Cefdinir siv los kho dab tsi?

• Nreeb Navigation
• Cefdinir yog dab tsi?
  1. Lus txhais
  2. Cov teebmeem tshuaj
• Cefdinir Siv
• Cefdinir Cov Teeb Meem
  1. Cefdinir Dosge
  2. Sab los
• Ceev faj
• xaus

Cefdinir yog dab tsi?

1. Kev Txhais Tau

CefdinirCov mis mos molecular yog C14H13N5O5S2, thiab lub npe tshuaj yog ([6R- [6α, 7β (Z)]]]-7-[[(2-amino-4-thiazolyl)-(oximino) acetyl] Amino] -3- vinyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, hauv 0.1mol/L phosphate buffer [0.1 Me ntsis soluble hauv mol/L disodium hydrogen phosphate tov-0.1 mol/L potassium dihydrogen phosphate tov (2: 1)], tab sis tsis yaj hauv dej, ethanol lossis ether.

Cefdinir belongs rau 3rd tiam cephalosporin, uas tuaj yeem tiv thaiv kev sib txuas ntawm cov kab mob phab ntsa cell. Nws muaj cov kab mob tua kab mob zoo rau ob qho kab mob gram-positive thiab gram-negative, tshwj xeeb tshaj yog rau cov txiv hmab daj daj thiab streptococci ntawm cov kab mob gram-positive.

Cefdinir tsis tsuas yog yuav tsis ua kom puas los ntawm lactamase tsim los ntawm cov kab mob, tab sis kuj tseem muaj cov tshuaj tua kab mob zoo tshaj tiv thaiv cov kab mob tsim los ntawm lactamase. Clinically, nws tuaj yeem siv los kho kev ua pa, tso zis, pob ntseg thiab qhov ntswg tshwm sim los ntawm Staphylococcus, Streptococcus, Pneumococcus, Neisseria gonorrhoeae, Escherichia coli, Klebsiella, Proteus mirabilis, Haemophilus influenzae, thiab lwm yam Mob caj pas thiab tawv nqaij.

Dab tsi yuav tsum tau ceeb toom yog tias cov neeg mob uas ua xua rau tshuaj penicillin yuav tsum tsis txhob siv cephalosporin tshuaj tua kab mob. Yog tias koj cov tawv nqaij ua xua rau nws, nws tuaj yeem hloov nrog tshuaj tshwj xeeb tshuaj tua kab mob xws li roxithromycin.

2. Cov teebmeem tshuaj

Nws muaj ntau yam ntawm cov kab mob tua kab mob tiv thaiv kab mob Gram-positive thiab Gram-negative bacteria, tshwj xeeb tshaj yog tiv thaiv Staphylococcus thiab Streptococcus ntawm cov kab mob Gram-positive. Nws muaj cov tshuaj tua kab mob muaj zog ntau dua li qhov ncauj yav dhau los cephalosporins. Hom kev ua yog bactericidal.

Nws ruaj khov rau beta lactamase tsim los ntawm ntau cov kab mob thiab muaj cov tshuaj tua kab mob zoo tiv thaiv beta lactamase ua cov kab mob. Lub tswv yim ntawm kev nqis tes yog tias nws yuav tiv thaiv kev sib txuas ntawm cov kab mob ntawm cov kab mob ntawm tes. Nws muaj kev sib raug zoo rau tshuaj penicillin khi cov protein (PBP) 1 (1a, 1bs), 2, 3, tab sis muaj cov chaw sib txawv sib txawv rau cov kab mob sib txawv.

Cov khoom no muaj cov tshuaj tiv thaiv kab mob dav dav tiv thaiv kab mob gram-positive thiab negative aerobes thiab anaerobes. Sib piv nrog lwm qhov ncauj uas twb muaj lawm cephalosporin tshuaj tua kab mob, cov tshuaj tua kab mob ntawm cov khoom no muaj zog tiv thaiv Staphylococcus, Streptococcus, Peptostreptococcus, Propionibacteriu. Ib qho kev sim tshuaj ntawm 1433 tus neeg mob (100 mg txhua lub sijhawm, 3 zaug hauv ib hnub) qhia pom tias qhov txiaj ntsig zoo ntawm cov khoom no tiv thaiv ntau yam kev kis mob: cov kab mob ua paug 89.2%, phais mob 90%, mob ua pa hnyav 82.8%, mob ua pa ntev mus 63.1 %, kab mob tso zis 82.8%, kab mob gynecological 88.4%, kab mob kev kho mob 94.3%, thiab kab mob otolaryngology 75%. Kev tshem tawm cov kab mob bacteriological ntawm cov kab mob gram-positive yog 91.9%, thiab kev tshem tawm cov kab mob ntawm cov kab mob gram-negative yog 91.4%.

