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ciprofloxacin cov kev mob tshwm sim

Ciprofloxacin phiv tshuaj yog dab tsi?

Muab lo rau  Kaum ib hlis 25, 2020, Kho los ntawm Jason, Qeb  
ciprofloxacin cov kev mob tshwm sim
ciprofloxacin cov kev mob tshwm sim

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Ciprofloxacin yog dab tsi?

1. Lus txhais

Ciprofloxacin yog hluavtaws tiam thib peb quinolone tshuaj nrog dav-spectrum tshuaj tua kab mob ua haujlwm thiab muaj txiaj ntsig zoo tua kab mob. Cov tshuaj tua kab mob tiv thaiv yuav luag txhua cov kab mob yog 2 txog 4 zaug muaj zog dua norfloxacin thiab enoxacin. Nws muaj cov kab mob tua kab mob tiv thaiv Enterobacter, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, thiab Staphylococcus aureus. Txawm li cas los xij, ciprofloxacin cov kev mob tshwm sim tuaj ceeb toom.

2. lub hom phiaj

Cov tshuaj tua kab mob tua kab mob sib kis tshiab muaj zog nkag mus tau zoo, ntshav siab thiab tsis muaj tshuaj lom, uas tsis yooj yim los tsim tshuaj tiv thaiv kab mob thiab tuaj yeem faib sai rau lwm lub cev. Cov tshuaj no tau nqus tau yooj yim ntawm qhov ncauj, thiab cov txiaj ntsig ntawm kev txhaj tshuaj intramuscular yog qhov zoo dua. Tus tshiab quinolone broad-spectrum tshuaj tua kab mob muaj zog ua rau Gram-positive thiab cov kab mob tsis zoo.

Cov tshuaj tua kab mob quinolone thib peb muaj cov tshuaj tua kab mob dav, thiab muaj zog tua cov kab mob tua kab mob. Nws muaj cov kab mob tua kab mob rau Gram-positive thiab cov kab mob tsis zoo suav nrog Pseudomonas aeruginosa, cov kab mob hauv plab thiab Staphylococcus aureus. Nws cov hydrochloride feem ntau siv hauv tsev kho mob rau kev kho kab mob ua pa, tso zis tso zis, mob plab, mob hauv lub cev, kab mob hauv plab, mob hauv lub cev, kab mob gynecological, mob pob txha thiab sib koom thiab mob hnyav

3. Cov Tshuaj thiab Toxicology

Nws yog los ntawm Cov tshuaj fluoroquinolones thiab muaj tib yam tshuaj tua kab mob zoo ib yam li norfloxacin. Nws cov tshuaj tua kab mob ua kom muaj zog tshaj plaws ntawm kev siv dav Cov tshuaj fluoroquinolones. Ntxiv rau nws cov tshuaj tua kab mob siab tiv thaiv kab mob gram-negative bacilli, nws kuj muaj cov tshuaj tua kab mob zoo tiv thaiv Staphylococcus, thiab nws cov txiaj ntsig tiv thaiv Pneumococcus thiab Streptococcus me ntsis phem dua li ntawm Staphylococcus.

Cov khoom no tseem muaj kev cuam tshuam los ntawm qee yam kab mob mycobacteria, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, thiab lwm yam. Raws li cov tshuaj tua kab mob, nws feem ntau ntseeg tias quinolones ua haujlwm ntawm A subunit ntawm cov kab mob cell cell DNA helicase, inhibiting DNA synthesis thiab replication thiab ua rau kab mob tuag.

4. Pharmacokinetics

Ciprofloxacin muaj cov tshuaj tua kab mob dav thiab muaj peev xwm tiv thaiv kab mob zoo. Cov khoom no txwv tsis pub cov kab mob DNA helicase thiab tiv thaiv kab mob rov ua dua, yog li nws txo qis kev tsim cov kab mob sai sai.

Nws yog tshuaj tua kab mob. Ciprofloxacin muaj hom kev ua tshwj xeeb thiab txawv ntawm lwm yam tshuaj tua kab mob tshwj tsis yog quinolones. Yog li, ciprofloxacin muaj peev xwm tiv thaiv kab mob ntau dua piv nrog penicillins, cephalosporinsaminoglycoside thiab tetracyclines cov kab mob tiv taus kab mob. Hauv kev sim vitro tau ua pov thawj tias kev siv ua ke ntawm ciprofloxacin, beta lactam cov, thiab cov tshuaj tua kab mob aminoglycoside tuaj yeem tsim cov tshuaj ntxiv lossis tsis muaj kev phom sij. Hauv vivo kev sim ua haujlwm sib cuam tshuam ntawm cov tshuaj feem ntau tshwm sim, tshwj xeeb hauv cov tsiaj nrog txo qis leukocytes.

Cov neeg noj qab haus huv noj 0.25g lossis 0.5g ntawm ciprofloxacin ua hydrochloride hais lus. Tom qab 1 txog 2 teev, Cmax yog 1.5μg/ml thiab 2.5μg/ml feem. Ib nrab-lub neej yog li 4 teev. Cov khoom lag luam feem ntau tau faib tawm hauv cov kua tsib, hnoos qeev, qaub ncaug, thiab pob txha, ntxiv rau hauv prostate, tab sis cov concentration hauv lub hlwb thiab tus txha caj qaum qis dua. Cov khoom tuaj yeem hloov pauv hauv lub siab thiab tso tawm hauv cov zis los ntawm ob lub raum, tswj cov tshuaj siab hauv cov zis.

Cov tshuaj tau nthuav dav dav hauv lub cev tom qab nqus tau, thiab tuaj yeem ncav cov qib tshuaj muaj txiaj ntsig zoo hauv cov kua dej hauv lub cev, mob qog noj ntshav, mob ntsws thiab cov ntaub so ntswg urogenital, thiab hnoos qeev. Kev tshem tawm ib nrab-lub neej ntawm cov khoom no yog 3.3 txog 4.9 teev, 29% mus rau 44% (qhov ncauj) thiab 45% mus rau 60% (tso ntshav tso ntshav) ntawm cov tshuaj raug tso tawm hauv cov zis raws li daim ntawv qub ntawm cov tshuaj, thiab ib feem ntawm nws yog tawm hauv daim ntawv ntawm cov metabolites los ntawm cov zis. Qhov siab ntawm cov tshuaj hauv cov kua tsib ntau dua li cov ntshav, thiab kwv yees li 15% txog 25% ntawm cov koob tshuaj tau tawm los ntawm cov quav.

Dab tsi yog ciprofloxacin siv rau?

1. Ciprofloxacin kho dab tsi?

Ciprofloxacin muaj kev siv tshuaj kho mob dav dua norfloxacin. Ntxiv rau cov kab mob tso zis, kab mob hauv plab, kab mob gonorrhea, thiab lwm yam, nws kuj tseem tuaj yeem siv los kho tus mob khaub thuas bacilli, E. coli, mob ntsws, Proteus mirabilis, Proteus vulgaris, Pob txha thiab sib kis kab mob, tawv nqaij thiab cov nqaij mos mob, mob ntsws, sepsis, thiab lwm yam tshwm sim los ntawm Professionella, Morganella, Pseudomonas aeruginosa, Enterobacter cloacae, Citrobacter frautus, Staphylococcus (suav nrog cov kab mob tiv taus methicillin), thiab lwm yam. norfloxacin; Kev tswj ntshav qab zib tuaj yeem siv rau kev kho mob hnyav dua, xws li enterobacteriaceae kab mob sepsis, kis kab mob hauv lub ntsws, kab noj hauv plab thiab kab mob hauv lub cev.

  • Cov kab mob ua pa: Ciprofloxacin tuaj yeem siv rau Pneumonia Klebsiella, Enterobacter, Proteus, Pseudomonas, Haemophilus, Branhamella, Legionella thiab Staphylococcus. Ciprofloxacin feem ntau tsis siv los ua cov tshuaj uas xaiv rau kev kho tus mob encephalococcal encephalitis hauv cov neeg mob sab nrauv.
  • Kab mob hauv pob ntseg nruab nrab (otitis media), kab mob hauv lub qhov ntswg (sinusitis), tshwj xeeb yog kev kis mob los ntawm cov kab mob Gram-negative suav nrog Pseudomonas lossis Staphylococcus.
  • Kab mob qhov muag.
  • Raum thiab/lossis cov kab mob tso zis.
  • Kab mob hauv lub cev: suav nrog mob plab zom mov, kab mob gonorrhea thiab prostatitis.
  • Kev mob plab (mob plab hnyuv, kab mob hauv plab, mob peritonitis).
  • Cov tawv nqaij thiab cov nqaij mos kis.
  • Kab mob thiab pob txha sib kis.
  • Sepsis, kab mob bacteremia.

2. Kev siv ciprofloxacin

  • Kev noj tshuaj txhua hnub rau cov neeg laus (raws li ciprofloxacin ua, tib yam hauv qab no) yog 0.5 txog 1.5 g, hais lus hauv 2 koob. Kev tso dej tawm 0.2 ~ 0.6g ib hnub, tab sis qhov nrawm yuav tsum tsis txhob nrawm heev; muab faib ua 2 qhov dej, txhua lub sijhawm kwv yees li 1 teev.
  • Pob txha thiab mob sib kis, 1.0 ~ 1.5ga hnub, faib ua 2 ~ 3 zaug, chav kawm ntawm kev kho yog 4 ~ 6 lub lis piam lossis ntev dua.
  • Mob ntsws thiab tawv nqaij thiab mob nqaij mos yog 1 rau 1.5 g txhua hnub, faib ua 2 zaug, thiab chav kawm ntawm kev kho yog 7 txog 14 hnub.
  • Ciprofloxacin Lactate rau Kev Txhaj Tshuaj
  • Kev mob plab hnyuv 1g txhua hnub, faib ua 2 zaug, chav kawm ntawm kev kho mob yog 5-7 hnub. Mob khaub thuas yog 1.5g txhua hnub, faib ua 2 koob, thiab chav kawm ntawm kev kho mob yog 10 txog 14 hnub. 5. Rau cov kab mob tso zis, noj 0.5 ~ 1g txhua hnub, faib ua 2 zaug, chav kawm ntawm kev kho yog 7 ~ 14 hnub; kev kho mob rau cov mob hnyav lossis nyuaj yuav tsum tau txuas ntxiv kom tsim nyog.
  • Kab mob Gonorrhea 0.25 ~ 0.5g ntawm qhov ncauj ib zaug.
  • Hauv cov xwm txheej hnyav, nws tuaj yeem tswj hwm los ntawm kev tso dej tawm, 0.4 ~ 0.6g ib hnub, faib ua 2 qhov tso dej tawm.
  • Cov khoom yuav tsum tau noj ntawm lub plab khoob. Txawm hais tias cov zaub mov tuaj yeem ncua nws txoj kev nqus, tag nrho cov nqus (bioavailability) tsis tau raug txo, yog li nws kuj tseem tuaj yeem noj tom qab noj mov kom txo qis kev zom zaub mov. Nws raug nquahu kom haus 250 ml dej tib lub sijhawm.
  • Crystaluria tuaj yeem tshwm sim, tshwj xeeb tshaj yog thaum tus neeg mob cov zis pH siab dua 7, yog li ntawd cov alkalinizer yuav tsum zam tib lub sijhawm. Kev haus dej txhua hnub yuav tsum txaus kom ua kom cov zis tso zis ntau dua 1200 ~ 1500ml.

3. Daim ntawv thov tshuaj Veterinary

Cov khoom no yog cov tshuaj tua kab mob dav-spectrum. Nws muaj cov tshuaj tua kab mob muaj zog tshaj tiv thaiv kab mob gram-negative ntawm fluoroquinolones tam sim no siv Veterinary tshuaj; nws kuj muaj qhov cuam tshuam zoo rau cov kab mob gram-positive. Ib qho ntxiv, nws tseem muaj cov tshuaj tua kab mob muaj zog ntawm mycoplasma anaerobes thiab Pseudomonas aeruginosa.

Nws tau siv los cuam tshuam nrog ntau yam kab ke ntawm tag nrho lub cev, thiab muaj txiaj ntsig zoo rau kev zom zaub mov, ua pa rau lub cev, cov kab mob urogenital, tawv nqaij thiab cov nqaij mos mos thiab kis kab mob mycoplasma.

Ciprofloxacin phiv los

1. Sab los

Nws cov kev mob tshwm sim feem ntau suav nrog kev mob plab zom mov (3-4%), cov tsos mob hauv nruab nrab hauv lub paj hlwb (2%), kev tsis haum tshuaj (0.5-1.0%) thiab kev kuaj sim txawv txav (3-4%), uas qee zaum tuaj yeem ua rau qaug dab peg thiab txawm tias convulsions (Kev siv tshuaj ntau dhau yuav tshwm sim). Cov teeb meem tsis zoo feem ntau me me, yog li nws tsis tshua muaj kev cuam tshuam txuas ntxiv ntawm kev kho mob. Crystaluria, mob caj dab lossis txhav, lub teeb pom kev zoo, thiab qhov muag tsis pom kev tuaj yeem tshwm sim qee zaum thaum kho. Nws tuaj yeem ua rau mob plab me me lossis tsis xis nyob, xeev siab, kub cev, tsis qab los. Cov kab mob hauv lub paj hlwb me me xws li kiv taub hau, tsaug zog, mob taub hau, tsis muaj zog, cov tsos mob yuav ploj mus (rov zoo li qub) tom qab siv tshuaj.

Kev ua xua, ua pob, khaus, ua rau lub ntsej muag lossis tawv nqaij, thiab tuaj yeem ua rau mob sib quas ntus. Nws kuj tseem tuaj yeem ua rau ncua sijhawm aminotransferase nce siab, khaws cov kua thiab lwm yam. Lub siab puas tuaj yeem pom hauv tus neeg mob.

Nws tuaj yeem ua rau lub raum puas, nce urea nitrogen, thiab lub raum tsis txaus. Kuj tseem muaj qhov txo qis hauv cov xim dawb cov qe ntshav thiab platelets, nce hauv eosinophils, thiab mob qhov ncauj. Kev ua xua tuaj yeem ua rau ua pa nyuaj ua pa mucosal txhaws caj pas, ua tsis taus pa, tawv nqaij vasculitis, sib koom tes thiab mob nqaij, thiab mob hnyav tuaj yeem ua rau muaj kev phom sij rau lub neej. Cov kab mob ntawm txoj hnyuv: xeev siab, raws plab, ntuav, mob plab, mob plab, tsam plab, tsis txaus ntseeg.

Yog tias koj pom mob raws plab ntev heev thaum lossis tom qab kho, koj yuav tsum sab laj nrog koj tus kws kho mob, vim qhov no tuaj yeem ua rau mob plab hnyav (pseudomembranous enteritis), uas yuav tsum tau kho sai. Thaum qhov no tshwm sim, koj yuav tsum tsis txhob siv ciprofloxacin, thiab muab kev kho kom tsim nyog (vancomycin hais lus 4 × 250 mg/hnub), thiab txwv tsis pub siv cov tshuaj tua kab mob hauv plab.

A. Lub paj hlwb:
Kiv taub hau, mob taub hau, qaug zog, ntxhov siab, tshee;

B. Qhov tsawg tshaj plaws yog:
Insomnia, qhov txawv txav ntawm qhov mob ib ce, tawm hws, taug kev tsis ruaj khov, qaug dab peg, nce siab hauv siab, ntxhov siab, npau suav hmo ntuj, tsis meej pem, nyuaj siab, thiab ua rau pom kev tsis meej, thiab ib tus neeg mob muaj lub siab xav. Hauv qee tus neeg mob, cov kev tsis zoo no tuaj yeem tshwm sim thaum pib siv tshuaj. Lub sijhawm no, koj tuaj yeem tso tseg kev noj cov tshuaj tsis zoo tam sim thiab ceeb toom rau koj tus kws kho mob.

