Chloramphenicol Test Fluorescence

Tshuaj tua kab mob Chloramphenicol tuaj yeem ua rau 50S subunit ntawm cov kab mob ribonucleoproteins thiab cuam tshuam rau kev sib xyaw cov protein.

Chloramphenicol tshuaj tua kab mob suav nrog chloramphenicol, sulfomycin, thiab tsis muaj ntxhiab chloramphenicol.

Sulfomycin: Cov khoom no yog methylsulfone derivative ntawm chloramphenicol. Nws yog cov tshuaj hluavtaws broad-spectrum tshuaj tua kab mob. Nws cov kab mob tua kab mob thiab cov tshuaj tua kab mob zoo ib yam li chloramphenicol. Nws feem ntau nthuav mus rau hauv cov kab mob cell thiab thim rov qab khi rau 50S ntawm cov kab mob ribosomes Ntawm cov subunit, kev loj hlob ntawm peptide saw tau raug thaiv (muaj peev xwm cuam tshuam qhov cuam tshuam ntawm transpeptidase), kev tsim cov peptide saw raug txwv, thiab kev sib xyaw ntawm protein yog tiv thaiv, yog li ua si cov tshuaj tua kab mob.

Tsis muaj ntxhiab chloramphenicol: Chloramphenicol palmitate tsis muaj qhov iab thiab tsim nyog rau menyuam yaus noj qhov ncauj. Chloramphenicol tau maj mam decomposed hauv cov hnyuv tom qab noj nws, yog li nws muaj qhov ua haujlwm ntev. Nws tau siv tib yam li chloramphenicol thiab tsuas yog siv rau qhov ncauj xwb.

Ntau hom kab mob tuaj yeem tsim kev tiv thaiv chloramphenicol. Ntawm lawv, E. coli, Shigella, thiab Proteus muaj ntau dua, thiab mob khaub thuas thiab Staphylococcus tsis tshua muaj. Cov kab mob tiv taus chloramphenicol kuj qeeb. Nws tuaj yeem tshwm sim los ntawm kev hloov pauv maj mam ntawm cov tshuaj tiv thaiv chloramphenicol, tab sis nws tuaj yeem ploj mus tau.

Chloramphenicol thim rov qab khi rau 50S subunit, thaiv qhov cuam tshuam ntawm transpeptidylase, thiab cuam tshuam nrog kev khi ntawm cov aminoacyl-tRNA davhlau ya nyob twg nrog 50S subunit, yog li thaiv qhov tsim ntawm peptide saw tshiab thiab inhibiting protein synthesis. Vim tias chloramphenicol tseem tuaj yeem ua ke nrog tib neeg mitochondria 70S, nws tseem tuaj yeem cuam tshuam tib neeg cov mitochondrial protein synthesis thiab ua rau muaj tshuaj lom rau tib neeg lub cev. Vim tias kev khi ntawm chloramphenicol rau 70S ribosomes tuaj yeem thim rov qab, nws suav tias yog cov tshuaj tua kab mob bacteriostatic, tab sis nws tseem tuaj yeem muaj cov kab mob tua kab mob rau qee cov kab mob ntawm cov tshuaj ntau ntau, txawm tias qis dua cov kab mob khaub thuas bacilli. Ua cov kab mob tua kab mob.

Chloramphenicol qhov muag dauv tau qhia rau kev kho mob ntawm qhov muag xws li trachoma, trachoma, Escherichia coli, Haemophilus influenzae, Klebsiella, Staphylococcus aureus, Streptococcus hemolyticus thiab lwm yam kab mob nkag siab. Conjunctivitis, keratitis, blepharitis, thiab lwm yam.

Chloramphenicol pob ntseg pob ntseg tau siv rau kev kho mob ntawm pob ntseg sab nraud, mob hnyav thiab mob hnyav otitis media tshwm sim los ntawm cov kab mob kis tau yooj yim.

1. Typhoid thiab lwm yam Kab mob Salmonella: cov tshuaj xaiv rau tus mob khaub thuas thiab paratyphoid tshwm sim los ntawm cov kab mob rhiab, mob plab zom mov los ntawm Salmonella feem ntau tsis haum rau cov khoom no. Yog tias tus kab mob hnyav, nws tseem tuaj yeem siv thaum ua ke nrog septicemia tuaj yeem ua tau; Hauv cov neeg laus uas muaj kab mob typhoid thiab paratyphoid, fluoroquinolones yog thawj qhov kev xaiv (tsis haum rau poj niam cev xeeb tub thiab menyuam yaus).
2. Ampicillin-resistant Haemophilus influenzae type B meningitis lossis Streptococcus pneumoniae, Neisseria meningitidis meningitis, thiab ua rau cov kab mob gram-negative meningitis tsis haum rau penicillin. Cov khoom no tuaj yeem siv ua ib qho ntawm cov tshuaj xaiv.
3. Lub paj hlwb, tshwj xeeb yog otogenic, feem ntau yog sib xyaw ua ke ntawm cov kab mob aerobic thiab anaerobic.
4. Cov kab mob anaerobic hnyav, xws li cov uas tshwm sim los ntawm Bacteroides fragilis, tshwj xeeb tshaj yog haum rau cov uas muaj qhov txhab cuam tshuam nrog lub hauv paus paj hlwb. Lawv tuaj yeem siv ua ke nrog tshuaj tua kab mob aminoglycoside los kho mob plab thiab mob plab hauv plab kom tswj kev sib kis kab mob aerobic thiab anaerobic.
5. Tsis muaj lwm yam tshuaj tua kab mob uas tsis muaj tshuaj lom tuaj yeem siv los kho ntau yam mob hnyav uas tshwm sim los ntawm cov kab mob rhiab, xws li sepsis thiab mob ntsws uas tshwm sim los ntawm Haemophilus influenzae, Salmonella thiab lwm yam Gram-negative bacilli, feem ntau nrog aminoglycosides. Ua ke.
6. Kev kis tus kab mob Rickettsia tuaj yeem siv rau kev kho mob Q ua npaws, Rocky Mountain pom kub taub hau, thiab mob qog noj ntshav.

Nws yog siv los kho kab mob sib kis, keratitis, blepharitis, trachoma, thiab lwm yam tshwm sim los ntawm E. coli, Haemophilus influenzae, Klebsiella, Staphylococcus aureus, hemolytic streptococcus thiab lwm yam kab mob rhiab.

1. Ocu-Chlor

1. Ak-Chlor
2. Chloromycetin
3. Chloroptic
4. Fenicol
5. Isopto Fenicol
6. Minims Chloramphenicol 05
7. Ophtho-Chloram
8. Pentamycetin Ophthalmic Tshuaj 025
9. Pentamycetin Ophthalmic Tshuaj 05
10. Pms-Chloramphenicol
11. Sopamycetin

Txawm hais tias kev siv chloramphenicol hauv tshuaj kho tsiaj raug txwv hnyav, chloramphenicol muaj qee qhov tseem ceeb siv tsiaj. Kev siv mis nyuj yog ib qho tseem ceeb siv. Qhov teeb meem ntawm chloramphenicol seem hauv cov mis yog ua hnyav zuj zus. Cov tshuaj chloramphenicol cov ntawv xeem sai cov khoom siv nws tus kheej tsim los ntawm Ballya tuaj yeem daws teeb meem zoo. Cov txiaj ntsig ntsuas tau ua raws EU tus qauv, tsis tsuas yog ua haujlwm yooj yim, tab sis kuj tseem siv sijhawm luv thiab raug siab. Ballya yuav ua qhov kev tshawb fawb tob hauv thaj chaw no yav tom ntej.