Koj puas tuaj yeem siv terramycin rau tib neeg?

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• Terramycin yog dab tsi?
  1. Lus txhais
  2. Lub cev nqaij thiab tshuaj muaj zog
  3. lub hom phiaj
  4. Cov teebmeem tshuaj
  5. Pharmacokinetics
• Terramycin siv
  1. indications
  2. siv
  3. ntau npaum
  4. Veterinary Siv
• Cov teebmeem ntawm Terramycin
  1. Kev phiv tshuaj
  2. Kev sib tham ntawm Terramycin
  3. lus ceeb toom
• xaus

Terramycin yog dab tsi?

1. Lus txhais

Terramycin yog lub ntsiav tshuaj daj daj lossis cov ntsiav tshuaj uas muaj suab thaj, uas yog tetracyclines, yooj yim soluble hauv dej thiab acidic. Nws yog qhov dav-spectrum ib nrab hluavtaws tshuaj tua kab mob uas yog tshuaj tua kab mob ntau dua li cov tshuaj tua kab mob.

Terramycin yog tus neeg sawv cev dav dav rau cov kab mob bacteriostatic, thiab ntau tus rickettsia, mycoplasma, chlamydia, spirochetes, amoeba thiab qee cov plasmodium nkag siab oxytetracycline. Enterococcus tiv taus nws. Lwm yam xws li Actinomyces, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, thiab lwm yam yog nkag siab oxytetracycline.

Terramycin muaj qee yam tshuaj tua kab mob tiv thaiv Neisseria gonorrhoeae thiab meningococcus, tab sis penicillin-resistant Neisseria gonorrhoeae kuj tseem tiv taus oxytetracycline. Tau ntau xyoo, vim kev siv dav ntawm tetracyclines, cov kab mob sib kis tau zoo tiv taus oxytetracycline, suav nrog cov kab mob gram-positive xws li staphylococci thiab feem ntau gram-negative bacilli. Muaj kev tiv thaiv kab mob sib txawv ntawm ntau hom tshuaj tua kab mob tetracycline.

Lub mechanism ntawm kev txiav txim ntawm oxytetracycline yog tias cov tshuaj muaj peev xwm tshwj xeeb khi rau Txoj Haujlwm ntawm 30S subunit ntawm cov kab mob ribosome txhawm rau txhawm rau txwv kev loj hlob ntawm peptide saw thiab cuam tshuam rau kev sib txuas ntawm cov kab mob protein.

Nws yog siv rau mob plab, mob ntsws, kab mob sib kis, mob ntsws, mob otitis media, kab mob ntawm daim tawv nqaij, thiab lwm yam. Nws kuj tseem siv los kho amoebic enteritis thiab mob plab.

2. Lub cev nqaij thiab tshuaj muaj zog

Cov tshuaj hydrochloride ntsev ntawm terramycin yog lub teeb daj crystalline lossis amorphous hmoov, tsis muaj ntxhiab thiab tsaus rau hauv tshav ntuj, thiab yooj yim puas hauv alkaline daws. Nws yog me ntsis soluble hauv ethanol thiab dej, soluble hauv sodium hydroxide tov thiab dilute hydrochloric acid.

3. lub hom phiaj

Nws tuaj yeem siv los kho kev ua pa, lub qhov zis, tawv nqaij thiab cov nqaij mos kis hauv dev thiab miv, suav nrog brucellosis, kab mob rickettsial thiab chlamydia hauv cov dev, colibacillosis hauv cov dev thiab miv, thiab miv los ntawm rickettsiae Cov ntshav tsis txaus kuj tseem siv los tiv thaiv kab mob leptospirosis hauv dev.

4. Cov teebmeem tshuaj

Oxytetracycline muaj cov tshuaj tiv thaiv kab mob zoo rau cov kab mob me me, yog cov tshuaj tua kab mob sai, thiab muaj cov kab mob tua kab mob rau qee yam kab mob ntawm qhov siab. Cov txheej txheem ntawm kev ua yog tias cov tshuaj tuaj yeem cuam tshuam tshwj xeeb rau A txoj haujlwm ntawm 30S subunit ntawm ribosome txhawm rau tiv thaiv kev sib txuas ntawm aminoacyl-tRNA ntawm txoj haujlwm no, yog li cuam tshuam kev loj hlob ntawm peptide saw thiab cuam tshuam cov protein sib txuas ntawm cov kab mob lossis lwm yam pathogenic microorganisms.

Oxytetracycline muaj zog tiv thaiv kab mob tiv thaiv Staphylococcus aureus, pneumococcus, Streptococcus pyogenes, Neisseria gonorrhoeae, meningococcus, Escherichia coli, Aerobacter, Shigella, Yersinia, Listeria monocytogenes, thiab lwm yam; ntxiv rau, oxytetracycline kuj tseem muaj zog ua rau rickettsia, mycoplasma, chlamydia, actinomycetes, thiab lwm yam.

5. Pharmacokinetics

Qhov ncauj nqus ntawm oxytetracycline hydrochloride tsis tiav (kwv yees li 30% -58% tuaj yeem nqus tau), thiab qhov ntim ntawm kev faib tawm yog li 0.9-1.9L/kg. Cov ntshav siab tshaj plaws tom qab siv qhov ncauj ntawm 1 g yog txog 3.9 mg/L. Cov tshuaj tau nthuav dav tom qab nqus tau, thiab tuaj yeem nkag mus rau hauv lub plab pleural thiab lub plab, thiab tseem tuaj yeem nkag mus rau hauv cov ntshav menyuam hauv plab los ntawm txoj hlab ntaws hauv plab, tab sis nws tsis yooj yim rau nkag mus rau cov ntshav-cerebrospinal kua teeb meem, yog li cov ntsiab lus ntawm tshuaj nyob rau hauv cov kua dej hauv lub paj hlwb tsawg.

Oxytetracycline kuj tseem tuaj yeem faib rau hauv daim siab, tus po, pob txha pob txha, pob txha, kho hniav thiab hniav txha hniav laus. Cov tshuaj no tseem tuaj yeem nce siab ntau hauv cov mis. Tus nqi khi ntawm cov protein oxytetracycline yog li 20%-35%. Ib nrab-lub neej ntawm cov neeg mob uas lub raum ua haujlwm zoo yog 6-10h, thiab ncua ib nrab-lub neej nrog lub raum tsis txaus.

Nws tuaj yeem ncav cuag 47-66h rau cov neeg mob anuria. Cov tshuaj no feem ntau yog tso tawm los ntawm lub plab zom mov, thiab 70% ntawm cov tshuaj tuaj yeem tso tawm hauv 24 teev ntawm kev tswj hwm, thiab cov tshuaj me me raug tso tawm los ntawm cov quav ntawm cov kua tsib. Hemodialysis tuaj yeem tshem tawm 10% -15% ntawm cov tshuaj.

Terramycin siv

1. indications

A. Oxytetracycline tuaj yeem siv ua lwm txoj kev kho rau cov kab mob hauv qab no:

• Rickettsiosis, suav nrog tus mob typhus, kis tus kab mob, thiab tsutsugamushi;
• Kev kis mob los ntawm Mycoplasma pneumoniae;
• Kab mob Chlamydia, suav nrog psittacosis, inguinal granuloma (kab mob lymphgranuloma venereal), tsis muaj kab mob urethritis tshwj xeeb, salpingitis thiab trachoma;
• Ua npaws rov qab los;
• Brucellosis (ua ke nrog aminoglycosides tshuaj);
• Tus kab mob;
• Plague (ua ke nrog cov tshuaj aminoglycoside);
• tularemia.

B. Oxytetracycline tuaj yeem siv los kho tus mob tetanus, roj av gangrene, yaws, mob syphilis, gonorrhea thiab leptospirosis ua xua rau tshuaj tua kab mob penicillin.

C. Oxytetracycline kuj tseem tuaj yeem siv los kho kab mob ua pa, kab mob hauv lub cev, tso zis thiab tawv nqaij thiab cov nqaij mos mos kis los ntawm cov kab mob rhiab.

D. Oxytetracycline kuj tseem tuaj yeem siv rau kev kho pob txuv.

2. siv

Vim li cas thiaj tsis txiav terramycin? Terramycin, tseem hu ua oxytetracycline, kuj tseem yog qhov sib xyaw nrog cov tub ntxhais polycyclic tetracenecarboxamide ntau. Nws belongs rau ib ntawm tetracyclines. Vim tias nws tus nqi qis, ntau tus neeg tau siv nws los kho cov kab mob ntses. Tam sim no nws siv aquaculture yog qhov txwv.

Txawm hais tias nws yog tshuaj txwv, nws tsis txhais tau tias nws muaj txiaj ntsig zoo. Txawm hais tias nws yog tshuaj tua kab mob dav-dav, nws feem ntau yog cov tshuaj tua kab mob bacteriostatic. Nws tsuas tuaj yeem tua cov kab mob thaum lub siab ua haujlwm siab. Nws muaj qhov ua tsis tau zoo ntawm cov kab mob gram-positive Staphylococcus, Streptococcus hemolyticus, thiab Clostridium ntau dua penicillins thiab cephalosporins; nws rhiab heev rau E. coli, Salmonella, thiab Pasteurella hauv cov kab mob Gram-negative, tab sis nws tsis zoo li aminoglycosides thiab chloramphenicol.

Txawm hais tias muaj cov kab mob tua kab mob thiab tua kab mob ntawm terramycin tsis zoo li lwm yam tshuaj tua kab mob, nws cov metabolism hauv lub cev qeeb, thiab nws tseem tuaj yeem nqa tawm hepato-hnyuv ncig zoo li doxycycline. Oxytetracycline yog me ntsis soluble hauv dej thiab yooj yim ua tsis tiav hauv kev daws teeb meem alkaline.

Nws cov hydrochloride ntsev feem ntau siv. Nws muaj cov khoom ruaj khov thiab cov hmoov daj daj, tab sis nws tsis ruaj khov tom qab tau yaj hauv dej. Kev nqus ntawm terramycin tsis xwm yeem thiab tsis tiav. Nws feem ntau yog nqus rau sab saud ntawm txoj hnyuv me. Thaum muaj polyvalent hlau ions xws li txhuas, magnesium, calcium, hlau, thiab manganese hauv txoj hnyuv, lawv tuaj yeem tsim cov tshuaj tsis haum nrog chelates, yog li txo qhov ua tau zoo.

Tom qab nqus tau, nws tau faib dav thiab yooj yim nkag mus rau hauv kab noj thoracic thiab plab kab noj hniav. Nws tau khaws cia hauv cov kua tsib, tus po, cov hniav thiab cov pob txha hauv lub cev. Nws tuaj yeem mob siab rau hauv daim siab thiab zais los ntawm cov kua tsib. Cov tshuaj ntau hauv cov kua tsib tuaj yeem ncav cuag ntau dua 10 npaug ntawm cov tshuaj concentration hauv cov ntshav. Ib feem ntawm cov tshuaj kho mob yuav raug tso tawm rau hauv cov hnyuv nrog rau cov kua tsib, nqus tau thiab rov siv dua, thiab nkag mus rau lub plab hepato-hnyuv.

Thaum siv terramycin, nws yuav tsum tau sau tseg tias qhov ntau npaum li cas yog qhov loj heev, thiab qhov ntau npaum li cas yog 5-100 mg rau ib phaus ntawm lub cev hnyav. Yog tias qhov ntau npaum li cas, lossis sijhawm siv lub qhov ncauj ntev dhau, nws yuav ua rau muaj teeb meem hauv plab hnyuv, mob plab thiab kis tau ob npaug. Tshwj xeeb tshaj yog rau lub raum tsis ua haujlwm ntawm lub cev, oxytetracycline feem ntau yog tso tawm los ntawm ob lub raum, uas yuav ua rau qeeb ntawm kev tso tawm, ua rau lub neej ib nrab, thiab ua rau lub siab ua rau lub siab. Zoo li doxycycline, nws tsis tsim nyog siv nyob rau hauv cov xwm txheej alkaline. Cov nyhuv ntawm kev noj tshuaj ntawm lub plab khoob yog qhov zoo dua.

3. ntau npaum

• Cov neeg laus: 0.25 ～ 0.5g txhua lub sijhawm, ib zaug txhua 6 teev.
• Menyuam: Cov menyuam hnub nyoog tshaj 8 xyoo, 6.25 ～ 12.5 mg/kg txhua lub sijhawm, ib zaug txhua 6 teev.

4. Veterinary Siv

Oxytetracycline muaj cov tshuaj tua kab mob dav dav. Nws kuj tseem muaj qee yam cuam tshuam rau cov kab mob rhiab xws li pneumococcus, streptococcus, qee yam staphylococci, Bacillus anthracis, tetanus, Mycoplasma hyopneumoniae, Chlamydia, thiab spirochetes.

Muaj nuj nqi thiab taw qhia:

• Nws muaj cov txiaj ntsig tseem ceeb ntawm kev kho mob npua paratyphoid ua npaws, eperythrocytes, anthracnose, mob hawb pob, mob plab, thiab mob ntsws swine.
• Nqaij qaib mob plab thiab chlamydia kuj tseem tuaj yeem siv los txo kev ntxhov siab, nce qe ntau lawm, thiab txhawb nqa hnyav ntawm cov noog hluas.
• Cov khoom siv hauv dej tau siv los kho tus kab mob Vibrio, kab mob dephosphorization, kab mob rot, kab mob eel, kab mob trout, kab mob eel liab, thiab lwm yam.

ntau npaum:

• Kev haus dej sib xyaw: ntxiv 400 kg dej rau 100g ib lub hnab rau 3-5 hnub
• Kev sib xyaw pub mis: txhua lub hnab ntawm 100g cov khoom sib xyaw 200 kg, siv tas li rau 3-5 hnub

Cov teebmeem ntawm Terramycin

1. Kev phiv tshuaj

• Terramycin tuaj yeem tso rau hauv cov hniav thiab pob txha, ua rau qib sib txawv ntawm cov xim thiab daj ntawm cov hniav, dysplasia ntawm txha hniav laus thiab hniav lwj, thiab dysplasia ntawm pob txha.
• Cov kab mob plab zom mov: Qhov ncauj terramycin tuaj yeem ua rau cov tsos mob ntawm lub plab xws li xeev siab, ntuav, tsis xis nyob hauv plab, mob plab, thiab raws plab.
• Kev puas tsuaj rau lub siab: Kev siv lub qhov ncauj ntev ntawm oxytetracycline hauv cov tshuaj loj tuaj yeem ua rau lub siab puas, feem ntau pom tau tias yog daim siab steatosis. Cov neeg mob uas muaj daim siab thiab lub raum tsis ua haujlwm ua ntej, thiab cov poj niam thaum cev xeeb tub lig yuav muaj tshwm sim ntau dua.
• Kev ua xua: ua npaws lossis ua pob ua pob rau ntawm daim tawv nqaij. Qhov tom kawg tuaj yeem tshwm sim ua pob khaus, erythema multiforme, eczema zoo li erythema, thiab lwm yam, thiab tseem tuaj yeem ua rau daim tawv nqaij ua xua. Qee zaum, cov tsos mob xws li ua xua anaphylactic, mob hawb pob, thiab purpura tuaj yeem tshwm sim.
• Cov kev hloov pauv hauv ib puag ncig hemogram: lymphocytes txawv txav, granulocyte cov tshuaj lom lom, thrombocytopenia thiab txo granulocyte tuaj yeem tshwm sim hauv kev siv tshuaj ntev.
• Lub hauv nruab nrab lub paj hlwb: qee zaum ua rau lub siab ua rau lub siab nce ntxiv thaum noj tshuaj, pom tau tias mob taub hau, ntuav, kho qhov muag disc edema, thiab lwm yam.
• Kab mob sib kis ob zaug: Kev siv tshuaj mus ntev tuaj yeem ua rau kis mob ob zaug. Kev kis tus kab mob ob zaug feem ntau tshwm sim raws li txoj hnyuv, ua pa thiab tso zis tso zis los ntawm cov tshuaj-resistant Staphylococcus aureus, Gram-negative bacilli thiab fungi. Hauv cov mob hnyav, nws tuaj yeem ua rau mob sepsis.
• Lwm tus: Kev siv tshuaj mus ntev tuaj yeem txo qis cov ntoo ib txwm nyob hauv tib neeg lub cev, ua rau muaj cov vitamin tsis txaus, ua rau cov kab mob kis tau tus kab mob, nqhis dej, mob caj pas, cheilitis angular, glossitis, tsaus lossis ua xim ntawm cov nplaim paj.

2. Kev sib tham ntawm Terramycin

• Oxytetracycline tuaj yeem txhim kho nws cov nephrotoxicity thaum siv ua ke nrog tshuaj loog methoxyflurane.
• Oxytetracycline thiab cov tshuaj muaj zog zoo li furosemide tuaj yeem ua rau lub raum puas tsuaj thaum siv ua ke.
• Oxytetracycline tuaj yeem txhim kho kev mob siab rau daim siab thaum siv ua ke nrog lwm cov tshuaj hepatotoxic (xws li tshuaj tiv thaiv qog nqaij hlav cancer).
• Thaum oxytetracycline siv sib npaug nrog antacids xws li sodium bicarbonate, nce pH hauv plab tuaj yeem txo qis kev nqus thiab ua haujlwm ntawm oxytetracycline.
• Oxytetracycline tuaj yeem tsim cov tshuaj tsis haum nrog cov hlau ions hauv nws thaum nws siv ua ke nrog calcium gluconate, calcium lactate thiab magnesium laxatives thiab lwm yam tshuaj uas muaj calcium, magnesium, thiab hlau ions, txo kev nqus tshuaj.
• Thaum cov tshuaj hypolipidemic cholestyramine lossis colestipo tau siv ua ke nrog oxytetracycline, nws tuaj yeem cuam tshuam rau kev nqus ntawm oxytetracycline.
• Terramycin thiab cov tshuaj tiv thaiv qhov ncauj uas muaj cov tshuaj estrogen tuaj yeem txo qhov ua tau zoo ntawm kev tiv thaiv kev tiv thaiv thiab nce ntshav ntxiv.

3. lus ceeb toom

• Hla kev ua xua: Cov neeg uas ua xua rau ib yam tshuaj tetracycline tuaj yeem ua xua rau lwm yam tshuaj tetracycline.
• Siv nrog ceev faj: cov neeg mob uas muaj kab mob siab ua ntej; cov uas muaj lub raum tsis zoo.
• Oxytetracycline hauv cov menyuam yaus hnub nyoog qis dua 8 xyoo tuaj yeem ua rau daj daj ntawm cov hniav tas mus li, txha hniav laus tsis ua haujlwm thiab tiv thaiv kev loj hlob ntawm pob txha. Yog li ntawd, menyuam yaus hnub nyoog qis dua 8 xyoos yuav tsum tsis txhob siv oxytetracycline.
• Oxytetracycline tuaj yeem nkag mus rau hauv menyuam hauv plab los ntawm cov ntshav tso ntshav tso rau hauv thiab tso rau hauv thaj chaw calcium ntawm cov hniav thiab cov pob txha, ua rau muaj tetracycline cov hniav, txha hniav laus tsis zoo thiab tiv thaiv kev loj hlob ntawm cov pob txha hauv plab. Yog li ntawd, poj niam cev xeeb tub yuav tsum tsis txhob siv terramycin.
• Terramycin tuaj yeem zais los ntawm niam mis, thiab kev mloog zoo hauv cov mis yog qhov siab. Txawm hais tias terramycin tuaj yeem tsim cov tshuaj tsis haum nrog cov calcium hauv cov mis thiab muaj qhov nqus tau me me, nws tuaj yeem ua rau cov hniav tsis zoo ib yam, Cov hniav tsis zoo thiab cuam tshuam kev loj hlob ntawm tus menyuam pob txha, yog li cov poj niam pub niam mis yuav tsum ntsuas qhov zoo thiab qhov tsis zoo ua ntej txiav txim siab siv nws. .
• Txheeb xyuas lossis saib xyuas thaum noj tshuaj: lub siab thiab lub raum ua haujlwm yuav tsum tau tshuaj xyuas tas li thaum siv tshuaj;
• Rau cov uas tau kho nrog oxytetracycline tau ntev, cov ntshav ntshav yuav tsum ntsuas yog tias tsim nyog.

xaus

Nyob rau tag nrho, cov nyhuv antibacterial ntawm terramycin tsis zoo li chloramphenicol, cephalosporins, penicillin thiab aminoglycosides, tab sis terramycin tau zom cov zom zaub mov qeeb thiab tuaj yeem tsim kev nkag mus rau hauv lub cev. Txawm li cas los xij, oxytetracycline muaj ntau cov kev phiv thiab nws siv ntau dhau hauv kev lag luam aquaculture tau ua rau terramycin raug txwv los ntawm kev lag luam aquaculture.

BALLYA muab a ballya-tetracyclines-xeem qhia rau koj yog tias muaj tetracyclines(suav nrog terramycin) seem hauv zib ntab, nqaij qaib thiab nqaij npuas.

References

• DailyMed: Terramycin
• Tshuaj: Terramycin nrog Polymyxin B.