Gentamicin Test

Cov Khoom Siv Ib Leeg, nrawm los tshuaj xyuas Gentamicin seem hauv cov mis thiab khoom noj siv mis los ntawm kev siv colloidal kub immunochromatography thev naus laus zis. Sai li 7-10 feeb rau cov txiaj ntsig.

Gentamicin yog cov tshuaj tua kab mob aminoglycoside, feem ntau yog siv los kho cov kab mob sib kis, tshwj xeeb yog cov uas tshwm sim los ntawm gram-cov kab mob tsis zoo. Gentamicin tuaj yeem khi rau 30s subunit ntawm cov kab mob ribosome thiab thaiv cov kab mob sib txuas ua cov protein. Gentamicin yog ib qho ntawm ob peb cov tshuaj tua kab mob, yog li nws tau siv dav hauv kev npaj xov xwm.

Kev siv tshuaj tua kab mob dav dav tau ua tiav ntawm nws tus kheej los ntawm Tuam Tshoj yog kev tshawb fawb thiab thev naus laus zis ua tiav thaum lub sijhawm proletarian Cultural Revolution. Nws tau tsim thawj zaug hauv xyoo 1967 thiab tau txheeb xyuas tau zoo thaum kawg xyoo 1969. Nws tau lub npe "Gentamicin", uas txhais tau tias ua kev zoo siab rau "Ninth Congress" thiab ua tau zoo ntawm cov neeg ua haujlwm.

Gentamicin tau pom thawj zaug los ntawm Weinstein xyoo 1963. Nws yog cov tshuaj tiv thaiv kab mob ntau yam aminoglycoside tsim los ntawm Micromonospora, suav nrog C1, C2, C1a, C2a thiab C2b. Cov khoom tseem ceeb ntawm gentamicin C1, C2 thiab C1a tau siv dav hauv tsev kho mob. Ntawm lawv, C1a muaj qhov ua haujlwm tiv thaiv kab mob siab tshaj plaws, uas yog lub hauv paus ntawm kev tsim hluavtaws Etimicin, ua raws C2b, tseem hu ua sajiamycin. 

Cov tshuaj tua kab mob no tuaj yeem khi rau 16S rRNA ntawm 30S subunit ntawm cov kab mob ribosome, ua rau nyeem tsis raug ntawm cov caj ces, yog li thaiv cov synthesis ntawm cov kab mob protein, yog li lawv feem ntau yog siv los kho kab mob, tshwj xeeb yog kev kis mob los ntawm cov kab mob gram-negative . Txawm li cas los xij, vim tias muaj cov tshuaj nephrotoxicity siab heev thaum siv tiag, lawv daim ntawv thov tshuaj kho mob muaj tsawg.

Cov ntawv nyeem tau qhia tias nws cov nephrotoxicity yog vim muaj kev khi tshwj xeeb ntawm gentamicin rau 73kDa molecular chaperone HSP73, uas ua rau txo qis hauv kev ua haujlwm ntawm chaperone protein, tab sis nws cov tshuaj lom tshwj xeeb thiab cov kev phiv tshuaj tseem nyob rau qhov tseem ceeb. 

Gentamicin muaj cov tshuaj tua kab mob zoo rau ntau yam kab mob gram-negative thiab kab mob gram-positive, thiab tiv thaiv ntau yam enterobacteriaceae xws li Escherichia coli, Klebsiella, Proteus, Salmonella, Gagella, Enterobacter, Serratia thiab Pseudomonas aeruginosa. Neisseria thiab Haemophilus influenzae muaj kev nkag siab me ntsis rau cov khoom no. Nws kuj tseem muaj qee yam cuam tshuam rau Brucella, Yersinia pestis, Acinetobacter thiab Campylobacter fetus.

Nws muaj cov tshuaj tua kab mob zoo txog li 80% ntawm cov kab mob methicillin-sensitive Staphylococcus (suav nrog Staphylococcus aureus thiab coagulase-negative Staphylococcus), tab sis feem ntau ntawm cov kab mob methicillin-resistant tiv taus cov khoom no. Cov txiaj ntsig ntawm Streptococcus thiab Streptococcus pneumoniae tsis zoo, thiab feem ntau ntawm Enterococcus tiv taus cov khoom no. Thaum gentamicin sulfate ua ke nrog beta lactam cov, feem ntau ntawm lawv tuaj yeem tau txais cov tshuaj tiv thaiv kab mob sib xyaw. 

Cov txheej txheem ntawm kev ua ntawm gentamicin sulfate yog khi rau 30S subunit ntawm cov kab mob ribosomes thiab tiv thaiv kev sib txuas ntawm cov kab mob protein ntau. Xyoo tsis ntev los no, gram-negative bacilli tau nce kev tiv thaiv gentamicin ntau. Txawm li cas los xij, siv cov tshuaj gentamicin uas twb muaj lawm rau fermentation ntau lawm muaj cov impurities siab, thiab nws nyuaj rau ua tau raws li qhov xav tau ntawm xyoo 2010 tsab ntawm Suav Tshuaj Kho Mob.

Rau Escherichia coli, Aerobacter, Klebsiella, Proteus mirabilis, qee yam tsis muaj txiaj ntsig zoo Proteus, Pseudomonas aeruginosa, qee yam Neisseria, qee yam tsis muaj xim Serratia thiab Shigella, thiab lwm yam. 

Cov kab mob xiav-tsis zoo muaj cov tshuaj tua kab mob. Ntawm cov kab mob gram-positive, Staphylococcus aureus (suav nrog kev tuav cov kab mob lactamase) ua rau cov khoom no zoo; Streptococcus (suav nrog Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis, thiab lwm yam) yog txhua tus tiv taus cov khoom no. 

Cov kab mob Anaerobic (Bacteroides), Mycobacterium tuberculosis, Rickettsia, fungi thiab kab mob kuj tseem tiv taus cov khoom no. Xyoo tsis ntev los no, vim kev siv dav ntawm cov khoom no, cov tshuaj tiv taus kab mob tau nce zuj zus. Pseudomonas aeruginosa, Klebsiella, Serratia, thiab Indo-positive Proteus muaj cov tshuaj tiv thaiv siab rau cov khoom no.

Gentamicin yog cov tshuaj tua kab mob aminoglycoside, uas muaj zog tua cov kab mob gram-tsis zoo nyob rau theem ruaj khov. Nws yog cov kab mob tua kab mob nyob rau theem ruaj khov thiab tau siv dav hauv kev tiv thaiv thiab kho mob kab mob tsiaj.

Gentamicin sulfate yog siv rau hauv cov qaib, thiab nws nquag tso zis tso zis, ua rau lub raum loj tuaj, ua xua ua xua thiab ua pa nyuaj siab, thiab nws yog qhov tshwj xeeb tshaj yog muaj teeb meem rau lub paj hlwb thiab lub paj hlwb ntawm cov qaib. Thiab rov siv dua yog nquag ua rau muaj kev tiv thaiv tshuaj.

Kev noj ntev ntawm gentamicin qhov seem muaj qee yam tshuaj lom thiab phiv rau tib neeg lub paj hlwb, uas tuaj yeem ua rau lub cev tsis ua haujlwm, ua rau kiv taub hau thiab tsis hnov ​​lus; thiab nws cuam tshuam rau ob lub raum ntau dua, uas tuaj yeem ua rau lub raum kawg nkhaus duct. 

Cov tsos mob feem ntau suav nrog cov proteinuria thiab cov zis tubular, uas ua rau ua rau lub raum tsis ua haujlwm. Nws kuj tuaj yeem ua rau ua xua thiab ua rau tsis haum tshuaj. Ntxiv mus, cov neeg mob uas lub raum ua haujlwm tsis zoo (cuam tshuam rau kev tso tshuaj) tuaj yeem ua rau cov tshuaj ntau ntxiv thiab ua rau pob ntseg puas tsuaj.

Yog tias tib neeg noj zaub mov tsiaj uas muaj cov tshuaj tua kab mob nyob ntev, nws yooj yim yaum kom muaj cov kab mob tiv taus tshuaj, uas yuav ua rau cov tshuaj tua kab mob poob lawv tus nqi hauv kev kho kab mob, thiab coj teeb meem rau kev kho tib neeg kab mob, thiab qee yam kab mob kab mob uas tsis tuaj yeem tswj tau los ntawm cov tshuaj kuj tseem tuaj yeem tshwm sim. 

Cov kev tshawb fawb tau pom tias cov tshuaj tiv thaiv kab mob qis rau lub sijhawm ntev tuaj yeem ua rau muaj kev tiv thaiv kab mob Staphylococcus aureus, nrog rau tshwm sim ntawm cov kab mob tiv taus Escherichia coli.

1. 7 feeb nyeem cov txiaj ntsig

2. Kev txwv tsis pub teb rau EU thiab Asmeskas FDA cov cai

3. Tsis yog cov kws tshaj lij lossis cov cuab yeej xav tau

4. Yooj yim rau kev khiav lag luam thiab nyeem

Kev Ntsuas Gentamicin, raws li txoj kev sib tw sib xyaw xim kub, yog siv rau kev ntsuas Gentamicin cov seem hauv cov kua mis thiab ua tau raws li EU MRL. Cov khoom siv no tuaj yeem thov rau ntawm qhov chaw sim nrawm los ntawm ntau lub chaw haujlwm.

Cov piv txwv suav nrog: mis nyuj nyoos, mis hmoov, mis nyuj pasteurized.

Gentamicin Test tuaj yeem pab cov tuam txhab tsim khoom, cov koom haum tswj hwm, thiab pej xeem saib xyuas cov khoom lag luam zoo thiab pab tib neeg tiv thaiv lawv txoj kev noj qab haus huv.

1. Micro-Well Reagent: 8 kuaj/raj, 12 raj/thawv

2. Xeem Sawb: 8pcs/raj, 96pcs/box

3. Phau Ntawv Qhia: 1pc

1. Qauv Raj

2. Pipette & Pipette Tip

3. Zoo-Phaj

1. Ntxiv 200ul mis mus rau hauv lub qhov dej, tom qab ntawd xa dej mus thiab nqis rau 10 zaug kom sib xyaw cov qauv nrog cov tshuaj reagent hauv lub qhov dej.

2. Tom qab ntawd muab tso rau 5 feeb.

3. Ntxig daim kab xev ntsuas mus rau hauv lub qhov dej zoo nrog lub qauv ncoo puv dipped.

4. Tom qab 5 feeb, nyeem cov txiaj ntsig.

Thaum tshuaj tua kab mob tau siv thawj zaug rau tib neeg, peb suav tias lawv yog "tshuaj khawv koob". Raws li qhov teeb meem ntawm kev siv tshuaj tua kab mob txuas ntxiv mus zuj zus, lawv qhov kev tiv thaiv kuj tseem ua rau muaj kev puas tsuaj loj rau tib neeg.

Yog li, hauv lub neej txhua hnub, peb yuav tsum zam zaub mov nrog tshuaj tua kab mob seem. Thawj kauj ruam rau kev pab tus kheej: peb yuav tsum kuaj cov tshuaj tua kab mob seem.

Thov txheeb xyuas daim ntawv teev npe online thiab tiv tauj peb tus sawv cev muag khoom ntawm email: info@ballyabio.com lossis ua daim ntawv tiv toj hauv qab no: