Koj puas tuaj yeem siv terramycin rau tib neeg?

Terramycin yog dab tsi?

1. Lus txhais

Terramycin yog lub ntsiav tshuaj daj daj lossis cov ntsiav tshuaj uas muaj suab thaj, uas yog tetracyclines, yooj yim soluble hauv dej thiab acidic. Nws yog qhov dav-spectrum ib nrab hluavtaws tshuaj tua kab mob uas yog tshuaj tua kab mob ntau dua li cov tshuaj tua kab mob.

Terramycin yog tus neeg sawv cev dav dav rau cov kab mob bacteriostatic, thiab ntau tus rickettsia, mycoplasma, chlamydia, spirochetes, amoeba thiab qee cov plasmodium nkag siab oxytetracycline. Enterococcus tiv taus nws. Lwm yam xws li Actinomyces, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, thiab lwm yam yog nkag siab oxytetracycline.

Terramycin muaj qee yam tshuaj tua kab mob tiv thaiv Neisseria gonorrhoeae thiab meningococcus, tab sis penicillin-resistant Neisseria gonorrhoeae kuj tseem tiv taus oxytetracycline. Tau ntau xyoo, vim kev siv dav ntawm tetracyclines, cov kab mob sib kis tau zoo tiv taus oxytetracycline, suav nrog cov kab mob gram-positive xws li staphylococci thiab feem ntau gram-negative bacilli. Muaj kev tiv thaiv kab mob sib txawv ntawm ntau hom tshuaj tua kab mob tetracycline.

Lub mechanism ntawm kev txiav txim ntawm oxytetracycline yog tias cov tshuaj muaj peev xwm tshwj xeeb khi rau Txoj Haujlwm ntawm 30S subunit ntawm cov kab mob ribosome txhawm rau txhawm rau txwv kev loj hlob ntawm peptide saw thiab cuam tshuam rau kev sib txuas ntawm cov kab mob protein.

Nws yog siv rau mob plab, mob ntsws, kab mob sib kis, mob ntsws, mob otitis media, kab mob ntawm daim tawv nqaij, thiab lwm yam. Nws kuj tseem siv los kho amoebic enteritis thiab mob plab.

2. Lub cev nqaij thiab tshuaj muaj zog

Cov tshuaj hydrochloride ntsev ntawm terramycin yog lub teeb daj crystalline lossis amorphous hmoov, tsis muaj ntxhiab thiab tsaus rau hauv tshav ntuj, thiab yooj yim puas hauv alkaline daws. Nws yog me ntsis soluble hauv ethanol thiab dej, soluble hauv sodium hydroxide tov thiab dilute hydrochloric acid.

3. lub hom phiaj

Nws tuaj yeem siv los kho kev ua pa, lub qhov zis, tawv nqaij thiab cov nqaij mos kis hauv dev thiab miv, suav nrog brucellosis, kab mob rickettsial thiab chlamydia hauv cov dev, colibacillosis hauv cov dev thiab miv, thiab miv los ntawm rickettsiae Cov ntshav tsis txaus kuj tseem siv los tiv thaiv kab mob leptospirosis hauv dev.

4. Cov teebmeem tshuaj

Oxytetracycline muaj cov tshuaj tiv thaiv kab mob zoo rau cov kab mob me me, yog cov tshuaj tua kab mob sai, thiab muaj cov kab mob tua kab mob rau qee yam kab mob ntawm qhov siab. Cov txheej txheem ntawm kev ua yog tias cov tshuaj tuaj yeem cuam tshuam tshwj xeeb rau A txoj haujlwm ntawm 30S subunit ntawm ribosome txhawm rau tiv thaiv kev sib txuas ntawm aminoacyl-tRNA ntawm txoj haujlwm no, yog li cuam tshuam kev loj hlob ntawm peptide saw thiab cuam tshuam cov protein sib txuas ntawm cov kab mob lossis lwm yam pathogenic microorganisms.

Oxytetracycline muaj zog tiv thaiv kab mob tiv thaiv Staphylococcus aureus, pneumococcus, Streptococcus pyogenes, Neisseria gonorrhoeae, meningococcus, Escherichia coli, Aerobacter, Shigella, Yersinia, Listeria monocytogenes, thiab lwm yam; ntxiv rau, oxytetracycline kuj tseem muaj zog ua rau rickettsia, mycoplasma, chlamydia, actinomycetes, thiab lwm yam.

5. Pharmacokinetics

Qhov ncauj nqus ntawm oxytetracycline hydrochloride tsis tiav (kwv yees li 30% -58% tuaj yeem nqus tau), thiab qhov ntim ntawm kev faib tawm yog li 0.9-1.9L/kg. Cov ntshav siab tshaj plaws tom qab siv qhov ncauj ntawm 1 g yog txog 3.9 mg/L. Cov tshuaj tau nthuav dav tom qab nqus tau, thiab tuaj yeem nkag mus rau hauv lub plab pleural thiab lub plab, thiab tseem tuaj yeem nkag mus rau hauv cov ntshav menyuam hauv plab los ntawm txoj hlab ntaws hauv plab, tab sis nws tsis yooj yim rau nkag mus rau cov ntshav-cerebrospinal kua teeb meem, yog li cov ntsiab lus ntawm tshuaj nyob rau hauv cov kua dej hauv lub paj hlwb tsawg.

Oxytetracycline kuj tseem tuaj yeem faib rau hauv daim siab, tus po, pob txha pob txha, pob txha, kho hniav thiab hniav txha hniav laus. Cov tshuaj no tseem tuaj yeem nce siab ntau hauv cov mis. Tus nqi khi ntawm cov protein oxytetracycline yog li 20%-35%. Ib nrab-lub neej ntawm cov neeg mob uas lub raum ua haujlwm zoo yog 6-10h, thiab ncua ib nrab-lub neej nrog lub raum tsis txaus.

Nws tuaj yeem ncav cuag 47-66h rau cov neeg mob anuria. Cov tshuaj no feem ntau yog tso tawm los ntawm lub plab zom mov, thiab 70% ntawm cov tshuaj tuaj yeem tso tawm hauv 24 teev ntawm kev tswj hwm, thiab cov tshuaj me me raug tso tawm los ntawm cov quav ntawm cov kua tsib. Hemodialysis tuaj yeem tshem tawm 10% -15% ntawm cov tshuaj.

Terramycin siv

Terramycin-Siv
Terramycin-Siv

1. indications

A. Oxytetracycline tuaj yeem siv ua lwm txoj kev kho rau cov kab mob hauv qab no:

B. Oxytetracycline tuaj yeem siv los kho tus mob tetanus, roj av gangrene, yaws, mob syphilis, gonorrhea thiab leptospirosis ua xua rau tshuaj tua kab mob penicillin.

C. Oxytetracycline kuj tseem tuaj yeem siv los kho kab mob ua pa, kab mob hauv lub cev, tso zis thiab tawv nqaij thiab cov nqaij mos mos kis los ntawm cov kab mob rhiab.

D. Oxytetracycline kuj tseem tuaj yeem siv rau kev kho pob txuv.

2. siv

Vim li cas thiaj tsis txiav terramycin? Terramycin, tseem hu ua oxytetracycline, kuj tseem yog qhov sib xyaw nrog cov tub ntxhais polycyclic tetracenecarboxamide ntau. Nws belongs rau ib ntawm tetracyclines. Vim tias nws tus nqi qis, ntau tus neeg tau siv nws los kho cov kab mob ntses. Tam sim no nws siv aquaculture yog qhov txwv.

Txawm hais tias nws yog tshuaj txwv, nws tsis txhais tau tias nws muaj txiaj ntsig zoo. Txawm hais tias nws yog tshuaj tua kab mob dav-dav, nws feem ntau yog cov tshuaj tua kab mob bacteriostatic. Nws tsuas tuaj yeem tua cov kab mob thaum lub siab ua haujlwm siab. Nws muaj qhov ua tsis tau zoo ntawm cov kab mob gram-positive Staphylococcus, Streptococcus hemolyticus, thiab Clostridium ntau dua penicillins thiab cephalosporins; nws rhiab heev rau E. coli, Salmonella, thiab Pasteurella hauv cov kab mob Gram-negative, tab sis nws tsis zoo li aminoglycosides thiab chloramphenicol.

