Danofloxacin yog hom tshuaj fluoroquinolone, uas yog cov tsiaj tshwj xeeb tshuaj. Nws feem ntau yog siv los ua nws cov mesylate ntsev, danofloxacin mesylate. Txhua tus muaj zog tiv thaiv kab mob. Qhov seem ntawm quinolones ntau dhau yuav ua rau cov kab mob tiv taus thiab ua rau muaj kev phom sij rau tib neeg kev noj qab haus huv. EU qhov txwv qis tshaj plaws rau fluoroquinolones suav nrog danofloxacin hauv cov tsiaj zaub mov yog: nqaij leeg 100μg / kg, Mob siab thiab raum 200μg / kg, nqaij qaib thiab npua nqaij noj tau 50μg / kg.
Danofloxacin mechanism ntawm kev nqis tes ua
Cov tshuaj ntau hauv cov ntaub so ntswg tuaj yeem ncav cuag 5-7 zaug ntawm cov ntshav. Kev tswj qhov ncauj, txhaj tshuaj intramuscular thiab txhaj tshuaj subcutaneous tau nrawm dua thiab ua tiav. Lub bioavailability ntawm nqaij qaib qhov ncauj thawj coj yog 100%; bioavailability ntawm npua qhov ncauj tswj hwm yog 89%; bioavailability ntawm nyuj qhov ncauj tswj hwm yog 72%. Tshaj tawm los ntawm ob lub raum. Danofloxacin mesylate tau nrawm nrawm thiab faib rau hauv crucian carp, thiab tshem tawm qeeb; cov tshuaj muaj kev nkag mus tau zoo thiab nthuav dav hauv cov ntaub so ntswg, thiab kev siv tshuaj ntau ntxiv hauv cov ntaub so ntswg yog qhov siab dua li ntawm cov ntshav los ntawm 12h txog 168h (P <0.05). Hepatopancreas thiab ob lub raum muaj cov tshuaj siab tshaj plaws hauv txhua cov ntaub so ntswg. Kev tshem tawm ib nrab-lub neej ntawm lub raum, hepatopancreas, ntshav, nqaij thiab tawv nqaij yog 33h, 44h, 48h, 51h thiab 177h, feem. Tom qab 120 teev ntawm kev tswj hwm, cov tshuaj nyob hauv daim tawv nqaij yog 1.99 ± 0.32 μg / g, tom qab 168 teev ntawm kev tswj hwm, cov tshuaj nyob hauv daim tawv nqaij yog 1.72 ± 0.31 μg / g, thiab hauv cov leeg 0.70 ± 0.32 μg / g , piv nrog lwm cov ntaub so ntswg hauv daim tawv nqaij Kev tshem tawm ntawm cov tshuaj yog qhov qeeb tshaj plaws, thiab nws tau pom zoo raws li cov ntaub so ntswg sib xyaw ntawm DFM hauv crucian carp.
Danofloxacin synthesis
Siv trans-4-hydroxy-L-proline ua raw khoom, nws tau txais los ntawm kev tiv thaiv amino, txo carboxyl, hydroxysulfonylation, kaw lub nplhaib, thiab tiv thaiv kom tau txais (15, s4) -2-methyl-2,5 -Diazabicyclo [ 2.2.1] heptane hydrobromide, uas yog tom qab ntawd cuam tshuam nrog cyclopropanecarboxylic acid los tsim danofloxacin.
Danofloxacin siv li cas?
Cov lus qhia rau kev siv Danofloxacin
Cov khoom no yog cov tshuaj tua kab mob dav-spectrum. Nws muaj cov tshuaj tua kab mob muaj zog tiv thaiv Pasteurella, Mycoplasma thiab Escherichia coli. Feem ntau siv rau avian colibacillosis, avian cholera, kab mob ua pa ntev, thiab lwm yam, los kho kab mob los ntawm tsiaj cov kab mob thiab mycoplasma hauv nyuj, npua, thiab qaib.
Danofloxacin ntau npaum li cas
Kev txhaj tshuaj intramuscular, 1 hnub, danofloxacin mesylate ib kg lub cev hnyav, tsiaj txhu 10-20 mg, nqaij qaib 20-40 mg, faib ua ob qho kev txhaj tshuaj. Cov dej haus sib xyaw: nqaij qaib 15-30 mg rau ib liter dej.
Dab tsi tshwm sim ntawm Danofloxacin?
Danofloxacin toxicity
Dorfloxacin tau hais lus tso dej nrog Sturgeon ntawm koob tshuaj 800, 1040, 1352, 1757.60, 2248.88, 2970.34 mg / kg, thiab txhaj tshuaj intraperitoneally nrog 400, 440, 532.4, 585.6, thiab 644.2 mg / kg. Saib xyuas tus cwj pwm thiab kev tuag ntawm cov ntses sim rau 10 hnub sib law. LD50 ntawm darofloxacin txhaj tshuaj intraperitoneally los ntawm Shi tus sturgeon yog 429.47 mg / kg, thiab LD50 ntawm dalofloxacin los ntawm qhov ncauj infusion yog 1502.10 mg / kg. Lub siab lub hlwb ntawm cov ntses tuag tau ntim nrog lipid droplets, lub mitochondria tau tawg, qhov ntxhib endoplasmic reticulum qauv tau xoob thiab tawg, thiab lysosome tau tawg.
Danofloxacin mesylate yog dab tsi?
Danofloxacin mesylate feem ntau muaj cov tshuaj tua kab mob zoo rau cov kab mob Gram-positive (G +), qee yam kab mob anaerobic thiab mycoplasma. Rhiab rau Staphylococcus aureus, Streptococcus hemolyticus, Pneumococcus, Legionella pneumophila, Mycoplasma, tseem nkag siab Clostridium, Clostridium welchii, Tetanus, thiab Bacteroides. Danofloxacin mesylate tau siv tshuaj kho mob kis los ntawm epirubicin thiab erythromycin; Kab mob Mycoplasma ua rau muaj kab mob ua pa ntev thiab mob hawb pob hauv qaib; Necrotizing enteritis hauv qaib; Treponema pallidum dysentery thiab toxoplasmosis; Actinomycosis. Cov txheej txheem tiv thaiv kab mob quinolone feem ntau txiav txim siab tshwj xeeb rau inhibit DNA helicase, ua haujlwm ntawm A subunit ntawm DNA helicase, cuam tshuam kev ua haujlwm ntawm helicase, thaiv qhov ib nrab khaws cia rov ua dua ntawm cov kab mob DNA, ua rau tsis muaj kev puas tsuaj rau chromosomes, thiab cov kab mob tsis faib ntxiv lawm , cov tshuaj tua kab mob ua kom zoo dua li ntawm sulfonamides thiab tshuaj tua kab mob.
Danofloxacin mesylate solubility
Danofloxacin mesylate yog dawb rau lub teeb daj crystalline hmoov, tsis muaj ntxhiab, iab, yooj yim soluble hauv dej, me ntsis soluble hauv methanol, yuav luag tsis yaj hauv chloroform.
Danofloxacin mesylate txhaj tshuaj
Txo kev tsim cov kab mob tiv taus tshuaj thiab ua kom muaj txiaj ntsig zoo ntawm levofloxacin mesylate thiab lwm yam tshuaj tua kab mob. Levofloxacin tsuas yog siv los kho lossis tiv thaiv kev kis tus kab mob uas tau los lossis xav tias yuav tshwm sim los ntawm cov kab mob rhiab. Thaum xaiv lossis hloov kho kab mob kev kho tshuaj tua kab mob, cov txiaj ntsig ntawm kab mob kev coj noj coj ua thiab kev sim tshuaj tiv thaiv kab mob yuav tsum raug txiav txim siab.
Dab tsi tuaj yeem kuaj pom los ntawm BALLYA Danofloxacin Test?
Cov piv txwv suav nrog: nqaij npuas, nqaij qaib, mis nyuj, thiab lwm yam Siv dav hauv kev lag luam nqaij npuas thiab kev lag luam mis nyuj.
Qhov tseem ceeb ntawm kev sim Danofloxacin
Txhawm rau tiv thaiv tib neeg kom muaj zaub mov noj qab haus huv thiab zam cov zaub mov tsis huv. Danofloxacin yog teeb meem rau tib neeg, tsis tuaj yeem siv ntau hauv lub cev.
1. Nqa cov nqaij npua pov tseg thiab ua kom muaj supernatant 2. Ntxiv cov supernatant rau daim kab xev 3. Tos li 15 feeb kom tiav 4. Cov ntsiab lus ntawm kev ua haujlwm, xa mus rau cov lus qhia hauv pob khoom
Cov kev txwv ntawm BALLYA Danofloxacin Test?
BALLYA Danofloxacin Test yog ib qho khoom siv xeem zoo. Nws tsuas yog siv los tshuaj xyuas lub hom phiaj. Yog tias muaj cov xwm txheej zoo lossis xav tias kis mob, tej zaum siv lwm txoj hauv kev txhawm rau txhawm rau tshawb nrhiav ntxiv, xws li, ELISA, PCR, qPCR, thiab lwm yam.
xaus
Danofloxacin tau siv dav ua cov tshuaj anabolic hauv ntau yam lag luam. Kev lag luam ua npua tsim nyog tau txais kev saib xyuas tshwj xeeb. Nqaij npuas muab cov neeg noj zaub mov zoo, ua rau nws tsis tseem ceeb hauv lub neej txhua hnub. Qhov teeb meem ntawm danfloxacin cov tshuaj hormones nyob hauv cov nqaij npuas tau ua rau tib neeg mob, yog li nws yog qhov yuav tsum tau txheeb xyuas nqaij npuas kom raws sijhawm. BALLYA Danofloxacin Test yog muab los ntawm BALLYA tuaj yeem ua tau zoo thiab txheeb xyuas sai sai tias muaj cov danfloxacin seem hauv nqaij npuas. Tsis yog tsuas yog kev ua haujlwm yooj yim, lub sijhawm sim luv, tab sis tus ntsuas tuaj yeem tau txais qhov kev xeem hauv thawj zaug.
Qhov twg yuav BALLYA Danofloxacin Test?
Tau txais daim ntawv pub dawb tam sim no thiab txaus siab rau 10% luv nqi!
