NSG 3 Sensors

Cov khoom siv Tri Sensor, ceev kom ntes Neomycin, Streptomycin thiab Gentamicin residues nyob rau hauv cov mis nyuj thiab cov khoom siv mis nyuj los ntawm kev siv colloidal kub tiv thaiv kab mob-chromatography technology. Sai li 7-10 feeb kom tau txais txiaj ntsig.

Neomycin yog thawj 2-DOS (2-deoxystreptamine) aminoglycoside tshuaj tua kab mob tshawb pom. Nws yog ib qho metabolite los ntawm Streptomyces fradiae los ntawm Waksman li al. hauv 1949. 

Cov sib tov sib cais 2 muaj 3 hom ABC nrog cov qauv tshuaj sib txawv thiab kev ua haujlwm lom neeg, thiab cov khoom tseem ceeb yog neomycin B thiab C, thiab neomycin A tsuas yog ib qho txiaj ntsig, uas yog ib qho ntawm cov khoom degradation ntawm neomycin BC. 

Cov qauv qauv muaj ntau-NH2 ua haujlwm pab pawg. Cov kev tshawb fawb tau pom tias ntau NH2, qhov kev ua haujlwm muaj zog dua.

Cov nyhuv antibacterial zoo ib yam li kanamycin. Nws tuaj yeem siv rau kev kho qhov ncauj ntawm tus menyuam mos raws plab thiab tshuaj lom dyspepsia. Nws tseem tuaj yeem siv rau kev npaj ua ntej kev phais plab hnyuv thiab kev kho mob ntawm cov kab mob hauv zos. Noj 3 mus rau 4 zaug hauv ib hnub, 1 g txhua zaus. 

Cov khoom no tuaj yeem ua rau pob ntseg thiab lub raum puas thiab tuaj yeem cuam tshuam ua pa, yog li nws yuav tsum tsis txhob siv ntau ntau.

Nws belongs rau tib cov tshuaj tua kab mob aminoglycoside xws li streptomycin, kanamycin thiab gentamicin. Nws yog tsim los ntawm Streptomyces freundii. Nws muaj txiaj ntsig zoo rau cov kab mob Gram-positive thiab Gram-negative. 

Cov khoom lag luam feem ntau yog sib xyaw ntawm neomycin B thiab C. Neomycin tau ua tiav kev sib tw nrog kanamycin thiab ib nrab hla kev tiv thaiv nrog streptomycin; zoo ib yam li cov tshuaj tua kab mob zoo sib xws, nws muaj nephrotoxicity thiab inner pob ntseg toxicity, thiab nws kev puas tsuaj rau pob ntseg feem ntau irreversible. Cov tshuaj tua kab mob no yeej tsis tso cai siv lawm.

Lub ntsiab tivthaiv ntawm neomycin yog neomycin B, uas muaj cov kab mob ntawm neomycin C. Neomycin yog ib qho tshuaj tua kab mob aminoglycoside thiab cov kab mob bactericidal nyob rau theem nyob ruaj khov. 

Nws cov txheej txheem ntawm kev ua haujlwm yog los ntawm kev thauj mus los ntawm cov cell membrane, irreversibly khi rau ib los yog ob peb cov proteins ntawm cov kab mob ribosome 30S subunit, cuam tshuam nrog kev tsim cov thawj compound ntawm mRNA thiab 30S subunit, uas ua rau cov synthesis ntawm txawv txav proteins; Cov proteins txawv txav khi rau cov kab mob cell membrane ua rau cov cell membrane permeate thiab tuag.

Neomycin zoo tiv thaiv aerobic gram-negative bacilli thiab qee cov kab mob gram-zoo. Ntawm cov kab mob gram-negative bacilli, nws muaj zog tiv thaiv kab mob tiv thaiv Enterobacter xws li Escherichia coli, Serratia, Proteus, Morganella, thiab lwm yam; Ntawm cov kab mob gram-zoo, nws muaj zog tiv thaiv kab mob tiv thaiv Staphylococcus aureus, Diphtheria bacillus thiab Bacillus anthracis. 

Nws muaj cov tshuaj tua kab mob muaj zog thiab cov kab mob tsis zoo tiv thaiv kab mob streptococcus, pneumococcus thiab enterococcus. Neomycin tsis zoo rau cov kab mob anaerobic, Pseudomonas aeruginosa, fungi, kab mob, thiab rickettsiae.

Agricultural streptomycin yog tshuaj tua kab mob zais cia los ntawm kab mob streptomyces griseus. Nws muaj ib tug systemic kho nyhuv. 

Nws tuaj yeem nkag mus rau hauv cov nroj tsuag lub cev thiab kis mus rau lwm qhov chaw nrog cov txiaj ntsig zoo ntawm cov kab mob nroj tsuag. Nws tuaj yeem tswj cov kab mob kab mob zoo, xws li txiv apples, pear hluav taws blight, haus luam yeeb wildfire, xiav pwm, mos rot ntawm cabbage, txiv lws suav kab mob rot, lig blight, qos noob qos yaj ywm rot, dub shank, dib angular nplooj chaw, downy mildew. , raum taum downy mildew, kab mob blight, celery kab mob blight, sesame kab mob nplooj. 

Nws yog tsuas yog siv los tswj cov kab mob nplooj ntoos blight, kab mob nplooj ntoos, citrus canker, thiab dib kab mob angular nplooj. Nws tuaj yeem siv rau kev txau, hauv paus irrigation thiab noob soaking.

Streptomycin yog tshuaj tua kab mob aminoglycoside. Los ntawm kev ua ntawm ribosomes nyob rau hauv cov kab mob, nws inhibits cov kab mob protein synthesis thiab rhuav tshem cov kev ncaj ncees ntawm cov kab mob cell membranes.

Gentamicin yog cov khoom sib xyaw ua ke uas tsim los ntawm Micromonospora. Tam sim no nws yog ib qho ntawm cov tshuaj tua kab mob tseem ceeb siv kho mob los tiv thaiv ntau yam kab mob gram-tsis zoo. 

Vim muaj kev siv dav dav ntawm gentamicin, tam sim no muaj qee tus lej ntawm Resistant hom muaj. 

Clinically, nws feem ntau yog siv rau cov kab mob hauv lub cev lossis hauv zos uas tshwm sim los ntawm cov kab mob Gram-negative xws li Escherichia coli, Shigella, Klebsiella pneumoniae, Proteus, Pseudomonas aeruginosa, Thiab lwm yam

Gentamicin yog ib qho tshuaj aminoglycoside. Nws cov txheej txheem ntawm kev ua haujlwm yog ua rau ribosomes hauv cov kab mob, inhibit cov kab mob protein synthesis, thiab rhuav tshem kev ncaj ncees ntawm cov kab mob cell membranes. 

Gentamicin tuaj yeem ua ntej diffuse los ntawm cov txheej cell membrane porin los ntawm passive diffusion, thiab tom qab ntawd nkag mus rau hauv lub cell los ntawm cov cell membrane los ntawm lub cev thauj mus los, thiab irreversibly khi rau cov cais ribosomal 30S subunit, ua rau kev puas tsuaj ntawm A site, thiab tom qab ntawd:

A. Tiv thaiv kom raug qhov chaw ntawm ammonia tRNA ntawm txoj haujlwm A, tshwj xeeb tshaj yog cuam tshuam kev khi ntawm methionyl tRNA, yog li cuam tshuam nrog kev sib dhos ntawm cov ribosomes ua haujlwm thiab inhibiting tsim ntawm 70S pib ua haujlwm.

B. Induce qhov tsis sib haum xeeb ntawm tRNA thiab mRNA code triplet, ua rau 30S subunit ntawm cov ribosome tsis zoo nyeem cov caj ces yuam kev, ua rau cov amino acid tsis ncaj ncees lawm tso rau hauv cov qauv protein, ua rau muaj qhov txawv txav thiab tsis ua haujlwm ntawm cov protein synthesis.

C. tiv thaiv qhov kev txiav tawm los ntawm kev khi rau txoj haujlwm A, kom cov saw hlau peptide tsis tuaj yeem raug tso tawm, thiab tiv thaiv kev sib cais ntawm 70S tiav ribosome.

D. cuam tshuam cov txheej txheem depolymerization thiab kev sib dhos ntawm polyribosomes, ua rau cov ribosome hauv cov kab mob depleted.

Lub khob cij yog lub rooj zaum ntawm lub neej. Kev nyab xeeb zaub mov tau dhau los ua qhov teeb meem tseem ceeb ntawm cov neeg. Cov xwm txheej "lub plawv liab" yav dhau los, "tshuaj nqaij qaib" xwm txheej, thiab "cov qe tooj liab" thiab "cov qaib loj hlob sai" tau ua rau tib neeg ntshai. 

Thaum kev lag luam yws tias cov neeg sau xov xwm tau nce mus deb thiab deb ntawm peb, peb kuj yuav tsum sawv, thiab kev lag luam yuav tsum tau qhuab qhia tus kheej. Kev nkag siab txog cov nqaij qaib cov tshuaj seem thiab lawv cov kev phom sij rau tib neeg lub cev yog qhov tsim nyog rau kev siv tshuaj kho mob kom raug, thiab ua raws li cov cai tswj kev tshem tawm cov tshuaj, kom cov neeg Suav tuaj yeem txaus siab rau cov nqaij qaib noj qab nyob zoo thiab qe khoom.

Cov seem ntawm cov tshuaj hauv tsev raug xa mus rau cov tshuaj seem, uas xa mus rau cov tshuaj uas tseem tshuav hauv cov nqaij qaib, qe, pob txha, nqes, plaub, thiab quav tom qab noj tshuaj. Cov tshuaj residues ua rau muaj kev tsis haum tshuaj los ntawm kev noj los yog kev sib cuag, los yog sib sau ua ke hauv lub cev, thiab ncav cuag qee yam tshuaj lom, uas tuaj yeem ua rau muaj kev phom sij loj rau tib neeg lub cev.

Cov seem ntawm tag nrho cov tshuaj tua kab mob tuaj yeem ua rau cov kab mob txhim kho kev tiv thaiv, txhawb kev tsim cov kab mob resistant thiab cov kab mob super, txo tib neeg lub cev rhiab heev rau cov tshuaj tua kab mob, lossis txawm tias ua tsis tau zoo, cuam tshuam ncaj qha rau tib neeg kev noj qab haus huv.

Cov neeg sawv cev ntawm cov tshuaj penicillins suav nrog penicillin G thiab amoxicillin, thiab lwm yam, uas feem ntau siv los kho cov nqaij qaib oophoritis, salpingitis, thiab tswj cov kab mob thib ob ntawm cov kab mob sib kis tsawg. 

Feem ntau ntawm cov tshuaj penicillin tshuav nyob rau hauv nqaij qaib nqaij thiab lub thawv qe raug rhuav tshem los ntawm gastric acid thiab digestive enzymes tom qab noj, thiab tsis tshua muaj tshuaj lom. Cov tshuaj Penicillin yog cov tshuaj lom tsawg tshaj plaws ntawm txhua yam tshuaj tua kab mob, tab sis lawv feem ntau ua rau muaj kev tsis haum tshuaj. 

Kev tsis haum tshuaj tsuas yog pom thaum haus mis nyuj; penicillins nyob rau hauv nqaij qaib nqaij thiab qe feem ntau ua rau muaj kev tsis haum tshuaj, tshwm sim raws li urticaria, kub taub hau, sib koom o thiab mob, cellulitis thiab angioedema. Vim tib neeg muaj qhov tshwj xeeb ntawm kev ua xua rau penicillin (1% txog 8%), ob qho tib si WHO thiab FAO tau hais tias tsis pub penicillin residues nyob rau hauv cov nqaij thiab nqaij qaib qe.

Aminoglycoside tshuaj tua kab mob, sawv cev los ntawm neomycin, gentamicin thiab kanamycin, feem ntau yog siv los kho cov nqaij qaib enteritis, enterotoxic syndrome thiab E. coli. Hom tshuaj residue no paub txog nws cov neurotoxicity. 

Nws feem ntau ua rau kev puas tsuaj rau lub paj hlwb, xws li kev taug kev tsis ruaj khov, tsis txaus ntseeg thiab lag ntseg. Qhov thib ob, nws muaj cov nyhuv curare-zoo li los thaiv cov kab mob neuromuscular endplate, ua rau cov leeg tuag tes tuag taw thiab tuag tes tuag taw. 

Nws kuj tseem ua rau lub raum puas, uas tuaj yeem ua rau muaj kev nce ntxiv ntawm cov lysosomes hauv cov tubules sib thooj, o ntawm mitochondria, tso cov microvilli ntawm txhuam ciam teb, hematuria, ntshav qab zib mellitus, proteinuria thiab tubular zis.

1. 8 feeb nyeem cov txiaj ntsig

2. Kev txwv tsis pub teb rau EU thiab Asmeskas FDA cov cai

3. Kev ntsuas ib leeg rau txhua qhov qauv piv txwv

4. Tsis yog cov kws tshaj lij lossis cov cuab yeej xav tau

5. Qhov muag txhais lus lossis ntsuas ntau, tsim nyog rau kev sim thiab siv hauv chaw

6. Chav sov cia

7. Cov-tsis muaj tshuaj lom thiab tsis muaj mob

Neomycin Streptomycin Gentamicin Combo Test yog ib qho tshuaj tiv thaiv kab mob colloidal kub-chromatography uas kuaj pom Neomycin, Streptomycin thiab Gentamicin hauv cov mis nyuj nyoos, mis hmoov, mis nyuj pasteurized thiab ua tau raws li EU MRL. Cov khoom siv no tuaj yeem siv rau ntawm qhov chaw sim nrawm los ntawm ntau lub tuam tsev.

Cov piv txwv suav nrog: mis nyuj nyoos, mis hmoov, mis nyuj pasteurized.

LOD tuaj yeem hloov pauv raws li qhov xav tau lossis qhov txawv ntawm qhov sib txawv, thov mus saib hauv phau ntawv qhia kom paub meej ntxiv.

Neomycin Streptomycin Gentamicin Combo Test tuaj yeem pab cov tuam txhab lag luam, cov koom haum tswj hwm, thiab cov pej xeem saib xyuas cov khoom zoo thiab pab tib neeg kom lawv noj qab haus huv.

1. Micro-Well Reagent: 8 kuaj/raj, 12 raj/thawv

2. Xeem Sawb: 8pcs/raj, 96pcs/box

3. Phau Ntawv Qhia: 1pc

1. Qauv Raj

2. Mini Pipette & Pipette Ntsis

3. Zoo-Tais

1. Ntxiv 200ul mis mus rau hauv lub qhov dej, tom qab ntawd xa dej mus thiab nqis rau 10 zaug kom sib xyaw cov qauv nrog cov tshuaj reagent hauv lub qhov dej.

2. Tom qab ntawd muab tso rau 3 feeb.

3. Ntxig daim ntawv xeem rau hauv micro-zoo-phaj nrog cov qauv ncoo siab dipped.

4. Tom qab 5 feeb, nyeem cov txiaj ntsig.

Thaum tshuaj tua kab mob tau siv thawj zaug rau tib neeg, peb suav tias lawv yog "catholicon". Raws li qhov teeb meem ntawm kev siv tshuaj tua kab mob txuas ntxiv mus zuj zus, lawv qhov kev tiv thaiv kuj tseem ua rau muaj kev puas tsuaj loj rau tib neeg.

Yog li, hauv lub neej txhua hnub, peb yuav tsum zam zaub mov nrog tshuaj tua kab mob seem. Thawj kauj ruam rau kev pab tus kheej: peb yuav tsum kuaj cov tshuaj tua kab mob seem.

Thov txheeb xyuas phau ntawv teev npe online thiab tiv tauj peb tus sawv cev muag ntawm email: info@ballyabio.com ib lossis sau daim foos tiv toj hauv qab no: