BTStr 3 Sensors

Cov khoom siv Tri Sensor, ceev ceev los kuaj xyuas betalactam, tetracycline thiab streptomycin residues hauv cov mis nyuj thiab cov khoom siv mis nyuj los ntawm kev siv cov tshuab colloidal kub immune-chromatography technology. Sai li 7-10 feeb kom tau txais txiaj ntsig.

Tshuaj tua kab mob beta-lactam xws li penicillin thiab nws cov derivatives, cephalosporins, monoamide rings, carbapenems thiab penicillene enzyme inhibitors thiab lwm yam. β-lactam tshuaj tua kab mob (β-lactams) xa mus rau cov chav kawm loj ntawm cov tshuaj tua kab mob nrog β-lactam nplhaib hauv cov qauv tshuaj. Yeej txhua yam tshuaj tua kab mob uas suav nrog β-lactam core hauv lawv cov qauv molecular muaj rau β-lactams Cov tshuaj tua kab mob.

Lawv tau siv dav siv tshuaj tua kab mob, suav nrog penicillins thiab cephalosporins uas feem ntau siv hauv kev kho mob, nrog rau cov tshuaj tshiab tshiab cephalosporins, thiomycins, monocyclic β-lactams, thiab lwm yam. Cov tshuaj tua kab mob zoo li no muaj qhov zoo ntawm cov kab mob muaj zog, tsis muaj tshuaj lom, kev qhia dav thiab zoo. kev kho mob ua tau zoo. 

Cov txheej txheem tshuaj lom neeg ntawm cov tshuaj no, tshwj xeeb tshaj yog kev hloov pauv ntawm cov saw sab, tau tsim ntau yam tshuaj tua kab mob nrog cov tshuaj tua kab mob sib txawv thiab cov tshuaj tiv thaiv kab mob thiab ntau yam khoom siv tshuaj kho mob.

Cov txheej txheem ntawm kev ua ntawm ntau yam antibiotics-lactam tshuaj tua kab mob zoo ib yam. Lawv tuaj yeem tiv thaiv cell phab ntsa mucopeptide synthase, uas yog penicillin khi cov protein (PBPs), yog li ua rau cuam tshuam kev sib txuas ntawm cell phab ntsa mucopeptides, ua rau cov kab mob cell phab ntsa puas thiab nthuav cov kab mob. 

Ib qho ntxiv, qhov ua rau tuag ntawm cov kab mob yuav tsum suav nrog ua rau muaj kev ua haujlwm autolysin ntawm cov kab mob, thiab cov kab mob hloov pauv yam tsis muaj autolysin qhia ua haujlwm. Cov tsiaj tsis muaj phab ntsa ntawm tes thiab tsis cuam tshuam los ntawm cov tshuaj β-lactam. Yog li ntawd, cov tshuaj no tau xaiv cov tshuaj tua kab mob rau cov kab mob thiab muaj tshuaj lom tsawg rau tus tswv tsev.

Tetracycline cov txheej txheem ntawm kev ua yog tias cov tshuaj tuaj yeem khi rau A txoj haujlwm ntawm 30S subunit ntawm ribosome los tiv thaiv kev sib txuas ntawm aminoacyl-tRNA ntawm txoj haujlwm no, yog li inhibiting kev loj hlob ntawm peptide chains thiab cuam tshuam cov protein synthesis ntawm cov kab mob lossis lwm yam. kab mob pathogenic microorganisms. 

Nws feem ntau tsis siv rau cov kab mob kab mob, tab sis feem ntau yog siv rau cov kab mob rickettsial, brucellosis, lymphogranuloma, mycoplasma mob ntsws, spirochetes, chlamydia, thiab lwm yam. Qhov ncauj nqus tsis tiav. Tetracycline tuaj yeem tso rau hauv cov kua mis thiab nkag mus rau hauv tus menyuam hauv plab, ua rau muaj kev cuam tshuam tsis zoo rau cov xeeb ntxwv. Intravenous drip tswj tam sim no tsis tshua siv.

Tetracycline hydrochloride muaj ib tug dav-spectrum anti-pathogenic microorganism nyhuv, yog ib tug ceev ceev antibacterial neeg sawv cev, thiab muaj ib tug bactericidal nyhuv ntawm tej yam kab mob ntawm high concentrations. 

Cov txheej txheem ntawm kev ua yog tias cov tshuaj tuaj yeem cuam tshuam tshwj xeeb rau A txoj haujlwm ntawm 30S subunit ntawm ribosome txhawm rau tiv thaiv kev sib txuas ntawm aminoacyl-tRNA ntawm txoj haujlwm no, yog li cuam tshuam kev loj hlob ntawm peptide saw thiab cuam tshuam cov protein sib txuas ntawm cov kab mob lossis lwm yam pathogenic microorganisms.

Qhov thib ob, tetracyclines tuaj yeem ua rau muaj kev hloov pauv ntawm cov kab mob ntawm cov kab mob ntawm cov kab mob hauv lub cev, yog li kev xau ntawm nucleotides thiab lwm yam khoom tseem ceeb hauv cov cell, yog li txwv tsis pub DNA rov ua dua. 

Tetracycline muaj zog tiv thaiv kab mob tiv thaiv Staphylococcus aureus, pneumococcus, Streptococcus pyogenes, Neisseria gonorrhoeae, meningococcus, Escherichia coliAerobacter, Shigella, Yersinia, Listeria monocytogenes, Rickettsia, Mycoplasma, Chlamydia, Actinomycetes, thiab lwm yam.

Streptomycin yog ib tug dav-spectrum alkaline tshuaj tua kab mob muab rho tawm los ntawm kab lis kev cai broth ntawm Streptomyces griseus. Cov mis mos molecular yog C21H39N7O12, cov qauv molecular yog complex, muaj streptoguanidine, streptose thiab N-methyl-L-glucose. 

Nws feem ntau muaj nyob rau hauv daim ntawv ntawm sulfate, dawb los yog daj me ntsis crystals, odorless thiab iab, hygroscopic, yooj yim soluble nyob rau hauv dej, insoluble nyob rau hauv methanol, ethanol, acetone, chloroform thiab ether, thiab kuj ruaj khov.

Vim tias streptomycin muaj ib pawg aldehyde hauv nws cov molecule, uas tsis ruaj khov thiab dhau los ua dihydrostreptomycin tom qab hydrogenation. Cov tshuaj streptomycin feem ntau yog streptomycin A thiab streptomycin B. Streptomycin muaj cov tshuaj tua kab mob muaj zog ntawm Mycobacterium tuberculosis thiab yog ib qho tseem ceeb tshuaj tiv thaiv TB. Qhov tsawg kawg nkaus inhibitory concentration rau Mycobacterium tuberculosis feem ntau yog 0.5μg / ml.

Agricultural streptomycin yog tshuaj tua kab mob zais los ntawm Streptomyces griseus. Nws muaj ib tug systemic kho nyhuv. Nws tuaj yeem nkag mus rau hauv cov nroj tsuag lub cev thiab kis mus rau lwm qhov chaw nrog cov txiaj ntsig zoo ntawm cov kab mob nroj tsuag. Nws tuaj yeem tswj cov kab mob kab mob zoo, xws li txiv apples, pear hluav taws blight, haus luam yeeb wildfire, xiav pwm, mos rot ntawm cabbage, txiv lws suav kab mob rot, lig blight, qos noob qos yaj ywm rot, dub shank, dib angular nplooj chaw, downy mildew. , raum taum downy mildew, kab mob blight, celery kab mob blight, sesame kab mob nplooj. Nws yog tsuas yog siv los tswj cov kab mob nplooj ntoos blight, kab mob nplooj ntoos, citrus canker, thiab dib kab mob angular nplooj. Nws tuaj yeem siv rau kev txau, hauv paus irrigation thiab noob soaking.

Kev tshawb pom ntawm streptomycin tau ua rau muaj txiaj ntsig zoo rau kev kho tuberculosis. Tuberculosis yog ib yam kab mob kho tsis tau thaum pib ntawm lub xyoo pua 20th, thiab ntau txhiab tus neeg tuag rau nws txhua xyoo. Xyoo 1888, Waxman hauv Tebchaws Meskas qee zaus pom tias cov kab mob tuberculosis ploj tom qab nkag mus rau hauv av. 

Tom qab 3 xyoos ntawm kev tshawb fawb, nws tau pom tias muaj qee yam kab mob uas tsis muaj tshuaj lom hauv cov av uas tuaj yeem tua cov kab mob tuberculosis. Xyoo 1939, Waxman tau muab ntau yam pwm thiab cov kab mob sib kis los ntawm cov av hauv cov av, cais lawv ib qho los ntawm ib qho ntawm ntau qhov kev sim, thiab thaum kawg tau rho tawm streptomycin los ntawm kab lis kev cai broth ntawm streptomyces hauv xyoo 1943, uas muaj txiaj ntsig zoo hauv kev kho tuberculosis.

Tom qab ntawd, nws tau pom tias streptomycin kuj tseem siv tau rau cov kab mob meningitis. Xyoo 1952 Waxman yeej qhov Nobel nqi zog hauv tshuaj rau qhov no. Tuam Tshoj tau pib yug me nyuam thiab tsim cov kab mob streptomycin hauv xyoo 1958.

Streptomycin yog tshuaj tua kab mob aminoglycoside. Los ntawm kev ua ntawm ribosomes nyob rau hauv cov kab mob, nws inhibits cov kab mob protein synthesis thiab rhuav tshem cov kev ncaj ncees ntawm cov kab mob cell membranes. 

Cov tshuaj tuaj yeem ua ntej dhau los ntawm cov porins ntawm cov cell membrane sab nraud los ntawm kev sib kis tsis zoo, thiab tom qab ntawd nkag mus rau hauv lub cell los ntawm qhov kev thauj mus los no, thiab irreversibly khi rau cov ribosome 30s subunit cais, ua rau kev puas tsuaj ntawm A site, thiab tom qab ntawd: tiv thaiv. qhov tseeb qhov chaw ntawm tRNA ntawm txoj hauj lwm A thiab cuam tshuam nrog kev sib sau ua ke ntawm kev ua haujlwm ribosome thiab inhibiting kev tsim ntawm 70s pib complex; inducing lub mismatch ntawm tRNA thiab mRNA code triplet, ua rau lub 30s subunit ntawm lub ribosome tsis zoo nyeem cov noob caj noob ces, ua rau txawv txav thiab tsis-functional protein synthesis; cuam ​​tshuam qhov kev txiav txim siab los ntawm kev khi rau qhov chaw A, kom cov saw hlau peptide tsis tuaj yeem raug tso tawm, thiab tiv thaiv kev sib cais ntawm cov ribosomes tsis zoo hauv 70s; cuam ​​tshuam cov txheej txheem depolymerization thiab kev sib dhos ntawm polyribosomes, ua rau cov kab mob hauv vivo Ribosome depletion.

Tom qab Tuam Tshoj tau koom nrog WTO, cov khoom lag luam nqaij qaib rov qab los ntawm txawv teb chaws qhia peb tias cov kev cuam tshuam rau kev xa tawm cov khoom nqaij qaib nkag mus rau thoob ntiaj teb kev ua lag luam tau thicker. 

Txhawm rau ua raws li OIE cov kev nyiam huv zaub mov thiab kev nyab xeeb, peb yuav tsum hloov peb txoj kev tsim tsiaj txhu ib txwm muaj, txwv tsis pub siv tshuaj thiab tshuaj tua kab mob ntau tshaj li tus qauv. Tam sim no, kev phom sij ntawm cov tshuaj residues ncaj qha cuam tshuam rau kev noj qab haus huv thiab kev nyab xeeb, thiab yog tias tsis tswj hwm, nws yuav ua rau muaj kev phom sij rau tib neeg kev noj qab haus huv.

Streptomycin tuaj yeem ua rau pob ntseg tsis zoo thiab ua rau lub raum tsis ua haujlwm. Pub mis nyuj nrog streptomycin tuaj yeem ua rau muaj kev phom sij rau cov menyuam yaus los ntawm cov streptomycin seem hauv cov nqaij. Kev siv cov tshuaj chloramphenicol tuaj yeem ua rau muaj ntshav tsis txaus. 

Qhov tseem ceeb yog qhov ntawd chloramphenicol yuav npog cov tsos mob thiaj li ua rau muaj kev tuag ntau ntxiv. Tsis tas li ntawd, nyob rau hauv xyoo tas los no, cov khoom seem ntawm cov khoom broiler tau siv los tsa mink, thiab cov tshuaj seem hauv cov hnyuv nqaij qaib tau tua cov mink txhua xyoo. Kev tshuaj xyuas thiab kev soj ntsuam ntawm cov hnyuv nqaij qaib pom tias cov tshuaj chloramphenicol ntau tshaj peb npaug ntawm cov nyiaj tau teev tseg thiab cov ntsiab lus ntawm maduramycin tshaj tsib npaug ntawm cov nyiaj tso cai. Cov qaib no tuag ntawm kev lom vim overfeeding ntawm cov tshuaj residues.

Cov tshuaj tua kab mob tseem nyob hauv ib puag ncig, rov faib rau hauv av, dej thiab sediments, uas yuav cuam tshuam rau ecological ib puag ncig xws li cov nroj tsuag, av microbial systems, thiab cov dej hauv av. Thiab los ntawm cov khoom noj khoom haus ntawm lub ntiaj teb lom neeg, lawv yuav ua rau tib neeg lub cev puas tsuaj thiab ib puag ncig ntuj. 

Cov teb chaws tsim kho nyob hauv Europe thiab Amelikas tau ua tiav cov kev cai txwv tsis pub ntxiv cov tshuaj tua kab mob rau tsiaj pub. Cov European Union tau pib ncua kev ntxiv ntau cov tshuaj tua kab mob loj rau tsiaj pub rau xyoo 1970s. Txog tam sim no, European Union tau pom zoo tias tsis muaj tshuaj tua kab mob ntxiv rau tsiaj pub. Lub US Food and Drug Administration (FDA) npaj yuav txwv tsis pub siv cov tshuaj tua kab mob hauv cov tsiaj txhu pub rau peb xyoos txij li xyoo 2014.

1. 8 feeb nyeem cov txiaj ntsig

2. Kev txwv tsis pub teb rau EU thiab Asmeskas FDA cov cai

3. Kev ntsuas ib leeg rau txhua qhov qauv piv txwv

4. Tsis yog cov kws tshaj lij lossis cov cuab yeej xav tau

5. Qhov muag txhais lus lossis ntsuas ntau, tsim nyog rau kev sim thiab siv hauv chaw

6. Chav sov cia

7. Cov-tsis muaj tshuaj lom thiab tsis muaj mob

Betalactam Tetracycline Streptomycin Combo Test yog ib qho kev ntsuam xyuas colloidal kub immunochromatography uas kuaj pom Beta-lactams, Tetracycline thiab Streptomycin hauv cov mis nyuj nyoos, mis hmoov, mis nyuj pasteurized thiab raws li EU MRL. Cov khoom siv no tuaj yeem siv rau ntawm qhov chaw sim nrawm los ntawm ntau lub tuam tsev.

Cov piv txwv suav nrog: mis nyuj nyoos, mis hmoov, mis nyuj pasteurized.

LOD tuaj yeem hloov pauv raws li qhov xav tau lossis qhov txawv ntawm qhov sib txawv, thov mus saib hauv phau ntawv qhia kom paub meej ntxiv.

Betalactam Tetracycline Streptomycin Combo Test tuaj yeem pab cov tuam txhab lag luam, cov koom haum tswj hwm, thiab cov pej xeem saib xyuas cov khoom zoo thiab pab tib neeg kom lawv noj qab haus huv.

1. Micro-Well Reagent: 8 kuaj/raj, 12 raj/thawv

2. Xeem Sawb: 8pcs/raj, 96pcs/box

3. Phau Ntawv Qhia: 1pc

1. Qauv Raj

2. Pipette & Pipette Tip

3. Zoo-Phaj

1. Ntxiv 200ul mis mus rau hauv lub qhov dej, tom qab ntawd xa dej mus thiab nqis rau 10 zaug kom sib xyaw cov qauv nrog cov tshuaj reagent hauv lub qhov dej.

2. Tom qab ntawd muab tso rau 3 feeb.

3. Ntxig qhov ntsuas ntsuas mus rau hauv lub qhov dej zoo nrog cov qauv ntsuas phoo tag nrho.

4. Tom qab 5 feeb, nyeem cov txiaj ntsig.

Thaum tshuaj tua kab mob tau siv thawj zaug rau tib neeg, peb suav tias lawv yog "nostrum". Raws li qhov teeb meem ntawm kev siv tshuaj tua kab mob txuas ntxiv mus zuj zus, lawv qhov kev tiv thaiv kuj tseem ua rau muaj kev puas tsuaj loj rau tib neeg.

Yog li, hauv lub neej txhua hnub, peb yuav tsum zam zaub mov nrog tshuaj tua kab mob seem. Thawj kauj ruam rau kev pab tus kheej: peb yuav tsum kuaj cov tshuaj tua kab mob seem.

Thov txheeb xyuas phau ntawv teev npe online thiab tiv tauj peb tus sawv cev muag ntawm email: info@ballyabio.com ib lossis sau daim foos tiv toj hauv qab no: