiab muaj zog tiv thaiv kab mob. Tom qab kev tswj hwm, nws tau nqus sai, nrog kev ua kom muaj txiaj ntsig zoo, ntev ib nrab ntawm lub neej thiab ua haujlwm tau zoo nyob ntev. Xyoo tsis ntev los no, ceftiofur tau siv dav hauv thaj chaw kho tsiaj.
Ceftiofur belongs rau beta lactam cov. thiab BALLYA muab a betalactam xeem los qhia koj yog tias muaj cov beta lactams seem hauv cov khoom siv mis uas koj noj txhua hnub.
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