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Dab tsi yog-lincomycin

Lincomycin yog dab tsi?

Muab lo rau  Lub ob hlis ntuj 5, 2021, Kho los ntawm Jason, Qeb  

Lincomycin yog dab tsi?

1. Lus txhais

Lincomycin tuaj yeem ua rau 50S subunit ntawm ribosome rhiab heev los tiv thaiv kev txuas ntxiv ntawm peptide saw, yog li inhibiting protein synthesis ntawm cov kab mob cell. Lincomycin belongs rau cov tshuaj tua kab mob lincomycin.

Lincomycin tshuaj tua kab mob suav nrog lincomycin tshuaj thiab clindamycin. Nws cov txheej txheem ntawm kev ua haujlwm zoo ib yam li ntawm cov macrolides, thiab nws tseem tuaj yeem thim rov qab rau 50S subunit ntawm cov kab mob ribosome, txwv tsis pub cov kab mob sib xyaw ua ke los ntawm thaiv cov transpeptidation thiab mRNA tshem tawm. Cov nyhuv ntawm ob yam tshuaj ntawm cov kab mob gram-positive zoo ib yam li ntawm erythromycin tshuaj. Cov tshuaj tua kab mob ntawm clindamycin yog 4 txog 8 zaug muaj zog dua li ntawm lincomycin. Lawv muaj qhov cuam tshuam rau qee yam aerobic gram-negative cocci, Mycoplasma hominis thiab Chlamydia trachomatis, tab sis enterococcus, gram-negative bacilli, methicillin-resistant Staphylococcus aureus (MRSA), thiab Mycoplasma pneumoniae tsis nkag siab lawv.

2. siv

Raws li tshuaj tua kab mob, nws feem ntau yog siv los kho kab mob ua pa ntev hauv cov qaib thiab kis kab mob los ntawm penicillin g tiv taus Staphylococcus aureus thiab Streptococcus. Nws kuj tseem tuaj yeem txhawb kev loj hlob ntawm qaib.

3. Cov teebmeem tshuaj

Lincomicina ua rau 50S subunit ntawm ribosome ntawm cov kab mob nkag siab txhawm rau tiv thaiv kev txuas ntxiv ntawm peptide saw, yog li txwv tsis pub cov protein sib sau ua ke ntawm cov kab mob. Lincomicina feem ntau yog tus neeg sawv cev bacteriostatic, tab sis nyob rau qhov siab, nws kuj muaj cov kab mob tua kab mob rau cov kab mob uas nkag siab zoo.

4. Pharmacokinetics

Nws tuaj yeem nqus tau los ntawm txoj hnyuv, thiab tsis ua kom lub plab zom mov. Tsuas yog 20-30% tau nqus los ntawm kev tswj hwm qhov ncauj ntawm lub plab khoob, thiab qis dua thaum noj tom qab noj mov. Tsuas yog cov kua dej hauv lub cev tom qab nqus tau, nws tau nthuav dav thiab nthuav tawm sai sai hauv ntau yam ntawm lub cev thiab cov ntaub so ntswg, thiab muaj qhov siab ntau pom hauv ob lub raum, kua tsib thiab zis. Qhov ua tau zoo tuaj yeem mus txog qhov muag tom qab txhaj tshuaj. Lincomicina tuaj yeem nkag mus tau sai hauv lub cev menyuam hauv plab los ntawm txoj hlab ntshav, thiab cov ntshav hauv menyuam hauv plab tuaj yeem ncav cuag 25% ntawm niam cov ntshav siab. Tus nqi khi cov protein yog 77 txog 82%.

Lincomycin feem ntau yog metabolized hauv lub siab, qee cov metabolites muaj cov tshuaj tua kab mob, thiab cov txheej txheem metabolic ntawm cov menyuam yog siab dua li cov neeg laus. T1/2 yog 4 txog 5.4 teev. Thaum lub raum tsis ua haujlwm, T1/2 yog 10 txog 13 teev; thaum lub siab ua haujlwm qis, T1/2 yog 9 teev. Lub sijhawm rau cov ntshav ntshav kom mus txog qhov siab tshaj yog 2 txog 4 teev tom qab kev tswj hwm qhov ncauj, 0.5 teev tom qab txhaj tshuaj intramuscular. Lincomicina tuaj yeem tso tawm los ntawm ob lub raum, kab mob hauv lub cev thiab txoj hnyuv. Tom qab kev tswj hwm qhov ncauj, 40% raug tso tawm hauv cov quav hauv nws daim ntawv qub, lossis nws tuaj yeem tso rau hauv mis. Lincomycin tsis raug tshem tawm los ntawm cov ntshav lossis tso ntshav tawm hauv lub cev, thiab tsis tas yuav siv ntxiv tom qab phais.

Lincomycin siv

Lincomycin-siv
Lincomycin-siv

1. indications

Lincomycin inhibits synthesis protein ntawm cov kab mob thiab muaj cov tshuaj tua kab mob rau feem ntau cov kab mob gram-positive. Cov tshuaj tua kab mob ntawm lincomicina ntawm cov kab mob gram-positive zoo ib yam li erythromycin tshuaj, tab sis txhua tus kab mob gram-negative (suav nrog meningococcus, gonococcus, Haemophilus influenzae, thiab lwm yam) tiv taus nws. Cov kab mob rhiab tuaj yeem suav nrog Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Staphylococcus aureus, thiab Bacillus diphtheriae.

Cov kab mob Anaerobic rhiab rau lincocin suav nrog Bacteroides, Fusobacterium, Propionibacterium, Eubacterium, Bifidobacterium, Peptostreptococcus, feem ntau peptococcus, Perfringens, Tetanus, thiab qee yam actinomycetes Bacteria thiab lwm yam.

Lincocin tsis nkag siab rau Streptococcus faecalis, qee qhov clostridia, Nocardia, poov xab, fungi thiab kab mob. Staphylococcus tuaj yeem maj mam txhim kho kev tiv thaiv rau lincomycin. Staphylococcus tiv taus erythromycin tshuaj feem ntau qhia pom kev tiv thaiv kab mob rau lincomycin.

Tom qab kev tswj hwm qhov ncauj ntawm 500 mg, kev nqus tau nrawm, cov ntshav ntshav nce mus txog nws qhov siab tshaj hauv 2 txog 4 teev, thiab qhov tsawg kawg nkaus inhibitory concentration (MIC) tuaj yeem tswj tau li 6 txog 8 teev rau feem ntau cov kab mob Gram-positive. 600 mg lincomycin tau muab tso rau hauv cov leeg, cov ntshav cov ntshav nce mus txog qhov siab tshaj hauv ib nrab teev, thiab tuaj yeem kuaj pom los ntawm 24 teev. 600mg ntawm cov khoom no tau muab tso rau hauv 500ml ntawm 5% kev daws cov piam thaj rau 2 teev, thiab cov ntshav muaj txiaj ntsig zoo tuaj yeem tswj tau txog 14 teev. Ib feem me me tau tso tawm hauv cov zis, thaum cov kua tsib yog txoj hauv kev tso tawm ntau.

Nws tau faib dav hauv lub cev thiab tuaj yeem nkag mus rau qee yam kabmob tseem ceeb thiab cov ntaub so ntswg. Nws tuaj yeem mus txog qhov muaj txiaj ntsig zoo hauv cov qaub ncaug, hnoos qeev, cov nqaij pob txha thiab pob qij txha. Nws tuaj yeem hla los ntawm cov menyuam hauv plab thiab mis, tab sis nws tsis yooj yim kom dhau los ntawm tib neeg cov meninges. t1/2 yog 4 txog 5.4 teev.