Txawm hais tias muaj cov kab mob tua kab mob thiab tua kab mob ntawm terramycin tsis zoo li lwm yam tshuaj tua kab mob, nws cov metabolism hauv lub cev qeeb, thiab nws tseem tuaj yeem nqa tawm hepato-hnyuv ncig zoo li doxycycline. Oxytetracycline yog me ntsis soluble hauv dej thiab yooj yim ua tsis tiav hauv kev daws teeb meem alkaline.

Nws cov hydrochloride ntsev feem ntau siv. Nws muaj cov khoom ruaj khov thiab cov hmoov daj daj, tab sis nws tsis ruaj khov tom qab tau yaj hauv dej. Kev nqus ntawm terramycin tsis xwm yeem thiab tsis tiav. Nws feem ntau yog nqus rau sab saud ntawm txoj hnyuv me. Thaum muaj polyvalent hlau ions xws li txhuas, magnesium, calcium, hlau, thiab manganese hauv txoj hnyuv, lawv tuaj yeem tsim cov tshuaj tsis haum nrog chelates, yog li txo qhov ua tau zoo.

Tom qab nqus tau, nws tau faib dav thiab yooj yim nkag mus rau hauv kab noj thoracic thiab plab kab noj hniav. Nws tau khaws cia hauv cov kua tsib, tus po, cov hniav thiab cov pob txha hauv lub cev. Nws tuaj yeem mob siab rau hauv daim siab thiab zais los ntawm cov kua tsib. Cov tshuaj ntau hauv cov kua tsib tuaj yeem ncav cuag ntau dua 10 npaug ntawm cov tshuaj concentration hauv cov ntshav. Ib feem ntawm cov tshuaj kho mob yuav raug tso tawm rau hauv cov hnyuv nrog rau cov kua tsib, nqus tau thiab rov siv dua, thiab nkag mus rau lub plab hepato-hnyuv.

Thaum siv terramycin, nws yuav tsum tau sau tseg tias qhov ntau npaum li cas yog qhov loj heev, thiab qhov ntau npaum li cas yog 5-100 mg rau ib phaus ntawm lub cev hnyav. Yog tias qhov ntau npaum li cas, lossis sijhawm siv lub qhov ncauj ntev dhau, nws yuav ua rau muaj teeb meem hauv plab hnyuv, mob plab thiab kis tau ob npaug. Tshwj xeeb tshaj yog rau lub raum tsis ua haujlwm ntawm lub cev, oxytetracycline feem ntau yog tso tawm los ntawm ob lub raum, uas yuav ua rau qeeb ntawm kev tso tawm, ua rau lub neej ib nrab, thiab ua rau lub siab ua rau lub siab. Zoo li doxycycline, nws tsis tsim nyog siv nyob rau hauv cov xwm txheej alkaline. Cov nyhuv ntawm kev noj tshuaj ntawm lub plab khoob yog qhov zoo dua.

3. ntau npaum

4. Veterinary Siv

Oxytetracycline muaj cov tshuaj tua kab mob dav dav. Nws kuj tseem muaj qee yam cuam tshuam rau cov kab mob rhiab xws li pneumococcus, streptococcus, qee yam staphylococci, Bacillus anthracis, tetanus, Mycoplasma hyopneumoniae, Chlamydia, thiab spirochetes.

Muaj nuj nqi thiab taw qhia:

ntau npaum:

Cov teebmeem ntawm Terramycin

Terramycin-Sab-Teeb Meem
Terramycin-Sab-Teeb Meem

1. Kev phiv tshuaj

2. Kev sib tham ntawm Terramycin

3. lus ceeb toom

xaus

Nyob rau tag nrho, cov nyhuv antibacterial ntawm terramycin tsis zoo li chloramphenicol, cephalosporins, penicillin thiab aminoglycosides, tab sis terramycin tau zom cov zom zaub mov qeeb thiab tuaj yeem tsim kev nkag mus rau hauv lub cev. Txawm li cas los xij, oxytetracycline muaj ntau cov kev phiv thiab nws siv ntau dhau hauv kev lag luam aquaculture tau ua rau terramycin raug txwv los ntawm kev lag luam aquaculture.

BALLYA muab a ballya-tetracyclines-xeem qhia rau koj yog tias muaj tetracyclines(suav nrog terramycin) seem hauv zib ntab, nqaij qaib thiab nqaij npuas.

References