C. Cov kab mob hauv lub cev:
Cov kev phiv los ntawm cov kab mob hauv nruab nrog cev tsis tshua muaj, qee zaum nws tuaj yeem pom tias saj tsis zoo, ua rau pom kev tsis zoo (ob lub zeem muag, pom lub ntsej muag xim), tinnitus thiab hnov ​​lus raug puas ntsoog ib ntus, tshwj xeeb tshaj yog nyob ib puag ncig ib puag ncig.

D. Ua xua heev:
Qee qhov xwm txheej, kev ua xua tuaj yeem tshwm sim thaum pib thawj zaug. Hauv qhov no, nres qhov tshuaj thiab ceeb toom rau tus kws kho mob tam sim.

E. Cov tawv nqaij cov tshuaj tiv thaiv:
Xws li pob tawv nqaij, khaus, ua npaws. Kev tsim cov hlwv (peechiae) ntawm daim tawv nqaij nrog los ntshav (ntshav blisters) thiab crusted nodules (papules) qhia txog vasculitis.

F. Stevens Johnson thiab Lyell syndrome:
Cov kab mob nephritis interstitial, kab mob siab, thiab daim siab necrosis tsis tshua ua rau lub siab tsis ua haujlwm. Hauv qee tus neeg mob, txawm li cas los xij, kev ua xua tuaj yeem tshwm sim ntawm thawj qhov kev tswj hwm (piv txwv li lub ntsej muag, vascular thiab laryngeal edema; ua pa nyuaj, ua rau lub cev tuag taus G); thaum cov xwm txheej no tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd.

G. Kab mob plawv:
Tachycardia: yaug, mob taub hau, thiab syncope.

2. Ceev faj

  • Cov khoom no yuav tsum tsis txhob siv rau cov uas ua xua rau quinolones.
  • Cov khoom no tsis haum rau menyuam yaus, poj niam cev xeeb tub thiab poj niam pub niam mis.
  • Nws raug nquahu kom txo qhov koob tshuaj thaum lub raum ua haujlwm tsis zoo (koob tshuaj yog ib nrab thaum qhov kev tshem tawm creatinine tsawg dua 20ml/min). Cov uas muaj lub siab ua haujlwm tsis zoo yuav tsum ntsuas qhov zoo thiab qhov tsis zoo.
  • Cov neeg uas muaj keeb kwm mob vwm lossis mob hauv nruab nrab lub paj hlwb yuav tsum siv nws nrog ceev faj. Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum tau txhaj tshuaj raws li qib ntawm lub raum tsis zoo thaum siv cov khoom no. Lub mechanism ntawm kev txiav txim ntawm Cov tshuaj fluoroquinolone cov tshuaj xws li norfloxacin yog los txwv tsis pub DNA sib txuas. Thiab nws tau lees paub tias Cov tshuaj fluoroquinolones tuaj yeem ua rau pob txha mos ntawm cov nas hluas. Yog li ntawd, cov tshuaj no yuav tsum tsis txhob siv rau menyuam yaus thiab poj niam cev xeeb tub. Kev pub niam mis yuav tsum raug ncua thaum nws siv vim tias cov tshuaj tuaj yeem zais rau hauv niam mis.

xaus

Ciprofloxacin muaj cov tshuaj tua kab mob dav dav, thiab nws cov tshuaj tua kab mob yog qhov muaj zog tshaj plaws quinolones. Txawm li cas los xij, muaj ntau qhov ua tau ciprofloxacin cov kev mob tshwm sim, uas yuav tsum tau them nyiaj mloog rau, tshwj xeeb tshaj yog rau poj niam cev xeeb tub thiab menyuam yaus.

ciprofloxacin-xeem
ciprofloxacin-xeem

BALLYA muab rau quinolones erythromycin combo test cov los qhia koj yog tias muaj cov quinolones seem thiab erythromycin tshuaj residues hauv khoom noj siv mis cov khoom koj noj txhua hnub.

References

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Zoo siab tsim los ntawm BALLYA
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