Nws feem ntau yog siv rau kev kis kab mob ua pa, mob pob txha pob txha, sib koom ua ke thiab cov nqaij mos mos, kis kab mob hauv lub cev thiab sepsis los ntawm Staphylococcus, Streptococcus, thiab Streptococcus pneumoniae. Nws kuj tseem tuaj yeem siv rau qee kis mob anaerobic.

Lincomycin siv rau kev kho mob ntawm osteomyelitis. Nws yog qhov tsim nyog rau kev tswj hwm qhov ncauj: Ua pa kab mob ua rau mob los ntawm Staphylococcus, Streptococcus pyogenes, pneumococcus thiab anaerobic cov kab mob, tawv nqaij thiab cov nqaij mos mos kis, poj niam deev menyuam thiab mob plab thiab mob plab los ntawm cov kab mob anaerobic kis lwm yam. , kev txhaj tshuaj lincomycin tseem tuaj yeem siv rau sepsis tshwm sim los ntawm streptococcus thiab staphylococcus, pob txha thiab kis mob sib kis, phais kho mob kho mob pob txha thiab mob sib kis, thiab mob ntshav tau los ntawm cov pob txha pob txha tshwm sim los ntawm staphylococci Yan thiab lwm yam. Lub siab ntawm lincomycin uas nkag mus rau hauv cov kua dej hauv lub cev tsis tuaj yeem mus txog qib uas muaj txiaj ntsig thiab tsis haum rau kev kho tus mob meningitis.

2. Kev siv thiab ntau npaum li cas

  • Qhov ncauj noj 1.5 ~ 2g ib hnub rau cov neeg laus (raws li lincomycin, tib yam hauv qab no), faib ua 3 ~ 4 zaug; menyuam yaus noj 30 ~ 60 mg/kg txhua hnub, faib ua 3 ~ 4 zaug; me nyuam mos liab tsawg dua 4 lub lis piam yuav tsum tsis txhob noj nws.
  • Kev txhaj tshuaj intramuscular feem ntau yog 0.6g txhua 8-12 teev rau cov neeg laus; cov menyuam tau muab 15-30 mg/kg raws li lub cev hnyav txhua hnub, hauv kev faib tshuaj.
  • Txhaj tshuaj 0.6g ib zaug rau cov neeg laus, yaj nws hauv 100-200ml infusion, thiab tso nws li 1 txog 2 teev, ib zaug txhua 8 txog 12 teev. Cov menyuam yaus tau txais koob tshuaj txhua hnub ntawm 10-20 mg/kg hauv 2 txog 3 zaug.
  • Txhawm rau tiv thaiv qhov tshwm sim ntawm kub taub hau rheumatic, chav kawm ntawm kev kho mob hemolytic streptococcal nrog cov tshuaj hauv chav kawm no yuav tsum yog yam tsawg 10 hnub.
  • Txhawm rau kho tus kab mob pseudomembranous enteritis los ntawm lincomycin lossis clindamycin, kev txiav ib leeg rau cov mob me me yuav tsum muaj txiaj ntsig. Cov neeg mob uas muaj mob hnyav mus rau mob hnyav yuav tsum tau ntxiv dej, electrolytes thiab protein ntau. Yog tias kev kho mob saum toj no tsis muaj txiaj ntsig, vancomycin tshuaj yuav tsum tau hais lus, 125-500 mg txhua 6 teev, rau 5-10 hnub. Hoob thib ob ntawm vancomycin tuaj yeem muab rau qhov rov tshwm sim. Qhov ncauj metronidazole lossis bacitracin kuj ua tau zoo; metronidazole 250-500 mg, 3 zaug ib hnub, 25,000 units ntawm bacitracin, 4 zaug ib hnub.
  • Qhov rhiab heev ntawm hom sib txawv rau lincomycin tuaj yeem sib txawv, yog li kev sim tshuaj kom nkag siab yog qhov tseem ceeb.