Cefdinir Siv

Txawm hais tias kev siv tshuaj tua kab mob hauv Suav teb loj heev, nws tseem txheeb xyuas qhov muaj zog ntawm cov tshuaj tua kab mob los ntawm lwm qhov. Raws li cov ntaub ntawv cuam tshuam thiab cov ntaub ntawv, qhov nruab nrab kev siv tshuaj tua kab mob hauv Suav teb yog 138 grams, uas yog kaum npaug ntawm Tebchaws Askiv, yog qeb thib ib hauv ntiaj teb. Ib qho ntxiv, kev siv tshuaj tua kab mob hauv cov neeg mob hauv tsev kho mob hauv Suav tau txog 80%, thiab kev siv cov tshuaj tua kab mob dav dav thiab cov ntawv thov sib koom ua ke tau mus txog 58%, deb tshaj li thoob ntiaj teb qib ntawm 30%.

Cefdinir yog ib ntawm cephalosporins, uas feem ntau ua los tua cov kab mob los ntawm inhibiting synthesis ntawm kab mob cell phab ntsa. Nws cov kab mob tua kab mob yog qhov dav, suav nrog qee cov kab mob gram-positive, nrog rau cov kab mob gram-negative. Yog li ntawd, cefdinir tuaj yeem siv hauv tsev kho mob los kho kab mob ntawm ntau qhov chaw tshwm sim los ntawm cov kab mob rhiab.

Cov kab mob no tshwm sim hauv cov pa ua pa sab saud thiab pom tau tias yog pharyngitis, laryngitis, thiab tonsillitis. Nws kuj tuaj yeem tshwm sim hauv txoj hlab ntsws qis, xws li mob ntsws thiab mob ntsws. Nws kuj tseem tuaj yeem tshwm sim hauv cov zis, xws li cystitis, urethritis, thiab pyelonephritis. Nws kuj tseem tuaj yeem tshwm sim hauv cov txheej txheem kev ua me nyuam, xws li cov khoom siv ntxiv thiab prostatitis. Nws kuj tuaj yeem tshwm sim rau ntawm daim tawv nqaij thiab cov nqaij mos, ua rau pom raws li cov hauv paus hniav, tawv nqaij tawv nqaij, erysipelas, cellulitis, thiab lwm yam.

Tus nqi tseem ceeb ntawm Cefdinir Capsules tuaj yeem xav txog ntau qhov chaw. Ua ntej tshaj plaws, Cefdinir Capsules yog ib txwm muaj. Nws muaj cov txiaj ntsig muaj zog tiv thaiv ntau yam kab mob hauv kev kho mob. Nws tuaj yeem kho ntau yam kab mob tib lub sijhawm nrog cov txiaj ntsig zoo ntawm kev siv tshuaj. Nws muaj txiaj ntsig kho tau zoo hauv kev kho mob gonococcal urethritis, mob ntsws adnexal thiab kab mob hauv lub tsev menyuam, nrog rau mob mastitis thiab perianal liab, thiab tiv thaiv kev kis mob tom qab ua haujlwm thiab ntau yam kab mob loj, tab sis tsawg tus neeg tuaj yeem ntsib plab zom mov, tsis xis nyob hauv plab, tawv nqaij tawv nqaij, thiab tsis muaj ntshav tom qab noj nws.

Cefdinir tuaj yeem kho tus kab mob hauv qab no los ntawm Proteus mirabilis, Providencia, Haemophilus influenzae thiab lwm yam kab mob Staphylococcus, Streptococcus, Pneumococcus, Peptostreptococcus, Propionibacterium, Neisseria gonorrhoeae, Moraxella catarrhalis, Escherichia coli thiab Klebsiella uas nkag siab rau cefdinir:

1. Pharyngitis, tonsillitis, mob ntsws ntev, mob ntsws;
2. otitis media, sinusitis;
3. Pyelonephritis, cystitis, gonococcal urethritis;
4. Annexitis, intrauterine kab mob, bartholinitis;
5. Kev kis tus kab mob thib ob ntawm mastitis, ua paug ncig lub qhov quav, raug mob lossis phais qhov txhab;
6. Folliculitis, furuncle, boils, carbuncle, kis tus kab mob, erysipelas, cellulitis, lymphangitis, paronychia, subcutaneous abscess, mob pob txuv, mob ntev pyoderma;
7. Blepharitis, sty, meibomitis.

Cefdinir Side Effects

1. Cefdinir Dosge

Tom qab sib faib nrog dej, hais qhov ncauj lossis nqos nws ncaj qha. Cov koob tshuaj niaj hnub rau cov neeg laus yog 100 mg ib zaug, peb zaug ib hnub. Qhov koob tshuaj ib txwm rau menyuam yaus yog 9-18 mg/kg ib hnub twg hauv peb qhov kev faib faib. Qhov ntau npaum li cas tuaj yeem nce lossis txo kom tsim nyog raws li hnub nyoog thiab cov tsos mob, lossis raws li qhia los ntawm kws kho mob.

2. Sab los

• Dermatology: lom epidermal necrolysis (<0.1%) yuav tshwm sim. Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias ua npaws, mob taub hau, mob sib koom, erythema/blisters tshwm rau ntawm daim tawv nqaij lossis daim nyias nyias, lossis tawv nqaij xav tias nruj/hlawv/mob, cov tshuaj yuav tsum nres tam sim thiab tsim nyog kho yuav tsum tau ua.
• Kev ua xua: ua xua tuaj yeem tshwm sim, xws li ua tsis taus pa, erythema, angioedema, thiab urticaria, nrog rau qhov tshwm sim ntawm <0.1%. Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias muaj qhov txawv txav tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd thiab yuav tsum tau kho sai.
• Shock: Kev poob siab yuav tshwm sim, nrog rau qhov tshwm sim ntawm <0.1%. Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias muaj cov tsos mob xws li tsis xis nyob, tsis xis nyob hauv lub qhov ncauj, hawb pob, kiv taub hau, cem quav, tinnitus lossis tawm hws tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd thiab tsim nyog kho yuav tsum ua.
• Hematology: Pancytopenia (<0.1%), agranulocytosis (<0.1%, cov tsos mob thawj zaug yog kub cev, mob caj pas, mob taub hau, tsis pom kev), thrombocytopenia (<0.1%, cov tsos mob pib yog Ecchymosis, purpura) lossis hemolytic anemia (<0.1%, cov tsos mob pib yog kub cev, hemoglobinuria, thiab ntshav tsis txaus). Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias muaj qhov txawv txav tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd thiab yuav tsum tau kho sai.
• Colitis: Cov kab mob loj heev (<0.1%) tuaj yeem tshwm sim, xws li pseudomembranous colitis paub tseeb los ntawm cov ntshav. Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias muaj cov tsos mob xws li mob plab lossis mob raws plab ntau zaus tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd thiab yuav tsum tau kho kom raug.
• Mob ntsws sib kis lossis mob PIE: Mob ntsws sib kis lossis mob PIE tau lees paub los ntawm kev ua npaws, hnoos, ua pa nyuaj, lub hauv siab xoo hluav taws xob lossis eosinophilia tuaj yeem tshwm sim (<0.1%). Yog tias muaj cov tsos mob tshwm sim, cov tshuaj yuav tsum raug txiav tam sim thiab txais kev kho kom tsim nyog, xws li kev siv cov tshuaj adrenocorticoid.
• Kab mob hauv lub raum: Kab mob hauv lub raum hnyav (<0.1%) tuaj yeem tshwm sim, xws li mob raum tsis ua haujlwm. Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias muaj qhov txawv txav tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd thiab yuav tsum tau kho sai.
• Kab mob siab tsis txaus, ua haujlwm tsis zoo hauv lub siab lossis jaundice: mob siab ua rau lub cev hnyav tuaj yeem tshwm sim (<0.1%), xws li kab mob siab ua kom tiav nrog qhov nce siab ntawm alanine aminotransferase, aspartate aminotransferase lossis alkaline phosphatase, lub siab tsis ua haujlwm (<0.1%) lossis jaundice (<0.1%) ). Cov neeg mob yuav tsum tau ua tib zoo saib. Yog tias muaj qhov txawv txav tshwm sim, cov tshuaj yuav tsum nres tam sim ntawd thiab yuav tsum tau kho sai.

Ceev faj

Raws li kev coj ua, tom qab txiav txim siab nkag siab ntawm cov kab mob me me rau cov khoom no, chav kawm ntawm kev kho cov khoom no yuav tsum raug txwv rau lub sijhawm luv tshaj uas yuav tsum tau kho tus neeg mob kom tiv thaiv kev tsim cov kab mob tiv taus.

Nws raug nquahu kom zam kev sib xyaw nrog kev npaj hlau. Yog tias kev siv ua ke tsis tuaj yeem zam tau, kev npaj hlau yuav tsum siv 3 teev tom qab noj cov khoom no.

Vim tias muaj peev xwm ua rau poob siab thiab lwm yam kev tsis haum tshuaj, yuav tsum tau qhia ntxaws txog keeb kwm kev ua xua.

Cov neeg mob hauv qab no yuav tsum siv nws nrog ceev faj:

1. Cov uas muaj keeb kwm ua xua rau penicillin tshuaj tua kab mob;
2. Cov neeg uas nquag ua rau mob hawb pob, ua pob ua xua, urticaria thiab lwm yam tsos mob rau lawv tus kheej lossis lawv cov txheeb ze;
3. Cov neeg mob uas lub raum tsis ua haujlwm hnyav: Txij li thaum cefdinir tau nyob hauv cov ntshav ntawm cov neeg mob uas muaj lub raum tsis ua haujlwm ntev, qhov koob tshuaj yuav tsum raug txo thiab lub sijhawm nruab nrab ntawm kev tswj hwm yuav tsum tau txuas ntxiv raws li qhov mob hnyav ntawm lub raum tsis ua haujlwm. Rau cov neeg mob uas mob hemodialysis, koob tshuaj pom zoo yog 100 mg ib hnub ib zaug;
4. Cov neeg mob uas muaj mob hnyav, tsis tuaj yeem noj zaub mov zoo lossis tsis noj zaub mov zoo, cov neeg laus, cachexia, thiab lwm yam (Vim tias tsis muaj vitamin K tuaj yeem tshwm sim, yuav tsum tau soj ntsuam kev soj ntsuam tas li).
5. Thaum ua ke nrog cov khoom ntxiv hlau (xws li hmoov mis lossis khoom noj khoom haus nkag mus), quav liab thiab tso zis liab tuaj yeem tshwm sim.
6. Hais txog kev siv tshuaj thaum cev xeeb tub, nws txoj kev nyab xeeb tseem tsis tau paub meej. Rau cov poj niam cev xeeb tub lossis poj niam uas xav tias yuav xeeb tub, qhov zoo thiab qhov tsis zoo ntawm cov tshuaj yuav tsum raug ntsuas, thiab nws tuaj yeem siv tau tsuas yog thaum cov kws tshaj lij ua rau raug mob.
7. Qhov zoo thiab qhov tsis zoo ntawm kev siv tshuaj yuav tsum raug ntsuas los ntawm cov poj niam uas pub niam mis, thiab yuav tsum siv tsuas yog thaum cov kws tshaj li qhov tsis zoo.
8. Kev nyab xeeb ntawm kev siv tshuaj rau menyuam mos ntxov thiab cov menyuam yug tshiab uas tsis muaj lub cev hnyav tsis tau lav.
9. Vim tias kev ua haujlwm tsis zoo ntawm lub cev, cov neeg mob laus laus tuaj yeem ua rau muaj kev phiv tshuaj.
10. Vim tsis muaj vitamin K tsis txaus, cov neeg mob laus tuaj yeem muaj ntshav ntws.

Tsis tas li ntawd, qhov cuam tshuam ntawm kev siv tshuaj ntau dhau cefdinir cov tseem tsis tau kawm. Hauv txoj kev tshawb fawb ntawm mob hnyav, mob hnyav, thiab mob txhab, ib qhov ncauj ntawm 5600 mg/kg tsis ua rau muaj kev phiv. Lwm yam beta lawm tshuaj tua kab mob tuaj yeem ua rau muaj kev phiv hauv qab no thaum lawv siv ntau dhau: xeev siab, ntuav, raws plab thiab ntuav. Ntshav lim ntshav tuaj yeem tshem tawm cefdinir cov los ntawm tib neeg lub cev. Hemodialysis muaj txiaj ntsig zoo rau cov neeg mob uas muaj tshuaj lom lom tshwm sim los ntawm kev noj tshuaj ntau dhau, tshwj xeeb tshaj yog rau cov neeg mob uas lub raum tsis txaus.

xaus

Cefdinir belongs rau 3rd tiam cephalosporin. Txawm hais tias rau nws cov kab mob tua kab mob lossis ua haujlwm tua kab mob, nws tau zoo dua qub piv nrog ob tiam dhau los ntawm cephalosporins. Tab sis nws kuj muaj qee qhov tshwj xeeb tshwm sim, xws li quav liab thiab tso zis liab, uas xav tau peb saib xyuas.

BALLYA muab a Betalactam cephalexin combo test kit qhia rau koj yog tias muaj beta lactam cov cov seem thiab cephalosporin seem hauv cov khoom siv mis uas koj noj txhua hnub.

References

• PubChem: Cefdinir
• Wikem: Cefdinir