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Danofloxacin Test For Chicken(R&D)

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beta-lactams-Test-Kit

For various types of chicken

Specs:96T / box
Testing Time:7-10 mins
Worldwide shipping, free sample

Instrution For Danofloxacin Test For Chicken

Introduction
Single Test Kit, rapid to detect an antibiotic residues in milk and dairy product by using colloidal gold immunochromatography technology. As soon as 7-10 minutes to results.

Application
For raw milk, whole milk powder, Pasteurized milk.

Spicifications
1. Specificity
Not cross-react with macrolides, aminoglycosides, sulfonamides drugs, etc.

2. Limit of Detection
Refer to instruction.

Storage & Shelf-Life
At 2~8℃ out of sunlight, 12 months

Compolents (96T / box)
Instruction                          1
Tube                                     12

Equipments (Option)
Timer
Incubator
Mini Pipette(200μL)
Tips for mini pipette
Reader

Operations
1. Take 200 μL milk specimen, add into micro well, mix with the pink agent 10 times.
Remark: avoid specimen residues too much in the well.
2. Incubate 3 minutes
3. Insert strips into the wells
4. Incubate 5 minutes
5. Take out strips and read results by eye or reader.

Interpretation
Visual inspection
1. If C line visible, interpret according to the instruction. T line compare with C line to interpret positive or negative.
2. If C & T are invisible, it’s invalid detection, repeat testing again.

Reader Interpretation
Refer to the instruction

Results Illustration

If you want to know more, please contact us

Trivia questions: Do you know danofloxacin?

About danofloxacin

Danofloxacin is a kind of fluoroquinolone medicine, which belongs to animal special drugs. It is generally used as its mesylate salt, danofloxacin mesylate. All have strong antibacterial activity. Excessive residues of quinolones are likely to induce bacterial resistance and cause harm to human health. The EU's maximum residue limit for fluoroquinolones including danofloxacin in food animals is: muscle 100μg / kg, Liver and kidney 200μg / kg, poultry and pig edible tissue 50μg / kg.

Mechanism of action of danofloxacin

The drug concentration in lung tissue can reach 5-7 times of plasma. Oral administration, intramuscular injection and subcutaneous injection are more rapid and complete. The bioavailability of chicken oral administration is 100%; the bioavailability of pig oral administration is 89%; the bioavailability of cattle oral administration is 72%. Excreted mainly through the kidneys. Danofloxacin mesylate is rapidly absorbed and distributed in crucian carp, and eliminated slowly; the drug has strong penetration and wide distribution in tissues, and the drug concentration in tissues is significantly higher than that in plasma from 12h to 168h (P <0.05). The hepatopancreas and kidneys had the highest drug concentration in all tissues. The elimination half-lives of kidney, hepatopancreas, plasma, muscle and skin were 33h, 44h, 48h, 51h and 177h, respectively. After 120 hours of administration, the drug concentration in the skin was 1.99 ± 0.32 μg / g, after 168 hours of administration, the drug concentration in the skin was 1.72 ± 0.31 μg / g, and in muscle was 0.70 ± 0.32 μg / g, compared with other tissues in the skin The elimination of the drug is the slowest, and it is recommended as the residual accumulation tissue of DFM in crucian carp.

Danofloxacin synthesis

Using trans-4-hydroxy-L-proline as the raw material, it is obtained by amino protection, carboxyl reduction, hydroxysulfonylation, ring closure, and deprotection to obtain (15, s4) -2-methyl-2,5 -Diazabicyclo [2.2.1] heptane hydrobromide, which is then reacted with cyclopropanecarboxylic acid to produce danofloxacin.

Danofloxacin uses

Danofloxacin indications

This product is a broad-spectrum bactericide. It has strong antibacterial activity against Pasteurella, Mycoplasma and Escherichia coli. Mainly used for avian colibacillosis, avian cholera, chronic respiratory disease, etc., to treat diseases caused by animal bacteria and mycoplasma in cattle, pigs, and chickens.

Danofloxacin dosage

Intramuscular injection, 1 day, danofloxacin mesylate per kg body weight, livestock 10-20 mg, poultry 20-40 mg, divided into two injections. Mixed drink: poultry 15-30 mg per liter of water.

Danofloxacin side effects

Danofloxacin toxicity

Dorfloxacin was orally irrigated with Sturgeon sturgeon at doses of 800, 1040, 1352, 1757.60, 2248.88, 2970.34 mg / kg, and intraperitoneally injected with 400, 440, 532.4, 585.6, and 644.2 mg / kg. Observe the behavior and death of the experimental fish for 10 consecutive days. The LD50 of darofloxacin injected intraperitoneally by Shi's sturgeon was 429.47mg / kg, and the LD50 of dalofloxacin by oral infusion was 1502.10mg / kg. The liver cells of the dead fish were filled with lipid droplets, the mitochondria were broken, the rough endoplasmic reticulum structure was loose and broken, and the lysosome was broken.

Danofloxacin mesylate

Danofloxacin mesylate mainly has a strong antibacterial effect on Gram-positive bacteria (G +), certain anaerobic bacteria and mycoplasma. Sensitive to Staphylococcus aureus, Streptococcus hemolyticus, Pneumococcus, Legionella pneumophila, Mycoplasma, also sensitive to Clostridium, Clostridium welchii, Tetanus, and Bacteroides. Danofloxacin mesylate is clinically used for infections caused by epirubicin and erythromycin; Mycoplasma infection causes chronic respiratory disease and swine asthma in chickens; Necrotizing enteritis in chickens; Treponema pallidum dysentery and toxoplasmosis; Actinomycosis. The quinolone antibacterial mechanism is generally considered to specifically inhibit DNA helicase, acting on the A subunit of DNA helicase, inhibiting the function of helicase, blocking the semi-retained replication of bacterial DNA, causing irreversible damage to chromosomes, and bacteria no longer dividing Therefore, the antibacterial effect is more thorough than that of sulfonamides and antibiotics.

Danofloxacin mesylate solubility

Danofloxacin mesylate is white to light yellow crystalline powder, odorless, bitter, easily soluble in water, slightly soluble in methanol, almost insoluble in chloroform.

Danofloxacin mesylate injection

Reduce the production of drug-resistant bacteria and ensure the effectiveness of levofloxacin mesylate and other antibacterial drugs. Levofloxacin is only used to treat or prevent infections that have been or are highly suspected to be caused by sensitive bacteria. When selecting or modifying antimicrobial treatment regimens, the results of bacterial culture and drug susceptibility testing should be considered.
Levofloxacin mesylate oral preparations and injections can be used to treat the following mild, moderate and severe infections caused by sensitive strains of the following bacteria in adults (≥18 years old). If intravenous drip is more beneficial to the patient (such as the patient cannot tolerate oral administration, etc.), levofloxacin mesylate injection can be used.

Summary

Excessive residues of quinolones are likely to induce bacterial resistance and cause harm to human health. The EU's maximum residue limit for fluoroquinolones including danofloxacin in food animals is: muscle 100μg / kg, Liver and kidney 200μg / kg, poultry and pig edible tissue 50μg / kg.
The detection of danofloxacin is very necessary. The Danofloxacin Test For Chicken kit provided by BALLYA can effectively and quickly detect whether chicken contain danofloxacin residues. Not only is the operation simple and the detection time is short.

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