Doxycycline yog ib hom ntawm tetracyclines, uas tuaj yeem kho tus mob Mycoplasma chlamydia. Nws yog daj ntseg daj lossis daj crystalline hmoov, tsw ntxhiab thiab iab. Nws yooj yim soluble hauv dej thiab methanol, me ntsis soluble hauv ethanol thiab acetone, thiab tsis yaj hauv chloroform.
Doxycycline yog hom tshuaj tua kab mob tshwj xeeb uas tuaj yeem tua tau ntau yam kab mob hauv lub cev uas nyuaj rau tua los ntawm lwm cov tshuaj tua kab mob, suav nrog cov kab mob thiab kab mob parasites. Parasites tuaj yeem tswj hwm cov cell ua cov kab mob hauv lub cev ntev, yog li nws nyuaj rau tua los ntawm ntau yam tshuaj tua kab mob. Tab sis doxycycline cov kev mob tshwm sim tsis yog yam uas peb yuav tsum saib xyuas.
Tsis zoo li lwm hom tshuaj tua kab mob, doxycycline tuaj yeem nkag mus rau hauv cov ntaub so ntswg thiab thaum kawg nkag mus rau cov cell, qhov twg cov tshuaj tua kab mob tuaj yeem tua cov kab mob. Ntau yam kab mob hauv lub cev uas nkag siab rau doxycycline suav nrog ntau yam kab mob uas ua rau muaj kab mob zoonotic, chlamydia, legionella, thiab plasmodium. Lwm yam kab mob me me muaj xws li spirochetes thiab kab mob ua rau pob txuv, Bacillus anthracis, thiab Vibrio cholerae.
Nws cov kab mob tua kab mob yog ib puag ncig zoo ib yam li ntawm tshuaj tetracycline thiab oxytetracycline, thiab lub zog tiv thaiv kab mob hauv vivo thiab hauv vitro muaj zog dua li ntawm tetracycline. Cov kab mob me me muaj kev tiv thaiv kev hla mus rau doxycycline, tetracycline thiab oxytetracycline.
Nws feem ntau yog siv rau kab mob ua pa sab saud, tonsillitis, kab mob hauv lub cev, mob lymphadenitis, cellulitis, mob ntsws ntev, thiab lwm yam tshwm sim los ntawm cov kab mob gram-positive thiab bacilli gram-negative. Nws kuj tseem siv los kho tus mob typhus, Tsutsugamushi, mycoplasma pneumonia, thiab lwm yam. Nws tseem tuaj yeem siv los kho tus mob raws plab, thiab tiv thaiv kab mob falciparum malaria thiab Leptospira.
Doxycycline hydrochloride feem ntau siv, uas yog lub teeb daj lossis daj crystalline hmoov; ntxhiab thiab iab. Nws yooj yim soluble hauv dej thiab methanol, me ntsis soluble hauv ethanol thiab acetone, thiab tsis yaj hauv chloroform. Qee cov tshuaj siv hluavtaws uas muaj doxycycline muaj feem cuam tshuam nrog cov tshuaj ions hlau hauv dej, tsim cov tshuaj liab thiab txo qhov ua tau zoo.
Doxycycline tuaj yeem cuam tshuam nrog kev muaj peev xwm ntawm cov kab mob microbial los tsim cov protein. Cov protein yog lub hauv paus tseem ceeb ntawm lub neej. Kev tsim cov protein hauv cov hlwb feem ntau ua tiav hauv ribosomes, thiab cov txheej txheem no yog qhov tsim nyog rau kev muaj sia nyob ntawm txhua lub cev. Doxycycline tua cov kab mob thiab cab, tab sis tsis muaj kev cuam tshuam rau peb tus kheej lub hlwb. Qhov laj thawj yog tias tib neeg lub cev muaj cov qauv ribosomal sib txawv ntawm cov kab mob yooj yim.
Nws feem ntau yog siv los kho kev ua pa, tso zis thiab tso pa tawm los ntawm cov kab mob rhiab. Cov kab mob tua kab mob yog ib yam tib yam li tetracycline thiab oxytetracycline, thiab lub zog tua kab mob muaj zog dua li tetracycline. Cov kab mob me me muaj kev tiv thaiv ze rau doxycycline, tetracycline thiab oxytetracycline. Nws kuj tseem siv rau kev kho tus mob typhus, Qiang trypanosomiasis, mycoplasma pneumonia, thiab lwm yam.
