Enrofloxacin siv los kho dab tsi?

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• Enrofloxacin yog dab tsi?
  1. Lus txhais
  2. Lub cev nqaij thiab tshuaj muaj zog
  3. Pharmacokinetics
  4. Cov teebmeem tshuaj
• Enrofloxacin siv los kho dab tsi?
  1. Qhov taw qhia ntawm Enrofloxacin
  2. lub hom phiaj
  3. ntau npaum
  4. Tshuaj Ua Ke
• Kev phiv tshuaj Enrofloxacin
  1. Kev phiv tshuaj Enrofloxacin
  2. Teeb meem xav tau mloog
• Baytril
  1. Introduction
  2. muaj nuj nqi
• xaus

Enrofloxacin yog dab tsi?

1. Lus txhais

Enrofloxacin tseem hu ua ethyl ciprofloxacin ua. Nws yog xim daj lossis lub teeb daj crystalline hmoov nrog saj iab, thiab tsis yaj hauv dej. Cov khoom no raug xaiv los ua tshuaj tshwj xeeb rau tsiaj los ntawm lub xeev.

2. Lub cev nqaij thiab tshuaj muaj zog

Enrofloxacin yog cov tshuaj sib txuas ua kab mob bacteriostatic tus neeg sawv cev ntawm Cov tshuaj fluoroquinolones thiab yooj yim soluble hauv cov kuab tshuaj organic xws li sodium hydroxide tov, methanol, thiab methyl cyanide.

3. Pharmacokinetics

Kev nqus ntawm qhov ncauj thiab txhaj tshuaj sai thiab ua tiav, thiab cov ntshav cov ntshav nce mus txog nws qhov siab tshaj li 0.5-2 teev. Tsuas yog lub hauv nruab nrab lub paj hlwb, yuav luag txhua cov ntaub so ntswg muaj cov tshuaj ntau dua li cov ntshav, uas muaj txiaj ntsig zoo rau kev kho mob ntawm cov kab mob sib kis thiab cov nqaij sib sib zog nqus. Cov khoom no raug tshem tawm los ntawm lub raum thiab tsis yog lub raum, thiab kwv yees li 15% -50% ntawm cov tshuaj qub tau tso tawm los ntawm cov zis. Kev zom zaub mov hauv cov tsiaj feem ntau yog tshem tawm cov pab pawg ethyl thiab dhau los ciprofloxacin ua.

Enrofloxacin yog tiam thib peb Cov tshuaj fluoroquinolone rau kev siv tsiaj txhu. Nws muaj cov kab mob tua kab mob dav dav thiab muaj txiaj ntsig zoo tiv thaiv cov kab mob nyob rau theem ruaj khov thiab loj hlob. Nws cov kab mob tua kab mob yog nyob ntawm qhov siab. Cov kab mob rhiab heev yuav tuag tsis pub dhau 20-30 feeb tom qab hu rau cov khoom no.

Cov khoom no muaj cov tshuaj tua kab mob zoo rau ntau yam Gram-negative bacilli thiab cocci, suav nrog Pseudomonas aeruginosa, Klebsiella, Escherichia coli, Enterobacter, Campylobacter , Shigella , Salmonella, Cua Spp., Haemophilus, Yersinia, Serratia, Vibrio, Proteus, thiab lwm yam. Nws tseem muaj txiaj ntsig zoo tiv thaiv Brucella, Pasteurella, Erysipelas, Bordetella, Staphylococcus (suav nrog penicillin tsim thiab methicillin tiv taus kab mob), Mycoplasma thiab Chlamydia. Txawm li cas los xij, cov txiaj ntsig ntawm feem ntau streptococci sib txawv, thiab cuam tshuam rau feem ntau cov kab mob anaerobic tsis muaj zog.

Cov khoom no tau nqus sai tom qab kev tswj hwm qhov ncauj lossis txhaj tshuaj txhaj rau cov tsiaj txhu thiab nqaij qaib, tau nthuav dav dav hauv lub cev, thiab muaj kev tshem tawm ib nrab-lub neej ntev dua. Tus dev tau txais 50% cov ntshav siab tshaj hauv 15 feeb tom qab kev tswj hwm qhov ncauj, thiab qhov siab tshaj hauv 1 teev.

Khoom noj hauv plab tuaj yeem ncua tus nqi nqus, tab sis tsis cuam tshuam rau nqus. Qhov ncauj qhov ncauj ntawm cov qaib, luav, dev thiab menyuam nyuj yog 84%, 61%, 100%thiab 100%, feem. Txawm li cas los xij, kev tswj hwm qhov ncauj ntawm cov neeg laus ruminants (nyuj, yaj, ntxhuav) tsawg dua 10%. Kev noj qab haus huv ntawm kev txhaj tshuaj intramuscular hauv feem ntau cov tsiaj yog siab dua 85%. Kev zom cov khoom ntawm cov khoom no hauv lub cev yog qhov nyuaj, tab sis lawv tuaj yeem hloov pauv mus rau ciprofloxacin ua nyob rau hauv sib txawv qib.

4. Cov teebmeem tshuaj

Cov khoom no yog cov tshuaj tua kab mob dav-spectrum tshwj xeeb cuam tshuam rau mycoplasma. Nws muaj cov kab mob tua kab mob ntawm Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolyticus, Staphylococcus aureus, Streptococcus, thiab lwm yam.

Enrofloxacin tuaj yeem siv ua tshuaj tsiaj. Nws muaj ib nrab-lub neej ntev hauv lub cev tsiaj thiab muaj cov nqaij zoo faib. Nws yog ib tus neeg ua haujlwm dav dav ua kab mob bacteriostatic. Nws muaj cov tshuaj tua kab mob rau cov kab mob Gram-positive, cov kab mob tsis zoo thiab mycoplasma. Nws tau siv ib zaug rau kev tswj tus kab mob Vibrio thiab E. coli hauv cov ntses ua teb.

Cov khoom no yog cov khoom siv hluavtaws thib peb quinolone tshuaj tshuaj tua kab mob, tseem hu ua ethyl ciprofloxacin ua. Nws tau pom zoo los ntawm FDA thaum Lub Kaum Hli 4, 1996. Nws yog quinolone tshuaj tua kab mob tshwj xeeb rau cov tsiaj txhu thiab cov khoom hauv dej. Nws tuaj yeem khi rau cov kab mob DNA gyrase subunit A, yog li txwv tsis pub cov enzyme txiav thiab koom ua haujlwm, tiv thaiv kab mob DNA rov ua dua, thiab nthuav tawm cov tshuaj tua kab mob.

Nws muaj cov tshuaj tiv thaiv kab mob dav dav thiab muaj zog permeability. Cov khoom no muaj zog tua cov kab mob gram-negative thiab cov tshuaj tua kab mob zoo rau cov kab mob gram-positive. Nws muaj qhov ncauj zoo nqus thiab ntshav siab. Nws ruaj khov thiab tuaj yeem nthuav dav hauv cov ntaub so ntswg. Nws cov metabolite yog ciprofloxacin ua, uas tseem muaj cov tshuaj tua kab mob muaj zog. Nws muaj cov tshuaj tua kab mob muaj zog tiv thaiv yuav luag txhua cov kab mob hauv cov tsiaj hauv dej. Nws muaj txiaj ntsig zoo tiv thaiv kev kis mob hnyav tshwm sim los ntawm cov tshuaj tiv thaiv kab mob, thiab tsis muaj kev tiv thaiv kab mob rau lwm yam tshuaj tua kab mob.

Enrofloxacin siv los kho dab tsi?

1. Qhov taw qhia ntawm Enrofloxacin

Enrofloxacin tuaj yeem siv los kho kab mob ntawm daim tawv nqaij, kab mob tso zis, kab mob ua pa thiab mob txhab. Tab sis nws tsis muaj txiaj ntsig zoo tiv thaiv kev kis mob los ntawm cov kab mob anaerobic, kab mob, cab los yog pwm. Nws muaj txiaj ntsig zoo tiv thaiv kab mob daj daj ntawm npua, ua npua dawb ntawm npua, ua npua npua, salmonellosis (tseem hu ua paratyphoid ua npaws), atrophic rhinitis ntawm npua, mycoplasmal mob ntsws ntawm npua hawb pob), mob caj pas, mob qog noj ntshav, mob qog noj ntshav, mob npua xws li sow agalactia syndrome) thiab swine streptococcus.

2. lub hom phiaj

Enrofloxacin tau siv dav hauv tsiaj txhu thiab nqaij qaib los tiv thaiv thiab kho cov kab mob hauv qab no.

• Colibacillosis ntawm nyuj thiab menyuam nyuj, Pasteurella hemolyticus, kab mob ua pa los ntawm Mycoplasma bovis, Salmonella calves infection, mastitis, thiab lwm yam.
• Npua streptococcus, hemolytic E. coli enterotoxemia (edema disease), salmonellosis, mycoplasma pneumonia, pleuropneumonia, mastitis-metritis-agalactia syndrome thiab piglet dawb thiab daj raws plab.
• Kev ua pa, zom zaub mov, ua rau lub cev thiab kab mob ntawm daim tawv nqaij tshwm sim los ntawm cov kab mob lossis mycoplasma hauv dev thiab miv. Sab nraud otitis, pyometra, pyoderma thiab lwm yam kev kho mob hauv ib cheeb tsam kuj tseem ua tau zoo.
• Cov nqaij qaib kis los ntawm Salmonella, Escherichia coli, Pasteurella, Haemophilus, Staphylococcus, Streptococcus thiab ntau yam mycoplasmas.

3. ntau npaum

A. Kab mob ua pa thiab kab mob hauv plab

Piglets feem ntau muaj hnoos thiab raws plab tom qab yug menyuam tas, feem ntau yog tshwm sim los ntawm kab mob xws li parapigs thiab kis mob pleuropneumonia. Enrofloxacin muaj zog tua cov kab mob no. Cov phiaj xwm tshwj xeeb: Ntxiv 1 kg ntawm 10% enrofloxacin thiab siv nws rau 7 hnub rau cov menyuam npua hauv txhua tuj ntawm kev pub mis tom qab txiav tawm. Yog tias npua teb muaj lub nplhaib lossis lwm yam kab mob sib kis, nws tuaj yeem ua ke nrog Huangqi, Fuzheng Jiedu San lossis Qingwen Baidu San.

B. Yogint o lossis sepsis tshwm sim los ntawm streptococcus

nrog Enrofloxacin txhaj tshuaj, amoxicillin + Antong txhaj tshuaj intramuscular ib zaug ib hnub rau 3 hnub.

C. Rau kev kho mob swine asthma

Ntxiv 1 kg ntawm 10% Enrofloxacin thiab 1 kg ntawm 10% doxycycline hydrochloride rau txhua tuj ntawm pub rau 7-10 hnub yog qhov ua tau zoo.

D. Tiv thaiv kom tsis txhob kis kab mob pleuropneumonia thiab swine pneumonia hauv npua rog

Ntxiv 1 kg ntawm 10% enrofloxacin thiab 1 kg ntawm 10% florfenicol rau txhua tuj ntawm pub rau 7 hnub.

E. Kev tiv thaiv thiab kho mob sow metritis

Ntxiv 1 kg ntawm 10% enrofloxacin thiab 10% spectinomycin tshuaj -lincomycin tshuaj ib tuj ntawm pub; txhaj tshuaj intramuscular ntawm enrofloxacin 2.5 mg rau ib kg ntawm lub cev hnyav.

F. Kev kho mob npua exudative dermatitis

Siv 0.1% potassium permanganate dej (dej sov) lossis 3% hydrogen peroxide los ntxuav cov kab mob thiab cov exudates ntawm npua mob. Tom qab ntxuav tas, siv cov dej khib nyiab sib xyaw ua ke thiab tshuaj penicillin, ib hnub ib zaug rau 2-3 zaug. Txhaj tshuaj 10% enrofloxacin txhaj tshuaj + ceftiofur rau kev txhaj tshuaj intramuscularly, ib hnub ib zaug rau 2-3 zaug.

4. Tshuaj Ua Ke

• Txhawm rau zam kev tshwm sim ntawm kev tiv thaiv tshuaj thiab txhim kho nws cov txiaj ntsig, ua ke ntawm enrofloxacin thiab beta lawm tshuaj tua kab mob (xws li amoxicillin, tshuaj penicillin), tshuaj tua kab mob aminoglycoside (gentamicin, Amikacin, neomycin, thiab lwm yam) tetracyclines (doxycycline, oxytetracycline) muaj cov teebmeem ntxiv lossis ua haujlwm sib xyaw. Piv txwv li, kev sib xyaw ntawm kev txhaj tshuaj enrofloxacin thiab amoxicillin hmoov tuaj yeem txhim kho nws cov kev ua tau zoo thiab nthuav dav cov kab mob tua kab mob.
• Kev noj tshuaj ntau npaum li cas ntawm enrofloxacin + amoxicillin + Fuzheng Jiedu hmoov tau ua lub luag haujlwm zoo heev hauv kev tiv thaiv thiab kho kab mob ntawm cov kab mob thib ob rau kab mob porcine.
• Siv 2.5% enrofloxacin txhaj thiab 10% kanamycin txhaj tshuaj sulfate (15 mg/kg) ib hnub ib zaug rau 3 hnub, uas muaj cov tshuaj kho tau zoo rau mob hawb pob.
• Kev sib xyaw ua ke ntawm cov khoom no nrog aminoglycosides, tiam thib peb cephalosporins thiab broad-spectrum penicillins tej zaum yuav muaj cov tshuaj tua kab mob sib xyaw ua ke ntawm qee cov kab mob (tshwj xeeb yog Pseudomonas aeruginosa lossis Enterobacteriaceae).
• Hauv kev sim vitro, kev sib xyaw ua ke ntawm cov khoom no thiab clindamycin tau txhim kho cov tshuaj tua kab mob ntawm cov kab mob anaerobic (Peptostreptococcus, Lactobacillus thiab Bacteroides fragilis).

Kev phiv tshuaj Enrofloxacin

1. Cov kev phiv tshuaj

Raws li qhov xwm txheej ib txwm pom zoo, koob tshuaj pom zoo yuav tsis ua rau muaj kev phom sij. Txawm li cas los xij, nyob rau xyoo tsis ntev los no, tau tshaj tawm txog cov kev mob tshwm sim hauv qee kis hauv tsev thiab txawv teb chaws. Piv txwv li, kws tshawb fawb Lavxias tau tshaj tawm tias ntawm koob tshuaj 5 mg/kg ntawm lub cev qhov hnyav, ib hnub ib zaug, siv los kho tus menyuam yaus raws plab raws li hnub nyoog 2 hnub, thiab feem ntau ntawm cov menyuam npua tuag hauv ob peb feeb tom qab txhaj tshuaj. Nyob rau tib lub sijhawm, muaj dej ntau ua npuas los ntawm lawv lub qhov ncauj.

2. Teeb meem xav tau mloog

• Yog tias koj siv enrofloxacin los kho txhua yam kab mob swine, hauv thawj 2 hnub thiab 3 hnub ntawm nws qhov kev tawm tsam hnyav, yuav tsum tau txhaj tshuaj intramuscular kom ntseeg tau tias muaj txiaj ntsig, thiab tom qab ntawd nws yuav tsum tau muab sib xyaw pub noj yog tias npua tsis muaj qab los noj mov.
• Npua rhiab rau enrofloxacin (tshwj xeeb yog npua hnub nyoog ntxov) raug txwv. Ua ntej txhaj tshuaj intramuscular ntawm pawg loj ntawm cov tub ntxhais hluas npua, nws raug nquahu kom muab ib rau ob npua rau kev kuaj ua ntej. Nws yog txwv tsis pub rau npua nrog cov nqaij mos txhim kho pob txha mos, cev xeeb tub npua, npua nrog kab mob paj hlwb nrog ntuav, thiab npua nrog tshuaj tsis kam rau quinolones.
• Enrofloxacin tsis tuaj yeem ua ke nrog chloramphenicol, tshuaj tetracycline, macrolide tshuaj tua kab mob, theophylline thiab steroids.
• Cov tshuaj uas muaj cov tshuaj sib npaug thiab sib npaug (Ca, Mg, AI, Fe), xws li antacids, aluminium sulfate thiab tshuaj noj kom zoo, tuaj yeem ua ke nrog Enrofloxacin los ua ib qho chelate, yog li inhibiting qhov nqus tau ntawm Enrofloxacin.
• Nws tuaj yeem pub rau tsiaj tsiaj lossis siv ua raw khoom los tsim cov nqaij thiab pob txha noj.
• Enrofloxacin muaj qhov tsis zoo. Enrofloxacin yuav tsum tau lo, txwv tsis pub nws yuav ua pov tseg vim npua yuav tsis noj nws.
• Zam ib yam tshuaj mus sij hawm ntev. Nws raug pom zoo kom siv hloov nrog lwm cov tshuaj lossis sib xyaw nrog lwm cov tshuaj txhawm rau txo kev txhim kho kev tiv thaiv tshuaj.
• Cov koob tshuaj loj feem ntau ua rau muaj kev phiv. Npua uas rhiab rau enrofloxacin (tshwj xeeb yog cov menyuam npua thaum ntxov) raug txwv. Ua ntej txhaj tshuaj intramuscular rau hauv pawg loj ntawm cov tub ntxhais hluas npua, nws raug nquahu kom muab 1-2 npua rau kev sim.
• Enrofloxacin muaj cov teebmeem antagonistic nrog macrolide hmoov tshuaj tua kab mob, florfenicol, thiab lwm yam.

Baytril

1. Introduction

Baytril yog qhov tshuaj lom neeg sib txuas tshiab tshaj plaws tshwj xeeb tsim los ntawm Bayer hauv Tebchaws Yelemees rau kev siv tsiaj. Nws yog nemesis ntawm cov kab mob gram-negative, kab mob gram-positive thiab mycoplasma. Nws yog cov tshuaj tshwj xeeb rau kev kho mob ntau yam kab mob thiab kab mob mycoplasma xws li npua, nyuj, dev thiab lwm yam. Nws muaj cov txiaj ntsig zoo ntawm cov kab mob ntawm kev ua me nyuam ntawm cov tsiaj plaub. Sib txawv los ntawm cov tshuaj tua kab mob ntawm cov tshuaj ib txwm muaj, Baytril ncaj qha nkag mus rau hauv cov keeb ntawm cov kab mob thiab ua kom muaj cov kab mob tua tau sai thiab nrawm los ntawm kev thaiv DNA synthesis.

2. muaj nuj nqi

• Cov khoom xyaw nquag: 50 mg Enrofloxacin ib ml
• Cov khoom lag luam: cov tshuaj tua kab mob sib kis tshiab tshaj plaws. Nws muaj cov ntsia hlau tshwj xeeb cov kab mob fungus, uas ncaj qha tua cov kab mob, thiab muaj zog tiv thaiv kab mob. Nws tuaj yeem siv ua ke nrog txhua yam tshuaj. Nws muaj qhov dav dav thiab tsis tsim tshuaj tiv thaiv yam tsis muaj kev tiv thaiv khaub thuas. Nws txo cov neeg tuag mus rau qhov zoo.
• Cov txheej txheem ntawm kev ua: Sib txawv los ntawm cov tshuaj tua kab mob ntawm cov tshuaj ib txwm muaj, Baytril ncaj qha nkag mus rau hauv cov kab mob ntawm cov kab mob thiab ua kom muaj cov kab mob tua tau sai thiab nrawm los ntawm kev thaiv DNA synthesis.
• Qhov taw qhia: Porcine Pleuropneumonia (HP), Atrophic Rhinitis Epidemic Pneumonia (SEP), Swine Pneumonia, Escherichia coli raws plab, Umbilical Corditis, Salmonella Arthritis, Swine Erysipelas, Mob Hlwb, Tsis Muaj Kab Mob Mis (MMA) cov tsiaj plaub ua rau menyuam yaus
• Kev siv thiab siv ntau npaum li cas: hma, raccoon, mink, tsiaj tsiaj, npua, nyuj, dev, miv, thiab lwm yam: 0.5ml rau 10 kg lub cev hnyav. Rau cov kab mob ib txwm muaj, txhaj tshuaj intramuscular, ib hnub ib zaug, rau peb hnub sib law liag; thaum kho nrog MMA, tsuas yog siv tshuaj rau 1-2 hnub. Rau cov kab mob ua pa thiab mob hnyav Salmonella, yuav tsum tau muab ob npaug rau txhaj tshuaj txhaj rau 5 hnub.
• Taboo: Nws raug txwv tsis pub siv rau cov dev thiab miv, uas tuaj yeem ua rau lub plab dysplasia lossis femoral lub taub hau necrosis.

xaus

Enrofloxacin yog ib tug quinolone tshuaj compound bacteriostatic agent, tseem hu ua ethyl ciprofloxacin ua. Nws yog cov tshuaj tsiaj tshwj xeeb nrog rau kev kho kom zoo thiab siv dav.

BALLYA muab rau quinolones erythromycin combo test kit los qhia koj yog tias muaj cov quinolones seem (suav nrog enrofloxacin) thiab erythromycin tshuaj cov khoom seem uas koj noj txhua hnub.

References

• University of Illinois College ntawm Veterinary Tshuaj: Enrofloxacin
• Frontiersin: Kev pheej hmoo koom nrog hauv kev siv Enrofloxacin rau Salmonella Enteritidis lub Salmonella Heidelberg hauv Kev Nqaij Nqaij Qaib