nafcilin yog qhov ncauj thiab txhaj tshuaj penicillin uas yog tshuaj ib nrab ua ke rau 6-aminopenicillin. Nws yog hmoov dawb lossis daj daj, tsw ntxhiab me ntsis, yooj yim soluble hauv dej, chloroform thiab ethanol. Nws ruaj khov rau acid thiab penicillinase. Clinically, nws yog siv rau penicillin-resistant Staphylococcus kab mob thiab lwm yam kab mob penicillin-sensitive kab mob.
Nws cov dej num tiv thaiv tshuaj tiv taus Staphylococcus aureus nyob ze tshuaj oxacillin, tab sis muaj zog dua methicillin. Nws yog qhov tshwj xeeb tshaj yog tiv thaiv hemolytic streptococcus thiab pneumococcus. Nws muaj qhov ncauj nqus tsis tiav, ntshav qis thiab tso zis tsawg. Ntshav siab ntawm kev txhaj tshuaj intramuscular siab dua li kev tswj hwm qhov ncauj, tab sis nws tseem qis. Cov tshuaj suav suav suav tshuaj hauv cov kua tsib siab dua li cov ntshav, thiab 90% tawm los ntawm cov kua tsib. Cov ntshav khi cov protein ntau yog siab (kwv yees li 87%).
Muaj ntau daim ntawv tshuaj ntau npaum thiab kev qhia tshwj xeeb ntawm nafcillin. Kev npaj sib txawv ntawm cov tuam txhab tsim khoom tuaj yeem muaj cov tshuaj sib txawv thiab tsis zoo tshwm sim vim cov txheej txheem tsim khoom sib txawv. Thov nrog koj tus kws kho mob tham txog kev xaiv tshwj xeeb.
Hom kab no yog acid-resistant thiab enzyme-resistant semi-synthetic tshuaj penicillin. Nws ruaj khov rau cov kua qaub thiab tuaj yeem noj qhov ncauj lossis niam txiv. Nws ruaj khov rau penicillinase. Nafcillin tiv taus staphylococcus uas ua rau penicillinase lossis tiv taus Penicillin g vim lwm yam. Nws muaj cov txiaj ntsig tshwj xeeb ntawm hemolytic streptococcus, viridis streptococcus, thiab tseem muaj cov tshuaj tua kab mob thiab tua kab mob tseem ceeb ntawm hemolytic cocci, viridis streptococcus thiab pneumococcus thiab lwm yam kab mob gram-positive.
Yam tsawg kawg ntawm kev txwv ntawm nafcillin rau Staphylococcus aureus uas nkag siab thiab tiv taus penicillin yog 0.4 thiab 0.48ug/ml, feem. Yam tsawg kawg ntawm kev txwv tsis pub muaj rau pneumococcus, streptococcus viridis, meningococcus, thiab gonococcus yog feem 0.02, 0.4, 0.8 thiab 3.1ug/ml.
Tom qab txhaj tshuaj intramuscular ntawm 0.5 g ntawm nafcillin, cov ntshav cov ntshav tau mus txog qhov siab ntawm 7.93ug/ml tom qab ib nrab teev. Tom qab noj 1g ntawm nafcillin rau cov neeg ib txwm muaj, cov ntshav cov ntshav tuaj yeem mus txog qhov siab tshaj hauv 1 teev, kwv yees li 14.34ug/ml. Qhov ncauj probenecid tuaj yeem ua kom ntshav siab ob npaug. Cov ntshav ib nrab-lub neej ntawm nafcillin ntau dua 1.5 teev.
Nafcillin tau nthuav dav dav, thiab cov tshuaj muaj txiaj ntsig zoo tau tsom mus rau hauv lub zais zis, raum, ntsws, plawv, lub plab, hnyuv thiab daim siab; siab tshaj plaws yog nyob rau hauv txoj hnyuv me, daim siab, thiab lub raum;
Tom qab txhaj tshuaj intramuscular ntawm 1.5g ntawm nafcillin, hauv cov kua synovial ntawm lub hauv caug sib koom ua ke, kev kho mob siab tuaj yeem mus txog hauv nruab nrab; cov concentration siab tau khaws cia hauv cov kua tsib. Tsis pub dhau 4 teev tom qab txhaj tshuaj, 93% ntawm cov tshuaj pom hauv cov kua tsib. Nafcillin muaj qhov nqus tau zoo hauv txoj hnyuv.