Hauv kev kho mob mus sij hawm ntev, nws tau pom tias doxycycline yog cov tshuaj tua kab mob zoo. Nws yog qhov ua yeeb yam ntev thiab dav-spectrum semi-hluavtaws tetracycline tshuaj tua kab mob ua los ntawm oxytetracycline. Qhov laj thawj yog vim li cas doxycycline siv los kho mob ntsws ntev ua haujlwm zoo yog:
Vim tias doxycycline tuaj yeem tua kab mob ntau yam uas cuam tshuam rau kev ua pa ntawm lub cev, nws feem ntau yog siv los kho mob ntsws thiab mob ntsws. Nyob rau tib lub sijhawm, cov tshuaj tua kab mob no tseem siv dav los kho pob txuv doxycycline thiab cov kab mob urogenital. Doxycycline feem ntau muab ua tshuaj ntsiav lossis ntsiav tshuaj ntawm qhov ncauj, tab sis qee zaum nws kuj tau muab los ntawm txhaj tshuaj. Tom qab noj tshuaj doxycycline, nws yuav ua rau muaj txiaj ntsig rau qee lub sijhawm, uas txhais tau hais tias cov tshuaj tuaj yeem siv tsis tau tsuas yog kho, tab sis kuj yog kev tiv thaiv kev kho mob rau lub cev.
Tam sim no, doxycycline tau siv dav los ntawm cov neeg ncig tebchaws lossis cov tub rog ua haujlwm rau cov tebchaws nyob rau thaj chaw sov los tiv thaiv qee yam kab mob, xws li tiv thaiv tib neeg los ntawm kev kis tus kab mob npaws npaws. Doxycycline kuj tseem tuaj yeem tiv thaiv kab mob ntau yam uas ua rau raws plab. Txhawm rau tiv thaiv kev kis mob tau zoo, thaum cov neeg mob muaj kev pheej hmoo kis mob, lawv yuav tsum siv tshuaj txhua hnub.
Doxycycline muaj peev xwm tawm tsam cov npe kab mob uas siv hauv kev ua tsov rog, suav nrog Bacillus anthracis. Yog li cov tshuaj no tuaj yeem siv ua txoj hauv kev tiv thaiv kom muaj txiaj ntsig los tiv thaiv tib neeg los ntawm kev pheej hmoo ntawm kev ua tsov rog los ntawm cov kab mob lossis qhov txaus ntshai los ntawm cov neeg phem tawm bacillus anthracis.
Kev txhim kho ntawm doxycycline yog ua raws cov kws tshawb fawb tshawb pom tshuaj penicillin, uas yog cov khoom ib txwm ua los ntawm cov pwm tshwj xeeb. Ntau lub tuam txhab kws tshuaj tau pib tshawb xyuas cov txheej txheem thiab cov khoom ntawm ntau lub ntuj sib txuas los tua cov kab mob, xws li cov uas tsim los ntawm lwm cov kab mob thiab nroj tsuag. Cov txheej txheem no hu ua bio-discovery. Cov khoom sib xyaw ntuj no tuaj yeem nqa qee yam tshuaj tua kab mob, thiab tom qab hloov cov khoom sib xyaw ua ke tuaj yeem txhim kho cov tshuaj sib xyaw tam sim no.
Zoo li ntau yam tshuaj tua kab mob, doxycycline yog rhiab heev rau cov tshuaj tua kab mob uas tiv taus cov tshuaj tua kab mob, thiab muaj pov thawj pom tias qhov kev raug mob no tau pib tshwm sim hauv ntau yam kab mob uas doxycycline tau siv dav, xws li kev kho pob txuv. Qhov no txhais tau tias kev siv doxycycline yuav tsum raug txo lossis qee qhov hloov los ntawm qee yam tshuaj siv. Tau kawg, cov kws tshawb fawb yuav tsum tau tshawb fawb ntau ntxiv thiab tshawb fawb nyob rau theem tom ntej txhawm rau nrhiav lwm txoj hauv kev tshiab.
Qhov feem ntau tau tshaj tawm cov kev mob tshwm sim ntawm doxycycline yog mob plab lossis kub cev, uas feem ntau tsis zoo rau cov neeg mob, tab sis cov neeg mob tuaj yeem tiv thaiv kev phiv tshwm sim los ntawm doxycycline los ntawm kev haus dej ntau. Nees nkaum feem pua ntawm cov neeg uas siv cov tshuaj feem ntau muaj cov tshuaj tiv thaiv kab mob, uas yog qhov tshwj xeeb tshaj yog rau cov neeg taug kev uas siv tshuaj rau kev tiv thaiv kab mob npaws hauv cov tebchaws sov.
Doxycycline yuav tsum tsis txhob siv rau menyuam yaus thiab poj niam cev xeeb tub, nws yuav ua rau cov xim siv tas mus li, thiab nws tseem yuav muaj lwm yam kev tsis zoo rau kev txhim kho pob txha ntawm tus menyuam hauv plab. Doxycycline kuj tseem tuaj yeem ua rau muaj tshuaj lom ntawm cov tshuaj tiv thaiv kab mob-methotrexate.
Tsis ntev los no, thaum cov kws tshawb fawb tau sib cav txog cov kev phiv los ntawm kev siv tshuaj tua kab mob malarial Mefloquine siv hauv kev tiv thaiv cov tub rog thiab cov neeg tawg rog, lawv hais txog lub luag haujlwm tseem ceeb doxycycline ua si hauv kev hloov tshuaj Mefloquine. Yog lawm, tam sim no feem ntau ntseeg tias mefloquine yuav tsum yog cov tshuaj muaj txiaj ntsig zoo los tiv thaiv tus mob npaws, tab sis qhov txaus siab dua, cov txiaj ntsig ntawm kev tshawb fawb yav dhau los tau qhia tias muaj coob tus neeg nyiam siv mefloquine rau doxycycline. Qhov no yuav cuam tshuam txog kev phiv tshuaj doxycycline, thiab vim tias doxycycline xav tau noj txhua hnub, nws yuav ua rau muaj kev tsis txaus ntseeg ntau rau cov neeg mob.
Cov kev tshawb fawb tsis ntev los no tau pom tias doxycycline tuaj yeem cuam tshuam rau cov txheej txheem tshwj xeeb hauv tib neeg lub hlwb, tshwj xeeb yog chav kawm ntawm cov enzymes uas tseem ceeb heev rau lub cev ua rau cov lus teb. Cov yam ntxwv no yuav muaj txiaj ntsig zoo, thiab nws tuaj yeem pab tshawb fawb txhim kho kev kho mob rau ntau yam kab mob, kho tshiab rau kab mob sib kis, suav nrog mob qog noj ntshav (tshwj xeeb yog mob qog noj ntshav nrog pob txha), kab mob autoimmune (suav nrog mob rheumatoid mob caj dab thiab ntau yam sclerosis), kab mob atherosclerotic (plaques uas ua rau mob plawv). Txawm li cas los xij, kev thov cov kev kho mob tshiab tam sim no tsuas yog nyob hauv theem sim. Cov kws tshawb fawb tau hais tias lawv yuav tshawb nrhiav txuas ntxiv mus.
Doxycycline yog tshuaj tua kab mob tetracycline uas ua haujlwm tau zoo rau kev kis kab mob ua pa thiab tseem tuaj yeem coj mus rau cov teb chaws sov uas yog kev tiv thaiv kev tiv thaiv txhawm rau tiv thaiv qee yam kab mob cuam tshuam. Cov kev mob tshwm sim ntawm Doxycycline muaj tseeb tiag, tab sis nws tseem tseem ceeb heev rau tib neeg kev noj qab haus huv. Yav tom ntej ntawm doxycycline yog kev cia siab.
BALLYA muab a ballya-tetracyclines-xeem qhia rau koj yog tias muaj tetracyclines seem hauv zib ntab, nqaij qaib thiab nqaij npuas.
References