Los ntawm 1-phenyl-3-methylpyrazolone-5 los ntawm methylation thiab hydrolysis. Hauv lub tank qhuav methylation, ntxiv pyrazolone, tom qab ntawd ntxiv dimethyl sulfate, sov kom txog 160 ° C, ua haujlwm rau 6 teev, thiab dej kub kom rhaub rau 2 teev. Muab cov tshuaj methylation reactant tso rau hauv lub tank hydrolysis ntim nrog sodium hydroxide tov, thiab do thiab hydrolyze ntawm 100-110 ° C rau 3 teev.
Tom qab sawv ntsug rau kev faib tawm, nqa cov roj antipyrine txheej thiab muab tso rau hauv lub tank crystallization, dilute nrog dej distilled, do, thiab txias kom qis dua 10 ° C, ua kom muaju muaju, lim, ntxuav nrog dej, thiab tig qhuav kom tau txais cov antipyrine nyoos. Cov khoom lag luam nyoos tau rov ua dua tshiab nrog cov dej ntxhia, thiab cov pa roj carbon activated tau hloov xim kom tau txais cov khoom tiav.
Kev ua haujlwm methylation tseem tuaj yeem siv methyl chloride lossis methyl bromide ua cov khoom siv raw, thiab ua cov tshuaj methylation no rau hauv cov tshuaj methanol, uas yog sib tov thiab ua haujlwm nrog 1-naphthyl-3-methylpyridone hauv me ntsis ntxiv.
Tom qab ntawd cov tshuaj methanol tau evaporated, cov tshuaj tiv thaiv tau yaj hauv dej, ua rau me ntsis alkaline nrog sodium hydroxide, antipyrine raug rho tawm nrog benzene, tom qab ntawd rov ua dua tshiab los ntawm benzene, thiab thaum kawg ua kom huv nrog cov pa roj carbon thiab rov ua dua tshiab nrog dej.
Lwm txoj hauv kev yog siv equimolar N, N-phenylmethylhydrazine thiab ethyl acetoacetate hauv cov roj da dej ntawm 130-160 ° C hauv qab reflux. Cov tshuaj antipyrine tau muab rho tawm los ntawm cov kua ua kua tuab nrog cov dej npau, thiab tom qab ntawd cov dej tau ua kom qhuav kom tau txais cov muaju.
2. Cov khoom yog tshuaj tua kab mob thiab ua kom loog. Hom tshuaj tsis-steroidal anti-inflammatory tshuaj muaj zog antipyretic, analgesic, anti-inflammatory thiab anti-rheumatic teebmeem.
Txawm li cas los xij, vim muaj kev phom sij loj, kev siv tshuaj kho mob tau maj mam poob qis, thiab qee yam qub qub tau maj mam tshem tawm.