Nafcillin feem ntau yog tawm los ntawm cov kua tsib thiab tso zis. Tom qab 6 teev ntawm kev txhaj tshuaj intramuscular thiab kev tswj hwm qhov ncauj ntawm Nafcillin, 14% thiab 7% ntawm cov koob tshuaj tau tso tawm hauv cov zis, 18-19% tau tso tawm hauv cov zis nyob rau hnub thib peb, thiab tso zis hnub thib yim 21% thiab 19.4% tag nrho cov nyiaj tawm hauv cov quav; tsis hais txog qhov ncauj lossis txhaj tshuaj intramuscular, tsis pub dhau 12 teev, 10% ntawm cov tshuaj raug tso tawm hauv cov quav.
Txog hnub yim, tag nrho cov nyiaj tso tawm hauv cov quav yog txog li 50%, tso zis qis thiab tso zis ntev mus ntev tuaj yeem yog qhov laj thawj tseem ceeb vim li cas nafcillin tswj tau cov kab mob ua kom ntev thiab muaj txiaj ntsig zoo. Nafcillin muaj cov protein ntau khi rau cov protein ntau, tab sis muaj qhov cuam tshuam me ntsis rau nws cov tshuaj tua kab mob.
Nws yog acid-resistant thiab enzyme-resistant semi-hluavtaws penicillin. Nws ruaj khov rau cov kua qaub thiab tuaj yeem tswj hwm qhov ncauj lossis niam txiv. Nws tseem ruaj khov rau penicillinase. Nafcillin muaj cov teebmeem tshwj xeeb ntawm Staphylococcus tiv taus penicillin g, hemolytic streptococcus thiab viridis streptococcus. Nws muaj cov tshuaj tua kab mob thiab tua kab mob tseem ceeb rau cov kab mob Gram-positive xws li hemolytic streptococcus, viridis streptococcus thiab pneumococcus.
Nafcillin tsim nyog rau penicillin-resistant Staphylococcus kab mob thiab lwm yam kab mob penicillin-sensitive kab mob, xws li: sepsis, bacteremia, endocarditis, empyema, mob hauv siab, mob ntsws, osteomyelitis, meningitis, peritonitis, cellulitis, ua npaws liab, tonsillitis, pharyngitis, otitis media , erysipelas, kab mob tso zis, mob ntsws, Tetanus, roj gangrene, anthrax, diphtheria, gonorrhea, gonococcal mob caj dab thiab mob ophthalmia.
Nafcillin yog ib nrab hluavtaws penicillin tiv taus beta lactamase cov thiab acid. Nws ruaj khov rau penicillinase thiab muaj cov kab mob tua kab mob thiab tua kab mob. Nws yog qhov tsim nyog rau kev kho tus mob staphylococcal tiv taus penicillin thiab lwm yam kab mob kis rau penicillin, xws li sepsis, endocarditis, empyema, mob hauv siab, mob ntsws, osteomyelitis, thiab lwm yam. ntau dua 85% rau kev kho mob tshuaj tiv thaiv kab mob Staphylococcus aureus.
Xyoo tsis ntev los no, kab mob nosocomial tshwm sim los ntawm ntau yam tshuaj tiv taus Staphylococcus aureus tsis yog tsuas yog teeb meem pos uas cov kws kho mob yuav tsum tau ntsib ntau zaus, tab sis kuj ua rau muaj kev hem thawj loj rau kev noj qab haus huv ntawm txhua tus tib neeg. Vancomycin, ib zaug paub tias yog "kab kawg hauv qab" ntawm kev kho mob tiv thaiv kab mob, ib txwm yog qhov kev kho mob zoo dua rau kev kis kab mob zoo. Txawm li cas los xij, vancomycin-resistant Staphylococcus aureus tau raug cais nyob hauv ntau lub tebchaws, uas yog qhov tseem ceeb rau kev txhim kho kev kho mob tiv thaiv kab mob tshiab, yog li ntawv thiaj li yuav tsum tau thov kom thov ·
Thaum pib, qhov ua tau zoo ntawm Staphylococcus aureus rau penicillin tau siab dua 90%, yog li feem ntau ntawm cov tshuaj tua kab mob tau ua lub luag haujlwm kho mob zoo hauv kev kho kab mob los ntawm Staphylococcus aureus. Txawm li cas los xij, nrog kev siv tshuaj tua kab mob ntau yam, penicillin-resistant Staphylococcus aureus kuj tau tshwm sim, thiab lwm yam tshuaj tua kab mob-resistant Staphylococcus aureus, xws li tshuaj tetracycline, erythromycin tshuaj, thiab lwm yam, kuj tau tshawb pom. Yog li ntawd, ntev li ntev los, kev kho mob tiv thaiv kab mob Staphylococcus aureus tsis ua tiav qhov kev cia siab. Kev hloov pauv tshuaj tiv thaiv kab mob microbial yog qhov tshwm sim ntawm kev hloov pauv hauv ib qho chaw tshwj xeeb ntawm DNA molecules, thiab tsis muaj dab tsi cuam tshuam nrog cov tshuaj muaj nyob. Lub hav zoov ntawm qee yam tshuaj tsuas yog txhais tau tias cais tawm qee yam tshuaj tiv thaiv kab mob.
Syphilis yog kab mob sib kis los ntawm tus kab mob Treponema pallidum, uas yog kab mob sib kis los ntawm kev sib deev. Hauv thawj theem, nws yog kab mob sib kis, uas tuaj yeem nkag mus rau txhua lub nruab nrog cev thiab cov ntaub so ntswg thaum lub sijhawm txhim kho thiab ua rau muaj ntau yam tsos mob. Qee zaum nws tuaj yeem nyob ntsiag to tau ntau xyoo lossis tseem muaj sia nyob yam tsis muaj qhov tshwm sim, thiab chav kawm ntawm tus kab mob qeeb.
Tus kab mob no feem ntau kis mus rau lwm tus los ntawm kev coj tus cwj pwm kev sib deev, thiab nws tseem tuaj yeem kis mus rau lwm tiam neeg los ntawm kev tso menyuam. Vim tias muaj ntau yam tshwm sim ntawm tus mob syphilis, feem ntau yog cov nyom los ntawm kab mob. Yog li tshuaj tua kab mob uas kho ob qho tib si yuav tsum raug xaiv. Tam sim no, nws tau ua pov thawj tias nafcillin sodium uas yog dav-spectrum, nyab xeeb, tiv thaiv enzyme, thiab acid-resistant thib peb tiam penicillin muaj qhov cuam tshuam tshwj xeeb rau mob syphilis.
Kev tswj hwm qhov ncauj tuaj yeem ua rau muaj kev cuam tshuam ntawm txoj hnyuv: xeev siab, ntuav, tsis qab los, mob plab, raws plab. Cov uas ua xua rau penicillin yuav tsum tsis txhob siv nws. Qee qhov xwm txheej muaj leukopenia, tawv nqaij ua pob, ua npaws yeeb tshuaj, mob taub hau, thiab ua tsis taus pa. Cov koob tshuaj loj yuav ua rau muaj kev cuam tshuam rau lub paj hlwb, xws li tsis meej pem, qaug dab peg, thiab qaug dab peg. Cov menyuam yaus tuaj yeem muaj saj txawv hauv qhov ncauj (xws li saj nws yog xim hlau). Cov tawv nqaij necrosis thiab cov nqaij hauv ib puag ncig puas tuaj yeem tshwm sim tom qab txhaj tshuaj. Nws tuaj yeem ua rau lub raum puas, theem nrab nephritis theem nrab, tuaj yeem ua rau lub siab puas.
Nafcillin yog cov tshuaj yuav tshuaj thiab yuav tsum tau muab los ntawm kws kho mob raws koj qhov mob. Kev tswj tus kheej tuaj yeem ua rau muaj kev pheej hmoo: pov tseg cov peev txheej tshuaj, ncua kev mob, tsim kev tiv thaiv, thiab ua rau muaj kev phom sij loj rau cov tshuaj.
Raws li cov qauv uas tau tshaj tawm los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj Yeeb Tshuaj (FDA), nafcillin belongs rau qib B thaum cev xeeb tub: kev tshawb fawb txog kev tsim tsiaj tsis tau qhia tias muaj kev pheej hmoo rau tus me nyuam hauv plab, tab sis tsis muaj kev tshawb fawb tsim nyog nrog pab pawg tswj hwm tau ua hauv poj niam cev xeeb tub.
nafcilin, ib nrab hluavtaws penicillin, muaj qhov tshwj xeeb rau Staphylococcus uas tiv taus Penicillium g. Nws cov tshuaj tiv thaiv Staphylococcus aureus ua haujlwm ze rau oxacillin.
nafcilin belongs rau beta lactams. BALLYA muab a betalactam xeem los qhia koj yog tias muaj cov beta lactams seem hauv cov khoom siv mis uas koj noj txhua hnub.
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