Kev kuaj sulfonamides

Cov Khoom Siv Ib Leeg, nrawm kom pom cov tshuaj sulfonamides seem hauv cov mis thiab khoom noj siv mis los ntawm kev siv colloidal kub immunochromatography thev naus laus zis. Sai li 7-10 feeb rau cov txiaj ntsig.

Cov tshuaj Sulfa yog cov tshuaj tua kab mob tua kab mob uas tau siv hauv tsev kho mob tau ze li 50 xyoo, suav nrog: sulfamethazine (SM2), sulfisoxazole (SIZ), sulfadiazine (SD), sulfamethoxazole (SMZ), Sulfamethoxine (SMD), sulfadimethoxine (SDM), sulfacetamide ( SA), sulfadiazine silver ntsev (SD-Ag), methanesulfonate (SML).

Nws muaj qhov zoo ntawm cov tshuaj tua kab mob dav dav, ruaj khov, siv tau yooj yim, thiab tsis muaj zaub mov noj thaum tsim khoom. Tshwj xeeb tshaj yog tom qab pom pom cov tshuaj tua kab mob sib xyaw ua ke-trimethoprim (TMP) xyoo 1969, kev siv ua ke nrog sulfonamides tuaj yeem txhim kho nws cov tshuaj tua kab mob thiab nthuav dav kev kho mob. Yog li ntawd, txawm hais tias muaj ntau yam tshuaj tua kab mob tau tawm los, cov tshuaj sulfa tseem yog cov tshuaj kho mob tseem ceeb.

Sulfonamides muaj kev cuam tshuam los ntawm ntau cov kab mob Gram-positive thiab qee cov kab mob Gram-negative, Nocardia, Chlamydia thiab qee yam protozoa (xws li Plasmodium thiab Amoeba). Ntawm cov kab mob zoo, streptococcus thiab pneumococcus muaj qhov ua tau zoo heev; Staphylococcus thiab Perfringens muaj kev nkag siab me ntsis.

Ntawm cov kab mob tsis zoo, cov rhiab tshaj plaws yog meningococcus, Escherichia coli, Proteus, Shigella, Pneumoniae thiab Yersinia. Nws tsis muaj kev cuam tshuam rau cov kab mob, spirochetes thiab trypanosoma. Nws tsis yog tsuas yog tsis muaj txiaj ntsig rau Rickettsia, tab sis tuaj yeem txhawb nws txoj kev luam tawm. Nws feem ntau ntseeg tias qhov sib txawv ntawm lub zog tiv thaiv kab mob ntawm cov tshuaj sulfa sib txawv yog nyob hauv qhov ntau, tsis yog qhov zoo. Cov sib xyaw nrog lub zog loj rau ib hom kab mob muaj lub zog zoo rau lwm hom kab mob.

Cov kab mob tsis tuaj yeem siv folic acid ncaj qha hauv lawv qhov chaw loj hlob, tab sis siv p-aminobenzoic acid (PABA), dihydropteridine thiab glutamic acid hauv ib puag ncig los ua ke dihydrofolate nyob rau hauv catalysis ntawm dihydrofolate synthase hauv cov kab mob.

Dihydrofolate daim ntawv tetrahydrofolate nyob rau hauv qhov kev txiav txim ntawm dihydrofolate reductase. Tetrahydrofolate, raws li coenzyme ntawm ib-carbon unit transferase, koom nrog kev sib xyaw ntawm cov nucleic acid ua ntej (purine, pyrimidine). Nucleic acid yog ib feem tseem ceeb rau kev loj hlob ntawm cov kab mob thiab kev tsim tawm.

Cov txheej txheem tshuaj lom neeg ntawm cov tshuaj sulfa zoo ib yam li PABA, thiab nws tuaj yeem sib tw nrog PABA rau dihydrofolate synthase, uas cuam tshuam rau kev sib xyaw ntawm dihydrofolate, yog li txwv tsis pub cov kab mob loj hlob thiab rov tsim dua tshiab. Txij li cov tshuaj sulfa tuaj yeem txwv cov kab mob nkaus xwb tab sis tsis muaj cov kab mob tua kab mob, tshem tawm cov kab mob hauv lub cev thaum kawg nyob ntawm lub cev muaj peev xwm tiv thaiv.

Tom qab xyoo 1940, kev tshawb pom txuas ntxiv thiab txhim kho ntau yam tshuaj tua kab mob tau maj mam hloov sulfonamides hauv tsev kho mob. Tab sis cov tshuaj sulfa tseem muaj lawv qhov tshwj xeeb zoo, xws li cov tshuaj tua kab mob dav dav, cov khoom ruaj khov, siv tau yooj yim, tus nqi qis, thiab tsis noj zaub mov. 

Yog li ntawd, tshuaj sulfa tseem yog cov tshuaj tseem ceeb hauv kev tiv thaiv kev kis kab mob ntawm tsiaj txhu. Qhov phom sij ntawm cov tshuaj sulfa feem ntau suav nrog cov tshuaj lom, ua rau tsis haum, muaj kuab paug rau ib puag ncig, ua rau muaj kev sib kis ob zaug thiab tsim cov tshuaj tiv taus kab mob.

Tom qab siv sijhawm ntev ntawm cov khoom noj tsiaj uas muaj tshuaj sulfa, cov tshuaj txuas ntxiv mus rau hauv tib neeg lub cev. Thaum lawv nce mus rau qee qib, lawv yuav muaj tshuaj lom rau tib neeg lub cev thiab ua rau lub raum puas tsuaj, tshwj xeeb acesulfame hauv cov zis. Nws cov tshuaj yaj tau tsawg, thiab kev puas tsuaj rau lub raum yog qhov zoo tom qab nag lossis daus ntawm cov muaju.

Tom qab tau txais kev kho mob rau tsiaj, kwv yees li 60% txog 90% ntawm cov tshuaj sulfa yuav raug tso tawm los ntawm cov quav tsiaj, thiab lawv tseem tuaj yeem nyob ruaj khov tom qab nkag mus ib puag ncig, rhuav tshem cov kab mob me me hauv av thiab dej thiab ua rau muaj kuab paug ib puag ncig. Ib qho ntxiv, cov tshuaj sulfa muaj kev cuam tshuam loj rau kev ua pa hauv av, cov ntsiab lus ntawm cov organic, tus naj npawb ntawm cov kab mob me me thiab cov tsis muaj pob txha, cov pa oxygen hauv dej, tus naj npawb ntawm algae thiab phytoplankton hauv dej.

Sulfonamides feem ntau yog nyob hauv cov nqaij, qe, thiab mis nyuj hauv daim ntawv ntawm cov tshuaj qub lossis cov khoom ua kom puas. Tib neeg noj lawv los ntawm nqaij, qe, mis nyuj thiab lwm yam khoom noj tsiaj. Hauv qee kis, ua pob, xeev siab, ntuav, kiv taub hau thiab lwm yam tshuaj lom tuaj yeem tshwm sim. Sulfonamide residues kuj tuaj yeem ua rau tib neeg hematopoietic system, ua rau hemolytic anemia, agranulocytosis, thrombocytopenia thiab eosinophilia. Piv txwv li, hauv kev kho tus nyuj mastitis, yog tias lub sijhawm tso mis tsis tau siv, tom qab tib neeg noj cov mis no lossis cov khoom siv mis uas muaj cov tshuaj seem, ntawm cov neeg mob uas muaj kev fab tshuaj, cov me me muaj tawv nqaij khaus thiab tso zis, thiab qhov hnyav muaj vascularity Edema.

Txhawm rau kom ntseeg tau tias muaj kev nyab xeeb thiab muaj txiaj ntsig zoo ntawm cov tshuaj tsiaj, thiab kev nyab xeeb ntawm tib neeg tom qab noj cov zaub mov tsiaj, thaum siv tshuaj sulfa hauv kev siv tshuaj kho mob, nws tsis raug tso cai ua kom ntau npaum li qhov xav tau, cov tshuaj noj lossis ncua sijhawm kho los tiv thaiv kev txuam nrog cov tshuaj lom thiab ntxiv cov seem uas cuam tshuam rau tib neeg kev noj qab haus huv.

1.7 feeb nyeem cov txiaj ntsig

2. Kev txwv tsis pub teb rau EU thiab Asmeskas FDA cov cai

3. Tsis yog cov kws tshaj lij lossis cov cuab yeej xav tau

4. Yooj yim rau kev khiav lag luam thiab nyeem

Sulfonamides Test Kit yog colloidal kub tiv thaiv-chromatography kuaj uas tshwj xeeb uas tsim los txhawm rau txhawm rau txheeb xyuas sulfonamides seem hauv cov mis nyuj nyoos, mis hmoov, mis nyuj pasteurized thiab ua tau raws li EU MRL. Cov khoom siv no tuaj yeem thov rau ntawm qhov chaw sim nrawm los ntawm ntau lub chaw haujlwm.

Cov piv txwv suav nrog: mis nyuj nyoos, mis hmoov, mis nyuj pasteurized.

LOD tuaj yeem hloov pauv raws li qhov xav tau lossis qhov txawv ntawm qhov sib txawv, thov mus saib hauv phau ntawv qhia kom paub meej ntxiv.

Sulfonamides Test tuaj yeem pab cov tuam txhab tsim khoom, cov koom haum tswj hwm, thiab cov pej xeem saib xyuas cov khoom lag luam zoo thiab pab tib neeg tiv thaiv lawv txoj kev noj qab haus huv.

1. Micro-Well Reagent: 8 kuaj/raj, 12 raj/thawv

2. Xeem Sawb: 8pcs/raj, 96pcs/box

3. Phau Ntawv Qhia: 1pc

1. Qauv Raj

2. Pipette & Pipette Ntsis

3. Zoo-Tais

1. Ntxiv 200ul mis mus rau hauv lub qhov dej, tom qab ntawd xa dej mus thiab nqis rau 10 zaug kom sib xyaw cov qauv nrog cov tshuaj reagent hauv lub qhov dej.

2. Tom qab ntawd muab tso rau 5 feeb.

3. Ntxig daim ntawv xeem rau hauv micro-zoo-phaj nrog rau cov qauv ncoo puv dipped.

4. Tom qab 5 feeb, nyeem cov txiaj ntsig.

Thaum tshuaj tua kab mob tau siv thawj zaug rau tib neeg, peb suav tias lawv yog "tshuaj khawv koob". Raws li qhov teeb meem ntawm kev siv tshuaj tua kab mob txuas ntxiv mus zuj zus, lawv qhov kev tiv thaiv kuj tseem ua rau muaj kev puas tsuaj loj rau tib neeg.

Yog li, hauv lub neej txhua hnub, peb yuav tsum zam zaub mov nrog tshuaj tua kab mob seem. Thawj kauj ruam rau kev pab tus kheej: peb yuav tsum kuaj cov tshuaj tua kab mob seem.

Thov txheeb xyuas phau ntawv teev npe online thiab tiv tauj peb tus sawv cev muag ntawm email: info@ballyabio.com ib lossis sau daim foos tiv toj hauv qab no: