is an antibiotic drug, which produces a broad spectrum of bacteriostatic effects by inhibiting the activity of peptide acyltransferases, and has a broad antibacterial spectrum, including various Gram-positive, negative bacteria and mycoplasma. Sensitive bacteria include bovine and porcine haemophilus, Shigella dysenteriae, Salmonella, E. coli, pneumococcus, influenzae, streptococcus, staphylococcus aureus, chlamydia, leptospira, rickettsial, and the like.
Florfenicol mechanism of action
Antibiotics have a broad spectrum of bacteriostatic effects by inhibiting peptide acyltransferase activity, including a wide range of gram-positive, negative bacteria, and mycoplasma. Sensitive bacteria include bovine and porcine haemophilus, Shigella dysenteriae, Salmonella, E. coli, pneumococcus, influenzae, streptococcus, staphylococcus aureus, chlamydia, leptospira, rickettsial, and the like. This product can be diffused into bacterial cells through fat solubility, and mainly acts on the 50s subunit of the bacterial 70s ribosome, inhibits the transpeptidase, hinders the growth of the peptidase, and inhibits the formation of peptide chains, thereby preventing protein synthesis and achieving Antibacterial purpose. This product has a broad antibacterial spectrum and is effective against Gram-positive and Gram-negative bacteria and Mycoplasma. This product is quickly absorbed orally, widely distributed, long half-life, high blood concentration, and long blood maintenance time.
It is a new veterinary chloramphenicol broad-spectrum antibacterial agent successfully developed in the late 1980s.
It was first marketed in Japan in 1990. Norway approved the drug for salmonella in 1993. In 1995, France, the United Kingdom, Austria, Mexico, and Spain approved the treatment of bovine respiratory bacterial diseases. It has also been approved as a feed additive for pigs in Japan and Mexico to prevent and treat bacterial diseases in pigs, and China has now approved the drug.
The antibacterial spectrum and antibacterial activity of this product are slightly better than those of sulfomycin, and it has strong antibacterial activity against a variety of Gram-positive bacteria, Gram-negative bacteria and mycoplasma. Hemolytic Pasteurella, Pasteurella multocida, Actinobacillus pleuropneumoniae are highly sensitive to this product, and are highly resistant to Streptococcus, Shigella dysenteriae, Salmonella typhi, Klebsiella, large intestine Both Bacillus and Haemophilus influenzae are sensitive. Bacteria can develop acquired resistance to florfenicol and cross-resistance with sulfomycin, but due to the inactivation of acetyltransferase, bacteria resistant to chloramphenicol and this product is still sensitive to it.
It is mainly used for bacterial diseases of cattle, pigs, chickens and fish, such as bovine respiratory diseases caused by Pasteurella, Haemophilus, bovine infectious keratoconjunctivitis, actinomyces pleuropneumoniae, and fish scab. It can also be used to treat cow mastitis caused by various pathogenic bacteria.
Florfenicol can be used to treat colds and runny noses in dogs, it can be used to treat bacterial respiratory infections, and it is also effective for mycoplasma. There is no problem in treating common colds, but some viral infections have similar symptoms to colds, such as canine Flu, etc. At this time, using fenfenicol has no effect, it is recommended to seek medical treatment in a timely manner.
It is mainly used to treat various infections caused by sensitive bacteria, especially for respiratory diseases. This product is recommended as the first drug for pasteurellosis (pneumonia of pigs), infectious pleural pneumonia, and haemophilus parasuis. It can also be used to treat various respiratory diseases caused by Streptococcus (pneumonia), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (pig asthma).
It can also be used to treat various respiratory diseases caused by Streptococcus (pneumonia), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (pig asthma), salmonellosis (piglet paratyphoid), and E. coli disease (piglets Yellow and white pupa, piglet edema) and other bacterial diseases such as enteritis caused by sensitive bacteria.
It is mainly used to treat fish bacterial sepsis, enteritis, erythroderma, etc. caused by Pasteurella, Vibrio, Staphylococcus aureus, hydrophilic single cell, enterobacteria, etc.
Florfenicol in poultry
Treatment of intestinal diseases, respiratory diseases and mycoplasma infections caused by avian sensitive bacteria and mycoplasma infection. Such as avian colibacillosis, chicken whitefly, pasteurosis, typhoid fever, paratyphoid fever, cholera, bacterial infection of the intestinal tract of the bird, pericarditis, perihepatitis, peritonitis, bacterial swelling syndrome, necrotic enteritis, duck infectivity Serositis and so on. Symptoms: birds stretch their necks and open their mouths to breathe, panting, tracheal bleeding, shaking their heads, runny nose, swollen heads, bowel infections, salpingitis, etc.; autopsy is common: liver swelling of sick birds, yellow and white on the liver surface and hear Cellulose membrane, yellow cheese-like secretions, etc.
Has a strong immunosuppressive effect, about 6 times stronger than chloramphenicol.
Long-term oral administration can cause digestive disorders, symptoms of vitamin deficiency or double infection.
Embryo toxic, be used with caution during pregnancy and lactation.
Florfenicol human toxicity
It is hematologically toxic and although it does not cause irreversible bone marrow aplastic anemia, its reversible inhibition of red blood cell production is more common than chloramphenicol.
Overdose chickens have a faster onset and begin to show depression, loose feathers, sagging wings, neck closure with eyes closed, sacroiliac joints landing, standing unstable or falling to the ground due to loss of balance; chickens with slightly lower doses The onset was slightly slower, showing excitement, dyskinesia, shaking his neck, shaking his head, whole body tremor, whirring in circles, running forward unintentionally, and suddenly falling to the ground and convulsing to death; light doses and prolonged manifestations of depression, breath opening, feeding, Drinking water increased, loose feathers, squatting still, row of yellow-white or light green and watery thin stools, and finally gradually died and died.
Florfenicol poisoning treatment
After the chickens are diagnosed with florfenicol poisoning, stop using the drug immediately, add 3% to 5% glucose and various vitamins in drinking water, and add probiotics and acid preparations to feed and drinking water to restore stomach The intestinal environment and reconstruction of the bacterial population balance system can effectively control the disease within 4 to 5 days.
Florfenicol is a broad-spectrum antibacterial drug. Because of its fast absorption, wide distribution, and half-life field, oral florfenicol is favored by farmers and has a wide range of antibacterial properties. Florfenicol powder is mainly used to treat livestock and poultry diseases. But the treatable diseases are quite different. The more florfenicol is used, the more likely florfenicol remains in agricultural products.
The Florfenicol Rapid Test (tissue) kit provided by BALLYA
can effectively detect Florfenicol in agricultural products. This kit is not only simple to operate, but also has a short test time and high accuracy, and the test results comply with EU standards. Can effectively ensure the safety of agricultural products.