Kev Xeem Macrolides

Cov Khoom Siv Ib Leeg, nrawm los tshuaj xyuas Macrolides seem hauv mis thiab khoom siv mis los ntawm kev siv colloidal kub tiv thaiv-chromatography thev naus laus zis. Sai li 7-10 feeb rau cov txiaj ntsig.

Macrolide cov tshuaj tua kab mob (macrolides) yog cov tshuaj tua kab mob nrog lub nplhaib macrolide tsim los ntawm Streptomyces thiab Micromonospora. Lub nplhaib lactone loj tau siv los ua ligand txhawm rau txuas ib lossis ntau cov piam thaj lossis cov piam thaj hauv qab los ntawm cov saw glycoside. Ob peb tsis tuaj yeem txuas rau qab zib.

Macrolide cov tshuaj tua kab mob, ib tsev neeg ntawm cov txheej txheem tshuaj lom neeg uas muaj qhov tseem ceeb ntawm lub nplhaib lactone loj, txhua yam yog me ntsis alkaline, me ntsis dej-soluble. Tsev neeg tshuaj tua kab mob no feem ntau tawm tsam cov kab mob Gram-positive thiab qee yam kab mob Gram-negative. Nrog rau qhov tshwm sim ntawm kev kis tus mob Legionella ntau ntxiv, kev tiv thaiv los tiv thaiv legionella ntawm erythromycin tshuaj tau ua tib zoo mloog. Ntawm cov tshuaj tua kab mob no, feem ntau siv hauv Suav teb tam sim no suav nrog: erythromycin, azithromycin, roxithromycin, clarithromycin, thiab lwm yam.

Raws li cov qauv ntawm macrolides, hom tshuaj tua kab mob no tuaj yeem faib ua peb hom: uas yog, polyoxo macrolide, po-lyene macrolide, thiab ansa macrolide.

Macrolide tshuaj tua kab mob feem ntau yog tawm tsam cov kab mob gram-positive, gram-negative cocci thiab mycoplasma, tab sis feem ntau tsis muaj txiaj ntsig tiv thaiv kab mob gram-negative bacilli thiab cov kab mob acid-nrawm. Cov kab mob feem ntau yuav tsim kev tiv thaiv kab mob hauv chav kawm ntawm cov tshuaj tua kab mob no, thiab cov kab mob tuaj yeem muaj ib nrab lossis ua tiav hla kev tiv thaiv kab mob rau cov tshuaj tua kab mob zoo sib xws.

Ntawm lawv, erythromycin thiab oleandomycin tseem tuaj yeem ua rau cov tshuaj tsis haum. Tab sis tsis muaj kev tiv thaiv khaub thuas rau penicillin, streptomycin thiab chloramphenicol. Cov tshuaj tua kab mob hauv chav kawm no muaj tshuaj lom tsawg. Macrolide cov tshuaj tua kab mob txwv tsis pub cov protein sib sau ua ke thiab ua rau 50S subunit ntawm cov kab mob ribosome los cuam tshuam rau peptide hloov cov tshuaj tiv thaiv thaum txheej txheem txheej txheem protein. Txawm li cas los xij, cov txheej txheem ntawm kev ua ntawm ntau yam macrolides tsis zoo ib yam, thiab qee qhov tseem tsis tau tiav.

Cov tshuaj tua kab mob no feem ntau yog siv rau tonsillitis, ua npaws liab, erysipelas, lobar pneumonia, thiab lwm yam tshwm sim los ntawm gram-positive cocci, thiab tseem siv rau mob ntsws, Legionnaires tus kab mob, campylobacter enteritis, tus mob diphtheria thiab kab mob L-type. Ua los ntawm kev tso zis tso zis ntau ntxiv. Kev npaj ntawm qhov ncauj muaj ntshav qis thiab tsuas yog tsim rau kis mob me me.

Cov tshuaj Macrolide yog chav kawm tshuaj nrog cov qauv yooj yim ntawm lub nplhaib macrolide. Cov tshuaj sawv cev yog erythromycin. Txij li nws tau tshawb pom thiab thov hauv xyoo 1952, nws tau ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev kis kab mob nrog cov tshuaj tua kab mob. Nws cov tshuaj tiv thaiv kab mob suav nrog cuam tshuam rau cov kab mob, kev tswj hwm ntawm cov kab mob sib kis thiab cov kab mob tiv thaiv kab mob, lwm yam cuam tshuam rau lub cev, thiab cuam tshuam los ntawm lwm yam tsis paub lub tswv yim. Ntau thiab ntau qhov kev tshawb fawb tshawb fawb pom tau tias cov tshuaj tiv thaiv kab mob ntawm macrolides muaj qee yam muaj txiaj ntsig hauv kev kho kab mob ua pa ntev.

Nrog rau kev thov tshuaj tiv thaiv kab mob macrolide ntau ntxiv, cov kab mob tau tiv taus lawv ntau dua. Muaj kev tiv thaiv hla ntawm cov tshuaj tua kab mob macrolide, uas yog, cov kab mob uas tiv taus rau ib tus tswv cuab ntawm macrolide kuj tseem tiv taus rau lwm tus tswv cuab ntawm pawg tshuaj no, tab sis tsis yog tag nrho. Piv txwv li, Mycoplasma pneumoniae muaj qhov ua haujlwm siab rau erythromycin, tab sis nws tseem muaj txiaj ntsig zoo nrog roxithromycin thiab azithromycin. Qee zaum cov kab mob pom tau tias tiv taus hom tshuaj no. Lub sijhawm no, koj yuav tsum hloov lwm yam tshuaj tua kab mob, xws li quinolones. Kev tiv thaiv feem ntau yog sau los ntawm plasmids.

Tseem muaj ntau yam tsis paub uas yuav tsum tau kawm kom tob txog cov tshuaj tua kab mob thiab daim ntawv thov tus nqi ntawm cov tshuaj tua kab mob macrolide. Peb tos ntsoov rau cov kws tshawb fawb Suav thiab ua cov kev tshawb fawb yooj yim thiab tshawb fawb raws qhov xwm txheej tiag hauv Suav teb, tshwj xeeb yog ntau qhov chaw sib koom tes tshawb fawb, txhawm rau txhim kho Tuam Tshoj txoj kev siv tshuaj kho mob thiab tshawb fawb qib hauv daim teb no.

Txawm hais tias kev siv tshuaj tua kab mob hauv tsiaj txhu muaj txiaj ntsig zoo rau kev lag luam, qhov teeb meem ntawm kev tiv thaiv kab mob (suav nrog cov kab mob hauv cov tsiaj thiab cov kab mob sab hauv) uas tshwm sim los ntawm kev siv AGP tau nyiam ntau thiab ntau dua hauv ntiaj teb. 

Ob lub tebchaws tsim thiab tsim kho xav tau txheej txheem kev tswj hwm nruj, cov cai thiab txwv kev pub tshuaj noj. Vim tias cov kab mob tiv taus cov tsiaj no tuaj yeem nkag rau tib neeg lub cev ncaj qha lossis ncaj qha. Thaum pib xyoo 1968, Tebchaws Europe tsis tso cai tshuaj tua kab mob los siv ua AGP hauv tsiaj, thiab tsuas yog siv monensin, salinomycin, thiab flavomycin ua AGP.

Lub siab siv raws li AGP siab dua MIC uas txwv cov kab mob hauv plab. Yog li, AGP tuaj yeem ua rau cov kab mob txhim kho kev tiv thaiv cov tshuaj tua kab mob no thiab tshuaj kho kab mob tua kab mob.

Macrolides xws li spiramycin (SPM), tilmicosin tshuaj (IL), thiab tylosin (TYL) yog ib qho tshuaj siv tshuaj tua kab mob ntau tshaj plaws hauv chaw kho tsiaj. Feem ntau nws tau ntxiv rau pub thiab nws qhov kev siv yog thib ob rau tetracycline tshuaj tua kab mob. Vim tias tsis muaj qhov sib thooj theoretical qhia thiab kev tswj tsis txaus ntawm pub additives hauv Suav teb, qee tus neeg ua liaj ua teb feem ntau ntxiv cov tshuaj no ntau dhau txhawm rau txhawm rau nrhiav txiaj ntsig kev lag luam ntau dua. Yog li ntawd, nws yog qhov tsim nyog los tsim kom raug, yooj yim, nrawm, thiab tus nqi qis nrhiav txoj hauv kev los tswj kev lag luam nkag mus rau cov tshuaj zoo li no los ntawm cov khoom noj.

1. 7 feeb nyeem cov txiaj ntsig

2. Kev txwv tsis pub teb rau EU thiab Asmeskas FDA cov cai

3. Tsis yog cov kws tshaj lij lossis cov cuab yeej xav tau

4. Yooj yim rau kev khiav lag luam thiab nyeem

Macrolides Test, raws li txoj kev sib tw kub colloidal, yog siv rau kev ntsuas Macrolides seem hauv cov qauv mis thiab ua tau raws li EU MRL. Cov khoom siv no tuaj yeem thov rau ntawm qhov chaw sim nrawm los ntawm ntau lub chaw haujlwm.

Cov piv txwv suav nrog: mis nyuj nyoos, mis hmoov, mis nyuj pasteurized.

LOD tuaj yeem hloov pauv raws li qhov xav tau lossis qhov txawv ntawm qhov sib txawv, thov mus saib hauv phau ntawv qhia kom paub meej ntxiv.

Macrolides Test tuaj yeem pab cov tuam txhab tsim khoom, cov koom haum tswj hwm, thiab pej xeem saib xyuas cov khoom lag luam zoo thiab pab tib neeg tiv thaiv lawv txoj kev noj qab haus huv.

1. Micro-Well Reagent: 8 kuaj/raj, 12 raj/thawv

2. Xeem Sawb: 8pcs/raj, 96pcs/box

3. Phau Ntawv Qhia: 1pc

1. Qauv Raj

2. Pipette & Pipette Tip

3. Zoo-Tais-Phaj

1. Ntxiv 200ul mis mus rau hauv lub qhov dej, tom qab ntawd xa dej mus thiab nqis rau 10 zaug kom sib xyaw cov qauv nrog cov tshuaj reagent hauv lub qhov dej.

2. Tom qab ntawd muab tso rau 3 feeb.

3. Ntxig qhov ntsuas ntsuas mus rau hauv lub qhov dej zoo nrog cov qauv ntsuas phoo tag nrho.

4. Tom qab 5 feeb, nyeem cov txiaj ntsig.

Thaum tshuaj tua kab mob tau siv thawj zaug rau tib neeg, peb suav tias lawv yog "catholicon". Raws li qhov teeb meem ntawm kev siv tshuaj tua kab mob txuas ntxiv mus zuj zus, lawv qhov kev tiv thaiv tau dhau los ua kev puas tsuaj rau tib neeg.

Yog li, hauv lub neej txhua hnub, peb yuav tsum zam zaub mov nrog tshuaj tua kab mob seem. Thawj kauj ruam los pab tus kheej: peb xav tau kuaj cov tshuaj tua kab mob seem thawj.

Thov txheeb xyuas phau ntawv teev npe online thiab tiv tauj peb tus sawv cev muag ntawm email: info@ballyabio.com ib lossis sau daim foos tiv toj hauv qab no: