Physical and chemical properties
Appearance and properties: yellow powder or crystalline powder, odorless, slightly bitter after initial taste, very slightly soluble in water and ethanol, slightly soluble in chloroform, insoluble in ether, easily soluble in dimethylformamide and nitromethane
Density: 1.66 g / cm3
Melting point: 254-256ºC (dec.)
Boiling point: 353.4ºC at 760 mmHg
Refractive index: 1.669
Stability: stable, flammable, incompatible with strong oxidants.
Storage conditions: 0-6ºC

This product is a nitrofuran antibacterial. Antibacterial effect on Gram-positive and negative bacteria, including Salmonella, Shigella, E. coli, Klebsiella pneumoniae, Enterobacter, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Cholera Vibrio, Campylobacter and Bacteroides are also active against Trichomonas and Giardia under certain concentrations. Its mechanism of action is to interfere with bacterial oxidoreductase and thereby block the normal metabolism of bacteria.

1. Ethanolamine is used as a raw material to condense with urea to obtain β-hydroxyethyl urea, which is nitrosated and cyclized to obtain 3-nitroso-2-azolidinone. Further reduction with iron powder and condensation with 5-nitro-2-furfuryl glycol diacetate and formaldehyde yield furazolidone.
2. Condensation of ethanolamine with urea, nitrosation and cyclization with sodium nitrite, and finally reduction with iron powder with 5-nitro-2-furfuryl glycol diacetate and formaldehyde to obtain furazolidone.

This product has a broad-spectrum antibacterial effect and is effective against common Gram-negative and positive bacteria. However, it is difficult to absorb after oral administration, so the concentration of the drug in the intestine is high. It is clinically applicable to various intestinal infections, such as enteritis and diarrhea. It has certain control effects on piglet white pheasant, piglet paratyphoid, avian white pheasant, avian typhoid, chicken and turkey cecum hepatitis, and coccidiosis.

When used as a veterinary drug, furazolidone has a good effect on the prevention and treatment of certain protozoan diseases, water mold diseases, bacterial rotten gills, erythroderma, and bleeding diseases.
In the breeding industry, furazolidone can be used to treat intestinal infections in livestock and poultry, such as piglet yellow and white pheasant. In the aquaculture industry, furazolidone has a certain effect on the infection of cerebral myxosoma by Salmonella.

It is usually used to treat intestinal infections and coccidiosis in dogs, and it is effective against E. coli and dysentery.

For cat intestinal infections, coccidiosis, giardiasis have significant effects.

Furazolidone is the main component of tetriline, an ornamental fish medicine "yellow powder", which can interfere with the bacterial sugar metabolism process and oxidase system and exert bacteriostatic or bactericidal effects. So it can be used to treat bacterial diseases of ornamental fish disease. And the effect is very good.

Adverse reactions mainly include nausea, vomiting, diarrhea, headache, dizziness, drug fever, rash, anal itching, asthma, orthostatic hypotension, hypoglycemia, pulmonary infiltration, and occasionally hemolytic anemia, jaundice, and polyneuritis.

Excessive use of furazolidone may cause gastrointestinal reactions (such as nausea, vomiting, anorexia, diarrhea, generally mild reactions); allergic reactions such as hemolytic anemia, rash, drug fever, etc. PH deficiency can cause hemolytic anemia.
Overdose or long-term continuous medication can cause animal poisoning and severely cause animal death. It can cause irreversible damage to the central nervous system, and can cause diseases such as hemolytic liver necrosis in the human body.
Studies have also shown that furazolidone for long or high doses has varying degrees of toxic and side effects on liver, kidney, heart, hypothalamus and reproductive systems of animals.

(1) Combination with tricyclic antidepressants can cause acute toxic psychosis and should be avoided.
(2) This product can enhance the effect of levodopa.
(3) Sympathomimetic amines, tyramine-rich foods, appetite suppressants, monoamine oxidase inhibitors, etc. can enhance the effect of this product.

Furazolidone is listed as a banned drug by the Ministry of Agriculture of the People's Republic of China and cannot be detected in animal foods. The FDA also banned the use of nitrofurans (including furazolidone) in animal food in 2002. The State Food and Drug Administration announced today (February 15) that due to serious adverse reactions, it has decided to stop the production, sales and use of furazolidone-containing compound preparations in China.

Veterinary drugs play a very important role in the modern breeding industry, but in fact, some breeders or enterprises in order to save costs and obtain higher antibacterial effects, regardless of national regulations, repeatedly use antibacterial drugs or even use alternative veterinary drugs, resulting in animal origin Foods Although hydrogen nitrate is a broad-spectrum antibacterial drug, it has a bactericidal effect on most Gram-positive bacteria and Gram-negative bacteria, but research has found that these drugs are carcinogenic, mutagenic and teratogenic. Therefore, countries have listed it as an alternative veterinary drug.
The Furazolidone Rapid Test (0.5ppb) provided by BALLYA can effectively detect whether furazolidone is contained in the test object, ensuring the safety of consumers. The operation of the kit is very simple, and the detection time is short, the accuracy is high.

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