3. Siv tsiaj kho tsiaj

Yog tias koj tsis paub ua rau kub taub hau hauv npua, koj tuaj yeem siv Shuanghuanglian ntxiv rau lincomycin rau txhaj tshuaj intramuscular, uas muaj qhov pom tseeb. Kev txhaj tshuaj Lincomycin kuj tseem tuaj yeem siv thaum kho npua hnoos yog tias tsis paub ua rau npua hnoos. Yog tias koj npua tseem muaj mob hawb pob, ntxiv me ntsis dexamethasone rau lincomycin kom tau txais txiaj ntsig zoo dua.

Sows raug kev txom nyem los ntawm mastitis lossis mob hauv tsev menyuam tuaj yeem ua rau daj thiab dawb scour hauv npua. Lub sijhawm no, kev txhaj tshuaj lincomycin ntxiv rau dexamethasone ntawm lub tseb thiab oxytocin ntawm lwm sab tuaj yeem txiav tawm cov mob mastitis zoo los ntawm streptococcus thiab daj thiab dawb raws plab los ntawm kev mob qog noj ntshav. (Tau kawg, cov npua yuav tsum tau kho nrog tshuaj, xws li qhov ncauj Enrofloxacin lossis txhaj tshuaj intramuscular ntawm apramycin, los kho ob qho tsos mob thiab hauv paus ua rau)

Feem ntau, tom qab peb sows yug me nyuam, lincomycin kuj tseem tuaj yeem siv los tiv thaiv kev mob o. Siv nws ib zaug ib hnub rau 2 txog 3 hnub. Cov nyhuv ntawm cov tshuaj no tseem ntev dua thiab pom tseeb dua li ntawm penicillin. Cov txiaj ntsig zoo dua yog tias ua ke nrog tshuaj noj qhov ncauj "Brown Sugar Soup" rau lub tseb. Qee zaum thaum peb tsa npua, qee zaum npua yuav tawm tsam, thiab nws yog qhov tsis tuaj yeem ua npua yuav tom. Lub sijhawm no, peb tuaj yeem siv cov tshuaj lincomycin intramuscular txhaj tshuaj thiab vitamin C ntawm lwm sab. Qhov no yuav tsis tsuas yog txo qhov mob, tab sis kuj tseem tiv thaiv tus npua tom los ntawm tom tom.

Thaum peb pov npua rau lub caij ntuj sov, kis tau yooj yim tshwm sim. Yog tias ob milliliters ntawm lincomycin raug txhaj intramuscularly rau hauv txhua tus menyuam npua thaum lub sijhawm castration, kev kis tus kab mob tuaj yeem tswj tau zoo. Yog tias nws tau sib xws nrog gentamicin, cov txiaj ntsig zoo dua, tus nqi pheej yig dua, thiab cov txiaj ntsig tau pom tseeb dua li siv cephalosporin or tshuaj penicillin. Tom qab npua raug muab pov tseg, cov nyhuv nrog lincomycin hmoov zoo dua li ntawm amoxicillin. Yog tias npua ua liaj ua teb tseem nrog hnoos me ntsis, ces cov hmoov lincomycin yuav kho nws.

Lincomycin phiv los

Lincomycin-sib cuam tshuam
Lincomycin-sib cuam tshuam

1. Kev phiv tshuaj tiv thaiv

A. Kev kho plawv

Kev txhaj tshuaj txhaj tshuaj ntau dhau ntawm cov khoom no tuaj yeem ua rau cov ntshav poob qis, hloov pauv electrocardiogram, yaug thiab ua npaws, thiab qee zaum ua rau lub plawv dhia thiab ua pa nres. Xeev siab, ntuav, hypotension, dyspnea thiab electrocardiogram hloov tshwm sim hauv ib kis nrog 200 mg li ntawm 20 feeb. Yog li ntawd, thaum muab koob tshuaj loj tso rau hauv cov hlab ntshav, nws yuav tsum tau muab diluted thiab tom qab ntawd tso rau hauv cov hlab ntshav. Txhua txhua 2g yuav tsum tau diluted nrog 250ml kua yam tsawg kawg, thiab qhov dej cawv yuav tsum tsis pub tshaj 100ml ib teev. Kev siv tshuaj txhaj tshuaj tuaj yeem ua rau thrombophlebitis.

B. Lub plab zom mov

Cov khoom no yooj yim los ua kom nce ntxiv ntawm bilirubin cov. Kev zom zaub mov tuaj yeem tshwm sim hauv qhov ncauj lossis txhaj tshuaj. Feem ntau, cov tshuaj tiv thaiv me me thiab tuaj yeem ua rau pom kev tsis txaus ntseeg, xeev siab, ntuav, tsis xis nyob hauv plab thiab raws plab; raws plab tuaj yeem hloov pauv tau. Lub sijhawm ntawm kev zawv plab kuj tseem tuaj yeem txuas ntxiv, uas tshwm sim ntau dua li ntawm 3 txog 10 hnub tom qab siv tshuaj. Kev mob raws plab tuaj yeem tshwm sim los ntawm kev siv tshuaj ncaj qha, lossis nws tuaj yeem cuam tshuam nrog kev zom zaub mov hauv plab hnyuv.

Nws tau tshaj tawm hauv cov tebchaws txawv teb chaws tias kwv yees li 20-50% ntawm cov neeg muaj mob raws plab tom qab kev tswj hwm qhov ncauj ntawm cov khoom no. Feem ntau mob raws plab yog me me, tab sis mob hnyav pseudomembranous enteritis. Tam sim no nws tau paub tias qhov tshwm sim ntawm tus kab mob no cuam tshuam nrog kev nthuav dav ntawm Clostridium difficile thiab kev tsim cov tshuaj lom hauv cov hnyuv tom qab siv cov khoom no, thiab nws muaj feem ntau tshwm sim hauv cov neeg laus thiab cov neeg mob phais lub plab.

Ntxiv rau kev kho tus mob, kev tswj qhov ncauj ntawm vancomycin lossis metronidazole muaj cov txiaj ntsig zoo. Cov neeg mob uas ua haujlwm tsis zoo ntawm lub siab thaum kho nrog lincomycin tsis tshua muaj, thiab tsuas yog hauv cov neeg mob uas muaj koob tshuaj ntau (kwv yees li 4g/hnub) ntau dua 3 lub lis piam. Lwm pab pawg txhaj tshuaj lincomyicn 3.6g/hnub, aminotransferase thiab bilirubin cov nce ntxiv, kev kuaj lub siab tau nrog nrog kev hloov pauv pathological.

C. Hematopoietic qhov system

Nws tsis yog tshuaj lom heev rau cov txheej txheem hematopoietic, thiab qee zaum tuaj yeem ua rau neutropenia, eosinophilia, thiab thrombocytopenia. Feem ntau, cov tshuaj tiv thaiv me me thiab hloov pauv, thiab hemogram ntawm qee tus neeg mob tuaj yeem rov qab los ntawm kev siv tshuaj ntxiv. Lincomycin qee zaum tuaj yeem ua rau muaj kev tsis haum tshuaj, ua rau tawv nqaij, mob angioedema, mob ntshav qab zib, thiab tseem tuaj yeem ua rau lub hnub tsis haum. Qee zaum, exfoliative dermatitis tshwm sim.

2. Teeb meem xav tau mloog

  • Nws tuaj yeem ua rau cov txheej txheem zom zaub mov, xws li xeev siab, ntuav, glossitis, khaus qhov quav, thiab lwm yam. Kev siv mus sij hawm ntev tuaj yeem ua rau pseudomembranous enteritis, uas yog tshwm sim los ntawm kev loj hlob ntawm Clostridium difficile.
  • Nws tseem tuaj yeem ua rau muaj kev tsis haum tshuaj, xws li tawv nqaij ua pob, ua xua, erythema multiforme, leukopenia, thrombocytopenia, thiab lwm yam.
  • Nws tuaj yeem ua rau nce siab transaminase thiab jaundice. Siv nrog ceev faj hauv cov neeg mob uas lub siab ua haujlwm tsis zoo. Ntshav thiab lub siab ua haujlwm yuav tsum tau kuaj tsis tu ncua.
  • Tsis txhob ncaj qha mus txhaj cov tshuaj txhaj bolus. Kev txhaj tshuaj nrawm heev tuaj yeem ua rau lub plawv nres thiab hypotension. Rau kev tswj hwm txoj hlab ntshav, txhua 0.6 ~ 1g ntawm cov khoom no yuav tsum tau diluted nrog ntau dua 100ml Txoj kev lis ntshav, thiab lub sijhawm tso ntshav yuav tsum tsis pub tsawg dua 1 teev.
  • Tseem muaj kev phiv tshuaj xws li tinnitus thiab kiv taub hau.
  • Siv nrog ceev faj hauv poj niam cev xeeb tub thiab pub niam mis.
  • Txwv tsis pub siv rau cov menyuam mos uas muaj hnub nyoog qis dua 1 hlis.

3. Tshuaj Tiv Thaiv

  • Thaum siv cov tshuaj ua kom loog, cov hlab ntsha txhaws tuaj yeem ua kom muaj zog, ua rau cov leeg pob txha tsis muaj zog thiab ua pa nyuaj siab lossis tuag tes tuag taw (apnea). Nws kuj yuav tsum tau siv thaum lossis tom qab phais. Kev kho nrog tshuaj anticholinesterase lossis cov ntsev calcium xav kom ua tau zoo.
  • Lincomycins muaj cov teebmeem neuromuscular thaiv, thiab thaum ua ke nrog cov tshuaj tiv thaiv cov leeg nqaij asthenia, cov nyhuv tom kawg ntawm cov leeg pob txha yuav tsis muaj zog. Txhawm rau tswj hwm cov tsos mob ntawm myasthenia gravis, koob tshuaj anti-myasthenia yuav tsum tau hloov kho thaum lub sijhawm ua ke ntawm kev kho mob.
  • Chloramphenicol or erythromycin tshuaj tuaj yeem hloov pauv lincomycin ntawm lub xaib phiaj xwm, lossis txwv qhov kev khi ntawm qhov kawg mus rau 50S subunit ntawm cov kab mob ribosome. Yog li, lincomycin yuav tsum tsis txhob ua ke nrog chloramphenicol lossis erythromycin.
  • Opioid analgesics, kev nyuaj siab ua pa ntawm lincomycins thiab kev nyuaj siab hauv nruab nrab ntawm cov tshuaj opioids tuaj yeem ua rau muaj kev nyuaj siab ua pa ntev lossis ua pa tuag tes tuag taw (apnea) vim muaj qhov tshwm sim tshwm sim.
  • Lincomycin yog contraindicated nrog novobiocin thiab kanamycin nyob rau hauv tib lub vial intravenous infusion. Nws tau pom hauv lub raj ntsuas uas cov khoom no tau tawm tsam macrolide hmoov tshuaj tua kab mob. Lincomycin kuj tseem tuaj yeem cuam tshuam cov kab mob tua kab mob ntawm tshuaj penicillin thiab cephalosporin.

xaus

Sepsis, osteomyelitis thiab mob caj dab yog txhua yam mob hnyav, thiab cov tshuaj tua kab mob uas tuaj yeem kho cov kab mob no tau zoo lincomycin tshuaj. Txawm li cas los xij, lincomycin nquag cuam tshuam nrog lwm cov tshuaj, uas xav tau kev saib xyuas tshwj xeeb los ntawm cov neeg ua haujlwm kho mob thiab cov neeg mob.

BALLYA muab a lincomycin-macrolides-quinolone-erythromycin-combo-test-kit qhia rau koj yog tias muaj lincomycin, cov cov macrolides, quinolones thiab erythromycin seem hauv cov khoom siv mis uas koj noj txhua hnub.

References

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Zoo siab tsim los ntawm BALLYA
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